Results for 'John E. Joseph'

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  1.  30
    The arbre-tree sign: Pictures and words in counterpoint in the Cours de linguistique générale.John E. Joseph - 2017 - Semiotica 2017 (217):147-171.
    Journal Name: Semiotica Issue: Ahead of print.
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  2.  16
    A reply to P. A. M. Seuren, ‘Saussure and his intellectual environment’.John E. Joseph - 2016 - History of European Ideas 42 (6):848-850.
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  3.  52
    Saussure.John E. Joseph - 2012 - Oxford University Press.
    In the first comprehensive biography of Ferdinand de Saussure, John E. Joseph restores the full character and history of a man who is considered the founder of modern linguistics and whose ideas have influenced literary theory, philosophy, cultural studies, and virtually every other branch of humanities and the social sciences.
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  4.  6
    U.S. Energy Policy and U.S. Foreign Policy in the 1980s: Report of the Atlantic Council's Energy Policy Committee.John E. Gray, Henry H. Fowler & Joseph W. Harned - 1988 - Upa.
    Originally published by Ballinger, this book is a result of an Atlantic Council study of U.S. international relationships on energy. It examines the uncertainties of a political, strategic, economic, and technological nature that are involved in energy supply, as well as the unavoidable certainty of finite resources.
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  5.  52
    Zellig Harris: From American Linguistics to Socialist Zionism. By Robert F.John E. Joseph - 2013 - The European Legacy 18 (4):512-513.
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  6.  27
    Zellig Harris: From American Linguistics to Socialist Zionism. By Robert F. Barsky (Cambridge, MA: MIT Press, 2011), xvii+ 353 pp. $29.95/£ 22.95 cloth. [REVIEW]John E. Joseph - 2013 - The European Legacy:1-2.
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  7.  31
    Entrepreneurship and Peacebuilding: A Review and Synthesis.Harry J. Van Buren, John E. Katsos & Jay Joseph - 2023 - Business and Society 62 (2):322-362.
    Entrepreneurship is the dominant form of enterprise in conflict-affected settings, yet little is known about the role of entrepreneurship in peacebuilding. In response, this article undertakes a review of entrepreneurship in conflict-affected regions to integrate research from business and management with research from political science, international relations, and parallel domains. Three views of entrepreneurship emerge—the destructive view, economic view, and social cohesion view—showing how entrepreneurship can concurrently create conflict but also potentially generate peace. The article identifies new avenues for pro-peace (...)
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  8.  27
    Local Business, Local Peace? Intergroup and Economic Dynamics.Jay Joseph, John E. Katsos & Mariam Daher - 2020 - Journal of Business Ethics 173 (4):835-854.
    The field of “business for peace” recognizes the role that businesses can play in peacebuilding. However, like much of the discussion concerning business in conflict zones, it has prioritized the view of multinationals, often overlooking the role of indigenous local firms. The economic, social, and intergroup dynamics experienced by local businesses in conflict zones are understudied, with the current paper beginning by positioning micro- and small enterprises in the peacebuilding debate, then engaging with multidisciplinary works to understand how they foster (...)
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  9. Identity and language.John E. Joseph - 2005 - In Keith Brown (ed.), Encyclopedia of Language and Linguistics. Elsevier. pp. 486--492.
     
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  10.  45
    Beyond pure reason: Ferdinand de saussure's philosophy of language and its early romantic antecedents gasparov Boris new York: Columbia university press, 2013; XI + 227 pp.; $50.00 (hardback), $39.99 (ebook). [REVIEW]John E. Joseph - 2014 - Dialogue 53 (1):1-3.
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  11.  25
    Beyond pure reason: Ferdinand de saussure’s philosophy of language and its early romantic antecedents gasparov Boris new York: Columbia university press, 2013; XI + 227 pp.; $50.00 , $39.99. [REVIEW]John E. Joseph - 2014 - Dialogue 53 (1):197-199.
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  12.  28
    The Duty to Obey the Law: Selected Philosophical Readings.Leslie Green, Kent Greenawalt, Nancy J. Hirschmann, George Klosko, Mark C. Murphy, John Rawls, Joseph Raz, Rolf Sartorius, A. John Simmons, M. B. E. Smith, Philip Soper, Jeremy Waldron, Richard A. Wasserstrom & Robert Paul Wolff (eds.) - 1998 - Rowman & Littlefield Publishers.
