We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

Philosophers have recently revived the study of the ancient Greek topics of virtue and the virtues—justice, honesty, temperance, friendship, courage, and so on as qualities of mind and character belonging to individual people. But one issue at the center of Greek moral theory seems to have dropped out of consideration. This is the question of the unity of virtue, the unity of the virtues. Must anyone who has one of these qualities have others of them as well, indeed all of (...) them—all the ones that really do deserve to be counted as virtues? Even further, is there really no set of distinct and separate virtuous qualities at all, but at bottom only a single one—so that the person who has this single condition of “virtue” is entitled also to the further descriptions “honest” and “well-controlled” and “just” and “friendly” and “courageous” and “fostering” and “supportive,” and so on, as distinguishable aspects or immediate effects of his unitary “virtue”? (shrink)

Since its founding in 1943, Medievalia et Humanistica has won worldwide recognition as the first scholarly publication in America to devote itself entirely to medieval and Renaissance studies. Since 1970, a new series, sponsored by the Modern Language Association of America and edited by an international board of distinguished scholars and critics, has published interdisciplinary articles. In yearly hardbound volumes, the new series publishes significant scholarship, criticism, and reviews treating all facets of medieval and Renaissance culture: history, art, literature, music, (...) science, law, economics, and philosophy. (shrink)

© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

This book is a collection of secondary essays on America's most important philosophic thinkers—statesmen, judges, writers, educators, and activists—from the colonial period to the present. Each essay is a comprehensive introduction to the thought of a noted American on the fundamental meaning of the American regime.

The paper deals briefly with several definitional issues; discusses the concept of image as it determines the way managers see the world; as one aspect of the image, examines the contrasting views of conflict and cooperation in social and organizational relationships; and then presents a typology of corporate responses to pressures for socially responsible behavior: authoritarian, manipulative and bargaining. This typology was developed on the basis of the analysis of a large number of case histories of environmental conflicts, a number (...) of which are included for purposes of illustration. Several historical examples are cited. The inference drawn from this study is that decisions become more responsible as decision-makers come under the scrutiny of and pressure from those affected by the decisions. (shrink)

_A new theory of how and why we cooperate, drawing from economics, political theory, and philosophy to challenge the conventional wisdom of game theory_ Game theory explains competitive behavior by working from the premise that people are self-interested. People don’t just compete, however; they also cooperate. John Roemer argues that attempts by orthodox game theorists to account for cooperation leave much to be desired. Unlike competing players, cooperating players take those actions that they would like others to take—which Roemer (...) calls “Kantian optimization.” Through rigorous reasoning and modeling, Roemer demonstrates a simpler theory of cooperative behavior than the standard model provides. (shrink)

American health care is in the process of a significant social, institutional, and economic restructuring of the manner in which health services are provided in local communities. The Catholic health care ministry is undergoing the same sort of restructuring. The history of American health care demonstrates that the ministry has experienced at least two similar major restructurings of its institutional framework. The principle of cooperation has been the customary tool to assess the moral propriety of evolving social structures in which (...) the health care ministry has been housed. A process of discernment can lead to the conclusion that the central issue is not moral agency but rather how the ministry engages the secular culture of American society and American medicine. National Catholic Bioethics Quarterly 13.2 : 263–274. (shrink)

According to many in the West, the liberalizing effects of North America’s free market ideals will generate equality and justice worldwide. I hold that we should be critical of those who justify imposing liberal democratic ideals on underdeveloped nations by simply suggesting that they promote equality and justice. In the West, entrenched disparities have shaped liberal ideals in ways that make inequality and injustice look natural and normal. Indeed, gender, class, and racial oppression have existed right alongside liberal democratic ideals. (...) If liberal ideals can be molded to make inequality and injustice look natural and normal in the West, then these same ideals can justify economic interactions, technology transfers, military cooperation, and mutual benefit agreements that sustain global inequality and injustice. (shrink)

This book has two basic aims: to provide a clear and comprehensive account of the most prominent moral philosophies of ancient Greece and Rome, and to explain how for their adherents, these philosophies both motivated and constituted distinctive ways of life. Cooper succeeds admirably in achieving the first aim: he gives clear and concise accounts of the moral philosophies of Socrates, Aristotle, the Stoics, the Epicureans, the Pyrrhonists, and the Platonists. Each chapter explores not only the basic theories of (...) the school in question, but also some lingering questions readers may have about those theories’ implications. Cooper aims for his book to be both accessible to readers with little formal .. (shrink)

