Synthetic biology (SynBio) covers two main areas: application engineering, exemplified by metabolic engi- neering, and the design of life from artificial building blocks. As the general public is often reluctant to embrace synthetic approaches, preferring nature to artifice, its immediate future will depend very much on the public’s reaction to the unmet needs created by the pervasive demands of sustainability. On the other hand, this reluctance should not have a negative impact on research that will now take into account the (...) existence of the multiple transitions that cells face over time. The ages of life—birth, development, maturation, senescence and death—reflect specific key transitions and have, until now, rarely been taken into account in SynBio designs. This results in a mismatch between novelty and the very long evolutionary time that led to the existing chassis [remember that this is the common term used to describe the cellular framework as seen by synthetic biologists (de Lorenzo & Danchin, 2008)]. It also implies that, in general, transitions between growth stages will be taken into account with the appro- priate embodiment of highly specific processes. This is particularly important when adapting new models to their host, whether natural or artificial. Adaptation fol- lows two stages, short-term accommodation of new entities and long-term assimilation into the cell as a whole. This requires discrimination between classes of entities. We suggest that proteins playing the essential role of Maxwell’ demons, here named Maxwell’s dis- criminators (MxDs) to refer to their original function, will permit the assimilation and accommodation of artificial constructs. As a consequence, we can foresee that class discrimination, beyond mere recognition, will be implemented in SynBio 2.0, leading to an authentic par- adigm shift (Kuhn, 1996), based on conceptions that embody information as a genuine currency of reality. (shrink)

BackgroundMental stress and imbalance of its two neural stress systems, the autonomic nervous system and the hypothalamic–pituitary–adrenal axis, are associated with chronic prostatitis/chronic pelvic pain syndrome and erectile dysfunction. However, the comprehensive analyses of psychological stress and stress systems are under-investigated, particularly in CP/CPPS patients complicated by lower urinary tract symptoms and ED.Materials and methodsParticipants were 95 patients in CP/CPPS+ED group, 290 patients in CP/CPPS group, 124 patients in ED group and 52 healthy men in control group. The National Institutes (...) of Health Chronic Prostatitis Symptom Index, the International Index of Erectile Function-5 and the International Prostate Symptom Score were used for assessing the disease severity of CP/CPPS, LUTS and ED. Psychometric self-report questionnaires including the Beck Anxiety Inventory, Perceived Stress Scale, Type A Personality Test and Symptom Checklist 90 were completed for distress from physical symptoms. Twenty-five subjects per group were randomly selected for further investigating the changes of the HPA axis and ANS. Saliva samples were taken on 3 consecutive days at 8 specific times with strict reference to time of morning awakening for evaluation of free cortisol. Heart rate variability as marker of the ANS was measured using 24 h electrocardiography, and time-and frequency-domain variables were analyzed.ResultsThe BAI and SCL-90 scores were significantly higher in the CP/CPPS+ED, CP/CPPS and ED groups compared with the control group. The PSS scores of both groups with ED were significantly higher than the control group. Compared with the CP/CPPS group, the differences of PSS, SCL-90 and TAPT scores were statistically significant in CP/CPPS+ED patients. The IPSS scores were shown to have significantly positive correlations with BAI, PSS and SCL-90 in the CP/CPPS patients. However, in all subjects, the IIEF-5 scores were shown to have significantly negative correlations with BAI, PSS, SCL-90 and quality of life score in NIH-CPSI. Cortisol awakening response parameters and diurnal cortisol levels did not significantly vary between the four groups. Time-dependent parameters of HRV also did not differ significantly across groups. In the frequency domain analysis, low frequency was significantly lower in ED patients when compared with CP/CPPS+ED patients and healthy controls, high frequency power was significantly higher in healthy controls compared to patients with ED, CP/CPPS and CP/CPPS+ED, and the CP/CPPS+ED group had significantly higher LF/HF ratio than the control group.ConclusionCP/CPPS and ED patients score exceedingly high on most psychosocial variables. The symptom scores of LUTS and ED positively correlate with the severity of psychological stress. Our findings also suggest that the ANS sympathovagal imbalance is associated with ED and LUTS in CP/CPPS, whereas HPA axis activity is not. (shrink)