    The question 'Why should I obey the law?' introduces a contemporary puzzle that is as old as philosophy itself. The puzzle is especially troublesome if we think of cases in which breaking the law is not otherwise wrongful, and in which the chances of getting caught are negligible. Philosophers from Socrates to H.L.A. Hart have struggled to give reasoned support to the idea that we do have a general moral duty to obey the law but, more recently, the greater number (...)
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  13.  44
    Book Reviews Section 4.Geneva Gay, Paul Woodring, Harvey G. Neufeldt, Thomas M. Carroll, Richard W. Saxe, Maureen Macdonald Webster, Forrest E. Keesebury, Richard L. Hopkins, John Elias, Joseph M. Mccarthy, Charles R. Schindler, Robert L. Reid & Thomas D. Moore - 1973 - Educational Studies 4 (2):99-110.
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  14.  49
    European and American Philosophers.John Marenbon, Douglas Kellner, Richard D. Parry, Gregory Schufreider, Ralph McInerny, Andrea Nye, R. M. Dancy, Vernon J. Bourke, A. A. Long, James F. Harris, Thomas Oberdan, Paul S. MacDonald, Véronique M. Fóti, F. Rosen, James Dye, Pete A. Y. Gunter, Lisa J. Downing, W. J. Mander, Peter Simons, Maurice Friedman, Robert C. Solomon, Nigel Love, Mary Pickering, Andrew Reck, Simon J. Evnine, Iakovos Vasiliou, John C. Coker, Georges Dicker, James Gouinlock, Paul J. Welty, Gianluigi Oliveri, Jack Zupko, Tom Rockmore, Wayne M. Martin, Ladelle McWhorter, Hans-Johann Glock, Georgia Warnke, John Haldane, Joseph S. Ullian, Steven Rieber, David Ingram, Nick Fotion, George Rainbolt, Thomas Sheehan, Gerald J. Massey, Barbara D. Massey, David E. Cooper, David Gauthier, James M. Humber, J. N. Mohanty, Michael H. Dearmey, Oswald O. Schrag, Ralf Meerbote, George J. Stack, John P. Burgess, Paul Hoyningen-Huene, Nicholas Jolley, Adriaan T. Peperzak, E. J. Lowe, William D. Richardson, Stephen Mulhall & C. - 1991 - In Robert L. Arrington (ed.), A Companion to the Philosophers. Malden, Mass.: Wiley-Blackwell. pp. 109–557.
    Peter Abelard (1079–1142 ce) was the most wide‐ranging philosopher of the twelfth century. He quickly established himself as a leading teacher of logic in and near Paris shortly after 1100. After his affair with Heloise, and his subsequent castration, Abelard became a monk, but he returned to teaching in the Paris schools until 1140, when his work was condemned by a Church Council at Sens. His logical writings were based around discussion of the “Old Logic”: Porphyry's Isagoge, aristotle'S Categories and (...)
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  15. Forgas, Joseph P. & Bower, Gordon H.(1987). Mood effects on person.Jill M. Hooley, John E. Richters, Sheldon Weintraub & John M. Neale - 1988 - Cognition and Emotion 2 (1):71-80.
  16.  19
    Joseph Snow, The Poetry of Alfonso X, El Sabio: A Critical Bibliography. London: Grant and Cutler, 1977. Paper. Pp. 140. £ 6. [REVIEW]John E. Keller - 1980 - Speculum 55 (1):193.
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  17. Book reviews. [REVIEW]Werner Menski, Carl Olson, William Cenkner, Anne E. Monius, Sarah Hodges, Jeffrey J. Kripal, Carol Salomon, Deepak Sarma, William Cenkner, John E. Cort, Peter A. Huff, Joseph A. Bracken, Larry D. Shinn, Jonathan S. Walters, Ellison Banks Findly, John Grimes, Loriliai Biernacki, David L. Gosling, Thomas Forsthoefel, Michael H. Fisher, Ian Barrow, Srimati Basu, Natalie Gummer, Pradip Bhattacharya, John Grimes, Heather T. Frazer, Elaine Craddock, Andrea Pinkney, Joseph Schaller, Michael W. Myers, Lise F. Vail, Wayne Howard, Bradley B. Burroughs, Shalva Weil, Joseph A. Bracken, Christopher W. Gowans, Dan Cozort, Katherine Janiec Jones, Carl Olson, M. D. McLean, A. Whitney Sanford, Sarah Lamb, Eliza F. Kent, Ashley Dawson, Amir Hussain, John Powers, Jennifer B. Saunders & Ramdas Lamb - 2005 - International Journal of Hindu Studies 9 (1-3):153-228.
