BackgroundObtaining informed consent for participation in genomic research in low-income settings presents specific ethical issues requiring attention. These include the challenges that arise when providing information about unfamiliar and technical research methods, the implications of complicated infrastructure and data sharing requirements, and the potential consequences of future research with samples and data. This study investigated researchers’ and participants’ parents’ experiences of a consent process and understandings of a genome-wide association study of malaria involving children aged five and under in Mali. (...) It aimed to inform best practices in recruiting participants into genomic research.MethodsA qualitative rapid ethical assessment was undertaken. Fifty-five semi-structured interviews were conducted with the parents of research participants. An additional nine semi-structured interviews were conducted with senior research scientists, research assistants and with a member of an ethics committee. A focus group with five parents of research participants and direct observations of four consent processes were also conducted. French and translated English transcripts were descriptively and thematically coded using OpenCode software.ResultsParticipants’ parents in the MalariaGEN study had differing understandings of the causes of malaria, the rationale for collecting blood samples, the purposes of the study and the kinds of information the study would generate. Genomic aspects of the research, including the gene/environment interaction underlying susceptibility or resistance to severe malaria, proved particularly challenging to explain and understand.ConclusionsThis study identifies a number of areas to be addressed in the design of consent processes for genomic research, some of which require careful ethical analysis. These include determining how much information should be provided about differing aspects of the research and how best to promote understandings of genomic research. We conclude that it is important to build capacity in the design and conduct of effective and appropriate consent processes for genomic research in low and middle-income settings. Additionally, consideration should be given to the role of review committees and community consultation activities in protecting the interests of participants in genomic research. (shrink)

This study extends earlier findings on ethical leadership by testing the relationship of the seven dimensions of ethical leadership with job satisfaction, organization commitment, job embeddedness, and cynicism. It uses time-lagged data from 585 employees in Pakistan. Using confirmatory factor analysis and structural equation modeling, the study supports the concept of multidimensional ethical leadership in the Eastern setting and indicates that the dimensions of people orientation, fairness, power sharing, ethical guidance, and role clarification are associated with the majority of outcomes, (...) as suggested by social exchange theory. However, the concern for sustainability and integrity dimensions had a limited effect. (shrink)

Conventional and well-established guidelines for the ethical conduct of clinical research are necessary but not sufficient for addressing research dilemmas related to public health research. There is a particular need for a public health ethics framework when, in the face of an epidemic, research is urgently needed to promote the common good. While there is limited experience in the use of a public health ethics framework, the value and potential of such an approach is increasingly being appreciated. Here we use (...) two examples of adolescent women as potential candidates for participation in microbicide trials to illustrate how ethical decisions for public health research can be enhanced by drawing on both traditional research ethics guidance, and the emerging framework for public health ethics. (shrink)

Tagba is a tone language that presents tonal patterns that appear quite regular at first glance. However, these are difficult to model under standard autosegmental hierarchical assumptions regarding the placement of skeleton, segments and tones. In this paper, we will present Tagba tonology and demonstrate that it can be accounted for by readjusting the tiers of hierarchization. From this, we reason that the proposed hierarchy is parametric and language specific.

The aim of this study was to examine the gender differential effects of eating habits and physical activity on overweight and obesity among school-aged adolescents in Bangladesh. Nationally representative data extracted from the 2014 Global School-based Student Health Survey were utilized. The survey collected information related to physical and mental health from 2989 school-aged adolescents in Bangladesh. An exploratory data analysis and multivariate logistic regression model were employed in this study. Female adolescents were at a lower risk of being overweight (...) or obese than males, with a prevalence of 7.4%. The results showed that high consumption of vegetables, high soft drink consumption, high fast food consumption, sleep disturbance and regular walking or cycling to school were vital influencing factors for being overweight or obese among adolescents for both sexes. Sedentary activities during leisure time were also identified as significant predictors of being overweight or obese for males. Regular fruit and vegetable consumption, the avoidance of soft drinks and fast food, an increase in vigorous physical activity, regular attendance at physical education classes and fewer sedentary leisure time activities could all help reduce the risk of being overweight or obese for both sexes. (shrink)

