Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

Our topic is the ontology and persistence conditions of material objects. One widely held doctrine is that identity-over-time has causal commitments. Another is that identity-over-time is just identity as it relates one object that exists at two times. We believe that a tension exists between these two apparently sensible positions: very roughly, if identity is the primary conceptual component of identity-over-time and—as is plausible—identity is noncausal, then the conceptual origins of the causal commitments of identity-over-time become a mystery. We will (...) begin by formulating the two widely held doctrines and our puzzle more fully and more carefully. Then, the remainder of the paper will be devoted to analyzing views one might adopt that could minimize the tension. (shrink)

Our topic is the ontology and persistence conditions of material objects. One widely held doctrine is that identity-over-time has causal commitments. Another is that identity-over-time is just identity as it relates one object that exists at two times. We believe that a tension exists between these two apparently sensible positions: very roughly, if identity is the primary conceptual component of identity-over-time and—as is plausible—identity is noncausal, then the conceptual origins of the causal commitments of identity-over-time become a mystery. We will (...) begin by formulating the two widely held doctrines and our puzzle more fully and more carefully. Then, the remainder of the paper will be devoted to analyzing views one might adopt that could minimize the tension. (shrink)

Rutgers University New Brunswick, NJ 08903.

In recent years there has been a tendency in some quarters to see an affinity between the views of Kierkegaard and Wittgenstein on the subject of religious belief. It seems to me that this is a mistake, that Kierkegaard's views were fundamentally at odds with Wittgenstein's. That this fact is not generally recognized is, I suspect, owing to the obscurity of Kierkegaard's most fundamental assumptions. My aim here is to make those assumptions explicit and to show how they differ from (...) Wittgenstein's. (shrink)

In City of God 19.24, Augustine rejects Cicero's definition of res publica as a society founded on justice for a new definition focused on common objects of love. Robert Markus, Oliver O'Donovan, and a host of Augustinian political theologians have depicted this move as a positive gesture toward secular society. Yet this reading fails to account for why Augustine waited so long to address Cicero's definition, first discussed in Book 2, and for the radical dualism Augustine sets forth between the (...) two cities throughout his text. I argue, in line with Rowan Williams and John Milbank, for a minority reading of Book 19 that draws upon the narrative structure of City of God. In Books 3–5, Augustine recounts the history of the earthly city according to Rome's penchant for violence and idolatry, both a function of love for temporal goods. In Book 18, Augustine traces the history of the earthly city before Rome according to the same themes, completing a narrative argument that humanity has always been divided according to differing loves. Book 19 advances the idea that such idolatry is injustice—a failure to grant God the worship he is due. With the new definition of 19.24, Augustine retains Cicero's emphasis on the importance of virtue in civic society while characteristically shifting the terms of discussion from justice to love. While such a definition means that Rome can be called a res publica, it also prompts a negative judgment upon her history according to her objects of love. Given her violence and idolatry, Rome is no better than Assyria, Babylon, Egypt, and Greece—all subject to withering critique in Book 18. Thus, Augustine's new definition does not retract but extends the polemic of City of God. (shrink)

Ted Sider aptly and concisely states the self-visitation paradox thus: 'Suppose I travel back in time and stand in a room with my sitting 10-year-old self. I seem to be both sitting and standing, but how can that be?' (2001, 101). I will explore a relativist resolution of this paradox offered by, or on behalf of, endurantists.1 It maintains that the sitting and the standing are relative to the personal time or proper time of the time traveler and is intended (...) to yield the result that Ted is sitting at a certain initial personal/proper time but is not standing relative to that time. Similarly, it is also supposed to yield that Ted is standing relative to a later personal/proper time, but not sitting relative to that .. (shrink)

For Alesha to give valid and sufficient consent to a COVID-19 vaccine, she must possess both capacity and competency. Let us consider each in turn.Does Alesha have capacity? Is she approaching her...

