Studies in the yeast Saccharomyces cerevisiae have validated the major features of the double‐strand break repair (DSBR) model as an accurate representation of the pathway through which meiotic crossovers (COs) are produced. This success has led to this model being invoked to explain double‐strand break (DSB) repair in other contexts. However, most non‐crossover (NCO) recombinants generated during S. cerevisiae meiosis do not arise via a DSBR pathway. Furthermore, it is becoming increasingly clear that DSBR is a minor pathway for recombinational (...) repair of DSBs that occur in mitotically‐proliferating cells and that the synthesis‐dependent strand annealing (SDSA) model appears to describe mitotic DSB repair more accurately. Fundamental dissimilarities between meiotic and mitotic recombination are not unexpected, since meiotic recombination serves a very different purpose (accurate chromosome segregation, which requires COs) than mitotic recombination (repair of DNA damage, which typically generates NCOs). (shrink)

The functions of the Bloom syndrome helicase and its orthologs are well characterized in mitotic DNA damage repair, but their roles within the context of meiotic recombination are less clear. In meiotic recombination, multiple repair pathways are used to repair meiotic DSBs, and current studies suggest that BLM may regulate the use of these pathways. Based on literature from Saccharomyces cerevisiae, Arabidopsis thaliana, Mus musculus, Drosophila melanogaster, and Caenorhabditis elegans, we present a unified model for a critical meiotic role of (...) BLM and its orthologs. In this model, BLM and its orthologs utilize helicase activity to regulate the use of various pathways in meiotic recombination by continuously disassembling recombination intermediates. This unwinding activity provides the meiotic program with a steady pool of early recombination substrates, increasing the probability for a DSB to be processed by the appropriate pathway. As a result of BLM activity, crossovers are properly placed throughout the genome, promoting proper chromosomal disjunction at the end of meiosis. This unified model can be used to further refine the complex role of BLM and its orthologs in meiotic recombination. In meiotic recombination, Blm utilizes its helicase activity to disassemble early recombination intermediates, thereby retaining a pool of recombination sites from which some can be selected to enter the Class I crossover pathway while simultaneously promoting SDSA and preventing the use of the Class II pathway. (shrink)

In 2020, COVID-19, the Australia bushfires, and other global threats served as vivid reminders that human and nonhuman fates are increasingly linked. Human use of nonhuman animals contributes to pandemics, climate change, and other global threats which, in turn, contribute to biodiversity loss, ecosystem collapse, and nonhuman suffering. Jeff Sebo argues that humans have a moral responsibility to include animals in global health and environmental policy. In particular, we should reduce our use of animals as part of our pandemic (...) and climate change mitigation efforts and increase our support for animals as part of our adaptation efforts. Applying and extending frameworks such as One Health and the Green New Deal, Sebo calls for reducing support for factory farming, deforestation, and the wildlife trade; increasing support for humane, healthful, and sustainable alternatives; and considering human and nonhuman needs holistically. Sebo also considers connections with practical issues such as education, employment, social services, and infrastructure, as well as with theoretical issues such as well-being, moral status, political status, and population ethics. In all cases, he shows that these issues are both important and complex, and that we should neither underestimate our responsibilities because of our limitations, nor underestimate our limitations because of our responsibilities. Both an urgent call to action and a survey of what ethical and effective action requires, Saving Animals, Saving Ourselves is an invaluable resource for scholars, advocates, policy-makers, and anyone interested in what kind of world we should attempt to build and how. (shrink)

A Russian in Paris -- Russian contexts -- Madmen -- The possessed -- Godmen -- The Hegel lectures -- The last revolution -- Time no more -- The book of the dead -- The later writings -- Nobodies -- Roads or ruins? -- Why finality? -- The grand inquisitor.

This chapter is devoted to criticisms of the views of propositions defended by my co-authors, Jeff King and Scott Soames. The focus is on criticism of their attempts to explain the representational properties of propositions. The criticisms are varied, but one theme is a tension between their view that our actions can explain the representational properties of propositions and their commitment to the idea that propositions have their representational properties essentially.

This paper considers questions that small animals and AI systems raise for utilitarianism. Specifically, if these beings have more welfare than humans and other large animals, then utilitarianism implies that we should prioritize them, all else equal. This could lead to a ‘rebugnant conclusion’, according to which we should, say, create large populations of small animals rather than small populations of large animals. It could also lead to a ‘Pascal’s bugging’, according to which we should, say, prioritize large populations of (...) small animals even if they have a low chance of being sentient. I suggest that utilitarians should accept these implications in theory but might be able to avoid some of them in practice. (shrink)

Within the overarching framework of considering the purpose of education, this book addresses issues such as the standards movement, high-stakes testing and accountability, and corporate education reform. It raises ethical questions related to school practices and considers the question of who should decide the purpose of education.

