4 found
  1. Problems with Using Mechanisms to Solve the Problem of Extrapolation.Jeremy Howick, Paul Glasziou & Jeffrey K. Aronson - 2013 - Theoretical Medicine and Bioethics 34 (4):275-291.
    Proponents of evidence-based medicine and some philosophers of science seem to agree that knowledge of mechanisms can help solve the problem of applying results of controlled studies to target populations (‘the problem of extrapolation’). We describe the problem of extrapolation, characterize mechanisms, and outline how mechanistic knowledge might be used to solve the problem. Our main thesis is that there are four often overlooked problems with using mechanistic knowledge to solve the problem of extrapolation. First, our understanding of mechanisms is (...)
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    The Use of Mechanistic Evidence in Drug Approval.Jeffrey K. Aronson, Adam La Caze, Michael P. Kelly, Veli-Pekka Parkkinen & Jon Williamson - 2018 - Journal of Evaluation in Clinical Practice 24 (5):1166-1176.
    The role of mechanistic evidence tends to be under‐appreciated in current evidence‐based medicine, which focusses on clinical studies, tending to restrict attention to randomized controlled studies when they are available. The EBM+ programme seeks to redress this imbalance, by suggesting methods for evaluating mechanistic studies alongside clinical studies. Drug approval is a problematic case for the view that mechanistic evidence should be taken into account, because RCTs are almost always available. Nevertheless, we argue that mechanistic evidence is central to all (...)
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    The Use of Mechanistic Reasoning in Assessing Coronavirus Interventions.Jeffrey K. Aronson, Daniel Auker-Howlett, Virginia Ghiara, Michael P. Kelly & Jon Williamson - 2021 - Journal of Evaluation in Clinical Practice 27 (3):684-693.
    Evidence-based medicine, the dominant approach to assessing the effectiveness of clinical and public health interventions, focuses on the results of association studies. EBM+ is a development of EBM that systematically considers mechanistic studies alongside association studies. In this paper we provide several examples of the importance of mechanistic evidence to coronavirus research. Assessment of combination therapy for MERS highlights the need for systematic assessment of mechanistic evidence. That hypertension is a risk factor for severe disease in the case of SARS-CoV-2 (...)
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    Unity From Diversity: The Evidential Use of Anecdotal Reports of Adverse Drug Reactions and Interactions.Jeffrey K. Aronson - 2005 - Journal of Evaluation in Clinical Practice 11 (2):195-208.