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Karla Alex [9]Karla Karoline Sonne Kalinka Alex [4]
  1.  51
    Comparative ethical evaluation of epigenome editing and genome editing in medicine: first steps and future directions.Karla Alex & Eva C. Winkler - 2023 - Journal of Medical Ethics (doi: 10.1136/jme-2022-108888):1-9.
    Targeted modifications of the human epigenome, epigenome editing (EE), are around the corner. For EE, techniques similar to genome editing (GE) techniques are used. While in GE the genetic information is changed by directly modifying DNA, intervening in the epigenome requires modifying the configuration of DNA, for example, how it is folded. This does not come with alterations in the base sequence (‘genetic code’). To date, there is almost no ethical debate about EE, whereas the discussions about GE are voluminous. (...)
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  2.  28
    The Mutual Benefit of the Integration of Philosophy and Bioethics – Our Experience from an Interdisciplinary Research Project on (Epi-)Genome Editing.Karla Karoline Sonne Kalinka Alex & Eva C. Winkler - 2022 - American Journal of Bioethics 22 (12):61-63.
    We welcome Blumenthal-Barby’s et al. (2022) plaidoyer for the integration of philosophy in bioethics because of a perceived mutual benefit. Drawing on experience from a collaborative project, funde...
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  3.  4
    Comparative ethical evaluation of epigenome editing and genome editing in medicine: first steps and future directions.Karla Alex & Eva C. Winkler - 2024 - Journal of Medical Ethics 50 (6):398-406.
    Targeted modifications of the human epigenome, epigenome editing (EE), are around the corner. For EE, techniques similar to genome editing (GE) techniques are used. While in GE the genetic information is changed by directly modifying DNA, intervening in the epigenome requires modifying the configuration of DNA, for example, how it is folded. This does not come with alterations in the base sequence (‘genetic code’). To date, there is almost no ethical debate about EE, whereas the discussions about GE are voluminous. (...)
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  4.  59
    Ethischer Diskurs zu Epigenetik und Genomeditierung: die Gefahr eines (epi-)genetischen Determinismus und naturwissenschaftlich strittiger Grundannahmen.Karla Karoline Sonne Kalinka Alex & Eva C. Winkler - 2021 - In Boris Fehse, Ferdinand Hucho, Sina Bartfeld, Stephan Clemens, Tobias Erb, Heiner Fangerau, Jürgen Hampel, Martin Korte, Lilian Marx-Stölting, Stefan Mundlos, Angela Osterheider, Anja Pichl, Jens Reich, Hannah Schickl, Silke Schicktanz, Jochen Taupitz, Jörn Walter, Eva Winkler & Martin Zenke (eds.), Fünfter Gentechnologiebericht: Sachstand und Perspektiven für Forschung und Anwendung. pp. 299-323.
    Slightly modified excerpt from the section 13.4 Zusammenfassung und Ausblick (translated into englisch): This chapter is based on an analysis of ethical debates on epigenetics and genome editing, debates, in which ethical arguments relating to future generations and justice play a central role. The analysis aims to contextualize new developments in genetic engineering, such as genome and epigenome editing, ethically. At the beginning, the assumptions of "genetic determinism," on which "genetic essentialism" is based, of "epigenetic determinism" as well as "genetic" (...)
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  5.  45
    Is Dupras and Bunnik’s Framework for Assessing Privacy Risks in Multi-Omic Research and Databases Still Too Exceptionalist?Karla Alex & Eva C. Winkler - 2021 - American Journal of Bioethics 21 (12):80-82.
    Dupras and Bunnik’s strong statement against the normative approach of genetic exceptionalism, which can no longer be justified in the midst of multi-omic research, is of great importance fo...
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  6.  41
    Defusing the legal and ethical minefield of epigenetic applications in the military, defence and security context.Gratien Dalpe, Katherine Huerne, Charles Dupras, Katherine Cheung, Nicole Palmour, Eva Winkler, Karla Alex, Maxwell Mehlmann, John W. Holloway, Eline Bunnik, Harald König, Isabelle M. Mansuy, Marianne G. Rots, Cheryl Erwin, Alexandre Erler, Emanuele Libertini & Yann Joly - 2023 - Journal of Law and the Biosciences 10 (2):1-32.
    Epigenetic research has brought several important technological achievements, including identifying epigenetic clocks and signatures, and developing epigenetic editing. The potential military applications of such technologies we discuss are stratifying soldiers’ health, exposure to trauma using epigenetic testing, information about biological clocks, confirming child soldiers’ minor status using epigenetic clocks, and inducing epigenetic modifications in soldiers. These uses could become a reality. This article presents a comprehensive literature review, and analysis by interdisciplinary experts of the scientific, legal, ethical, and societal issues (...)
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  7. Ethical Discourse on Epigenetics and Genome Editing: The Risk of (Epi-) genetic Determinism and Scientifically Controversial Basic Assumptions.Karla Alex & Eva C. Winkler - 2021 - In Michael Welker, Eva Winkler & John Witte Jr (eds.), The Impact of Health Care on Character Formation, Ethical Education, and the Communication of Values in Late Modern Pluralistic Societies. Leipzig: Evangelische Verlagsanstalt & Wipf & Stock Publishers. pp. 77-99.
    Excerpt: 1. Introduction This chapter provides insight into the diverse ethical debates on genetics and epigenetics. Much controversy surrounds debates about intervening into the germline genome of human embryos, with catchwords such as genome editing, designer baby, and CRISPR/Cas. The idea that it is possible to design a child according to one’s personal preferences is, however, a quite distorted view of what is actually possible with new gene technologies and gene therapies. These are much more limited than the editing and (...)
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  8. Gibt es einen therapeutischen Imperativ zum genome editing in der menschlichen Keimbahn? [Is there a therapeutic imperative for editing the human germline genome? / Existe-t-il un impératif thérapeutique à l'édition du génome dans la lignée germinale humaine].Karla Alex & Christoph Rehmann-Sutter - 2022 - URPP Human Reproduction Reloaded | H2R (University of Zurich), Working Paper Series, 05/2022. Zurich and Geneva: Seismo 1 (5):1-21.
    Abstract: This working paper focuses on the question whether there is a therapeutic imperative that, in specific situations, would oblige us to perform genome editing at the germline level in the context of assisted reproduction. The answer to this central question is discussed primarily with reference to specific scenarios where preimplantation genetic diagnosis (PGD) does not represent an acceptable alternative to germline genome editing based on either medical, or ethical, or – from the perspective of the potential parents – moral (...)
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  9.  32
    Internationale Klausurwoche (BMBF): „Defining the value of medical interventions – Normative and empirical challenges“. [REVIEW]Karla Alex, Friederike Benning & Caroline Steigenberger - 2020 - Ethik in der Medizin 32 (1):107-110.