Two major twentieth century philosophers, of East and West, for whom the nothing is a significant concept are Nishida Kitarō and Martin Heidegger. Nishida’s basic concept is the absolute nothing upon which the being of all is predicated. Heidegger, on the other hand, thematizes the nothing as the ulterior aspect of being. Both are responding to Western metaphysics that tends to substantialize being and dichotomize the real. Ironically, however, while Nishida regarded Heidegger as still trapped within the confines of Western (...) metaphysics with its tendency to objectify, Heidegger’s impression of Nishida was that he is too Western, that is, metaphysical. Yet neither was too familiar with the other’s philosophical work as a whole. I thus compare and assess Nishida’s and Heidegger’s discussions of the nothing in their attempts to undermine traditional metaphysics while examining lingering assumptions about the Nishida–Heidegger relationship. Neither Nishida nor Heidegger means by “nothing” a literal nothing, but rather that which permits beings in their relative determinacy to be what they are and wherein or whereby we find ourselves always already in our comportment to beings. Nishida characterizes this as a place that negates itself to give rise to, or make room for, beings. For Heidegger, being as an event that clears room for beings, releasing each into its own, is not a being, hence nothing. We may also contrast them on the basis of the language they employ in discussing the nothing. Yet each seemed to have had an intuitive grasp of an un/ground, foundational to experience and being. And in fact their paths cross in their respective critiques of Western substantialism, where they offer as an alterantive to that substantialist ontology, in different ways, what I call anontology. (shrink)

It is intuitive that, under certain circumstances, it can be disrespectful or patronizing to excuse someone for an attitude. While it is easy enough to find instances where it seems disrespectful to excuse an attitude, matters are complicated. When and why, precisely, is it disrespectful to judge that someone is not responsible for his attitude? In this paper, I show, first, that the extant philosophical literature on this question is underdeveloped and overgeneralized: the writers who address the question suggest quite (...) strikingly that it is always disrespectful to excuse a sane, rational agent for his attitude, and their arguments rely on false generalizations about what is involved in excusing an attitude. I then sketch an account of respect to explain when and why it is disrespectful to excuse an attitude. Using this account, I show that one can coherently excuse an attitude even in some cases where that attitude was produced by a responsiveness to reasons. (shrink)

In this paper, I explore a possible a/theological response to what Nietzsche called the ‘death of God’—or Hölderlin’s and Heidegger’s ‘flight of the gods’—through a juxtaposition of the Christian-Pauline concept of kenōsis and the ancient Greek-Platonic notion of chōra, and by taking Nishida Kitarō’s appropriations of these concepts as a clue and starting point. Nishida refers to chōra in 1926 to initiate his philosophy of place and then makes reference to kenōsis in 1945 in his final work that culminates—without necessarily (...) completing—his oeuvre. What he had thereby accomplished is an inversion of Platonism resulting in the collapse of the transcendent/immanent—idea/genesis and by implication the Heaven/Earth—dichotomy. I then unpack the ethical implication of this kenotic chōra Nishida has left us with. It suggests from us a certain response to the desacralization or secularization of the world. I shall build upon this suggestion and unfold its implications by drawing from a variety of sources, starting with Nishida but including others, such as Meister Eckhart, Martin Heidegger, Jacques Derrida, Emmanuel Levinas, Gianni Vattimo, Reiner Schürmann, Mark Taylor, Jürgen Moltmann, and other philosophical and theological sources. (shrink)

Like their predecessors throughout the late nineteenth and twentieth centuries, popes John Paul II and Benedict XVI have emphasized the importance of philosophy in the Catholic intellectual tradition. In his encyclical _Fides et ratio _, John Paul II called on philosophers “to have the courage to recover, in the flow of an enduringly valid philosophical tradition, the range of authentic wisdom and truth.” Where the late pope spoke of an “enduringly valid tradition,” Jacques Maritain and other Thomists often (...) have referred to the “perennial tradition” or to “perennial philosophy.” __Words of Wisdom__ responds to John Paul's call for the development of this tradition with a much-needed dictionary of terms. As a resource for students in colleges, universities, and seminaries, as well as for teachers of the perennial tradition and interested general readers, __Words of Wisdom __occupies a unique place. It offers precise, yet clear and understandable accounts of well over a thousand key philosophical terms, richly cross-referenced. It also explains significant terms from other philosophical movements with which Thomism has engaged—either through debate or through judicious and creative incorporation. Moreover, it identifies a number of theological and doctrinal expressions to which perennial philosophy has contributed. Finally, it provides a comprehensive bibliography of works by Aquinas in English, expositions and discussions of perennial themes, and representative examples from the writings of all philosophers and theologians mentioned in dictionary entries. “A good dictionary is a great thing. In over 1,000 entries, __Words of Wisdom __manages to be concise, as it must be, and complete where it should be. Its notes on usage by contemporary scholars I find particularly helpful. Students and teachers alike will be grateful to Dr. Carlson for taking up the challenge of John Paul II to appreciate and illuminate the ‘great tradition of philosophy.’” —_David Ruel Foster, Athenaeum of Ohio _. (shrink)

