Investigation of the Percept is a short work that focuses on issues of perception and epistemology. Its author, Dignaga, was one of the most influential figures in the Indian Buddhist epistemological tradition, and his ideas had a profound and wide-ranging impact in India, Tibet, and China. The work inspired more than twenty commentaries throughout East Asia and three in Tibet, the most recent in 2014.This book is the first of its kind in Buddhist studies: a comprehensive history of a text (...) and its commentarial tradition. The volume editors translate the root text and commentary, along with Indian and Tibetan commentaries, providing detailed analyses of the commentarial innovations of each author, as well as critically edited versions of all texts and extant Sanskrit fragments of passages. The team-based approach made it possible to study and translate a corpus of treatises in Sanskrit, Tibetan, and Chinese and to employ the methods of critical philology and cross-cultural philosophy to provide readers with a rich collection of studies and translations, along with detailed philosophical analyses that open up the intriguing implications of Dignaga's thought and demonstrate the diversity of commentarial approaches to his text.This rich text has inspired some of the greatest minds in India and Tibet. It explores some of the key issues of Buddhist epistemology: the relationship between minds and their percepts, the problems of idealism and realism, and error and misperception. (shrink)
Numerous reports have noted decreasing numbers of antibiotic approvals. To determine the context for this decline, we examined all new molecule entities (NMEs) and new biologic licenses (NBLs) approved by the FDA from 1980–2009, and compared approval rates of the 61 approved antibiotics to trends in other drug classes. We also tracked withdrawals of approved drugs and found more withdrawals for antibiotics than other drug classes. After adjusting for drugs subsequently withdrawn, the record for antibiotic innovation is less dire than (...) previously reported. We also report problems with the quality of the approved antibiotics studied. Future policies providing incentives for new antibiotic development should not be based on simple numerical targets and key provisions should ensure appropriate quality as well as quantity of antibiotic drug innovation. (shrink)
This article focuses on the three natures (_trisvabhāva_) or three characters (_trilakṣaṇa_) doctrine as described in Indian Yogācāra treatises. This concept is fundamental to Yogācāra epistemology and soteriology, but terminology employed by contemporary buddhologists misconstrues and misrepresents some of its most important features, particularly with regard to the ‘ultimately real nature’ (_pariniṣpanna-svabhāva_), which is equated with terms that connote ultimate reality like ultimate truth (_paramārtha_), emptiness (_śūnyatā_), and reality limit (_bhūta-koṭi_), and which is described as a ‘purifying object of observation’ (...) (_viśuddhālambana_) that facilitates insight when properly understood by meditators. The article discusses how it is described in a range of Yogācāra treatises and compares this with how it has been conceived in academic studies of Indic Yogācāra literature. (shrink)
Antibiotic use triggers evolutionary and ecological responses from bacteria, leading to antibiotic resistance and harmful patient outcomes. Two complementary strategies support long-term antibiotic effectiveness: conservation of existing therapies and production of novel antibiotics. Conservation encompasses infection control, antibiotic stewardship, and other public health interventions to prevent infection, which reduce antibiotic demand. Production of new antibiotics allows physicians to replace existing drugs rendered less effective by resistance.In recent years, physicians and policymakers have raised concerns about the pipeline for new antibiotics, pointing (...) to a decline in the number of antibiotics approved since the 1980s. This trend has been attributed to high research and development costs, low reimbursement for antibiotics, and regulatory standards for review and approval. Professional societies and researchers around the world have called for renewed emphasis on antimicrobial stewardship, while also supporting antibiotic research and development through grants, changes to intellectual property laws to extend market exclusivity periods, and modification of premarket testing regulations to reduce antibiotic development time and expenses. (shrink)
Construal-level theory emphasizes that representing events at greater spatial, temporal, social, or hypothetical distance results in processing information at high construal levels (more conceptual, abstract). We posit that psychological distance and construal level are somewhat separable constructs, and can have different effects on emotion, and therefore, emotion regulation. We argue that psychological distance influences emotional appraisal, such that increasing distance results in lower emotion intensity, which can be leveraged to down-regulate emotions. However, we consider construal level a mindset, which can (...) occur with either high or low psychological distance. Furthermore, we argue that compared with psychological distance, construal level has a more nuanced relationship with emotion, and changing construal level for the purpose of changing emotion also requires considering the construal level of one's emotion-regulation goals. (shrink)
The Buddhist World joins a series of books on the world's great religions and cultures, offering a lively and up-to-date survey of Buddhist studies for students and scholars alike. It explores regional varieties of Buddhism and core topics including buddha-nature, ritual, and pilgrimage. In addition to historical and geo-political views of Buddhism, the volume features thematic chapters on philosophical concepts such as ethics, as well as social constructs and categories such as community and family. The book also addresses lived Buddhism (...) in its many forms, examining the ways in which modernity is reshaping traditional structures, ancient doctrines, and cosmological beliefs. (shrink)
Abhidharmasamuccaya: The Compendium of Higher Teaching by Asanga. Originally translated into French and annotated by Walpola Rahula. English translation by Sara Boin-Webb. Asian Humanities Press, Fremont, CA 2001. xxvii, 327 pp. $75.00. ISBN 0-89581-941-4.