In this insightful set of essays, the concept of the psychological humanities is defined and explored. A clear rationale is provided for its necessity in the study and understanding of the individual and identity in a discipline that is largely occupied by empirical studies that report aggregated data and its analysis. Contributors to this volume are leading scholars in theoretical psychology who believe that psychology must be about persons and their lives. In these essays, they draw from a variety of (...) disciplines that include art, literature, life writing, and history to make a case for the psychological humanities. A final chapter provides a critical commentary on the value of the psychological humanities. It is argued that psychology must draw on the knowledge and practices of the humanities, as well as the sciences and social sciences, in order to attain a greater understanding of personhood. This book is aimed at upper level undergraduate and postgraduate students and scholars of psychology, particularly theoretical psychology, philosophy of the mind, and those from a humanities background interested in exploring the concept of the psychological humanities. (shrink)

Discussions surrounding music and ethical responsibility bring to mind arguments about legal ownership and purchase. Yet the many ways in which we experience music with others are usually overlooked. Musical experience and practice always involve relationships with other people, which can place limitations on how we listen to and act upon music. In Music and Ethical Responsibility, Jeff Warren challenges current approaches to music and ethics, drawing upon philosopher Emmanuel Levinas's theory that ethics is the responsibilities that arise from (...) our encounters with other people. Warren examines ethical responsibilities in musical experiences including performing other people's music, noise, negotiating musical meaning, and improvisation. Revealing the diverse roles that music plays in the experience of encountering others, Warren argues that musicians, researchers, and listeners should place ethical responsibility at the heart of musical practices. (shrink)

John Dewey's Experience and Education is an important book, but first-time readers of Dewey's philosophy can find it challenging and not meaningfully related to the contemporary landscape of education. Jeff Frank's Teaching in the Now aims to reanimate Dewey's text--for first-time readers and anyone who teaches the text or is interested in appreciating Dewey's continuing significance--by focusing on Dewey's thinking on preparation. Frank, through close readings of Dewey, asks readers to wonder: How much of what we justify as preparation (...) in education is actually necessary? That is, every time we catch ourselves telling a student--you need to learn this in order to do something else--we need to stop and reflect. We need to reflect, because when we always justify the present moment of a student's education in terms of what will happen in the future, we may lose out on the ability to engage students' attention and interest now, when it matters. Dewey asks his readers to trust that the best way to prepare students for an engaging and productive future is to create the most engaging and productive present experience for students. We learn to live fully in the future, only by practicing living fully in the present. Although it can feel scary to stop thinking of the work of education in terms of preparation, when educators reclaim the present for students, new opportunities--for teachers, students, schools, democracy, and education--emerge. Teaching in the Now explores these opportunities in impassioned and engaging prose that makes Experience and Education come alive for readers new to Dewey or who have taught and read him for many years. (shrink)

Davidson aimed to explain predication in terms of truth. I explain what is distinctive about his approach by contrasting it with the widely held view that predication and truth must both be explained in terms of the properties of propositions. I consider Davidson's arguments against this propositionalist alternative, and conclude by exploring some commonalities between Davidson's approach and the more recent propositionalist views of King and Soames.

Drawing on a range of sources in philosophy and literature, but with particular reference to the work of Heidegger, makes a compelling case for the importance of place in philosophical discourse.

The Federation's abandonment of a profit‐and‐growth‐based economic system and money in favor of an economic system designed to facilitate personal development is a product of future successes in overcoming scarcity. Federation trekonomics can be well described in terms of Karl Marx's own vision of the first stage of a postscarcity, money‐free, classless society. The difficulties of interpretation that have provoked debate, the existence of Federation credits, the visible hierarchy in Starfleet, and the family ownership of some specialized means of production, (...) such as restaurants and vineyards, can be resolved if one acknowledges that Marx consistently described a first, complex transitional stage to full communism. For Marx, one of the primary social causes of stifled self‐creation is the rigid division of labor, both detailed and social. The social division of labor, involving a clear demarcation of different positions within a total economy, occurs in economic systems before capitalism (like feudalism). (shrink)

