RNA polymerase II is recruited to DNA double‐strand breaks (DSBs), transcribes the sequences that flank the break and produces a novel RNA type that has been termed damage‐induced long non‐coding RNA (dilncRNA). DilncRNAs can be processed into short, miRNA‐like molecules or degraded by different ribonucleases. They can also form double‐stranded RNAs or DNA:RNA hybrids. The DNA:RNA hybrids formed at DSBs contribute to the recruitment of repair factors during the early steps of homologous recombination (HR) and, in this way, contribute to (...) the accuracy of the DNA repair. However, if not resolved, the DNA:RNA hybrids are highly mutagenic and prevent the recruitment of later HR factors. Here recent discoveries about the synthesis, processing, and degradation of dilncRNAs are revised. The focus is on RNA clearance, a necessary step for the successful repair of DSBs and the aim is to reconcile contradictory findings on the effects of dilncRNAs and DNA:RNA hybrids in HR. (shrink)

This study investigated how problem solvers get into and out of a state of impasse while solving difficult problems. 47 participants had to decipher the secret method behind 33 magic tricks while r...

This study examines processes through which social personae are conveyed by male Japanese students at a public university in Yokohama. Focusing on the frame-setting function of first person pronominals in contexts where there is no intra/inter speaker variation in the choice of FPP, this paper analyzes how speakers manage identity-associated discursive alignments related to a shared Okinawa prefecture background. The common experience of being from Okinawa prefecture and attending university far from home is the primary reason that these speakers are (...) close friends. However, analysis reveals speakers’ continual and active contention and re-formulation of this shared ‘Okinawan-ness’ and the personae to which it is linked. In particular, FPPs are implicated in speakers’ discussion of heterogeneity and/or local differences with respect to their Okinawa prefecture background. Strategic use of FPPs thus emerges as a salient tactic for speakers’ active negotiation of conversation relevant personae categories even in interactional contexts without variation. (shrink)

Multiple authorship is the universal solution to multi-tasking in the sciences. Without a team, each with their own set of expertise, and each involved mostly in complementary ways, a research project will likely not advance quickly, or effectively. Consequently, there is a risk that research goals will not be met within a desired timeframe. Research teams that strictly scrutinize their modus operandi select and include a set of authors that have participated substantially in the physical undertaking of the research, in (...) its planning, or who have contributed intellectually to the ideas or the development of the manuscript. Authorship is not an issue that is taken lightly, and save for dishonest authors, it is an issue that is decided collectively by the authors, usually in sync with codes of conduct established by their research institutes or national ministries of education. Science, technology and medicine publishers have, through independent, or sometimes coordinated efforts, also established their own sets of guidelines regarding what constitutes valid authorship. However, these are, for the greater part, merely guidelines. A previous and recent analysis of authorship definitions indicates that the definitions in place regarding authorship and its validity by many leading STM publishers is neither uniform, nor standard, despite several of them claiming to follow the guidelines as set forward by the International Committee of Medical Journal Editors or ICMJE. This disparity extends itself to ghost and guest authorship, two key authorship-related issues that are examined in this paper to assess the extent of discrepancies among the same set of STM publishers and what possible influence they might have on publishing ethics. (shrink)

According to estimates more than 400 biobanks currently operate across Europe. The term ‘biobank’ indicates a specific field of genetic study that has quietly developed without any significant critical reflection across European societies. Although scientists now routinely use this phrase, the wider public is still confused when the word ‘bank’ is being connected with the collection of their biological samples. There is a striking lack of knowledge of this field. In the recent Eurobarometer survey it was demonstrated that even in (...) 2010 two-thirds of the respondents had never even heard about biobanks. The term gives the impression that a systematic collection of biological samples can constitute a ‘bank’ of considerable financial worth, where the biological samples, which are insignificant in isolation but are valuable as a collection, can be preserved, analysed and put to ‘profitable use’. By studying the practices of the numerous already existing biobanks, the authors address the following questions: to what extent does the term ‘biobank’ reflect the normative concept of using biological samples for the purposes of biomedical research? Furthermore, is it in harmony with the so far agreed legal–ethical consensus in Europe or does it deliberately pull science to the territory of a new, ambiguous commercial field? In other words, do biobanks constitute a medico-legal fiction or are they substantively different from other biomedical research protocols on human tissues? (shrink)