Philosophers and ecologists have proposed that ecological principles such as cooperation and ecosystern stability serve as a basis for environmental ethics. Requisite to understanding whether a cooperation based environmental ethic can be taken as an unqualified good is knowledge of the role of cooperation in the context of other interactions between species (e.g., cornpetition), and the significance of such interactions to ecosystem stability. Further, since the key ecological concept of stability has been ambiguously defined, the various definitions need to be (...) understood so that use of scientific information in philosophical discussion is accurate and consistent. (shrink)

Economics and evolutionary biology share a long history of interaction and parallel development. This pattern persists with regard to how the two fields address the issues of selfishness and cooperation. The recent renewed emphasis on empiricism in both fields provides a solid foundation on which to build a truly scientific unification of the behavioral sciences. (Published Online April 27 2007).

The Planteome project provides a suite of reference and species-specific ontologies for plants and annotations to genes and phenotypes. Ontologies serve as common standards for semantic integration of a large and growing corpus of plant genomics, phenomics and genetics data. The reference ontologies include the Plant Ontology, Plant Trait Ontology, and the Plant Experimental Conditions Ontology developed by the Planteome project, along with the Gene Ontology, Chemical Entities of Biological Interest, Phenotype and Attribute Ontology, and others. The project also provides (...) access to species-specific Crop Ontologies developed by various plant breeding and research communities from around the world. We provide integrated data on plant traits, phenotypes, and gene function and expression from 95 plant taxa, annotated with reference ontology terms. (shrink)

Cooperation, Contribution and Contestation: The Jain Community, Colonialism and Jainological Scholarship, 1800–1950. Edited by John E. Cort, Andrea Luithle-Hardenberg, and Leslie C. Orr. Studies in Asian Art and Culture, vol. 6. Berlin: eb verlAg, 2020. Pp. 615, plates. €69.

We shall argue that there is adequate moral justification for capital punishment with linkage, that is, with linkage to keeping non-murderers from dying. We present the argument with two aims in mind. The first is to question the conventional wisdom, seldom challenged even by proponents of capital punishment, that being an abolitionist is closely connected to having a civilized respect for human life. This conventional wisdom, we hope to show, is somewhat off the mark. To this end we exhibit structural (...) similarities between so-called lifeboat dilemmas and the public's relationship to a murderer. In a lifeboat dilemma one must choose between saving this life or that, since the lifeboat will not hold both persons. Now if this life were an innocent's and that one a murderer's, a choice to save the latter would not be met with accusations of callousness towards human life. We hope to project everyone's intuitions about this case onto the more baffling case of a society's relationship to the murderers and dying innocents in its midst. (shrink)

The first part of the chapter translates and discusses, section by section, Metaphysics Α 10. The second part rveiews in retrospect Aristotle's intentions in Metaphysics Α as a whole, and the progress of his argument through the 10 chapters of the book. It is Aristotle's intention to search for the first principles and causes of being, by reviewing and examining the opinions of his predecessors on this subject. A distinction must be made between Aristotle's report of his predecessors' opinions and (...) his critical discussion of the difficulties he thinks their views involve; at the end of the book Aristotle reminds us that we need to mull over these difficulties for ourselves: this is the programme set for Book B. (shrink)

"The demonization of the radical right ill serves us when now, more than ever before, it is vitally important to know all we can about this esoteric milieu's nature and potentialities…by…demonizing the many, we cloak the few, and, however unwittingly, facilitate the existence of evil in the world." —From the Introduction by Jeffrey Kaplan White power groups are universally vilified and feared. But to better understand the threat they pose, scholars and activists must try to better understand their disturbing ideas (...) and practices. In this controversial volume, Jeffrey Kaplan brings to light the workings of white supremacy movements in the United States and Europe in the years since World War II. The first half of the Encyclopedia is made up of over 100 entries—many of them essay-length—describing the people, groups and themes that make up the radical racist right. Some of the entries are written by movement activists themselves, providing useful insider accounts. The second half contains original resources circulated within the movement, each prefaced and placed in scholarly context by the editor. These documents, although offending, are invaluable to researchers and often available nowhere else. Cross-references and an index make the information easily accessible. For scholars of race, religion, politics or social movements, the Encyclopedia of White Power is an essential resource. (shrink)