Objectives: The corona virus disease-2019 pandemic spread globally, and we aimed to investigate the psychosocial impact on healthcare workers in China during the pandemic.Methods: In this systematic review and meta-analysis, we searched seven electronic databases for cross-sectional studies on psychosocial impact on HWs in relation to COVID-19 from January 1, 2020 to October 7, 2020. We included primary studies involving Chinese HWs during the pandemic, and data were extracted from the published articles. Our primary outcome was prevalence of anxiety, depression, (...) and stress disorders. We pooled prevalence value with their 95% confidence interval using random effect models and assessed study quality on the basis of an 11-item checklist recommended by the Agency for Healthcare Research and Quality. The study protocol was registered in PROSPERO.Results: We identified 25 articles comprising a total of 30,841 completed questionnaires and 22 studies for meta-analysis. The prevalence of anxiety, depression, and stress disorders was 34.4%, 31.1%, and 29.1% for HWs. The pooled prevalence of anxiety disorders for HWs from late January to early February was 46.4%, significantly higher than those in mid-term February and after late February. The pooled prevalence of depression disorders for HWs from late January to early February was 46.5%, significantly higher than those in mid-term February and after late February. HWs working in Hubei Province had a higher prevalence of anxiety and a lower prevalence of depression than those working in other regions. Nurses had a higher prevalence of anxiety and depression than other HWs.Conclusions: About one-third of HWs in China suffered anxiety, depression, and stress at the early epidemic of COVID-19. HWs in Hubei Province, especially nurses, had a higher prevalence of psychological disorders. During the pandemic, a negative psychological state may persist in a proportion of Chinese HWs, fluctuating with the control of the pandemic. The long-term impact should continue to be observed. Attention should be paid to HWs for their psychological impact due to the pandemic.Systematic Review Registration: The study protocol was registered with PROSPERO. (shrink)

Cognitive diversity is an important concept stemming from western management research in the 1990s. With the rapid development of science and technology, there is a growing interest in the composition of an academic research team, such as team diversity. However, there is no tool available for measuring team cognitive diversity for academic research teams. Based on Van der Vegt’s theoretical model of TCD, an Academic Research Team Cognitive Diversity Scale is developed and validated for an academic research team in our (...) research with two studies. In Study One, in-depth interviews and panel discussions were conducted to generate a preliminary questionnaire. In Study Two, the questionnaire was administered among academic research teams. Exploratory factor analysis revealed four factors regarding cognitive diversity: the way of thinking, knowledge and skills, the view of the world, and beliefs about what is right and wrong. The factor structure was further validated by confirmatory factor analysis. Moreover, correlation and regression analyses showed that academic research TCD was positively related to team creativity and performance. To sum up, our newly developed 15-item ATCDS is sufficiently reliable and valid to be used for understanding cognitive diversity among academic research teams. (shrink)