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  18. Rising starlet: the starlet sea anemone,Nematostella vectensis.John A. Darling, Adam R. Reitzel, Patrick M. Burton, Maureen E. Mazza, Joseph F. Ryan, James C. Sullivan & John R. Finnerty - 2005 - Bioessays 27 (2):211-221.
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  19.  26
    Are You Ready for the Next Outbreak? An Exercise in Legal Preparedness.John O. Agwunobi, Sara Feigenholtz, Donna E. Levin, Robert E. Ragland, Joseph M. Henderson & Frederic E. Shaw - 2004 - Journal of Law, Medicine and Ethics 32 (S4):77-78.
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  20.  25
    Mead, George Herbert, 133,135,171 Mill, John Stuart, 55,188, 242.Phillip E. Johnson, Thomas Kuhn, Abraham Lefkowitz, Henry Linville, John Locke, Helen Longino, Hermann Lotze, Arthur O. Lovejoy & Joseph Priestley - 2002 - In F. Thomas Burke, D. Micah Hester & Robert B. Talisse (eds.), Dewey's logical theory: new studies and interpretations. Nashville: Vanderbilt University Press.
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  21.  90
    Intrinsic functional network organization in high-functioning adolescents with autism spectrum disorder.Elizabeth Redcay, Joseph M. Moran, Penelope L. Mavros, Helen Tager-Flusberg, John D. E. Gabrieli & Susan Whitfield-Gabrieli - 2013 - Frontiers in Human Neuroscience 7.
  22.  14
    Editorial: Imaginative culture and human nature: Evolutionary perspectives on the arts, religion, and ideology.Joseph Carroll, John A. Johnson, Emelie Jonsson, Rex E. Jung & Valerie van Mulukom - 2022 - Frontiers in Psychology 13.
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  23.  44
    The trouble with authenticity: separating ideology from practice at the farmers' market. [REVIEW]John Smithers & Alun E. Joseph - 2010 - Agriculture and Human Values 27 (2):239-247.
    Farmers’ markets have enjoyed a resurgence in the past two decades in Canada, the United States, and the United Kingdom. This increase in popularity is attributed to a host of environmental, social, and economic factors, often related to the alleged benefits of local food, alternative farming, and producer–consumer interactions. Steeped in tradition, there are also widely held assumptions related to the type of food and food vendors that belong at a farmers’ market in addition to the type of experience that (...)
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  24. The american philosophical association eastern division: Abstracts of papers to be read at the fifty-fourth annual meeting, Harvard university, december 27-29, 1957. [REVIEW]John W. Lenz, Paul Oskar Kristeller, Willis Doney, Norman Kretzmann, Colin Murray Turbayne, Arthur Pap, E. M. Adams, T. A. Goudge, Edward H. Madden, Rudolf Allers, Hans Jonas, Lawrence W. Beals, Philip Nochlin, Ethel M. Albert, Mary Mothersill, John W. Blyth, Hector N. Castañeda, Milton C. Nahm & Joseph Margolis - 1957 - Journal of Philosophy 54 (24):773-794.
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  25.  80
    Book reviews and notices. [REVIEW]John Grimes, Robin Rinehart, Hillary Rodrigues, John M. Koller, Elaine Craddock, Ludo Rocher, Will Sweetman, Boyd H. Wilson, Edward C. Dimock, Thomas Forsthoefel, Hal W. French, Timothy C. Cahill, William J. Jackson, John Powers, Frederick M. Smith, Gavin Flood, Lelah Dushkin, Sheila McDonough, Frank J. Hoffman, Karni Pal Bhati, Anne E. Monius, Fred Dallmayr, Marcia Hermansen, Joseph A. Bracken, Carl Olson, William P. Harman, Donatella Rossi, Anna B. Bigelow & Jeffrey J. Kripal - 1998 - International Journal of Hindu Studies 2 (2):267-310.
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  26.  43
    Reviews : John E. Joseph and Talbot J. Taylor (eds), Ideologies of Language, London: Routledge, 1990, paper £10.99, viii + 245 pp. [REVIEW]Trevor Pateman - 1991 - History of the Human Sciences 4 (3):450-452.
  27.  43
    A discussion of the theory of international relations.John Dewey, T. V. Smith, Arthur O. Lovejoy, Joseph P. Chamberlain, William Ernest Hocking, E. A. Burtt, Glenn R. Morrow, Sidney Hook & Jerome Nathanson - 1945 - Journal of Philosophy 42 (18):477-497.
