New concepts may prove necessary to profit from the avalanche of sequence data on the genome, transcriptome, proteome and interactome and to relate this information to cell physiology. Here, we focus on the concept of large activity-based structures, or hyperstructures, in which a variety of types of molecules are brought together to perform a function. We review the evidence for the existence of hyperstructures responsible for the initiation of DNA replication, the sequestration of newly replicated origins of replication, cell division (...) and for metabolism. The processes responsible for hyperstructure formation include changes in enzyme affinities due to metabolite-induction, lipid-protein affinities, elevated local concentrations of proteins and their binding sites on DNA and RNA, and transertion. Experimental techniques exist that can be used to study hyperstructures and we review some of the ones less familiar to biologists. Finally, we speculate on how a variety of in silico approaches involving cellular automata and multi-agent systems could be combined to develop new concepts in the form of an Integrated cell (I-cell) which would undergo selection for growth and survival in a world of artificial microbiology. (shrink)
Drawing on propositions from the signaling theory and expectancy theory, this study hypothesizes that the perceived corporate citizenship of job seekers positively affects a firm’s attractiveness and career success expectation. This study’s proposed research hypotheses are empirically tested using a survey of graduating MBA students seeking a job. The empirical findings show that a firm’s corporate citizenship provides a competitive advantage in attracting job seekers and fostering optimistic career success expectation. Such findings substantially complement the growing literature arguing that corporate (...) citizenship brings firms competitive advantages without solid evidence from the perspective of recruitment and human resources. Finally, managerial implications and limitations of this study are also discussed. (shrink)
Deep brain stimulation to different sites allows interfering with dysfunctional network function implicated in major depression. Because a prominent clinical feature of depression is anhedonia--the inability to experience pleasure from previously pleasurable activities--and because there is clear evidence of dysfunctions of the reward system in depression, DBS to the nucleus accumbens might offer a new possibility to target depressive symptomatology in otherwise treatment-resistant depression. Three patients suffering from extremely resistant forms of depression, who did not respond to pharmacotherapy, psychotherapy, and (...) electroconvulsive therapy, were implanted with bilateral DBS electrodes in the nucleus accumbens. Stimulation parameters were modified in a double-blind manner, and clinical ratings were assessed at each modification. Additionally, brain metabolism was assessed 1 week before and 1 week after stimulation onset. Clinical ratings improved in all three patients when the stimulator was on, and worsened in all three patients when the stimulator was turned off. Effects were observable immediately, and no side effects occurred in any of the patients. Using FDG-PET, significant changes in brain metabolism as a function of the stimulation in fronto-striatal networks were observed. No unwanted effects of DBS other than those directly related to the surgical procedure were observed. Dysfunctions of the reward system--in which the nucleus accumbens is a key structure--are implicated in the neurobiology of major depression and might be responsible for impaired reward processing, as evidenced by the symptom of anhedonia. These preliminary findings suggest that DBS to the nucleus accumbens might be a hypothesis-guided approach for refractory major depression. (shrink)
Many scholars have suggested the relationship between corporate social performance and its ability to attract a large number of high-quality job applicants, because previous literature indicates that employees with strong social awareness help create a high-performance organization. For that reason, an important issue for successful business recruitment is how to boost the pursuit intention of job seekers. This study discusses such issue by proposing a model based on signaling theory and cognitive dissonance theory. In the proposed model of this study, (...) the positive relationships between four dimensions of corporate social performance and job pursuit intention are hypothetically moderated by socio-environmental consciousness. The proposed hypotheses of this research were empirically tested using the data from graduating students seeking a job. The empirical findings of this study complement previous literature by discussing how corporate social performance benefits business firms from a perspective of strengthened human resources and recruitment. Finally, managerial implications for business managers based on the findings herein are provided. (shrink)
Sharing and helping are important issues in ethical research. This study proposes a model based on flow theory by postulating key antecedents as the critical drivers of knowledge sharing and interemployee helping. Flow is the holistic sensation that employees feel when they act with total immersion and engagement, facilitating individuals' reciprocal activities such as knowledge sharing and interemployee helping. In the proposed model, knowledge sharing is influenced by flow experience directly and also indirectly via the mediation of interemployee helping. Accordingly, (...) the flow experience is influenced simultaneously by four exogenous factors related to individuals' perception about their work: work skills, self-fulfillment in challenges, perceived control, and vividness. This study contributes to the knowledge management literature by extending flow theory to the area of knowledge sharing and interemployee helping, by validating idiosyncratic antecedent drivers of the flow theory, and by performing a practical operationalization of the flow experience. This research also provides managerial implications for business leaders to boost their employees' ethical behavior in terms of sharing and helping. (shrink)
Corporate citizenship represents various organizational activities and status related to the organization's societal and stakeholder obligations. This study develops five different dimensions of corporate citizenship and examines the relationship between the five dimensions and purchase intention by including two key mediators. In the proposed model of this study, purchase intention is indirectly affected by economic, legal, ethical, general philanthropic, and strategic philanthropic citizenship via the mediation of corporate identification and brand trust. Empirical testing using a survey of 353 consumers from (...) various industries confirms most of our hypothesized effects. Last, managerial implications for corporate leaders and limitations of our findings are discussed in depth. (shrink)
