BackgroundObtaining informed consent for participation in genomic research in low-income settings presents specific ethical issues requiring attention. These include the challenges that arise when providing information about unfamiliar and technical research methods, the implications of complicated infrastructure and data sharing requirements, and the potential consequences of future research with samples and data. This study investigated researchers’ and participants’ parents’ experiences of a consent process and understandings of a genome-wide association study of malaria involving children aged five and under in Mali. (...) It aimed to inform best practices in recruiting participants into genomic research.MethodsA qualitative rapid ethical assessment was undertaken. Fifty-five semi-structured interviews were conducted with the parents of research participants. An additional nine semi-structured interviews were conducted with senior research scientists, research assistants and with a member of an ethics committee. A focus group with five parents of research participants and direct observations of four consent processes were also conducted. French and translated English transcripts were descriptively and thematically coded using OpenCode software.ResultsParticipants’ parents in the MalariaGEN study had differing understandings of the causes of malaria, the rationale for collecting blood samples, the purposes of the study and the kinds of information the study would generate. Genomic aspects of the research, including the gene/environment interaction underlying susceptibility or resistance to severe malaria, proved particularly challenging to explain and understand.ConclusionsThis study identifies a number of areas to be addressed in the design of consent processes for genomic research, some of which require careful ethical analysis. These include determining how much information should be provided about differing aspects of the research and how best to promote understandings of genomic research. We conclude that it is important to build capacity in the design and conduct of effective and appropriate consent processes for genomic research in low and middle-income settings. Additionally, consideration should be given to the role of review committees and community consultation activities in protecting the interests of participants in genomic research. (shrink)

The `problem of time' is a cluster of interpretational and formal issues in the foundations of general relativity relating to both the representation of time in the classical canonical formalism, and to the quantization of the theory. The purpose of this short chapter is to provide an accessible introduction to the problem.

In 1981 Unruh proposed that fluid mechanical experiments could be used to probe key aspects of the quantum phenomenology of black holes. In particular, he claimed that an analogue to Hawking radiation could be created within a fluid mechanical `dumb hole', with the event horizon replaced by a sonic horizon. Since then an entire sub-field of `analogue gravity' has been created. In 2016 Steinhauer reported the experimental observation of quantum Hawking radiation and its entanglement in a Bose-Einstein condensate analogue black (...) hole. What can we learn from such analogue experiments? In particular, in what sense can they provide evidence of novel phenomena such as black hole Hawking radiation? (shrink)

This collection of new essays interprets and critically evaluates the philosophy of Paul Feyerabend. It offers innovative historical scholarship on Feyerabend's take on topics such as realism, empiricism, mimesis, voluntarism, pluralism, materialism, and the mind-body problem, as well as certain debates in the philosophy of physics. It also considers the ways in which Feyerabend's thought can contribute to contemporary debates in science and public policy, including questions about the nature of scientific methodology, the role of science in society, citizen science, (...) scientism, and the role of expertise in public policy. The volume will provide readers with a comprehensive overview of the topics which Feyerabend engaged with throughout his career, showing both the breadth and the depth of his thought. (shrink)

Versuch eines pragmatischen Empirismus Karim Bschir. vom Rationalismus abzugrenzen, welcher neben der Erfahrung auch die reine Verstandestätigkeit als Erkenntnisquelle zulässt. Auf der anderen Seite benutzt man „Empirismus“ bzw.

I examine to what extend Varela’s remarks on problem-solving can be applied to mathematical problem-solving. I argue that despite similarities between Varela’s epistemological model and recent advances in mathematics education research on problem-solving, trying to fit ideas and concepts from the latter domain in the Varelian mold runs the risk of misconstruing fundamental aspects of mathematical problem-solving.

This paper expands Rami Ali’s dissolution of the gamer’s dilemma (Ethics Inf Technol 17:267-274, 2015). Morgan Luck’s gamer’s dilemma (Ethics Inf Technol 11(1):31-36, 2009) rests on our having diverging intuition when considering virtual murder and virtual child molestation in video games. Virtual murder is seemingly permissible, when virtual child molestation is not and there is no obvious morally relevant difference between the two. Ali argues that virtual murder and virtual child molestation are equally permissible/impermissible when considered under different modes of (...) engagement. To this end, Ali distinguishes between story-telling gameplay and simulation games, discussing both in depth. I build on the dissolution by looking into competitive gameplay in order to consider what the morally relevant difference between virtual murder and virtual child molestation might be when competing in a video game. I argue that when competitors consent to participate in a competition, the rules of the competition supersede everyday moral intuitions. As such, virtual competitions ought to represent such consent from virtual characters. Virtual children cannot be represented as giving consent to be molested because (1) children cannot be represented as giving sexual consent, and (2) consent to be possibly molested cannot be given. This creates a morally relevant difference between murder and molestation. By fully addressing competitive gameplay, I answer Luck’s worry that Ali’s dissolution is incomplete (Ethics Inf Technol 20:157-162, 2018). (shrink)