Is business intimately related to ethics or can the two be separated? I argue that examining this question by focusing on how the two areas might be separated is logically flawed. Examining how business and ethics are connected, however, can bear fruit. This examination shows that business is a proper subset of ethics. Understanding this intimate connection has two practical benefits. It removes the seemingly incommensurable conflict between financial and ethical responsibilities of managers and it gives us new and positive (...) insights into Milton Friedman’s view that the social responsibility of business is to increase its profits. (shrink)

What minimal role—if any—must consciousness of morally significant information play in an account of moral worth? According to one popular view, a right action is morally worthy only if the agent is conscious (in some sense) of the facts that make it right. I argue against this consciousness condition and close cousins of it. As I show, consciousness of such facts requires much more sophistication than writers typically suggest—this condition would bar from moral worth most ordinary, intuitively morally worthy agents. (...) Moreover, I show that the attraction to this flavor of consciousness condition rests on mistaken assumptions about what is required for a right act to be non-accidentally right and attributable to the agent. Drawing some lessons from the discussion, I defend a Value-Secured Reliability Theory of Moral Worth and show how a minimal yet indispensable role for consciousness falls out from it. On this independently plausible theory, an action can be morally worthy even when the agent is unaware of the right-making features of her action. (shrink)

The present dissertation consists of a developmental account of the problem of the ontological status of individuality as manifested initially in the metaphysical thought of Aristotle and subsequently developed by Thomas Aquinas, Duns Scotus, and Francis Suarez. ;The philosophical context for the problem of individuality's ontological status is set by the theme, prominent in Greek philosophy, of unity as a mark of what is most real and most perfect. The historical precedent for viewing individuality as fitting under this theme, and (...) thus as having ontological importance, is provided by Aristotle's doctrine of primary substance, which characterizes individuality as a type of unity that pertains to the most fundamental aspects of reality such as this man or this horse. Though this doctrine highlights the ontological primacy of individual entities, the specific issues of where individuality fits on the ontological map, and what role it plays in constituting substances, are discussed only indirectly by Aristotle. These matters remain mostly unaddressed until the thirteenth and fourteenth centuries, in which individuality becomes a focal point of philosophical discussion due to the integration of Aristotelian metaphysical thought into Christian doctrine and the accompanying recognition of individuality as a topic of critical importance. ;The problem of individuality's ontological status can be summarized in terms of two questions. First, what kind of thing is individuality, i.e., where does it fit on the ontological map? Second, how is individuality related to the other metaphysical aspects of a thing, such as their form, common nature, etc.? Aquinas's treatment of this problem reveals strong roots in the Aristotelian doctrines of substance and of unity as a transcendental attribute of being. Scotus's account likewise is developed in the context of the aforementioned Aristotelian notions, but is more extensive than Aquinas's and more suggestive of individuality's importance given Scotus's identification of metaphysics as the science of the transcendentals and of individuality as a transcendental. Suarez's treatment of the ontological status of individuality builds upon these notions, synthesizing the insights of his predecessors to formulate an account that is more explicit, more precise, and in many ways more rigorous than his predecessors' accounts. (shrink)

The following essay, “The Unsolved Issue of Consciousness” (Torinokosaretaru ishiki no mondai 取残されたる意識の問題), by Nishida Kitarō 西田幾多郎 from 1927 is significant in regard to the development of what has come to be called “Nishida philosophy” (Nishida tetsugaku 西田哲学). In what follows, in addition to providing some commentary on the important points of his essay, I would like to show its relevance or significance not only for those who would like to study Nishida’s thought but also for philosophy in general, especially (...) in the contemporary setting. It was first published in 1927 by Iwanami Publishers in a collection of essays by different authors, Philosophical Essays in Commemoration of the Sixtieth Birthday of Dr. .. (shrink)