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  28.  11
    The Deconstitutionalization of America: The Forgotten Frailties of Democratic Rule.Roger M. Barrus, John H. Eastby, Joseph H. Lane, David E. Marion & James F. Pontuso - 2004 - Lexington Books.
    The American Constitution held out the hope that ordinary people were capable of deciding their own fates, and in doing so it immeasurably elevated the dignity of common people. The organization and interplay of the parts that comprise the whole American government exist to provide people the opportunity to govern themselves and, at the same time, reveal the limits of democratic self-rule. The forgetting of these limits is not only destructive to the constitution but the nation as a whole.
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  29. Updated Review of the Evidence Supporting the Medical and Legal Use of NeuroQuant® and NeuroGage® in Patients With Traumatic Brain Injury.David E. Ross, John Seabaugh, Jan M. Seabaugh, Justis Barcelona, Daniel Seabaugh, Katherine Wright, Lee Norwind, Zachary King, Travis J. Graham, Joseph Baker & Tanner Lewis - 2022 - Frontiers in Human Neuroscience 16.
    Over 40 years of research have shown that traumatic brain injury affects brain volume. However, technical and practical limitations made it difficult to detect brain volume abnormalities in patients suffering from chronic effects of mild or moderate traumatic brain injury. This situation improved in 2006 with the FDA clearance of NeuroQuant®, a commercially available, computer-automated software program for measuring MRI brain volume in human subjects. More recent strides were made with the introduction of NeuroGage®, commercially available software that is based (...)
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  30.  14
    John E. Joseph. Language, Mind, and Body: A Conceptual History. x + 282 pp., figs., illus., notes, bibl., index. Cambridge: Cambridge University Press, 2018. £85 . ISBN 9781107149557. [REVIEW]Matthew Lauzon - 2019 - Isis 110 (3):572-574.
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  31.  23
    (1 other version)John E. Joseph. Limiting the Arbitrary: Linguistic Naturalism and Its Opposites in Plato’s Cratylus and Modern Theories of Language. . x+224 pp., bibl., index. Amsterdam/Philadelphia: John Benjamins Publishing, 2000. $64. [REVIEW]Giorgio Graffi - 2003 - Isis 94 (4):692-693.
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  32.  7
    “Every Marital Act Ought to be Open to New Life”: Toward a Clearer Understanding.Germain Grisez, Joseph Boyle, John Finnis & William E. May - 1988 - The Thomist 52 (3):365-426.
    In lieu of an abstract, here is a brief excerpt of the content:"EVERY MARITAL ACT OUGHT TO BE OPEN TO NEW LIFE'': TOWARD A CLEARER UNDERSTANDING I. INTRODUCTION NE FREQUENTLY encounters misinterpretations of the statement " Every marital act ought to be open to new life " and similar statements in recent Catholic teaching concerning contraception.1 There are two common misinterpretations. One is: No couple may engage in marital intercourse without the intention to procreate. The other is: No couple may (...)
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  33.  33
    Book Review Section 3. [REVIEW]John R. Thelin, Thomas R. Mcdaniel, Bruce Beezer, Joseph Watras, Sally Schumacher, Jennings L. Wagoner Jr, James M. Giarelli, Rodney P. Riegle, Richard Labrecque, Robert E. Roemer, John Martin Rich, John R. Palmer, Scott Enright & David Bensman - 1982 - Educational Studies: A Jrnl of the American Educ. Studies Assoc 13 (3&4):442-500.
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  34.  24
    Books in review.Lyle E. Angene, John J. Carey, Joseph Owens, Robert C. Good & Winfield E. Nagley - 1978 - International Journal for Philosophy of Religion 9 (4):258-263.
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  35.  50
    Book reviews. [REVIEW]Joseph Margolis, Roger Simonds, William E. McMahon, Walter Harding, John Howie & Harold J. Allen - 1970 - Journal of Value Inquiry 5 (1):57-77.
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  36.  47
    Book Review Section 2. [REVIEW]Gerald M. Reagan, John L. Harrison, Don Cochrane, Don-Chean Chu, J. Stephen Hazlett, Basil J. Reppas, Robert P. Craig, John L. Elias, Albert E. Bender, Joseph Fashing, Donald K. Sharpes & Russell Dennis - 1974 - Educational Studies 5 (4):247-258.