SummaryMalaria is a major cause of under-five mortality in Mali and many other developing countries. Malaria control programmes rely on households to identify sick children and either care for them in the home or seek treatment at a health facility in the case of severe illness. This study examines the involvement of mothers and other household members in identifying and treating severely ill children through case studies of 25 rural Malian households. A wide range of intra-household responses to severe illness (...) were observed among household members, both exemplifying and contravening stated social norms about household roles. Given their close contact with children, mothers were frequently the first to identify illness symptoms. However, decisions about care-seeking were often taken by fathers and senior members of the household. As stewards of the family resources, fathers usually paid for care and thus significantly determined when and where treatment was sought. Grandparents were frequently involved in diagnosing illnesses and directing care towards traditional healers or health facilities. Relationships between household members during the illness episode were found to vary from highly collaborative to highly conflictive, with critical effects on how quickly and from where treatment for sick children was sought. These findings have implications for the design and targeting of malaria and child survival programming in the greater West African region. (shrink)

This paper attempts to analyze the performance of 57 memberstates of the Organization of Islamic Cooperation based on selectedindicators of some sectors namely demography, economics, educationand technology and innovation. Specifically, it aims at firstly portraying anoverview of OIC performance based on six selected indicators followed byanalyzing the relationship between selected development variables withliteracy and exploring the state of OIC performance as indicated by theirachievement based on selected indicators. The study was undertaken vis-àvisthe prevailing theories on modernization and development as well (...) as thewidely asserted underdevelopment of the contemporary Muslim ummah asclaimed by numerous contemporary Muslim scholars. The data were solicitedamong others from the World Bank Database, Statistical, Economic, and SocialResearch and Training, Centre of Islamic Countries of OIC andsome previous studies. They were then analyzed using SPSS with the resultsbeing generated mainly through the use of descriptive statistics. Among others,the study found that there is a positive correlation between Muslim countries’urban population growth and literacy rate, there is a steady decline in thenumber of OIC countries as they are categorized from lower to higher incomecategory placement and the percentage of the scientific publications of all 57OIC countries is far below that of any one single developed nation. (shrink)

South Asian regional integration is seemingly confronting many challenges. The aim of this paper is to identify those challenges and also look for prospects. Although regional integration in South Asia has adopted a kind of institutionalization, it is yet to deliver any concrete outcomes. High-politics and the not-so-conducive regional economic structures hinder any effectual culmination. However, constructivism, as a theory, is given due credence in this paper when looking for future prospects. The paper highlights the issues, and attempts to offer (...) certain policy directions by analyzing the challenges and identifying the prospects in the on-going integration/cooperation process. (shrink)

Providing Single Sign-On (SSO) between service providers and enabling service providers to share user personal attributes are critical for both users to benefit from a seamless access to their services, and service providers to realize new business opportunities. Today, however, the users have several independent, partial identities spread over different service providers. Providing SSO and attribute sharing requires that links (federations) are established between (partial) identities. In SAML 2.0 (Maler et al. 2003), the links between identities are stored and managed (...) at the network side by the identity providers (network-side identity federation). This model prevents the service providers from mass-correlating the partial identities they have, but the users must fully trust the identity providers. In this paper, we propose a complementary approach where the users have a full control of the links between their partial identities. It is a client-side identity federation approach, which relies on the introduction of a new cryptographic tool, called invariable partially blind signature scheme, that may be of independent interest. (shrink)

"This volume provides a long-needed anthology of major writings related to the subject of violence.