With the rapid development of modern technology, people has stepped into an risky era. Ethical stipulation is the important means to reduce the risks. But in reality, ethical stipulation of technology always face some kind of dilemma which mainly come from two aspects: one is that when we try to regulate the subject oftechnology, we find that it always difficult to distinguish the responsibilities. The other aspect is that when we try to limit the result of technology, we often have (...) to give up because of lacking feasibility, which means we sink into the famous “Collingridge dilemma”. Are we able to get out of the dilemma? What should we doif we want to got out of it? First, in the modern technological system, individual’s action is taken over by group’s action according to the technological criterion. Any part of the modern technology need multiple subjects finish his job during the course. Therefore a new form of responsibility named group responsibility has been formed. Like Johnas said, in this ethics, ‘I’ will be replaced by ‘we’ and decision will be the business of a group. So it is difficult for us to find out that “I” from “us” once the technological risks happened. We lost the object of ethical stipulation as the result of no convinced standard and principals of prescribing the group responsibility. Second, when we try to stimulate some certain results of technology, we find we lack not only the wisdom of precisely judging or assessingtechnology itself, but also the ability of correcting the bad results if it has. Here again do we fall into the dilemma. This make it difficult for us to stipulate technology with ethic. From above discussion we can see, the stipulation, no matter from the aspect of technological responsibility or from aspect of the application of technology, has been sure to meet the dilemma. If the conflicts between a hypothesis and experiment cannot be eliminated, we have to rethink the theoryand come back again to technology itself and pursue the essence of technology again. Technology is a process from inventing, designing to forming material technological products; is a process from invisible technology to visible technology; is a process potential technology to real-life technology or intellective technology to reallife technology. Technology exists in process. The essential and innate characteristic is it’s process and dynamics. The transition oftechnological form involves many factors of economic, social, historical, constitutional and cultural. Technological creation of intellectual form is the duty of inventor or technologist. And it is entrepreneur’s job to use the technology or invention, and make them in large quantity, apply them in reality or get economic or other profit. Although there need be interaction, understanding, cooperation, support, coordination among scientist, technologist and enterpriser, they have different responsibility and delimitation. Technology exists in process, no doubt, so does modern technology. This decides that the ethical stipulation of modern technology should be a process stipulation. The essence of modern technological is not only the limitation of subject of technology either not only controlthe object of technology. It is the ethical stipulation in the unity of subject and object of technological dynamic process. This is basic point of understanding ethical stipulation of modern technology. Responsibility ethics consider that the group responsibility as the premise of technological stipulation.It noticed the static structure of modern technological system, but neglect the dynamic linkage between factors. And it only analysed the special construction, neglected the evolution of system of technological responsibility and the inter relationship between space dimension and time dimension. If we unfold the group responsibility along with the process of technology, we will see the different responsibility belong to different subject in different stage of the process. We can also see that different actors obey different norm or criteria according to their task. In this case, we can distinct the distribution of the group responsibility. Collingridge fixed the effective control on the two points of “before ”and ”after” the process of the technological action, namely, the stipulation for the staring point and stipulation of terminal point. But the whole process was neglected. According to the point of view of process stipulation.it is not the sudden occurrence for technology from “nothing ”to “having”. There are time and space during the process. From middle experiment to industrial experiment, the most characters of the result of technology will havebeen shown gradually, so will the social results. So we can give the small quantity an ethical evaluation and ethical choice which is possible and feasible. Over all, if we confirm the ethical stipulation of modern technology is a process regulation, we can delimitate the responsibility of the subjects of technology and also settle the prestipulation of the application of technology. At the end, we can eliminate the dilemma of ethical regulation of modern technology. (shrink)

"Culture shock" is the context of a place Yan'an Literature summarized. It has focused on anti-Japanese revolutionary base color of the militarization of social life, for the establishment of a modern nation-state "anxiety" mentality, and the potential "breakthrough" mentality. From the "culture shock" the perspective of Yan'an Literature, enabling Yan'an Literature from the "politics" into a deeper vision of the "cultural" space, and thus enrich our literature and the inherent complexity of Yan'an understanding. Through "culture shock", for the Yan'an Literature (...) we can update the knowledge structure. "Assaulting culture" as a linguistic background of Yan'an literature reflected concentratively the militarized daily living in the revolutionary base area of ​​defending against Japanese invasion, the anxious psychology for setting up a modern national country, and a potential "assaulting" mentality. It can enrich and renew our knowledge of the internal complex of Yan'an literature to study from the perspective of "assaulting culture" since it expands the research fields to from "politics" to "culture". (shrink)