Karim Fathi liefert erstmalig einen Überblick über die unterschiedlichen Diskurse und Strategien der Komplexitätsbewältigung auf der Ebene von Teams, Organisationen und Gesellschaften. Unter der Leitdifferenz kommunikativer Komplexitätsbewältigung untersucht er Fragen wie: Welche Strategien und Methoden ergeben sich im Umgang mit komplexen, vieldimensionalen und unvorhersehbaren Problemen? Wie können Kommunikationsprozesse so gestaltet werden, dass sie höhere kollektive Intelligenz ermöglichen? Sein universell anwendbarer Ansatz unterstützt komplexe Problemlöseprozesse auf allen Ebenen und fördert transdisziplinäres Denken in Zeiten globalen strukturellen Wandels.

Econophysics is a new and exciting cross-disciplinary research field that applies models and modelling techniques from statistical physics to economic systems. It is not, however, without its critics: prominent figures in more mainstream economic theory have criticized some elements of the methodology of econophysics. One of the main lines of criticism concerns the nature of the modelling assumptions and idealizations involved, and a particular target are ‘kinetic exchange’ approaches used to model the emergence of inequality within the distribution of individual (...) monetary income. This article will consider such models in detail, and assess the warrant of the criticisms drawing upon the philosophical literature on modelling and idealization. Our aim is to provide the first steps towards informed mediation of this important and interesting interdisciplinary debate, and our hope is to offer guidance with regard to both the practice of modelling inequality, and the inequality of modelling practice. _1_ Introduction _1.1_ Econophysics and its discontents _1.2_ Against burglar economics _2_ Modelling Inequality _2.1_ Mainstream economic models for income distribution _2.2_ Econophysics models for income distribution _3_ Idealizations in Kinetic Exchange Models _3.1_ Binary interactions _3.2_ Conservation principles _3.3_ Exchange dynamics _ 4 _ Fat Tails and Savings _ 5 _ Evaluation. (shrink)

We claim that, as it stands, the Deutsch–Wallace–Everett approach to quantum theory is conceptually incoherent. This charge is based upon the approach’s reliance upon decoherence arguments that conflict with its own fundamental precepts regarding probabilistic reasoning in two respects. This conceptual conflict obtains even if the decoherence arguments deployed are aimed merely towards the establishment of certain ‘emergent’ or ‘robust’ structures within the wave function: To be relevant to physical science notions such as robustness must be empirically grounded, and, on (...) our analysis, this grounding can only plausibly be done in precisely the probabilistic terms that lead to conceptual conflict. Thus, the incoherence problems presented necessitate either the provision of a new, non-probabilistic empirical grounding for the notions of robustness and emergence in the context of decoherence, or the abandonment of the Deutsch–Wallace–Everett programme for quantum theory. (shrink)

In recent decades, non-representational approaches to mental phenomena and cognition have been gaining traction in cognitive science and philosophy of mind. In these alternative approach, mental representations either lose their central status or, in its most radical form, are banned completely. While there is growing agreement that non-representational accounts may succeed in explaining some cognitive capacities, there is widespread skepticism about the possibility of giving non-representational accounts of cognitive capacities such as memory, imagination or abstract thought. In this paper, I (...) will critically examine the view that there are fundamental limitations to non-representational explanations of cognition. Rather than challenging these arguments on general grounds, I will examine a set of human cognitive capacities that are generally thought to fall outside the scope of non-representational accounts, i.e. numerical cognition. After criticizing standard representational accounts of numerical cognition for their lack of explanatory power, I will argue that a non-representational approach that is inspired by radical enactivism offers the best hope for developing a genuine naturalistic explanatory account for these cognitive capacities. (shrink)