This paper attempts to rethink the philosophy of Muhammad Iqbal and challenge the still prevailing tendency in Iqbal scholarship to view it merely as an outcome of the influence of the ideas of various Western/European philosophers. I present Iqbal’s arguments in their particular historical and intellectual context to show that they developed in response to a specific philosophical problem and that Iqbal looked for a solution to that problem in Islamic tradition. I suggest that Iqbal’s philosophy is best understood in (...) the context of, and as a response to, the problem of nihilism as it was debated in modern German philosophy during ‘the pantheism controversy’ in the eighteenth and nineteenth centuries. To demonstrate this, I analyse Iqbal’s article on ʿAbd al-Karīm al-Jīlī to show his concern with the problem of nihilism, and his solution to it based on al-Jīlī’s Sufism. (shrink)

Karim Schelkens | : Dans cette contribution, l’auteur étudie l’affirmation souvent entendue selon laquelle John Henry Newman a influencé les enseignements de Vatican II. L’accent est mis sur l’ouverture conciliaire au dialogue oecuménique, et sur la façon dont les idées de Newman ont été accueillies par une génération intermédiaire de théologiens, qui à leur tour les ont amenées dans la salle conciliaire. Cet article illustre notamment comment l’héritage de Newman a été reçu dans les milieux européens francophones de la (...) première moitié du xxe siècle. Pour ce faire, l’auteur étudie la façon dont Louis Bouyer, Yves Congar et Johannes Willebrands partageaient un intérêt commun pour le patrimoine théologique de Newman, et comment la présence de ces trois théologiens à la Conférence Catholique pour les Questions oecuméniques a servi de porte d’entrée au tournant oecuménique de Vatican II. | : In this contribution, the author investigates the often heard claim that John Henry Newman influenced the teachings of Vatican II. The focus lies on the conciliar opening toward ecumenical dialogue, and the way in which Newman’s ideas have been received by an intermediary generation of theologians, who in turn brought them to the conciliar hall. In particular, this article illustrates how Newman’s legacy was received in French-speaking European milieus of the first half of the twentieth century. In order to do so, the author studies the way in which Louis Bouyer, Yves Congar and Johannes Willebrands shared a common interest in Newman’s theological heritage, and how the presence of all three of these theologians in the Catholic Conference on Ecumenical Questions served as a gateway to Vatican II’s ecumenical turn. (shrink)

Versuch eines pragmatischen Empirismus Karim Bschir. vom Rationalismus abzugrenzen, welcher neben der Erfahrung auch die reine Verstandestätigkeit als Erkenntnisquelle zulässt. Auf der anderen Seite benutzt man „Empirismus“ bzw.

On one popular view, the general covariance of gravity implies that change is relational in a strong sense, such that all it is for a physical degree of freedom to change is for it to vary with regard to a second physical degree of freedom. At a quantum level, this view of change as relative variation leads to a fundamentally timeless formalism for quantum gravity. Here, we will show how one may avoid this acute ‘problem of time’. Under our view, (...) duration is still regarded as relative, but temporal succession is taken to be absolute. Following our approach, which is presented in more formal terms in, it is possible to conceive of a genuinely dynamical theory of quantum gravity within which time, in a substantive sense, remains. 1 Introduction1.1 The problem of time1.2 Our solution2 Understanding Symmetry2.1 Mechanics and representation2.2 Freedom by degrees2.3 Voluntary redundancy3 Understanding Time3.1 Change and order3.2 Quantization and succession4 Time and Gravitation4.1 The two faces of classical gravity4.2 Retaining succession in quantum gravity5 Discussion5.1 Related arguments5.2 Concluding remarks. (shrink)