Most departments in any field of science that have a sound academic basis have discussion groups or journal clubs in which pertinent and relevant literature is frequently discussed, as a group. This paper shows how such discussions could help to fortify the post-publication peer review movement, and could thus fortify the value of traditional peer review, if their content and conclusions were made known to the wider academic community. Recently, there are some tools available for making PPPR viable, either as (...) signed or anonymous comments, or in a hybrid format. Thus, limited platforms are currently in place to accommodate and integrate PPPR as a supplement to traditional peer review, allowing for the open and public discussion of what is often publicly-funded science. This paper examines ways in which the opinions that emerge from journal clubs or discussion groups could help to fortify the integrity and reliability of science while increasing its accountability. A culture of reward for good and corrective behavior, rather than a culture that protects silence, would benefit science most. (shrink)

In this paper, we have two goals: Firstly, we intend to examine the most robust recent formulation of the problem of religious diversity or disagreement. We will argue that Sanford Goldberg’s version is better than John Greco’s. Secondly, we aim to examine different solutions and develop a new one based on Ernest Sosa’s virtue epistemology as a response to the problem of religious diversity or disagreement.

Based on a deliberative democracy, this book uses a hermeneutic-critical methodology to study bibliographical sources and practical issues in order to analyse the possibilities, limits and consequences of the digital transformation of democracy. Drawing on a two-way democracy, the aim of this book is intended as an aid for thinking through viable alternatives to the current state of democracy with regard to its ethical foundations and the moral knowledge implicit in or assumed by the way we perceive and understand democracy. (...) It is intended to stimulate reflection and discussion on the basis that, by addressing what we understand as democracy, we can inevitably influence the reality known as democracy. Democracy’s evident regression in today’s world makes this all too apparent: it has become a hostage to all kinds of autocracies and technopopulisms, which are supported to a greater or lesser extent by the current algorithmic revolution. (shrink)

In the present study, we explored the effects of high arousal on cognitive performance when facing a situation of risk. We also investigated how these effects are moderated by either positive or ne...

The diverse and paradoxical nature of globalization processes has given rise to new social constellations that shape transnational, national and local spaces. The historicity of identities, their past and present conditions, the changes they went through, the ways they influence the feeling of full membership in a community and the differentiation derived from cultural diversity and pluralism underscore the need for revisiting theoretical explorations. This paper addresses past and present social, cultural and religious processes in an era of transformations derived (...) from the complexity of today’s interconnected world and on the light of historical encounters. The need for revising the singularity of social and cultural trajectories and the religious trends gravitating in society is approached through snapshots of a twofold historical encounter: between Modernity and Latin America, and between Judaism and Modernity. Both express entrenched dilemmas of the binaries periphery-center and universal-particular. While one of them raised the issue of the dominant program of Modernity as a Western project, the other was entailed in the assumptions of one hegemonic religious constellation. (shrink)

Doutrina criteriológica de Lenine.--Reflexões a partir do Materialismo e empiriocriticismo.

This article takes the interlinkages between law and politics as its starting point. It analyzes recent changes in the legislative style of education governance in Sweden as not only a spec...

This article takes the interlinkages between law and politics as its starting point. It analyzes recent changes in the legislative style of education governance in Sweden as not only a species of crisis management, but also a long-term response to a series of tensions arising out of the push toward what has been identified as ‘juridification’ in many Western nations—the reliance on law and judicial means for addressing core moral predicaments, public policy questions, and political controversies. The article outlines the (...) notion of juridification at a theoretical level and highlights juridification processes and their possible ramifications on education. It argues that recent changes in the legislative style of education governance in Sweden not only reveal much about the commitments and implicit assumptions of modern regulatory and evaluative regimes, but also reflect the general impact of the rationalization of social and political life on the organization of government. The article provides a case with which to examine some of the theoretical underpinnings and implicit conceptual assumptions of modern regulatory and evaluative regimes as well as educational institutions’ relationships with the State. It shows that regulatory frameworks define the conceptualizations of what educational institutions do and thus of what actually gets done. (shrink)

TPPP/p25 is a recently discovered, unstructured protein involved in brain function. It is found predominantly in oligodendrocytes in normal brain but is enriched in neuronal and glial inclusions of Parkinson's disease and other synucleinopathies. Its physiological function seems to be the dynamic stabilization of microtubular ultrastructures, as well as the projections of mature oligodendrocytes and ciliary structures. We reappraise the earlier belief that TPPP/p25 is a brain‐specific protein. We have identified and cloned two shorter (N‐terminal‐free) homologs of TPPP/p25 that behave (...) differently from each other and from TPPP/p25. Two unique cell models have been established and used to study the effect of the unstructured protein on the energy metabolism and the formation of pathological aggregates. Our data suggest that the intracellular level of TPPP/p25 influences the cell differentiation, proliferation and the formation of protein aggregates, and consequently, the etiology of central nervous system diseases. (shrink)

