This book covers all aspects of the disorder, from an historical survey of research to date, through the nature and anatomical bases of neglect, and on to review contemporary theories on the subject.

In this long awaited volume, John Marshall invites us to reconsider Rene Descartes as an ethicist.

A major account of the development of the political, religious, social and moral thought of John Locke.

We describe some of the signs and symptoms of left visuo-spatial neglect. This common, severe and often long-lasting impairment is the most striking consequence of right hemisphere brain damage. Patients seem to (over-)attend to the right with subsequent inability to respond to stimuli in contralesional space. We draw particular attention to how patients themselves experience neglect. Furthermore, we show that the neglect patient's loss of awareness of left space is crucial to an understanding of the condition. Even after left space (...) has been brought into the patient's consciousness (either by local cueing on the left or by an emphasis on global properties of the scene as a whole), this awareness of left space rapidly declines. We suggest that much of the symptomology of left neglect can be interpreted as a disconnection between brain mechanisms that are relatively specialized for local (detail) visual processing and global (panoramic) processing. This failure of communication between functional (subpersonal) mechanisms then has consequences for how perceptual and representational content enters into awareness. Failure of the local contents of left space to be consciously accessed is, in turn, an important aspect of why left neglect is so difficult to remediate. Patients can ''know'' that they have neglect but are cut off from the perceptual awareness that would enable them to overcome their attentional bias to the right. (shrink)

This book is a major intellectual and cultural history of intolerance and toleration in early modern and early Enlightenment Europe. John Marshall offers an extensive study of late seventeenth-century practices of religious intolerance and toleration in England, Ireland, France, Piedmont and the Netherlands and the arguments that John Locke and his associates made in defence of 'universal religious toleration'. He analyses early modern and early Enlightenment discussions of toleration, debates over toleration for Jews and Muslims as well as for Christians, (...) the limits of toleration for the intolerant, atheists, 'libertines' and 'sodomites', and the complex relationships between intolerance and resistance theories including Locke's own Treatises. This study is a significant contribution to the history of the 'republic of letters' of the 1680s and the development of early Enlightenment culture and is essential reading for scholars of early modern European history, religion, political science and philosophy. (shrink)

Cas9/guide RNA (gRNA)‐based gene drive systems are expected to play a transformative role in malaria elimination efforts., whether through population modification, in which the drive system contains parasite‐refractory genes, or population suppression, in which the drive system induces a severe fitness load resulting in population decline or extinction. DNA sequence polymorphisms representing alternate alleles at gRNA target sites may confer a drive‐resistant phenotype in individuals carrying them. Modeling predicts that, for observed levels of SGV at potential target sites and observed (...) rates of de novo DRA formation, population modification strategies are uniquely resilient to DRAs. We conclude that gene drives can succeed when fitness costs incurred by drive‐carrying mosquitoes are low enough to prevent strong positive selection for DRAs produced de novo or as part of the SGV and that population modification strategies are less prone to failure due to drive resistance. (shrink)

This paper examines the societal paradigm shift growing from the tension between traditional institutional structures, in law and medicine for example, and the expansion of the human population. Similarly, the definition of “reality” in relation to the technological ability to create “virtual reality” in this environment is examined as a cyberæsthetic component of this evolutionary process. The question is presented as to whether the mere algebraic expansion of the traditional systems is adequate to maintain the relationship between human beings and (...) technology despite the pressure of increasing population numbers. At issue is the proposition of whether the quality of human existence is diminished by the rapid onset of technological innovation. The corollary concept is the potential subjugation of human beings to the machine in the name of efficiency, with the movie “Metropolis” as the example from popular culture. Set in the context of the Three Laws, the paper presents an interdisciplinary examination as to the relationship between technological progress and the quality of life of the human species. (shrink)

This volume traces the evolution of Whig and Tory, Puritan and Anglican ideas across a tumultuous period of British history, from the mid-seventeenth century through to the Age of Enlightenment. This volume, a tribute to Mark Goldie, traces the evolution of Whig and Tory, Puritan and Anglican ideas across a tumultuous period of British history, from the mid-seventeenth century through to the Age of Enlightenment. Mark Goldie, Fellow of Churchill College and Professor of Intellectual History at Cambridge University, is one (...) of the most distinguished historians of later Stuart Britain of his generation and has written extensively about politics, religion and ideas in Britain from the Restoration through to the Hanoverian succession. Based on original research, the chapters collected here reflect the range of his scholarly interests: in Locke, Tory and Whig political thought, and Puritan, Anglican and Catholic political engagement, as well as the transformative impact of the Glorious Revolution. They examine events as well as ideas and deal not only with England but also with Scotland, France and the Atlantic world. Politics, Religion and Ideas in Seventeenth- and Eighteenth-Century Britain will be of interest to later Stuart political and religious historians, Locke scholars and intellectual historians more generally. JUSTIN CHAMPION is Professor of History at Royal Holloway, University of London. JOHN COFFEY is Professor of Early Modern History at the University of Leicester. TIM HARRIS is Professor of History at Brown University. JOHN MARSHALL is Professor of History at John Hopkins University. CONTRIBUTORS: Justin Champion, John Coffey, Conal Condren, Gabriel Glickman, Tim Harris, Sarah Irving-Stonebraker, Clare Jackson, Warren Johnston, Geoff Kemp, Dmitri Levitin, John Marshall, Jacqueline Rose, S.-J. Savonius-Wroth, Hannah Smith, Delphine Soulard. (shrink)

Wynn's claims are, in principle, entirely reasonable; although, as always, the devil is in the details. With respect to Wynn's discussion of the cultural evolution of artifactual symmetry, we provide a few more arguments for the utility of mirror symmetry and extend the enquiry into the tacit and explicit processing of natural and artifactual symmetry.

We outline some ways in which motor neglect (the underutilization of a limb despite adequate strength) and hysterical paralysis (failure to move a limb despite no relevant structural damage or disease) may throw light on the pathophysiology of catatonia. We also comment on the manifold inadequacies of distinguishing too firmly between symptoms of “neurologic origin” and of “psychiatric origin.”.