The goal of this paper is to critically examine the objections of John Locke’s contemporaries against the theory of substance or substratum. Locke argues in Essay that substratum is the bearer of the properties of a particular substance. Locke also claims that we have no knowledge of substratum. But Locke’s claim about our ignorance as to what substratum is, is contentious. That is, if we don’t know what substratum is, then what is the point of proposing it as a (...) bearer of properties? This question underlies the criticism Locke’s contemporaries raise against the notion of substratum. In section I, I lay out the context for Locke’s theory of substratum by pointing out his main motivation in proposing his theory. In section II, I give a brief analysis of the theory of substratum. In section III, I discuss the objections of Locke’s contemporaries against the theory of substratum.1 I focus on Edward Stillingfleet, Lee Henry, G. W. Leibniz and John Sergeant. In section IV, I conclude that there is no warrant to dismiss Locke’s theory of substance. (shrink)

Causation and Persistence is a detailed and extremely novel attempt to address perhaps the most basic of all philosophical issues. Ehring's book deserves careful attention, so I will not linger over laudatory remarks.

While across the animal kingdom offspring are born smaller than their parents, notable exceptions exist. Several dipteran species belonging to the Hippoboscoidea superfamily can produce offspring larger than themselves. In this essay, the blood-feeding tsetse is focused on. It is suggested that the extreme reproductive strategy of this fly is enabled by feeding solely on highly nutritious blood, and producing larval offspring that are soft and malleable. This immense reproductive expenditure may have evolved to avoid competition with other biting flies. (...) Tsetse also transmit blood-borne parasites that cause the fatal diseases called African trypanosomiases. It is discussed how tsetse life history and reproductive strategy profoundly influence the type of vector control interventions used to reduce fly populations. In closing, it is argued that the unusual life history of tsetse warrants their preservation in the areas where human and animal health is not threatened. (shrink)

In tackling the question of what is Japanese philosophy, the paper discusses: philosophy in general, the issue of Japanese philosophy, and the relevance of both philosophy and Japanese philosophy in our present age of globalization. Examining the definitions of philosophy provided by Kant, Hegel, and Heidegger, and looking at the philosophies of Nishida and Nishitani among others, I argue the source of philosophy—its originary and universal motivation—to be the question of meaning of existence. Japanese philosophy is no exception. I then (...) discuss whether there is something unique to Japanese philosophy in particular and look into the question of the essence of Japanese philosophy. Furthermore, I argue that in order to be true to the original motivation of philosophy, the study of Japanese philosophy, if it is itself to be considered philosophy, cannot be reduced to biography, history, or philology. It must be relevant to our life. I then conclude with a discussion of the relevance of Japanese philosophy and the philosophical study of Japanese philosophy to our life today. (shrink)

An anthology of contemporary readings in analytic aesthetics, this reference reflects the relationships among the central aesthetic concerns of recent years. Providing a new perspective on the contemporary philosophy of art, this volume examines the challenge of Postmodernism and how it may or may not affect the future of analytic aesthetics... offers a case study of the progress that has been made in handling the problem of expression in the arts... reconceptualizes the concepts of the art work, its properties, and (...) our experience and evaluation of it -- to take into account an expanding cultural, sociological contextualization, i.e., art as a culturally emergent product of social institutions and conventions... features several readings organized around clusters of writers discussing each other's ideas and proposals, including: Beardsley, Dickie, and Blizek -- Wolterstorff, Levinson, and Bender -- Stolnitz and Dickie -- Beardsley, Margolis, and Novitz -- and Sibley and Dickie. Suitable for professionals in the art industry and anyone interested in the philosophy or aesthetics of art. (shrink)

The traditional model and the contextual unanimity model are two probabilistic accounts of general causation subject to many well-known problems; e.g. cases of epiphenomena, causes raising their own probability, effects raising the probability of the cause, et cetera. After reviewing these problems and raising a new problem for the two models, I suggest the beginnings of an alternative probabilistic account. My suggestion avoids the problems encountered by earlier models, in large part, by an appeal to singular causation.