This paper explores the writings of Jose Rizal as a source of insight into the predominant role of Mary, as the Mother of God, in Christian devotion and salvation during the Spanish Colonial period in the Philippines. It demonstrates the implication of the contradiction of the feminine spiritual authority of Mary—as the mediatrix of salvation, on the one hand, and the symbol of religious oppression, on the other hand—to the construction of the Filipina identity in Philippine Colonial Catholicism. It proposes (...) a feminist reimagining of the feminine spiritual authority of Mary that is empowering for Filipino women. (shrink)

This paper proposes an integrated account of the etiology of OCD that accommodates both dysfunctional cognitions and sensorimotor features of compulsive action. It is argued that cognitive/metacognitive theories do not aspire to address all obsessive-compulsive phenomenal properties and that empirical evidence concerning some of these requires the incorporation of motor deficits as an independent factor in a plausible conception of OCD. The difference in agency attribution between obsessive-compulsive persons and schizophrenia patients with delusions of control is also accounted for in (...) terms of bottom-up processes. (shrink)

Our main question in this paper is as follow: (Q) What are the epistemic norms governing our responses in the face of disagreement? In order to answer it, we begin with some clarification. First, following McHugh (2012), if we employ a useful distinction in normativity theory between evaluative and prescriptive norms, there are two readings of (Q)––we explore such distinction in section 2. And secondly, we accept gnosticism, that is, the account that the fundamental epistemic good is knowledge. It is (...) with this assumption that we want to answer (Q). So, if gnosticism is true, what is the plausible answer to (Q)? In section 3 we argue for gnostic disagreement norms as response to (Q) and in section 4 we apply such norms to particular cases of disagreement. (shrink)

The dominant philosophical conceptions of obsessive-compulsive behavior present its subject as having a deficiency, usually characterized as volitional, due to which she lacks control and choice in acting. Compulsions (mental or physical) tend to be treated in isolation from the obsessive thoughts that give rise to them. I offer a different picture of compulsive action, one that is, I believe, more faithful to clinical reality. The clue to (most) obsessive-compulsive behavior seems to be the way obsessive thoughts, which are grounded (...) in an irrational cognitive style in matters of risk, danger, and responsibility, motivate compulsions through bizarre means–end reasoning. I show that the patient with obsessive-compulsive disorder (OCD) is not weak and passive with regard to the compulsive act; rather, the act is voluntary and regarded by the patient as an instrument of control. I also defend the idea that OCD-related cognitions are either beliefs or mental states with relevantly similar functional roles. (shrink)

In this paper, by applying a feminist bioethical perspective, we identify a new form of medical paternalism that still shapes contemporary legal policies on human egg cryopreservation performed without medical reasons. The fear of negligent, careless women who opt to delay their pregnancy for mere convenience is a widely known gender biased stereotype. Nevertheless, the opinions and judgments of medical professionals on this issue have not yet been sufficiently explored by in-depth research. In this essay, therefore, first we look at (...) the broader bioethical, legal, and social aspects of human egg cryopreservation. In the second part of the paper we discuss a unique qualitative study conducted with professionals working at Hungarian IVF clinics. We argue, based on a bioethical analysis of the collected data, that when new reproduction technologies provide opportunities for women to widen their range of reproductive choices, the traditional forms of medical paternalism can be reinforced by gendered paternalism, as well. We identify several elements of gendered paternalism that characterized the attitudes of the IVF staff and discuss the professionals’ resistance to elective egg freezing and vitrification of eggs for the future. We conclude by suggesting directions for future policy. Although we focus on the Hungarian case in this paper, we are aware that similar attitudes can be observed in some other countries where this technology has become available and requested by women, but where they also face difficulties in their access to it. (shrink)

Gervain et al. discuss both behavioral and neurophysiological AGL studies that investigate rule and structure learning processes in infants. The paper provides an overview of all the major AGL paradigms used to date to investigate infant learning abilities at the level of morpho‐phonology and syntax from a very early age onwards. Gervain et al. also discuss the implications of the results for a general theory of natural language acquisition.

The paper explores the status of NATURE metaphors in Hungarian folk songs with respect to their representation and transmission of folk culture and worldview. Employing a Cultural Linguistic analysis, metaphors are observed from three perspectives: in relation to cultural schemas, generic-level conceptual metaphors, and experiential motivation. NATURE metaphors are to a large extent framed by cultural experience regarding their experiential basis, conceptual structure and relation with other cultural conceptualizations.