7 found
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  1.  11
    Genetic Causation in Complex Regulatory Systems: An Integrative Dynamic Perspective.James DiFrisco & Johannes Jaeger - 2020 - Bioessays 42 (6):1900226.
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  2.  63
    Explanatory Integration Challenges in Evolutionary Systems Biology.Sara Green, Melinda Fagan & Johannes Jaeger - 2015 - Biological Theory 10 (1):18-35.
    Evolutionary systems biology aims to integrate methods from systems biology and evolutionary biology to go beyond the current limitations in both fields. This article clarifies some conceptual difficulties of this integration project, and shows how they can be overcome. The main challenge we consider involves the integration of evolutionary biology with developmental dynamics, illustrated with two examples. First, we examine historical tensions between efforts to define general evolutionary principles and articulation of detailed mechanistic explanations of specific traits. Next, these tensions (...)
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  3.  20
    Beyond Networks: Mechanism and Process in Evo-Devo.James DiFrisco & Johannes Jaeger - 2019 - Biology and Philosophy 34 (6):54.
    Explanation in terms of gene regulatory networks has become standard practice in evolutionary developmental biology. In this paper, we argue that GRNs fail to provide a robust, mechanistic, and dynamic understanding of the developmental processes underlying the genotype–phenotype map. Explanations based on GRNs are limited by three main problems: the problem of genetic determinism, the problem of correspondence between network structure and function, and the problem of diachronicity, as in the unfolding of causal interactions over time. Overcoming these problems requires (...)
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  4.  5
    Beyond Networks: Mechanism and Process in Evo-Devo.James DiFrisco & Johannes Jaeger - 2019 - Biology and Philosophy 34 (6):54.
    Explanation in terms of gene regulatory networks has become standard practice in evolutionary developmental biology. In this paper, we argue that GRNs fail to provide a robust, mechanistic, and dynamic understanding of the developmental processes underlying the genotype–phenotype map. Explanations based on GRNs are limited by three main problems: the problem of genetic determinism, the problem of correspondence between network structure and function, and the problem of diachronicity, as in the unfolding of causal interactions over time. Overcoming these problems requires (...)
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  5.  14
    The Comet Cometh: Evolving Developmental Systems.Johannes Jaeger, Manfred Laubichler & Werner Callebaut - 2015 - Biological Theory 10 (1):36-49.
    In a recent opinion piece, Denis Duboule has claimed that the increasing shift towards systems biology is driving evolutionary and developmental biology apart, and that a true reunification of these two disciplines within the framework of evolutionary developmental biology may easily take another 100 years. He identifies methodological, epistemological, and social differences as causes for this supposed separation. Our article provides a contrasting view. We argue that Duboule’s prediction is based on a one-sided understanding of systems biology as a science (...)
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  6.  24
    On the Dynamic Nature of Positional Information.Johannes Jaeger & John Reinitz - 2006 - Bioessays 28 (11):1102-1111.
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  7.  13
    Neither Fish nor Fowl.Johannes Jaeger - 2010 - Bioessays 32 (7):638-640.
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