_tableau_ can be given a full and satisfying explanation, while others cannot. We can explain in a full and satisfying way why the water in the mug is identical with H2O, why its liquidity is identical with a state of its molecular bonds, and why its heat is identical with its molecules being in motion. But we cannot explain in the same way why the neural processes which Joe undergoes when he looks at the mug are such as to make (...) the mug look green, and not red. The latter explanations have gaps. (shrink)
A great deal of music making that occurs amongst young people in our communities has its origins in self initiated out-of-school activity. This making reflects the social setting where the musical work is produced, including the manner in which the music is developed and how the musical activity is evaluated by the students. Recognising the origin of where the work is made is taken in this paper as an analogue of the thing (Heidegger, 1949). The thing in Heidegger, is not (...) seen as just an object, de-contextualised and removed from the artist or where the thing was made, but is seen as the embodiment of a shared experience of making and meaning. Following Heidegger’s discussion of the thing this paper considers the difficulty teachers face in evaluating the made musical object developed out-of-school. An instance is provided of 'Joe' devising electronic dance music within a virtual online community. (shrink)
This paper is a brief introduction to and interpretation of the work of Joe Orton, an English playwright of the 1960s who achieved notoriety through the violent and obscene content of his plays, his scandalous homosexual lifestyle and brutal death at the hands of his lover. Orton’s work is presented as a dramatic exemplification of distinctive themes pertaining to a radically materialistic strain in philosophy anticipated in Machiavelli and Spinoza but finding its fullest expression in Deleuze’s thought : the radical (...) immanence of the political, the critique of self-identity and clinical concepts of madness, and the anarchic and impersonal force of sexual desire. Orton achieves this aim through comic experimentation with language and a radicalisation of farce that serve to produce a laughter that is both destructive and affirmative : destructive of the boundaries artificially erected by reason , and affirmative of this process of destruction and the pre-subjective desire through which it is accomplished. (shrink)
The Doomsday argument purports to show that the risk of the human species going extinct soon has been systematically underestimated. This argument has something in common with controversial forms of reasoning in other areas, including: game theoretic problems with imperfect recall, the methodology of cosmology, the epistomology of indexical belief, and the debate over so-called fine-tuning arguments for the design hypothesis. The common denominator is a certain premiss: the Self-Sampling Assumption. We present two strands of argument in favor of this (...) assumption. Through a series of throught experiments we then investigate some bizarre _prima facie_ consequences - backward causation, psychic powers, and an apparent conflict with the Principal Principle. (shrink)
Rationalist accounts of self-knowledge are motivated in important part by the claim that only by looking to our reasons to discover our beliefs and desires are we active in relation to them and only thereby do we take responsibility for them. These kinds of account seem to predict that self-knowledge generated using third-personal methods or analogues of these methods will tend to undermine the capacity to exercise self-control. In this light, the insistence by treatment programs that addicts acknowledge that they (...) are addicts seems puzzling. I argue that because addicts—and perhaps ordinary akratics, to some extent at least, too—are vulnerable to losing control of their actions via losing control over their beliefs, advising them to look to their reasons for actions is counterproductive and facilitates loss of control. In contrast, an insistence on what I call impersonal self-knowledge, knowledge of some of one's states and dispositions generated by third-personal means, may help to reestablish control. (shrink)
This interview with Joseph Frank — best known as the author of a five-volume biography of Dostoevsky (published 1976 – 2002) and of Spatial Form in Modern Literature (1945) — was conducted in 2012 at Stanford and is published here, shortly after his death at age ninety-four, as a memorial to him. The conversation highlights Frank's representation of Dostoevsky as a critic and a satirist of the nihilist intelligentsia of nineteenth-century Russia — a portrayal that runs counter to the understanding (...) and use of his writings and his characters by Marxists, Nietzscheans, Freudians, Surrealists, crisis theologians, and Existentialists. Frank tells the story of how his friendship in the 1950s with Ralph Ellison, author of Invisible Man, led to Frank's teaching himself Russian in order to read Notes from Underground and write an article on the novella that changed the face of Dostoevsky scholarship. The conversation also provides hints as to how — as director of the Christian Gauss Seminars at Princeton and as a contributor to debates about Spatial Form in Critical Inquiry — he negotiated the intellectual trends and distractions of Grand Theory, which came to dominate literary criticism in the 1970s and confirmed Frank in his counterfocus on the importance of historical context, not only in criticism but also in literary creation. Above all, the interview shows how a scholar can overcome institutional pressures and the temptations of careerism by shrugging them off and concentrating attention on scholarship alone. (shrink)
Atran advances three theses: our folk-biological taxonomy is (1) universal, (2) innate, and (3) the product of natural selection. I argue that Atran offers insufficient support for theses (2) and (3) and that his evolutionary psychology thus amounts to nothing more than a just-so story.
This is a reply to W. Paul Franks’ critique (‘Why a Believer Could Believe that God Answers Prayers’) of my recent paper in Sophia (2007). I argue that Franks’ Plantinga-inspired criticism fails because it turns on the dubious assumption that the efficacy of prayer could provide evidence for the existence of God.