9 found
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  1.  93
    Explanatory Integration Challenges in Evolutionary Systems Biology.Sara Green, Melinda Fagan & Johannes Jaeger - 2015 - Biological Theory 10 (1):18-35.
    Evolutionary systems biology (ESB) aims to integrate methods from systems biology and evolutionary biology to go beyond the current limitations in both fields. This article clarifies some conceptual difficulties of this integration project, and shows how they can be overcome. The main challenge we consider involves the integration of evolutionary biology with developmental dynamics, illustrated with two examples. First, we examine historical tensions between efforts to define general evolutionary principles and articulation of detailed mechanistic explanations of specific traits. Next, these (...)
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  2.  43
    Genetic Causation in Complex Regulatory Systems: An Integrative Dynamic Perspective.James DiFrisco & Johannes Jaeger - 2020 - Bioessays 42 (6):1900226.
    The logic of genetic discovery has changed little over time, but the focus of biology is shifting from simple genotype–phenotype relationships to complex metabolic, physiological, developmental, and behavioral traits. In light of this, the traditional reductionist view of individual genes as privileged difference‐making causes of phenotypes is re‐examined. The scope and nature of genetic effects in complex regulatory systems, in which dynamics are driven by regulatory feedback and hierarchical interactions across levels of organization are considered. This review argues that it (...)
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  3.  44
    Beyond networks: mechanism and process in evo-devo.James DiFrisco & Johannes Jaeger - 2019 - Biology and Philosophy 34 (6):54.
    Explanation in terms of gene regulatory networks has become standard practice in evolutionary developmental biology. In this paper, we argue that GRNs fail to provide a robust, mechanistic, and dynamic understanding of the developmental processes underlying the genotype–phenotype map. Explanations based on GRNs are limited by three main problems: the problem of genetic determinism, the problem of correspondence between network structure and function, and the problem of diachronicity, as in the unfolding of causal interactions over time. Overcoming these problems requires (...)
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  4.  15
    The Fourth Perspective: Evolution and Organismal Agency.Johannes Jaeger - 2023 - In Matteo Mossio (ed.), Organization in Biology. Springer. pp. 159-186.
    This chapter examines the deep connections between biological organization, agency, and evolution by natural selection. Using Griesemer’s account of the reproducer, I argue that the basic unit of evolution is not a genetic replicator, but a complex hierarchical life cycle. Understanding the self-maintaining and self-proliferating properties of evolvable reproducers requires an organizational account of ontogenesis and reproduction. This leads us to an extended and disambiguated set of minimal conditions for evolution by natural selection—including revised or new principles of heredity, variation, (...)
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  5.  43
    The Comet Cometh: Evolving Developmental Systems.Johannes Jaeger, Manfred Laubichler & Werner Callebaut - 2015 - Biological Theory 10 (1):36-49.
    In a recent opinion piece, Denis Duboule has claimed that the increasing shift towards systems biology is driving evolutionary and developmental biology apart, and that a true reunification of these two disciplines within the framework of evolutionary developmental biology may easily take another 100 years. He identifies methodological, epistemological, and social differences as causes for this supposed separation. Our article provides a contrasting view. We argue that Duboule’s prediction is based on a one-sided understanding of systems biology as a science (...)
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  6.  33
    On the dynamic nature of positional information.Johannes Jaeger & John Reinitz - 2006 - Bioessays 28 (11):1102-1111.
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  7.  25
    Homology of process: developmental dynamics in comparative biology.James DiFrisco & Johannes Jaeger - forthcoming - Interface Focus.
    Comparative biology builds up systematic knowledge of the diversity of life, across evolutionary lineages and levels of organization, starting with evidence from a sparse sample of model organisms. In developmental biology, a key obstacle to the growth of comparative approaches is that the concept of homology is not very well defined for levels of organization that are intermediate between individual genes and morphological characters. In this paper, we investigate what it means for ontogenetic processes to be homologous, focusing specifically on (...)
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  8. Keeping the gene in its place.Johannes Jaeger & Nick Monk - 2013 - In Brian C. Goodwin, David Lambert, Chris Chetland & Craig Millar (eds.), The intuitive way of knowing: a tribute to Brian Goodwin. Edinburgh: Floris Books.
     
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  9.  24
    Neither fish nor fowl.Johannes Jaeger - 2010 - Bioessays 32 (7):638-640.
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