Embodied and extended cognition is a relatively new paradigm within cognitive science that challenges the basic tenet of classical cognitive science, viz. cognition consists in building and manipulating internal representations. Some of the pioneers of embodied cognitive science have claimed that this new way of conceptualizing cognition puts pressure on epistemological and ontological realism. In this paper I will argue that such anti-realist conclusions do not follow from the basic assumptions of radical embodied cognitive science. Furthermore I will show that (...) one can develop a form of realism that reflects rather than just accommodates the core principles of non-representationalist embodied cognitive science. (shrink)

Research and policy interest in questions of environmental waste is growing, especially plastic bag pollution. Where trash disposal and recycling are not highly regulated, the proliferation of plastic bags has created dramatic social and environmental consequences. In this article, we draw on 30 interviews with women who sell goods in markets in Mali as an entry point into investigating this issue through the interrelated dimensions of identity, gender, globalization, and the environment. We find the choices of women become suspect and (...) blamed for this environmental issue despite their having few socio-political options, while global and local political and economic elites have largely been responsible for implementing a series of policies and programs that have heightened the local effects of globalization while diminishing the services available to deal with the environmental and cultural dimensions of these changes. The issue of plastic bag pollution demonstrates the environmental consequences of development strategies that have emphasized economic growth with seemingly little concern or value for local cultures and environments, let alone the experiences and lives of poor women. (shrink)

Symplectic reduction is a formal process through which degeneracy within the mathematical representations of physical systems displaying gauge symmetry can be controlled via the construction of a reduced phase space. Typically such reduced spaces provide us with a formalism for representing both instantaneous states and evolution uniquely and for this reason can be justifiably afforded the status of fun- damental dynamical arena - the otiose structure having been eliminated from the original phase space. Essential to the application of symplectic reduction (...) is the precept that the first class constraints are the relevant gauge generators. This prescription becomes highly problematic for reparameterization invariant theories within which the Hamiltonian itself is a constraint; not least because it would seem to render prima facie distinct stages of a history physically identical and observable functions changeless. Here we will consider this problem of time within non-relativistic me- chanical theory with a view to both more fully understanding the temporal struc- ture of these timeless theories and better appreciating the corresponding issues in relativistic mechanics. For the case of nonrelativistic reparameterization invariant theory application of symplectic reduction will be demonstrated to be both unnec- essary; since the degeneracy involved is benign; and inappropriate; since it leads to a trivial theory. With this anti-reductive position established we will then examine two rival methodologies for consistently representing change and observable func- tions within the original phase space before evaluating the relevant philosophical implications. We will conclude with a preview of the case against symplectic re- duction being applied to canonical general relativity. (shrink)

À partir d’une recherche-action en hôpital de jour, l’article présente la mise en place d’un groupe de parole pour les parents et assistantes familiales s’occupant d’enfants avec autisme. Cette expérience a pour objet de travailler sur les apports possibles de l’approche groupale qui peuvent servir de levier pour mobiliser les ressources parentales et celles de l’enfant. En appui sur des références groupales psychanalytiques, les auteurs questionnent l’importance d’un travail clinique sur les difficultés à remplir le rôle de parent face à (...) des enfants et/ou un environnement quand les processus d’intersubjectivité et de subjectivité sont mis en défaut. Ils montrent à partir d’une illustration clinique les qualités du groupe dans ses modalités de contenance. Il s’agit de questionner les positions subjectives dans l’après-coup du moment traumatique inaugural du diagnostic et dans ses principes d’élaboration. (shrink)

A fundamental tenet of Paul Feyerabend’s pluralistic view of science has it that theory proliferation, that is, the availability of theoretical alternatives, is of crucial importance for the detection of anomalies in established theories. Paul Hoyningen-Huene calls this the Anomaly Importation Thesis, according to which anomalies are imported, as it were, into well-established theories from competing alternatives. This article pursues two major objectives: (a) to work out the systematic details of Feyerabend’s ideas on theory proliferation and anomaly import as they (...) are presented in his early publications and his Against Method and (b) to compare Feyerabend’s ideas on theory proliferation and anomaly import with corresponding features in Popper’s critical rationalist philosophy of science. As it turns out, neither the Principle of Proliferation nor the Anomaly Importation Thesis are necessarily incompatible with critical rationalism. In spite of Feyerabend’s general anti-Popperian attitude, I argue that theoretical pluralism can be seen as an advancement of the critical rationalist philosophy and that critical rationalism provides good arguments for pluralism. (shrink)

