20 found
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  1. The New Medical Model: A Renewed Challenge for Biomedicine.Jonathan Fuller - 2017 - Canadian Medical Association Journal 189:E640-1.
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  2. Universal Etiology, Multifactorial Diseases and the Constitutive Model of Disease Classification.Jonathan Fuller - 2018 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 67:8-15.
  3. The Confounding Question of Confounding Causes in Randomized Trials.Jonathan Fuller - forthcoming - British Journal for the Philosophy of Science.
    It is sometimes thought that randomized study group allocation is uniquely proficient at producing comparison groups that are evenly balanced for all confounding causes. Philosophers have argued that in real randomized controlled trials this balance assumption typically fails. But is the balance assumption an important ideal? I run a thought experiment, the CONFOUND study, to answer this question. I then suggest a new account of causal inference in ideal and real comparative group studies that helps clarify the roles of confounding (...)
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  4. Clinical Judgement: Multidisciplinary Perspectives.Benjamin Chin-Yee & Jonathan Fuller - 2018 - Journal of Evaluation in Clinical Practice 24 (3):635-637.
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  5. The Risk GP Model: The Standard Model of Prediction in Medicine.Jonathan Fuller & Luis J. Flores - 2015 - Studies in History and Philosophy of Science Part C 54:49-61.
  6. Rhetoric and Argumentation: How Clinical Practice Guidelines Think.Jonathan Fuller - 2013 - Journal of Evaluation in Clinical Practice 19 (3):433-441.
    Introduction: Clinical practice guidelines (CPGs) are an important source of justification for clinical decisions in modern evidence-based practice. Yet, we have given little attention to how they argue their evidence. In particular, how do CPGs argue for treatment with long-term medications that are increasingly prescribed to older patients? Approach and rationale: I selected six disease-specific guidelines recommending treatment with five of the medication classes most commonly prescribed for seniors in Ontario, Canada. I considered the stated aims of these CPGs and (...)
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  7.  16
    What Are Chronic Diseases?Jonathan Fuller - 2018 - Synthese 195 (7):3197-3220.
    What kind of a thing are chronic diseases? Are they objects, bundles of signs and symptoms, properties, processes, or fictions? Rather than using concept analysis—the standard approach to disease in the philosophy of medicine—to answer this metaphysical question, I use a bottom-up, inductive approach. I argue that chronic diseases are bodily states or properties—often dispositional, but sometimes categorical. I also investigate the nature of related pathological entities: pathogenesis, etiology, and signs and symptoms. Finally, I defend my view against alternate accounts (...)
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  8.  4
    Reasoning, Evidence, and Clinical Decision-Making: The Great Debate Moves Forward.Michael Loughlin, Robyn Bluhm, Stephen Buetow, Kirstin Borgerson & Jonathan Fuller - 2017 - Journal of Evaluation in Clinical Practice 23 (5):905-914.
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  9. Diseases, Patients and the Epistemology of Practice: Mapping the Borders of Health, Medicine and Care.Michael Loughlin, Robyn Bluhm, Jonathan Fuller, Stephen Buetow, Benjamin R. Lewis & Brent M. Kious - 2015 - Journal of Evaluation in Clinical Practice 21 (3):357-364.
  10. Rationality and the Generalization of Randomized Controlled Trial Evidence.Jonathan Fuller - 2013 - Journal of Evaluation in Clinical Practice 19 (4):644-647.
    Over the past several decades, we devoted much energy to generating, reviewing and summarizing evidence. We have given far less attention to the issue of how to thoughtfully apply the evidence once we have it. That’s fine if all we care about is that our clinical decisions are evidence-based, but not so good if we also want them to be well-reasoned. Let us not forget that evidence based medicine (EBM) grew out of an interest in making medicine ‘rational’, with the (...)
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  11. Prediction in Epidemiology and Medicine.Jonathan Fuller, Alex Broadbent & Luis J. Flores - 2015 - Studies in History and Philosophy of Science Part C.
  12.  25
    Meta-Research Evidence for Evaluating Therapies.Jonathan Fuller - 2018 - Philosophy of Science 85 (5):767-780.
    The new field of meta-research investigates industry bias, publication bias, contradictions between studies, and other trends in medical research. I argue that its findings should be used as meta-evidence for evaluating therapies. ‘Meta-evidence’ is evidence about the support that direct ‘first-order evidence’ provides the hypothesis. I consider three objections to my proposal: the irrelevance objection, the screening-off objection, and the underdetermination objection. I argue that meta-research evidence works by rationally revising our confidence in first-order evidence and, consequently, in the hypothesis—typically, (...)
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  13. Philosophy, Medicine and Health Care – Where We Have Come From and Where We Are Going.Michael Loughlin, Robyn Bluhm, Jonathan Fuller, Stephen Buetow, Ross E. G. Upshur, Kirstin Borgerson, Maya J. Goldenberg & Elselijn Kingma - 2014 - Journal of Evaluation in Clinical Practice 20 (6):902-907.
  14.  15
    Logos, Ethos and Pathos in Balance.Jonathan Fuller - 2014 - European Journal for Person Centered Healthcare 2 (1):22-29.
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  15.  12
    The Risk GP Model: The Standard Model of Prediction in Medicine.Jonathan Fuller & Luis J. Flores - 2015 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 54:49-61.
    With the ascent of modern epidemiology in the Twentieth Century came a new standard model of prediction in public health and clinical medicine. In this article, we describe the structure of the model. The standard model uses epidemiological measures-most commonly, risk measures-to predict outcomes (prognosis) and effect sizes (treatment) in a patient population that can then be transformed into probabilities for individual patients. In the first step, a risk measure in a study population is generalized or extrapolated to a target (...)
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  16. Translating Trial Results in Clinical Practice: The Risk GP Model.Jonathan Fuller & Luis J. Flores - 2016 - Journal of Cardiovascular Translational Research 9:167-168.
  17. Book Review. Philosophy of Epidemiology by A. Broadbent. [REVIEW]Jonathan Fuller - 2014 - Journal of Evaluation in Clinical Practice 20 (6):1002-1004.
  18.  5
    Theory, Experience and Practice.Michael Loughlin, Jonathan Fuller, Robyn Bluhm, Stephen Buetow & Kirstin Borgerson - 2016 - Journal of Evaluation in Clinical Practice 22 (4):459-465.
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  19.  4
    Philosophy of Epidemiology by A. Broadbent. Palgrave Macmillan, Basingstoke, 2013, £55.00, 228 Pp. ISBN 978 0 230 20210 8. [REVIEW]Jonathan Fuller - 2014 - Journal of Evaluation in Clinical Practice 20 (6):1002-1004.
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  20.  18
    Prediction in Epidemiology and Medicine.Jonathan Fuller, Alex Broadbent & Luis J. Flores - 2015 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 54:45-48.