In this article we argue for the existence of ‘analogue simulation’ as a novel form of scientific inference with the potential to be confirmatory. This notion is distinct from the modes of analogical reasoning detailed in the literature, and draws inspiration from fluid dynamical ‘dumb hole’ analogues to gravitational black holes. For that case, which is considered in detail, we defend the claim that the phenomena of gravitational Hawking radiation could be confirmed in the case that its counterpart is detected (...) within experiments conducted on diverse realizations of the analogue model. A prospectus is given for further potential cases of analogue simulation in contemporary science. 1 Introduction2 Physical Background2.1 Hawking radiation in semi-classical gravity2.2 Modelling sound in fluids2.3 The acoustic analogue model of Hawking radiation3 Simulation and Analogy in Physical Theory3.1 Analogical reasoning and analogue simulation3.2 Confirmation via analogue simulation3.3 Recapitulation4 The Sound of Silence: Analogical Insights into Gravity4.1 Experimental realization of analogue models4.2 Universality and the Hawking effect4.3 Confirmation of gravitational Hawking radiation5 Prospectus. (shrink)

Introduction to Synthese SI: Systematicity: The Nature of Science?

We develop a formal semantic analysis of the alarm calls used by Campbell’s monkeys in the Tai forest and on Tiwai island —two sites that differ in the main predators that the monkeys are exposed to. Building on data discussed in Ouattara et al. :e7808, 2009a; PNAS 106: 22026–22031, 2009b and Arnold et al., we argue that on both sites alarm calls include the roots krak and hok, which can optionally be affixed with -oo, a kind of attenuating suffix; in (...) addition, sentences can start with boom boom, which indicates that the context is not one of predation. In line with Arnold et al., we show that the meaning of the roots is not quite the same in Tai and on Tiwai: krak often functions as a leopard alarm call in Tai, but as a general alarm call on Tiwai. We develop models based on a compositional semantics in which concatenation is interpreted as conjunction, roots have lexical meanings, -oo is an attenuating suffix, and an all-purpose alarm parameter is raised with each individual call. The first model accounts for the difference between Tai and Tiwai by way of different lexical entries for krak. The second model gives the same underspecified entry to krak in both locations, but it makes use of a competition mechanism akin to scalar implicatures. In Tai, strengthening yields a meaning equivalent to non-aerial dangerous predator and turns out to single out leopards. On Tiwai, strengthening yields a nearly contradictory meaning due to the absence of ground predators, and only the unstrengthened meaning is used. (shrink)

A small but growing number of studies have aimed to understand, assess and reduce existential risks, or risks that threaten the continued existence of mankind. However, most attention has been focused on known and tangible risks. This paper proposes a heuristic for reducing the risk of black swan extinction events. These events are, as the name suggests, stochastic and unforeseen when they happen. Decision theory based on a fixed model of possible outcomes cannot properly deal with this kind of event. (...) Neither can probabilistic risk analysis. This paper will argue that the approach that is referred to as engineering safety could be applied to reducing the risk from black swan extinction events. It will also propose a conceptual sketch of how such a strategy may be implemented: isolated, self-sufficient, and continuously manned underground refuges. Some characteristics of such refuges are also described, in particular the psychosocial aspects. Furthermore, it is argued that this implementation of the engineering safety strategy safety barriers would be effective and plausible and could reduce the risk of an extinction event in a wide range of possible scenarios. Considering the staggering opportunity cost of an existential catastrophe, such strategies ought to be explored more vigorously. (shrink)

We propose a solution to the problem of time for systems with a single global Hamiltonian constraint. Our solution stems from the observation that, for these theories, conventional gauge theory methods fail to capture the full classical dynamics of the system and must therefore be deemed inappropriate. We propose a new strategy for consistently quantizing systems with a relational notion of time that does capture the full classical dynamics of the system and allows for evolution parametrized by an equitable internal (...) clock. This proposal contains the minimal temporal structure necessary to retain the ordering of events required to describe classical evolution. In the context of shape dynamics (an equivalent formulation of general relativity that is locally scale invariant and free of the local problem of time) our proposal can be shown to constitute a natural methodology for describing dynamical evolution in quantum gravity and to lead to a quantum theory analogous to the Dirac quantization of unimodular gravity. (shrink)