Dieu est Amour. Il est le Tout-Puissant, et l'homme, sa créature de prédilection, son enfant, se débat contre les forces du mal. Tel est le mystère! Le mal ne tourmente pas seulement la chair et le cœur de l'homme, il met en question sa confiance en Dieu et sa foi. Ce livre ne vise pas à donner à l'esprit une solution claire et suffisante, qui répondrait à ses questions. On ne résout pas un mystère. La tentation de se révolter contre (...) Dieu, à cause du mal qu'il permet, est fallacieuse, car la révolte n'a pas de sens en dehors de la Foi en ce Dieu qu'elle conteste; mais elle n'en a pas davantage à l'intérieur de cette Foi qui Le reconnaît comme infiniment bon et compatissant. Dieu est Amour et il est le Tout-Puissant : mais si son amour même introduisait au cœur de sa puissance une dimension de respect envers sa créature, qui se manifesterait en ce monde par une sorte d'impuissance? Si cette mystérieuse impuissance du Tout-Puissant était la condition nécessaire pour que l'Amour agisse en ce monde par la croix? Amère et incompréhensible ici-bas, la croix apparaîtra un jour comme elle est : instrument de victoire sur la mort, semence de vie et de joie dans la paix éternelle. C'est de cette « impuissance de Dieu » au sein de sa Toute-Puissance et au service de son Amour que l'auteur a osé traiter. (shrink)

La médecine personnalisée expérimente dans le cadre du cancer, ou thérapies ciblées, ou encore médecine prédictive, voire médecine de précision. toutes ces appellations sous-entendent un domaine qui s'ébauche tant au niveau de la recherche qu'à celui de la clinique. Ce domaine se constitue de pratiques, de normes qui s'élaborent et de règles qui établissent de véritables limites. Ce volume présente ce que les disciplines du droit, de la biologie, de la médecine et de la philosophie ont à dire conjointement sur (...) ce nouvel objet qui déjà intéresse au-delà du cancer toutes les maladies chroniques. Ce volume rassemble ainsi les réflexions de tous les pionniers de ce domaine sous la coordination de Michèle Jean-Stanton du Centre de Recherche de Droit Public (CRDP) de l'Université de Montréal et de Christian Hervé de l'Université Sorbonne Paris Cité. Leurs expressions, ainsi exposées à la suite d'un séminaire qu'ils ont tous suivi consciencieusement, affirment ainsi une certaine idée, une éthique même de ces nouvelles pratiques non encore totalement réglementées. (shrink)

Le droit, l'économie, la gestion, l'histoire, la linguistique, la sociologie abordent la question des règles à leur manière propre. Une confrontation de leurs approches apparaît nécessaire et féconde.

BackgroundAt the start of 2021, oncologists lacked the necessary scientific knowledge to adapt their clinical practices optimally when faced with cancer patients refusing or reluctant to be vaccinated against COVID-19, despite the marked vulnerability of these patients to severe, and even fatal forms of this new viral infectious disease. Oncologists at Foch Hospital were confronted with this phenomenon, which was observed worldwide, in both the general population and the population of cancer patients.MethodsBetween April and November 2021, the Ethics and Oncology (...) Departments of Foch Hospital decided to investigate this subject, through an empirical and interdisciplinary study in bioethics. Our scientific objective was to try to identify and resolve the principal bio-ethical issues, with a view to improving clinical practices in oncology during future major pandemics of this kind, from a highly specific bio-ethical standpoint. We used a mainly qualitative methodological approach based on questionnaires and interviews.ResultsIn April 2021, 29 cancer patients refused or were reluctant to be vaccinated. Seventeen of these patients said that making vaccination mandatory would have helped them to accept vaccination. In October 2021, only 10 cancer patients continued to maintain their refusal. One of the main reasons for the decrease in refusals was probably the introduction of the “pass sanitaire” in July 2021, which rendered vaccination indispensable for many activities. However, even this was not sufficient to convince these 10 cancer patients.ConclusionWe identified a key bio-ethical issue, which we then tried to resolve: vaccination policy. We characterized a major tension between “the recommendation of anti-COVID-19 vaccination” and “free will”, and the duty to “protect each other”. Mandatory vaccination, at least in France, could resolve this tension, with positive effects on quality of life, or survival, in cancer patients initially refusing or reluctant to be vaccinated, but only if collective and individual scales are clearly distinguished. (shrink)