Ender's Game, at face value, is a story about a young yet mature and extraordinarily gifted boy manipulated into saving the world. At another level, though, Ender's story raises ethical questions about war, leadership, and character. Perhaps the most important thing about the story is what it says about the virtues that make for good leadership. This chapter looks at Ender's story through the eyes of Plato and Aristotle, two philosophers deeply concerned with the virtues of leadership. Plato's concept of (...) virtue rests on two ideas: his analogy between the three‐part human soul and the state, and his four cardinal virtues: wisdom, courage, temperance, and justice. Aristotle's virtues fall into two broad categories: intellectual and moral. Intellectual virtues sharpen our capacity to reason, whereas moral virtues order the “passive” part of the soul that only acts rationally by following the lead of others. (shrink)

When assessing North American students' oral participation in classes, should all students be subject to the same evaluation criteria or should teachers make reasonable allowances for Asian students practicing humility? How do we weigh the promotion of 'courage' through character education initiatives with traditional Asian dispositions? Viewing Asian humility in Western classrooms and as it rubs up against liberal principles of equality or justice, and a virtue ethic raises a number of philosophical questions around authenticity, polyvalence, and relativity. I approach (...) first through the lens of liberal philosophy as the 'dilemma of diversity' meets a boundary with communitarianism, and then through the contextualist lenses of Wittgenstein, Heidegger, and Foucault. Drawing on Tully's political philosophy, I inspect humility as embedded in language-games and then open it to revision through comparative history, inviting participants in the teacher's game of assessment to renegotiate the rules: a process complicated by their reticence to speak up. I also use Medina and Scheman's political reading of Wittgenstein to discuss how teachers can discern humility as performative silence within the classroom, distinguishing between genealogical accounts that show how comportments could be otherwise from perspicuous inspection of interconnected language-games in current educational settings. (shrink)

To date, the philosophy of Max Stirner (1806-1856) has not attracted much academic attention. An early critic of Karl Marx and precursor of existentialist thought, he is nevertheless remembered as a radical Young Hegelian engaged in an unsuccessful attempt to move 'beyond Hegel'. Arguing that this image of Stirner is based on a faulty interpretation of his relationship to Hegelian philosophy, this book proposes an entirely new reading of his philosophical magnum opus Der Einzige und sein Eigentum. In this work, (...) traditional philosophy, epitomized by Hegel, is reduced to the property of the unique or single individual. This move must not only be seen a refusal to keep traditional philosophy alive by criticising it, but also entails an 'existentialist' inversion of the traditional relation between thinker and idea. This exciting new interpretation, which is demonstrated here by a detailed analysis of Der Einzige und sein Eigentum, clears the way for a philosophical rehabilitation of Stirner's ideas. (shrink)

This book engages the perspective of public reason and the position of religious believers through a mutual confrontation of Rawlsian political liberalism and Gandhian ideas. By teasing out concords and discords between Rawls and Gandhi, Jeff Shawn Jose innovatively advances the debate about the role of religion in the public sphere.

I argue that Husserlian phenomenology is metaphysically neutral, in the sense of being compatible with multiple metaphysical frameworks. For example, though Husserl dismisses the concept of an unknowable thing in itself as “material nonsense”, I argue that the concept is coherent and that the existence of such things is compatible with Husserl’s phenomenology. I defend this metaphysical neutrality approach against a number of objections and consider some of its implications for Husserl interpretation.

According to our traditional conception of agency, most human beings are agents and most, if not all, nonhuman animals are not. However, recent developments in philosophy and psychology have made it clear that we need more than one conception of agency, since human and nonhuman animals are capable of thinking and acting in more than one kind of way. In this paper, I make a distinction between perceptual and propositional agency, and I argue that many nonhuman animals are perceptual agents (...) and that many human beings are both kinds of agent. I then argue that, insofar as human and nonhuman animals exercise the same kind of agency, they have the same kind of moral status, and I explore some of the moral implications of this idea. (shrink)

This paper proposes that the relation between property instances and token causal powers is akin to the relation between primary substances and property instances on the Aristotelian account of property instantiation. This view permits an individual to have two tokens of the same type of causal power. Paul Audi has argued that this cannot be: two tokens of the same power type are discernible, he claims, only if they are borne by discernible individuals. In the context of this criticism, he (...) proposes that power tokens are individuated in part by the individuals bearing them. This paper responds to Audi’s criticism and argues against his preferred view. This paper thus establishes a theory of token causal powers where previously the literature contained only a presumed view and Audi’s objections. (shrink)

"Nietzche and Dostoevsky"are collectedessays on Nietzsche Dostoevsky andtwentieth-century intellectual history.".

The first interdisciplinary study of place, bringing together many of the key thinkers writing on the concept in the twenty-first century.