Starting from a generalized Hamilton-Jacobi formalism, we develop a new framework for constructing observables and their evolution in theories invariant under global time reparametrizations. Our proposal relaxes the usual Dirac prescription for the observables of a totally constrained system and allows one to recover the influential partial and complete observables approach in a particular limit. Difficulties such as the non-unitary evolution of the complete observables in terms of certain partial observables are explained as a breakdown of this limit. Identification of (...) our observables relies upon a physical distinction between gauge symmetries that exist at the level of histories and states, and those that exist at the level of histories and not states. This distinction resolves a tension in the literature concerning the physical interpretation of the partial observables and allows for a richer class of observables in the quantum theory. There is the potential for the application of our proposal to the quantization of gravity when understood in terms of the Shape Dynamics formalism. (shrink)

Review of ‘Physical Theory: Method and Interpretation’ edited by Lawrence Sklar.

Tagba is a tone language that presents tonal patterns that appear quite regular at first glance. However, these are difficult to model under standard autosegmental hierarchical assumptions regarding the placement of skeleton, segments and tones. In this paper, we will present Tagba tonology and demonstrate that it can be accounted for by readjusting the tiers of hierarchization. From this, we reason that the proposed hierarchy is parametric and language specific.

This is a clear and original investigation of God's nature and existence. First of all, it considers (among other things) two of God's traditional properties: being all-knowing and being all-powerful. It argues he cannot possess these properties. But, it argues this is in accord with him being worthy of worship. Secondly, it introduces the notion of evil being "overridden". It argues he has to bring about other free living things and it is plausible they have to be liable to experience (...) evil due to their conditions. But, it argues the evil in this world is "overridden". Thirdly, it considers the principal arguments for the claim he does not exist. (They refer to the evil in the world.) It argues they do not establish sufficient grounds for this claim. Finally, it considers some well-known arguments for the claim he exists. It argues they face difficulties. It sets out other arguments: eg, some arguments to increase any degree of belief one has that God can exist. It includes a number of Appendices: God's sovereignty; Are there sufficient grounds for the claim that, very probably, God does not exist?; Theodicy and some theodicies; Some further remarks on God and time; Some further remarks on a living thing which possesses the power to do this or that freely;... It covers as a whole the principal parts of the Philosophy of Religion. It unifies these parts to a significant degree. It proceeds regularly by way of formal and clear arguments. (shrink)

The analysis of the temporal structure of canonical general relativity and the connected interpretational questions with regard to the role of time within the theory both rest upon the need to respect the fundamentally dual role of the Hamiltonian constraints found within the formalism. Any consistent philosophical approach towards the theory must pay dues to the role of these constraints in both generating dynamics, in the context of phase space, and generating unphysical symmetry transformations, in the context of a hypersurface (...) embedded within a solution. A first denial of time in the terms of a position of reductive temporal relationalism can be shown to be troubled by failure on the first count, and a second denial in the terms of Machian temporal relationalism can be found to be hampered by failure on the second. A third denial of time, consistent with both of the Hamiltonian constraints roles, is constituted by the implementation of a scheme for constructing observables in terms of correlations and leads to a radical Parmenidean timelessness. The motivation for and implications of each of these three denials are investigated. (shrink)

Una de las actividades religiosas e intelectuales más importantes del pensamiento islámico es el iytihad. Supone la libre interpretación de los textos y de las cuestiones religiosas relacionadas con el derecho civil y religioso, basándose en El Corán, la Sunna y el hadit, entre otras fuentes islámicas.The iytihad, in one of the most important religious and intellectual activities of the Islamic thought, that suposses the free interpretation of the texts and religious questions related to the civil and religious law, being (...) based on the sources of Islamic jurisprudence: The Koran, the Sunna and The hadiz and the other sources. There are two types of interpreters, the firsts are disciples of the imams founders of the four rites or official schools of the Islam, and the seconds are the intellectuals, philosophers and writers that enjoy prestige, confidence and authoity among a great mass of the civil society. (shrink)

Zygon®, Volume 57, Issue 2, Page 418-442, June 2022.

We give in this paper a short semantical proof of the strong normalization for full propositional classical natural deduction. This proof is an adaptation of reducibility candidates introduced by J.-Y. Girard and simplified to the classical case by M. Parigot.