Understanding the mechanisms and the time and spatial evolution of penumbra following an ischemic stroke is crucially important for developing therapeutics aimed at preventing this area from evolving towards infarction. To help in integrating the available data, we decided to build a formal model. We first collected and categorised the major available evidence from animal models and human observations and summarized this knowledge in a flow-chart with the potential key components of an evolving stroke. Components were grouped in ten sub-models (...) that could be modelled and tested independently: the sub-models of tissue reactions, ionic movements, oedema development, glutamate excitotoxicity, spreading depression, NO synthesis, inflammation, necrosis, apoptosis, and reperfusion. Then, we figured out markers, identified mediators and chose the level of complexity to model these sub-models. We first applied this integrative approach to build a model based on cytotoxic oedema development following a stroke. Although this model includes only three sub-models and would need to integrate more mechanisms in each of these sub-models, the characteristics and the time and spatial evolution of penumbra obtained by simulation are qualitatively and, to some extent, quantitatively consistent with those observed using medical imaging after a permanent occlusion or after an occlusion followed by a reperfusion. (shrink)

The increasing availability of brain data within and outside the biomedical field, combined with the application of artificial intelligence (AI) to brain data analysis, poses a challenge for ethics and governance. We identify distinctive ethical implications of brain data acquisition and processing, and outline a multi-level governance framework. This framework is aimed at maximizing the benefits of facilitated brain data collection and further processing for science and medicine whilst minimizing risks and preventing harmful use. The framework consists of four primary (...) areas of regulatory intervention: binding regulation, ethics and soft law, responsible innovation, and human rights. (shrink)

Networks for the exchange and/or sharing of genetic data are developing in many countries. We focus here on the situations in the US and France. We highlight some recent and remarkable differences between these two countries concerning the mode of access to, and the storage and use of genetic data, particularly as concerns two-sided markets and dynamic consent or dynamic electronic informed consent. This brief overview suggests that, even though the organization and function of these two-sided markets remain open to (...) criticism, dynamic e-IC should be more widely used, especially in France, if only to determine its real effectiveness. (shrink)

Background Disclosure of obtaining informed consent from patients (ICP) and research ethics committee (REC) approval in published reports is sometimes omitted. To date, no disclosure data are available on surgical research. Objective Our aim was to assess whether REC approval and ICP were documented in surgical trials. Study design Overall, 657 randomised trials, published between 2005 and 2010 in 10 international journals, were included. We collected the report rate of REC approval and ICP and contacted the corresponding author when ethical (...) information was lacking. Results Among the 657 randomised controlled trials (RCT), 576 (87.7%) stated that an REC had approved the research, and 606 (92.2%) stated that ICP had been requested. Furthermore, 28 RCTs (4.3%) reported neither REC nor ICP. Conclusions The phase III randomised surgical trials that were analysed were shown to have respected fundamental ethical principles in approximately 90% of the cases examines. (shrink)

English summary: Nicolas Cusanus' position on Islam is not easily discerned. While in De Pace Fidei he seems to present an Irenic vision of the different religions and the dialog that could be established amongst them, in the Cribratio Alkorani, according to numerous interpretations, he seems more rigid, precluding any constructive dialog between Christianity and Islam. However, as this volume shows, matters are not quite that black and white: the contributions allow us to form a better idea of the coherence (...) of Cusanus' position on dialog and the relationship between the Cribratio Alkorani and his general theological views. French description: La position de Nicolas de Cues sur l'islam n'est pas facile... cerner. Dans le De Pace Fidei, il semble presenter une vision irenique des differentes religions et du dialogue qui pourrait s'etablir entre elles et ce discours general vaut en particulier pour l'islam, tandis que dans la Cribratio Alkorani, Nicolas, aux dire de nombreux interpretes, se montrerait beaucoup plus incisif, au point que ce livre ne pourrait absolument pas constituer le fondement d'un dialogue constructif entre le christianisme et l'islam. Mais un certain nombre de travaux du present volume, montre que les choses ne sont pas si tranchees. Certes, Nicolas de Cues ignorait pas mal de choses sur l'Islam et les documents qu'il utilise l'induisent dans un certain nombre de cas en erreur. Mais, par de l... la lettre, il ressort qu'il a remarquablement compris l'esprit coranique et que ces textes meritent... cet egard plus d'attention qu'ils n'en ont generalement recue. Le present recueil permet de se faire une idee plus precise de la coherence de la position de Nicolas de Cues sur le dialogue entre christianisme et islam et des liens entre les theses de la Cribatio Alkorani et la pensee globale du grand cardinal. Le livre est issu d'un Colloque tenu sur ce theme... l'Universite de Rennes le 9 avril et rassemble des contributions de Walter Andreas Euler, Tom Kerger, Genevieve Gobillot (deux textes), Susan Gottlober, Graziella Federici Vescovini Herve Pasqua.et Jean-Michel Counet. (shrink)