The ethics of Aristotle , and virtue ethics in general, have enjoyed a resurgence of interest over the past few decades. Aristotelian themes, with such issues as the importance of friendship and emotions in a good life, the role of moral perception in wise choice, the nature of happiness and its constitution, moral education and habituation, are finding an important place in contemporary moral debates. Taken together, the essays in this volume provide a close analysis of central arguments in Aristotle's (...) Nicomachean Ethics and show the enduring interest of the questions Aristotle raises. (shrink)

Green’s book outlines a wholistic vision of human nature, the Christian life, and life after death using “neuro-hermeneutics,” his approach to biblical interpretation integrated with neuroscience and psychology. He argues that a comprehensive vision of Christianity implies body-soul monism and undermines dualism. I respond that these sciences are consistent with dualist as well as monist anthropologies. I examine his exegetical arguments for anthropological monism from the eschatological texts of Luke–Acts and the Corinthian epistles, find them wanting, and show why they (...) actually imply dualism. I conclude that Green has neither undermined dualism nor warranted monism. (shrink)

NEITHER in the scholarly nor in the philosophical literature on Aristotle does his account of friendship occupy a very prominent place. I suppose this is partly, though certainly not wholly, to be explained by the fact that the modern ethical theories with which Aristotle’s might demand comparison hardly make room for the discussion of any parallel phenomenon. Whatever else friendship is, it is, at least typically, a personal relationship freely, even spontaneously, entered into, and ethics, as modern theorists tend to (...) conceive it, deals rather with the ways in which people are required to regard, and behave toward, one another, than with the organization of their private affairs. To the extent, then, that one shares this modern outlook one will tend to neglect, or treat merely as an historical curiosity, Aristotle’s efforts to define friendship and to place it within the framework of human eudaimonia, the theory of which is central to moral philosophy as he understands it. Yet in the Nicomachean Ethics the two books on φιλία make up nearly a fifth of the whole, and this seems to me a fair measure of the importance of this subject to the complete understanding both of Aristotle’s overall moral theory and even of many of the more circumscribed topics to which so much scholarly and philosophical attention has been devoted. If, as I suggest, the failure of commentators to appreciate its importance is partly the effect of distortions produced by the moral outlook that has predominated in modern moral philosophy, the careful study of these books may help to free us from constricting prejudices and perhaps even make it possible to discover in Aristotle a plausible and suggestive alternative to the theories constructed on the narrower base characteristic of recent times. (shrink)

This six volume Routledge Library Edition set is dedicated to the work of key nineteenth-century German thinker, Friedrich Nietzsche, whose hugely influential work in the field of philosophy continues to be felt to this day. The six volumes, published between 1948 and 1988, represent a truly wide-ranging analysis of Nietzsche’s life and work, offering an excellent overview of the cannon of critical analysis and interpretation on Nietzsche in the twentieth century. The collection covers Nietzsche’s perspectives and influence upon a variety (...) of sociological and philosophical debates, as well as placing his work in the context of contemporaries such as Richard Wagner, Fyodor Dostoyevsky and Max Stirner. (shrink)

I discuss the division of the soul in plato's "republic". i concentrate on the arguments and illustrative examples given in book iv, but i treat the descriptions of different types of person in viii-ix and elsewhere as further constituents of a single, coherent theory. on my interpretation plato distinguishes three basic kinds of motivation which he claims all human beings regularly experience in some degree. reason is itself the immediate source of certain desires. in addition, there are appetitive and also--quite (...) distinct from either of the other two--competitive motivations. (shrink)

Ḥunayn ibn Isḥāq on His Galen Translations. Edited and translated by John C. Lamoreaux. Eastern Christian Texts. Provo, UT: Brigham Young University Press, 2016. Pp. xxxiii + 207. $49.95.