ObjectiveTo investigate the attitudes of Chinese parents regarding the storage of dried blood spots collected for newborn screening (NBS) and their use in research.MethodsWe conducted a hospital-based survey of parents and examined parental attitudes regarding (a) allowing NBS sample storage, (b) permitting use of children’s NBS samples for research with parental permission, and (c) permitting use of children’s NBS samples for research without parental permission.ResultsThe response rate was 52 percent. Of parents surveyed, 68 percent would permit their infant’s NBS sample (...) to be stored for at least some length of time. If permission is obtained, 69 percent of parents “strongly agreed” or “agreed” to permit use of the NBS sample for research. If permission is not obtained, only 14 percent of parents “strongly agreed” or “agreed.” There was no significant association between permitting use of NBS samples for research and parental gender, education, household income, number of children, or site of residence.ConclusionsThis is the first survey of Chinese parents regarding the use of NBS samples for different types of research, with results indicating that most parents would permit their infant’s sample to be stored and would support the use of NBS dried blood spots for research purposes. (shrink)

The transition of gene switch induced by external noises and external signals is investigated in the genetic regulatory system. Results show that the state-to-state transition of gene switch as well as resonant behaviors, such as the explicit coherence resonance, implicit coherence resonance and control parameter coherence biresonance, can appear when noises are injected into the genetic regulatory system. The ECR is increased with the increase of the control parameter value when starting from the supercritical Hopf bifurcation parameter point, and there (...) exists a critical control parameter value for the occurrence of ECR. However, the ICR is decreased as the control parameter value is increased when starting from the subcritical Hopf bifurcation point. In particular, the coherence of ECR is higher and more sensitive to noise than that of ICR. When an external signal is introduced into the system, the enhancement or suppression of the CPCBR and the number of peaks strongly depend on the frequency and amplitude of the external signal. Furthermore, the gene regulation system can selectively enhance or decrease the noise-induced oscillation signals at preferred frequency and amplitude of an external signal. (shrink)

Post-stroke depression is a serious complication of stroke that significantly restricts rehabilitation. The use of immersive virtual reality for stroke survivors is promising. Herein, we investigated the effects of a novel immersive virtual reality training system on PSD and explored induced effective connectivity alterations in emotional networks using multivariate Granger causality analysis. Forty-four patients with PSD were equally allocated into an immersive-virtual reality group and a control group. In addition to their usual rehabilitation treatments, the participants in the immersive-virtual reality (...) group participated in an immersive-virtual reality rehabilitation program, while the patients in the control group received 2D virtual reality rehabilitation training. The Hamilton Depression Rating Scale, modified Barthel Index, and resting-state functional magnetic resonance imaging data were collected before and after a 4-week intervention. rsfMRI data were analyzed using multivariate GCA. We found that the immersive virtual reality training was more effective in improving depression in patients with PSD but had no statistically significant improvement in MBI scores compared to the control group. The GCA showed that the following causal connectivities were strengthened after immersive virtual reality training: from the amygdala, insula, middle temporal gyrus, and caudate nucleus to the dorsolateral prefrontal cortex; from the insula to the medial prefrontal cortex; and from the thalamus to the posterior superior temporal sulcus. These causal connectivities were weakened after treatment in the control group. Our results indicated the neurotherapeutic use of immersive virtual reality rehabilitation as an effective non-pharmacological intervention for PSD; the alteration of causal connectivity in emotional networks might constitute the neural mechanisms underlying immersive-virtual reality rehabilitation in PSD. (shrink)

本书是“以赛亚·伯林与当代中国国际研讨会”论文集,汇集了国内外著名学者伯林研究的最新成果,从伯林语境下自由与多元的关系出发,探讨了伯林思想对当代中国的经验与智慧有着怎样的启迪意义.

法学是春秋战国时期的一个主要学派。“法者,编著之图藉, 设之于官府, 而布之于百姓者也。”法家主张法、术、势的结合。法、指法律制度 ; 术, 指君王驾御群臣、掌握政权、推行法令的政策和手段 ; 势 ; 指君王的权势.

本书共有两篇,第一篇物质矛盾运动概论分为八章,包括矛盾形态和类型、运动形式及类别等。第二篇介绍了关于暗物质等宇宙历史中的若干问题。.