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  37.  28
    On PaintingThe Sociology of Literary TasteThe Mathematical Basis of the ArtsThe Schillinger System of Musical Composition.Leon Battista Alberti, John R. Spencer, Creighton Gilbert, Levin Schucking, E. W. Dickes, Brian Battershaw, Thomas Munro & Joseph Schillinger - 1967 - Journal of Aesthetics and Art Criticism 26 (1):148.
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  38.  19
    Philosophical Pragmatism and International Relations: Essays for a Bold New World.Brian E. Butler, Matthew J. Brown, Phillip Deen, Loren Goldman, John Kaag, John Ryder, Patricia Shields, Joseph Soeters & Eric Thomas Weber - 2013 - Lexington Books.
    Philosophical Pragmatism and International Relations bridges the gap between philosophical pragmatism and international relations, two disciplinary perspectives that together shed light on how to advance the study and conduct of foreign affairs. Authors in this collection discuss a broad range of issues, from policy relevance to peacekeeping operations, with an eye to understanding how this distinctly American philosophy, pragmatism, can improve both international relations research and foreign policy practice.
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  39.  14
    Essays on Ayn Rand's Anthem.Michael S. Berliner, Andy Bernstein, Harry Binswanger, Tore Boeckmann, Jeff Britting, Onkar Ghate, Lindsay Joseph, John Lewis, Shoshana Milgram, Amy Peikoff, Richard E. Ralston, Greg Salmieri & Darryl Wright (eds.) - 2005 - Lexington Books.
    The essays in this collection treat historical, literary, and philosophical topics related to Ayn Rand's Anthem, an anti-utopia fantasy set in the future. The first book-length study on Anthem, this collection covers subjects such as free will, political freedom, and the connection between freedom and individual thought and privacy.
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  40.  55
    Book Reviews Section 4.Adelia M. Peters, Mary B. Harris, Richard T. Walls, George A. Letchworth, Ruth G. Strickland, Thomas L. Patrick, Donald R. Chipley, David R. Stone, Diane Lapp, Joan S. Stark, James W. Wagener, Dewane E. Lamka, Ernest B. Jaski, John Spiess, John D. Lind, Thomas J. la Belle, Erwin H. Goldenstein, George R. la Noue, David M. Rafky, L. D. Haskew, Robert J. Nash, Norman H. Leeseberg, Joseph J. Pizzillo & Vincent Crockenberg - 1973 - Educational Studies 4 (3):169-185.
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  41.  24
    The Philosophical I: Personal Reflections on Life in Philosophy.Nicholas Rescher, Richard Shusterman, Linda Martín Alcoff, Lorraine Code, Sandra Harding, Bat-Ami Bar On, John Lachs, John J. Stuhr, Douglas Kellner, Thomas E. Wartenberg, Paul C. Taylor, Nancey Murphy, Charles W. Mills, Nancy Tuana & Joseph Margolis (eds.) - 2002 - Rowman & Littlefield Publishers.
    Philosophy is shaped by life and life is shaped by philosophy. This is reflected in The Philosophical I, a collection of 16 autobiographical essays by prominent philosophers.
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  42.  13
    Protein kinase cascades activated by stress and inflammatory cytokines.John M. Kyriakis & Joseph Avruch - 1996 - Bioessays 18 (7):567-577.
    Signal transduction pathways constructed around a core module of three consecutive protein kinases, the most distal being a member of the extracellular signal‐regulated kinase (ERK) family, are ubiquitous among eukaryotes. Recent work has defined two cascades activated preferentially by the inflammatory cytokines TNF‐α and IL‐1‐β, as well as by a wide variety of cellular stresses such as UV and ionizing radiation, hyperosmolarity, heat stress, oxidative stress, etc. One pathway converges on the ERK subfamily known as the ‘stress activated’ protein kinases (...)
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  43. On Experiencing Meaning: Irreducible Cognitive Phenomenology and Sinewave Speech.John Joseph Dorsch - 2017 - Phenomenology and Mind 12:218-227.
    Upon first hearing sinewaves, all that can be discerned are beeps and whistles. But after hearing the original speech, the beeps and whistles sound like speech. The difference between these two episodes undoubtedly involves an alteration in phenomenal character. O’Callaghan (2011) argues that this alteration is non-sensory, but he leaves open the possibility of attributing it to some other source, e.g. cognition. I discuss whether the alteration in phenomenal character involved in sinewave speech provides evidence for cognitive phenomenology. I defend (...)
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  44. Research ethics capacity development in Africa: Exploring a model for individual success.A. L. I. Joseph, Adnan A. Hyder & Nancy E. Kass - 2012 - Developing World Bioethics 12 (2):55-62.