Ethical reality is coextensive with human dignity. Therefore, one essential way to understand ethics is as the systematic effort to discern the imperatives of human dignity. Seeing ethics in this way highlights the fact that health care institutions have many centers of ethical responsibility (CERs) — the Chief Executive Officer, Board of Trustees, senior management team, etc. The Ethics Committee is only one such CER and not the most important one. These other CERs will benefit from identifying: (1) the fact (...) that they are consistently dealing with ethical reality and making ethical decisions; (2) some critical elements of good ethical decision-making: (i) having the appropriate community; (ii) making the guiding value priorities explicit and specific; (iii) gaining skill in using the needed intellectual tools; and (iv) fashioning appropriate process and structure for discernment. (shrink)

Introduction I. The Aim: Defining Whitehead's Categories of Existence Ontology is the study of being or beings. But what is being? Which are the beings? ...

Traditionally, the just war principle of last resort requires that, before resorting to war, every reasonable alternative measure must be attempted. My view is that traditional just war principles should be generalized, so as to be applicable to military actions of all sorts—for example, armed humanitarian interventions and counterinsurgency operations. In this paper, such a generalized just war theory is presupposed. In particular, I shall presuppose a generalized last resort principle that requires that, before using military force, every reasonable alternative (...) measure must be attempted. My thesis is that among these alternative measures is nonviolent action. For concreteness, the new U.S. counterinsurgency field manual is examined. The generalized last resort principle morally obligates a U.S. counterinsurgency operation to use the means of nonviolent action, whenever it is reasonable to do so. Pacifism and just war theory are often portrayed as rivals, but this paper explores one way in which just war theory could benefit from the tradition of nonviolence. (shrink)

It is important for our purposes to notice that in this first reduction of Theætetus' definition of knowledge as perception, Plato has introduced the distinction between sense object and physical object, for he has specifically said, "when the same wind is blowing, one of us feels chilly, the other does not." In using this example. Plato has, as Cornford observes, raised the question of how the several sense objects are related to the single physical object. This question is one of (...) the two major questions with which this paper will deal, since it is, as I have remarked, the more important question concerning the ontological status of sense-data. Cornford feels that Protagoras probably held that the physical object is both hot and cold, different observers perceiving different aspects of the same object. That is, Cornford suggests that Protagoras' own answer to this question of the relation between sense-data and physical objects is one of complete identification in every case. We will see that this theory is similar in many ways to the one worked out by Plato in the Theætetus, but the distinction between the physical object and the sense object, between the wind which feels hot and cold to different people, makes certain characteristic differences between Plato's and Protagoras' theory. Before going on to examine these differences, it is necessary to follow the further development of Plato's general theory of perception. (shrink)

Evans has written a different sort of book on Kierkegaard. It is, first of all, one that is intended for, in his words, the "ordinary reader." This undoubtedly does not mean that Evans is not interested in Kierkegaard's philosophical/theological readers; I suspect that he is. It is just that he has not aimed his book at this audience. This book should also be distinguished from most other books on Kierkegaard's thought since it is exclusively on the religious philosophy of Johannes (...) Climacus, Kierkegaard's pseudonym for two major works in his first literature. (shrink)

This paper addresses central issues in the debate about inclusive language for God by responding to Andrew Dell’Olio, who offered biblical, theological, linguistic, and ethical reasons for a “supplemental” use of feminine language for God. Since he leaves unclear whether “supplemental” means “secondary to” or “fully equal to” the masculine language of the biblical tradition, it is difficult to determine whether he makes his case. While a secondary role for feminine language for God is legitimate, I argue that giving feminine (...) language a status equal to the Bible’s masculine language for God is not warranted by the standard biblical and theological criteria of the Christian tradition. (shrink)

Hegel defines his Logic as the science that thinks about thinking.nbsp; But when we interpret that work as outlining what happens when we reason we are vulnerable to Fregersquo;s charge of psychologism.nbsp; I use Hegelrsquo;s tripartite distinction among understanding, dialectical and speculative reason as operations of pure thought to suggest how thinking can work with objective concepts.nbsp; In the last analysis, however, our ability to move from the subjective contingency of representations and ideas to the pure concepts we think develops (...) from mechanical memory, which separates sign from sense so hat we can focus simply on the latter.nbsp; By becoming aware of the connections that underlie our thinking processes we may be able to both move beyond the abstractions of symbolic logic and clarify what informal logicians call relevance. (shrink)