Hamiltonian constraints feature in the canonical formulation of general relativity. Unlike typical constraints they cannot be associated with a reduction procedure leading to a non-trivial reduced phase space and this means the physical interpretation of their quantum analogues is ambiguous. In particular, can we assume that “quantisation commutes with reduction” and treat the promotion of these constraints to operators annihilating the wave function, according to a Dirac type procedure, as leading to a Hilbert space equivalent to that reached by quantisation (...) of the problematic reduced space? If not, how should we interpret Hamiltonian constraints quantum mechanically? And on what basis do we assert that quantisation and reduction commute anyway? These questions will be refined and explored in the context of modern approaches to the quantisation of canonical general relativity. (shrink)

The canonical formalism of general relativity affords a particularly interesting characterisation of the infamous hole argument. It also provides a natural formalism in which to relate the hole argument to the problem of time in classical and quantum gravity. In this paper we examine the connection between these two much discussed problems in the foundations of spacetime theory along two interrelated lines. First, from a formal perspective, we consider the extent to which the two problems can and cannot be precisely (...) and distinctly characterised. Second, from a philosophical perspective, we consider the implications of various responses to the problems, with a particular focus upon the viability of a `deflationary' attitude to the relationalist/substantivalist debate regarding the ontology of spacetime. Conceptual and formal inadequacies within the representative language of canonical gravity will be shown to be at the heart of both the canonical hole argument and the problem of time. Interesting and fruitful work at the interface of physics and philosophy relates to the challenge of resolving such inadequacies. (shrink)

In 1990 J-L. Krivine introduced the notion of storage operators. They are $\lambda$ -terms which simulate call-by-value in the call-by-name strategy and they can be used in order to modelize assignment instructions. J-L. Krivine has shown that there is a very simple second order type in AF2 type system for storage operators using Gödel translation of classical to intuitionistic logic. In order to modelize the control operators, J-L. Krivine has extended the system AF2 to the classical logic. In his system (...) the property of the unicity of integers representation is lost, but he has shown that storage operators typable in the system AF2 can be used to find the values of classical integers. In this paper, we present a new classical type system based on a logical system called mixed logic. We prove that in this system we can characterize, by types, the storage operators and the control operators. (shrink)

Background: Recently, a singular survey titled “Measure of Moral Distress—Healthcare Professionals,” which addresses shortcomings of previous instruments, has been validated. Aim: To determine how moral distress affects nurses and physicians differently across the various wards of a community hospital. Participant and research context: We distributed a self-administered, validated survey titled “Measure of Moral Distress—Healthcare Professionals” to all nurses and physicians in the medical/surgical ward, telemetry ward, intensive care units, and emergency rooms of a community hospital. Findings: A total of 101 (...) surveys were included in the study. The mean Measure of Moral Distress—Healthcare Professionals score for all respondents was 143.0. The mean Measure of Moral Distress—Healthcare Professionals score was 1.75 greater for nurses than for physicians, and nurses were 2.52 times more likely to consider leaving their position due to moral distress. The mean Measure of Moral Distress—Healthcare Professionals score for moral distress was least prevalent in the medical/surgical ward and highest in the telemetry ward. The intensive care unit ward had a mean Measure of Moral Distress—Healthcare Professionals score mildly greater than the emergency room. Ethical considerations: No participant identifying information or information connecting a survey response to an individual was collected. This study was approved by the Raritan Bay Medical Center’s Institutional Review Board. Discussion: This study provides insight into the level of moral distress in the community hospital setting. Telemetry nurses experience significantly more than nurses in other wards. Telemetry nurses typically manage patients sicker than medical/surgical wards, however do not have the resources of the critical care units. This scenario presents challenges for telemetry nurses and may explain their elevated moral distress. Conclusion: In community hospitals, telemetry nurses experience a considerably greater amount of moral distress compared to their colleagues in other wards. As measured by the Measure of Moral Distress—Healthcare Professionals questionnaire, moral distress continues to be higher among nurses compared to physicians. (shrink)

Is philosophy continuous with science or does it have a distinctive domain of inquiry that differs from that of the special sciences? Collingwood claimed that philosophy has a distinctive subject matter and a distinctive method. Its distinctive subject matter is what he called the “absolute presuppositions” that govern the special sciences and its method consists in making these presuppositions explicit by showing that they are entailed by the questions asked in the special sciences. In this chapter the editors seek to (...) provide a guide to the diverging interpretations of Collingwood’s claim that metaphysics is not the study of pure being but of the presuppositions that govern knowledge of reality. They argue that a reassessment of his contribution to philosophical methodology is timely in the light of the recent revival of interest in second-order questions concerning the role and character of philosophical analysis. (shrink)