    The Johns Hopkins-Fogarty African Bioethics Training Program (FABTP) has offered a fully-funded, one-year, non-degree training opportunity in research ethics to health professionals, ethics committee members, scholars, journalists and scientists from countries across sub-Saharan Africa. In the first 9 years of operation, 28 trainees from 13 African countries have trained with FABTP. Any capacity building investment requires periodic critical evaluation of the impact that training dollars produce. In this paper we describe and evaluate FABTP and the efforts of its trainees.Our data (...)
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  45.  98
    “First, Do No Harm”?Stephen John & Joseph Wu - 2022 - Social Theory and Practice 48 (3):525-551.
    Screening for asymptomatic disease is a routine aspect of contemporary public health practice. However, it is also controversial, because it leads to overdiagnosis and overtreatment, with many arguing that programmes are “ineffective,” i.e., the “costs” outweigh the “benefits.” This paper explores a more fundamental objection to screening programmes: that, even if they are effective, they are ethically impermissible because they breach the principle of non-maleficence. In so doing, it suggests a new approach to the ethics of risk, justifying a concern (...)
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  46.  25
    Effects of extradimensional training on stimulus generalization.David R. Thomas, Frederick Freeman, John G. Svinicki, D. E. Scott Burr & Joseph Lyons - 1970 - Journal of Experimental Psychology 83 (1p2):1.
  47.  33
    Tutor, salon, convent: the formation of women philosophers in early modern France.John Joseph Conley - 2019 - British Journal for the History of Philosophy 27 (4):786-805.
    ABSTRACTExcluded from the university, women authors in early modern France acquired their philosophical culture from other venues. The tutorial, the salon, and the convent school are three of the e...
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  48.  71
    Research Ethics Capacity Development in Africa: Exploring a Model for Individual Success.Joseph Ali, Adnan A. Hyder & Nancy E. Kass - 2012 - Developing World Bioethics 12 (2):55-62.
    The Johns Hopkins‐Fogarty African Bioethics Training Program (FABTP) has offered a fully‐funded, one‐year, non‐degree training opportunity in research ethics to health professionals, ethics committee members, scholars, journalists and scientists from countries across sub‐Saharan Africa. In the first 9 years of operation, 28 trainees from 13 African countries have trained with FABTP. Any capacity building investment requires periodic critical evaluation of the impact that training dollars produce. In this paper we describe and evaluate FABTP and the efforts of its trainees.Our data (...)
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  49. New books. [REVIEW]A. E. Taylor, C. D. Broad, Bernard Muscio, R. M. MacIver, Joseph Rickaby, Leonard J. Russell, G. A. Johnston, Henry J. Watt, M. L., John Edgar, Arthur Robinson, J. Laird, R. R. Marett, J. L. McIntyre, W. L. Lorimer, C. V. Valentine, F. C. S. Schiller & Philip E. B. Jourdan - 1913 - Mind 22 (87):403-442.
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  50. Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis.David C. Whitcomb, Jessica LaRusch, Alyssa M. Krasinskas, Lambertus Klei, Jill P. Smith, Randall E. Brand, John P. Neoptolemos, Markus M. Lerch, Matt Tector, Bimaljit S. Sandhu, Nalini M. Guda, Lidiya Orlichenko, Samer Alkaade, Stephen T. Amann, Michelle A. Anderson, John Baillie, Peter A. Banks, Darwin Conwell, Gregory A. Coté, Peter B. Cotton, James DiSario, Lindsay A. Farrer, Chris E. Forsmark, Marianne Johnstone, Timothy B. Gardner, Andres Gelrud, William Greenhalf, Jonathan L. Haines, Douglas J. Hartman, Robert A. Hawes, Christopher Lawrence, Michele Lewis, Julia Mayerle, Richard Mayeux, Nadine M. Melhem, Mary E. Money, Thiruvengadam Muniraj, Georgios I. Papachristou, Margaret A. Pericak-Vance, Joseph Romagnuolo, Gerard D. Schellenberg, Stuart Sherman, Peter Simon, Vijay P. Singh, Adam Slivka, Donna Stolz, Robert Sutton, Frank Ulrich Weiss, C. Mel Wilcox, Narcis Octavian Zarnescu, Stephen R. Wisniewski, Michael R. O'Connell, Michelle L. Kienholz, Kathryn Roeder & M. Micha Barmada - unknown
    Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...)
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