"Y a-t-il une intelligibilité spécifique du problème de l'institution chez Sartre? La question est rarement posée car, trop souvent, on la considère comme d'emblée réglée: Sartre n'aurait pas été capable d'envisager la dimension institutionnelle autrement que sous une forme négative, celle de la pétrification et de la bureaucratisation de l'action insurrectionnelle d'un groupe. Fruit d'un travail collectif, cet ouvrage explore différentes déclinaisons de la notion d'institution dans la réflexion sartrienne des années 1950 et 1960, en montrant son importance pour articuler (...) la question de l'histoire, de la transformation politique et d'une éthique matérialiste. Au fil de ce parcours qui fait dialoguer Sartre avec Merleau-Ponty, Mauss, Lévi-Strauss, Derrida, Riesman, Guattari et bien d'autres, se dessine une conception originale de l'institution. En tant que dynamique historique d'invention collective, elle est porteuse d'une normativité ouverte : c'est moins la stabilité figée que l'instabilité créatrice qui la définit. C'est ce paradoxe d'une 'institution instable' que les contributions ici réunies proposent d'élucider."--. (shrink)

Ghost Image is made up of sixty-three short essays—meditations, memories, fantasies, and stories bordering on prose poems—and not a single image. Hervé Guibert’s brief, literary rumination on photography was written in response to Roland Barthes’s Camera Lucida, but its deeply personal contents go far beyond that canonical text. Some essays talk of Guibert’s parents and friends, some describe old family photographs and films, and spinning through them all are reflections on remembrance, narcissism, seduction, deception, death, and the phantom images (...) that have been missed. Both a memoir and an exploration of the artistic process, Ghost Image not only reveals Guibert’s particular experience as a gay artist captivated by the transience and physicality of his media and his life, but also his thoughts on the more technical aspects of his vocation. In one essay, Guibert searches through a cardboard box of family portraits for clues—answers, or even questions—about the lives of his parents and more distant relatives. Rifling through vacation snapshots and the autographed images of long-forgotten film stars, Guibert muses, “I don’t even recognize the faces, except occasionally that of an aunt or great-aunt, or the thin, fair face of my mother as a young girl.” In other essays, he explains how he composes his photographs, and how—in writing—he seeks to escape and correct the inherent limits of his technique, to preserve those images lost to his technical failings as a photographer. With strains of Jean Genet and recurring themes that speak to the work of contemporary artists across a range of media, Guibert’s Ghost Image is a beautifully written, melancholic ode to existence and art forms both fleeting and powerful—a unique memoir at the nexus of family, memory, desire, and photography. (shrink)

Le présent ouvrage vise à présenter des approches non-duales de la réalité issues d'aires géographiques et d'horizons disciplinaires différents: Advaita Vedanta, bouddhisme Chan et Dzogchen, soufisme, philosophie occidentale, sciences, arts et spiritualités contemporaines. Si le thème de la non-dualité est fréquent aujourd'hui dans divers types d'approches spirituelles, force est de constater qu'il n'a été que peu traité à un niveau académique. Les différents chapitres s'efforcent de cerner avec rigueur ces approches dans leur spécificité, préalable à toute véritable recherche transdisciplinaire. Ce (...) volume est le fruit d'un séminaire de métaphysique organisé à l'Université de Louvain au cours de l'année académique 2017-2018. Contributions de Michel Hulin, Viktoria Lyssenko, Philippe Cornu, Dylan Esler, Grégory Vandamme, Daniel Proulx, Hervé Pasqua, Jean-Michel Counet, Marc Maesschalck, Manoé Reynaerts, Alexis Filippucci, Bertrand Hespel, Olivier Sartenaer, Philippe Filliot, José Le Roy et Christophe Vielle. (shrink)