Jeff Benedict has seen both good and bad in his career as a journalist. Some of the best are the extraordinary people he has met who have made deliberate choices to live happier lives despite the extreme hardship that each of them have faced. Although life will knock us down from time to time, this book is an important reminder that we all can make a choice to get back up, brush ourselves off, and keep pressing forward. Replace anger (...) with forgiveness through studying the real-life examples of seven inspiring mentors. Avoid discouragement by purposefully recognizing God's hand in your life. Diminish the heartache from tragedy through the concentrated act of serving others. Gain insights from parents who were deliberate in safeguarding their children against harmful influences. Stand strong through life's adversity through the examples of powerful prayer. (shrink)

However much one may wish for nonviolent solutions to the problems of unjust and unrestrained human violence that Glover explores in Humanity, some of those problems at present require violent responses. One cannot read his account of the Clinton administration’s campaign to sabotage efforts to stop the massacre in Rwanda in 1994 – a campaign motivated by fear that American involvement would cost American lives and therefore votes – without concluding that Glover himself believes that military intervention was morally required (...) in that case. Military intervention in another state that is intended to stop one group within that state from brutally persecuting or violating the human rights of members of another group is now known as “humanitarian intervention.” Those against whom the intervention is directed are almost always the government and its supporters, though this is not a necessary feature of humanitarian intervention. It is, however, a conceptual condition of humanitarian intervention that it does not occur at the request or with the consent of the government. The use of force within another state with the consent of the government counts as assistance rather than intervention. The principal reason that humanitarian intervention is contentious is that it seems to violate the target state’s sovereign right to control its own domestic affairs. Because humanitarian intervention is a response to human rights violations within the target state, it is regarded as altogether different from wars of defense against aggression. Indeed, since aggression is normally understood to be war against a state that.. (shrink)

In this paper I ask how we should treat other beings in cases of uncertainty about sentience. I evaluate three options: an incautionary principle that permits us to treat other beings as non-sentient, a precautionary principle that requires us to treat other beings as sentient, and an expected value principle that requires us to multiply our subjective probability that other beings are sentient by the amount of moral value they would have if they were. I then draw three conclusions. First, (...) the precautionary and expected value principles are more plausible than the incautionary principle. Second, if we accept a precautionary or expected value principle, then we morally ought to treat many beings as having at least partial moral status. Third, if we morally ought to treat many beings as having at least partial moral status, then morality involves more cluelessness and demandingness than we might have thought. (shrink)

This book charges that just about every philosophical theory of mind or language developed over the past 50 years in the West is systematically inaccurate. Systemic oppression has influenced the processes that theories of mind or language purport to identify; however, that same systemic oppression has also made it so that most middle-to-upper class White men (including most philosophers of mind or language) are ignorant of systemic oppression. Consequently, most theories of mind or language are systematically inaccurate because they fail (...) to account for the influences of systemic oppression. Philosopher Jeff Engelhardt argues for the de-idealization of two influential theories in the philosophy of mind and language--social externalism and objective type externalism--and considers some consequences of the de-idealization project. -/- Following the work of Charles Mills, Engelhardt argues that ideal theories adopt oppression-obscuring assumptions while nonideal theories avoid them (or at least try to). Ideal theories assume that language users are basically equal, and that social institutions and structures are basically just, but scholarship on Western social relations, institutions, and structures shows that in fact each of these is systematically influenced by oppression. Consequently, ideal theories tend to be systematically inaccurate. Moreover, since oppression systematically produces ignorance of systemic oppression, such systematically inaccurate theories are likely the norm rather than the exception. -/- Engelhardt shows that once we've shown that oppression systematically influences the processes that determine linguistic meanings (according to content externalism), then we have reason to expand our notion of hermeneutical injustice, we have evidence that hermeneutical injustice occurs systematically, and we have grounds for expanding discussions of conceptual engineering to include questions about engineering the processes that determine concepts, not just concepts themselves. (shrink)