本書旨在探討董仲舒如何藉由《春秋》詮釋，進而建構其獨特之春秋學體系。內容含攝董仲舒春秋學所賴以形成之傳承統緒、理論基礎、詮釋方法，以及董仲舒解會《春秋》所得之「義法」、「歷史」、「災異」、「經權」等相 關理論。【秀威資訊科技股份有限公司製作】.

本书针对未成年人道德建设研究普遍缺乏学理性、忽视社会转型的影响和成年人因素等不足,试图从学理上把当今中国未成年人道德建设放在社会转型时期由成年人与未成年人所构成的代际关系框架中加以审视和反思,力求还原 中西文化中未成年人道德境况的历史本相,揭开当代未成年人双重道德境遇的现实面纱.

阴阳家出现在春秋战国时期,以阴阳五行学说作为立派基础,并将天象、地物和人事统一起来,形成了“天人合一”的最高哲学。我国古代的科学技术,如天文学、气象学、化学、算学、音乐和医学等,都是在阴阳五行学说的影 响下发展起来的.

Ben shu yi Ming ru Li Cai de jiang xue huo dong yu xue pai jian gou wei zhong xin, tan tao cong shi liu shi ji chu dao shi qi shi ji mo li xue qun ti zhong xin xing xue shuo he xue pai de chan sheng, chuan bo, kuo zhan yu chuan cheng de mo shi, bing zhuo zhong cong si xiang shi de jiao du jie shi zhe zhong mo shi chan sheng he yun (...) xing de si xiang gen yuan yu nei zai dong li. Quan shu zheng wen gong qi zhang, zhu yao nei rong fen wei shang xia liang bian, shang bian yi hong guan zong lun de fang shi, cong li xue jing dian "Da xue" de wen ben bian dong he quan shi jing zheng qie ru, tan tao zhong wan Ming li xue xue shuo he xue pai jian gou de li lun gen ju; xia bian yi Li Cai de "zhi xiu" xue shuo ji qi jiang xue huo dong zuo wei ge an yan jiu, tan tao li xue xue shuo he xue pai de chuan bo ji chuan cheng de she hui hua tu jing. (shrink)

《一代直聲百年盡瘁：梁簌溟鄉村建設運動研究》系統梳理了20世紀30年代梁漱溟主持的山東鄉村建設實驗的相關內容，以及不同時期相關實踐者和學者對其鄉村建設實驗進行的各種討論和爭議，試圖全方位挖掘梁漱溟鄉建 思想與實踐的深層學術價值和現實借鑒意義，冀望對今天的農村現代化建設和農村改革，尤其是“三農”問題的解決和優化提供有益的借鑒。.

本书共分5章。主要内容包括:明末清初西学东来及其对于中国思想文化的影响、鸦片战争前后的西学输入与国人的反应、洋务时期的西学输入等.

本书具有总论的性质,主要是从宏观上阐明和论述20世纪西方哲学东渐史的下述论题,全面展示20世纪西方哲学东渐的整体面貌,提示了20世纪西方哲学东渐的规律性。.

Self-serving leadership is a form of unethical leadership behavior that has destructive effect on its targets and the overall organization. Adopting a social cognition perspective, this study expands our knowledge of its adverse effect and the way to mitigate the effect. Integrating two sub-theories of social cognition, we propose a theoretical model wherein self-serving leadership hinders team creativity through psychological safety as well as knowledge hiding, with task interdependence acting as a contextual condition. Results from a sample of 107 R&D (...) teams revealed that self-serving leadership not only reduced team psychological safety, but also induced team knowledge hiding, both of which ultimately affected team creativity. The presence of high task interdependence buffered the destructive effect of self-serving leadership on team creativity via team psychological safety as well as the indirect effect via knowledge hiding. (shrink)