My ultimate purpose here is to examine, discuss, and interpret a difficult excerpt in Stobaeus’ 5th c. AD anthology, alleging to report—uniquely, it appears—a distinction Chrysippus drew between three different applications of the term stoixe›on or element (i.e., physical element).1 Stobaeus lists this passage as giving opinions specifically of Chrysippus “about the elements out of substance” (per‹ t«n §k t∞w oÈs€aw stoixe€vn), though in holding them he says Chrysippus was following Zeno, the leader of his sect. Hermann Diels (1879) identified (...) this selection as an excerpt (his fr. 21) from Arius Didymus’ late first century BC Epitome of Physical Doctrines.2 I print a translation below, with the text in an Appendix, as it is given in von Arnim (1903). The text is not without its problems, and I indicate in footnotes to the text which of the principal editors’ textual interventions I accept and follow in my translation. Whether this text presents a single, continuous excerpt from Arius Didymus, or instead some compilation of Stobaeus (or an earlier anthologist whose work Stobaeus employed) from dispersed passages of.. (shrink)

Knowledge, Nature, and the Good brings together some of John Cooper's most important works on ancient philosophy. In thirteen chapters that represent an ideal companion to the author's influential Reason and Emotion, Cooper addresses a wide range of topics and periods--from Hippocratic medical theory and Plato's epistemology and moral philosophy, to Aristotle's physics and metaphysics, academic scepticism, and the cosmology, moral psychology, and ethical theory of the ancient Stoics.Almost half of the pieces appear here for the first (...) time or are presented in newly expanded, extensively revised versions. Many stand at the cutting edge of research into ancient ethics and moral psychology. Other chapters, dating from as far back as 1970, are classics of philosophical scholarship on antiquity that continue to play a prominent role in current teaching and scholarship in the field. All of the chapters are distinctive for the way that, whatever the particular topic being pursued, they attempt to understand the ancient philosophers' views in philosophical terms drawn from the ancient philosophical tradition itself.Through engaging creatively and philosophically with the ancient texts, these essays aim to make ancient philosophical perspectives freshly available to contemporary philosophers and philosophy students, in all their fascinating inventiveness, originality, and deep philosophical merit. This book will be treasured by philosophers, classicists, students of philosophy and classics, those in other disciplines with an interest in ancient philosophy, and anyone who seeks to understand philosophy in philosophical terms. (shrink)

Cooper, Austin John Henry Newman was born in 1801, converted to the Catholic Church in 1845 and died in 1890. That is, he spent the first half of his life in the Church of England. He was to exercise a profound influence on both Communions in Australia. The young Newman was elected a Fellow of Oriel College, Oxford, in April 1822. Despite the declining fortunes of his family, his own career was off to a promising start. Two years (...) later he was ordained Deacon at Christ Church Cathedral, Oxford on 13 June 1824. This was a very solemn commitment indeed. He thought he should give himself totally to the service of the Gospel. This attitude prompted him to write to the CMS (the Church Missionary Society) in London seeking information regarding service as a missionary. He followed up his letter with a visit to the CMS London Headquarters on July 3, 1824 - just two weeks after his ordination as deacon. (shrink)

Cooperation can evolve in the context of cognitive activities such as perception, attention, memory, and decision making, in addition to physical activities such as hunting, gathering, warfare, and childcare. The social insects are well known to cooperate on both physical and cognitive tasks, but the idea of cognitive cooperation in humans has not received widespread attention or systematic study. The traditional psychological literature often gives the impression that groups are dysfunctional cognitive units, while evolutionary psychologists have so far studied cognition (...) primarily at the individual level. We present two experiments that demonstrate the superiority of thinking in groups, but only for tasks that are sufficiently challenging to exceed the capacity of individuals. One of the experiments is in a brain-storming format, where advantages of real groups over nominal groups have been notoriously difficult to demonstrate. Cognitive cooperation might often operate beneath conscious awareness and take place without the need for overt training, as evolutionary psychologists have stressed for individual-level cognitive adaptations. In general, cognitive cooperation should be a central subject in human evolutionary psychology, as it already is in the study of the social insects. (shrink)

I Deliberation, Practical Syllogisms , and Intuition. Introduction Aristotle's views on moral reasoning are a difficult and much disputed subject. ...