A comprehensive study of the ethics of killing in cases in which the metaphysical or moral status of the individual killed is uncertain or controversial. Among those beings whose status is questionable or marginal in this way are human embryos and fetuses, newborn infants, animals, anencephalic infants, human beings with severe congenital and cognitive impairments, and human beings who have become severely demented or irreversibly comatose. In an effort to understand the moral status of these beings, this book develops and (...) defends distinctive accounts of the nature of personal identity, the evaluation of death, and the wrongness of killing. The central metaphysical claim of the book is that we are neither nonmaterial souls nor human organisms but are instead embodied minds. In ethical theory, one of the central claims is that the morality of killing is not unitary; rather, the principles that determine the morality of killing in marginal cases are different from those that govern the killing of persons who are self‐conscious and rational. Another important theme is that killing in marginal cases should be evaluated in terms of the impact it would have on the victim at the time rather than on the value of the victim's life as a whole. What primarily matters is how killing would affect that which would be rational for the victim to care about at the time of death. By appealing to various foundational claims about identity, death, and the morality of killing, this book yields novel conclusions about such issues as abortion, prenatal injury, infanticide, the killing of animals, the significance of brain death, the termination of life support in cases of persistent vegetative state, the use of anencephalic infants as sources of organs for transplantation, euthanasia, assisted suicide, and advance directives in cases of dementia. In particular, the book defends the moral permissibility of abortion, infanticide, and euthanasia in certain cases and argues that brain death is not the appropriate criterion of death either for a person or a human organism. (shrink)

Aron Gurwitsch’s theory of the structure and dynamics of consciousness has much to offer contemporary theorizing about consciousness and its basis in the embodied brain. On Gurwitsch’s account, as we develop it, the field of consciousness has a variable sized focus or "theme" of attention surrounded by a structured periphery of inattentional contents. As the field evolves, its contents change their status, sometimes smoothly, sometimes abruptly. Inner thoughts, a sense of one’s body, and the physical environment are dominant field contents. (...) These ideas can be linked with (and help unify) contemporary theories about the neural correlates of consciousness, inattention, the small world structure of the brain, meta-stable dynamics, embodied cognition, and predictive coding in the brain. (shrink)

_How to Think Critically_ begins with the premise that we are all, every day, engaged in critical thinking. But just as we may develop bad habits in daily life if we don’t scrutinize our practices, so are we apt to develop bad habits in critical thinking if we are careless in our reasoning. Readers are presented with a traditional step-by-step method for analysis that can be applied to all argument forms. Hundreds of exercises (with solutions) are included, as are several (...) random statement generators that can be used to create thousands of additional examples. Truth tables, Venn diagrams, and other essential concepts are introduced not merely as objects for academic study but also as tools for better thinking and living. At a time when the value of critical thinking is recognized to be greater than ever, this book is an important resource both inside and outside the classroom. (shrink)

This article provides empirical results indicating that acting in a socially respon- sible and lawful manner is a necessary, though not sufficient, condition for increasing shareholder wealth. It meta-analyzes 27 event studies that have mea- sured the stock market's reaction to incidences of socially irresponsible and illicit behavior. It finds that for firms engaging in socially irresponsible and illicit behavior, the effect on shareholder wealth is negative (wealth decreases), statisti- cally significant (p <.001), and so substantial in size (D = (...) -.932) that the distribution of abnormal returns is shifted nearly a full standard deviation to the left (i.e., negatively) from their expected standard normal distribution. This result gives rationally self-interested firms a self-interested reason to act in a socially responsible and law-abiding manner. It also provides support for a moral position called enlightened self-interest, which prescribes that firms should act in a socially responsible manner to promote the shareholders' interests. (shrink)

Theories of the structure of affect make competing predictions about whether people can feel happy and sad at the same time. Considerable evidence that happiness and sadness can co-occur has accumulated in the past 15 years, but holes in the case remain. I describe those holes and suggest strategies for testing them in future research. I also explore the possibility that the case may never be closed, in part because the competing hypotheses may not be entirely falsifiable. Fortunately, hypotheses need (...) not be falsifiable to be useful. Research on mixed emotions has been generative and the body of research will continue to shed light on the structure of affect. (shrink)

Jeff McMahan urges us to reject the view, dominant throughout history, that mere participation in an unjust war is not wrong.

The question whether cognition is subserved by internal processes in the brain (internalism) or extends in to the world (active externalism) has been vigorously debated in recent years. I show how internalist and externalist ideas can be pursued in a common framework, using (1) open dynamical systems, which allow for separate analysis of an agent's intrinsic and embodied dynamics, and (2) supervenience functions, which can be used to study how low-level dynamical systems give rise to higher-level dynamical structures.

This paper argues against two prominent accounts of what it is to "promote a desire," found in the work of Stephen Finlay and Mark Schroeder.

This book provides an original and provocative combination of ethnomethodological analysis and the concepts of linguistic philosophy with a breadth and clarity unusual in this field of writing. It is designed to be read by sociologists, psychologists and philosophers and concerns itself with the contributions of Wittgenstein, defending the claim for his relevance to the human sciences. However, this book goes some way beyond the usual limitations of such interdisciplinary works by outlining some empirical applications of ideas derived from the (...) Wittgenstein tradition. (shrink)