Justin D’Arms and Daniel Jacobson have argued that to evaluate the funniness of a joke based on the consideration of whether it is morally appropriate to feel amused commits the “moralistic fallacy.” We offer a new and empirically informed reply. We argue that there is a way to take morality into consideration without committing this fallacy, that is, it is legitimate to say that for some people, witty but immoral jokes can fail to be funny because they are immoral. In (...) our account, one has an intramural moral reason not to feel amused if one focuses on the moral feature itself of a joke rather than the moral consequence implied in one’s reaction to the joke. When one judges a joke as not funny because of the intramural moral reason, one is in a negative emotional state with high arousal, for example, moral disgust or anger. This state is psychologically incompatible with amusement. That one has an intramural reason not to feel amused thus implies that one does not have a reason to feel amused. Moral consideration thus plays an indirect and appropriate role in the evaluation of the funniness of a joke. (shrink)

In this paper, I develop an account of appreciation. I argue that appreciation is an epistemic emotion in which the subject grasps the object in an affective way. The “grasping” and “feeling” components implies that in appreciation, we make sense of the object by having cognitive control over it, are motivated to maintain the valuable epistemic state of understanding, and experience the “aha” or “eureka” moment. This account offers a unified account of the many types of appreciation, including the aesthetic, (...) the moral, and the epistemic. In all these cases, appreciation requires some other first-order emotions as prerequisite. (shrink)

Because they are key components of aircraft, improving the safety, reliability and economy of engines is crucial. To ensure flight safety and reduce the cost of maintenance during aircraft engine operation, a prognostics and health management system that focuses on fault diagnosis, health assessment, and life prediction is introduced to solve the problems. Predicting the remaining useful life is the most important information for making decisions about aircraft engine operation and maintenance, and it relies largely on the selection of performance (...) degradation features. The choice of such features is highly significant, but there are some weaknesses in the current algorithm for RUL prediction, notably, the inability to obtain tendencies from the data. Especially with aircraft engines, extracting useful degradation features from multisensor data with complex correlations is a key technical problem that has hindered the implementation of degradation assessment. To solve these problems, deep learning has been proposed in recent years to exploit multiple layers of nonlinear information processing for unsupervised self-learning of features. This paper presents a deep learning approach to predict the RUL of an aircraft engine based on a stacked sparse autoencoder and logistic regression. The stacked sparse autoencoder is used to automatically extract performance degradation features from multiple sensors on the aircraft engine and to fuse multiple features through multilayer self-learning. Logistic regression is used to predict the remaining useful life. However, the hyperparameters of the deep learning, which significantly impact the feature extraction and prediction performance, are determined based on expert experience in most cases. The grid search method is introduced in this paper to optimize the hyperparameters of the proposed aircraft engine RUL prediction model. An application of this method of predicting the RUL of an aircraft engine with a benchmark dataset is employed to demonstrate the effectiveness of the proposed approach. (shrink)

In this paper I argue that there is a structural parallelism between law and physics in Leibniz since his early years, which has significant influence on the formation of his views. I start by examining Leibniz's early physical system and an analogy with juridical laws that he uses to explain the structure of physical laws. Then, I argue that this analogy stems from an envisioned parallelism between law and physics. Finally, I illustrate the significance of this legal-physical parallelism by arguing (...) that it underlies some of Leibniz's mature views. Most importantly, I argue that the parallelism explains the origin of architectonic principles or optimality principles in Leibniz's mature physics. (shrink)

Emotion is closely associated with language, but we know very little about how children express emotion in their own writing. We used a large‐scale, cross‐sectional, and data‐driven approach to investigate emotional expression via writing in children of different ages, and whether it varies for boys and girls. We first used a lexicon‐based bag‐of‐words approach to identify emotional content in a large corpus of stories (N>100,000) written by 7‐ to 13‐year‐old children. Generalized Additive Models were then used to model changes in (...) sentiment across age and gender. Two other machine learning approaches (BERT and TextBlob) validated and extended these analyses, converging on the finding that positive sentiments in children's writing decrease with age. These findings echo reports from previous studies showing a decrease in mood and an increased use of negative emotion words with age. We also found that stories by girls contained more positive sentiments than stories by boys. Our study shows the utility of large‐scale data‐driven approaches to reveal the content and nature of children's writing. Future experimental work should build on these observations to understand the likely complex relationships between written language and emotion, and how these change over development. (shrink)