In humans, there are two skeletal muscle α‐actinins, encoded by ACTN2 and ACTN3, and the ACTN3 genotype is associated with human athletic performance. Remarkably, approximately 1 billion people worldwide are deficient in α‐actinin‐3 due to the common ACTN3 R577X polymorphism. The α‐actinins are an ancient family of actin‐binding proteins with structural, signalling and metabolic functions. The skeletal muscle α‐actinins diverged ∼250–300 million years ago, and ACTN3 has since developed restricted expression in fast muscle fibres. Despite ACTN2 and ACTN3 retaining considerable (...) sequence similarity, it is likely that following duplication there was a divergence in function explaining why α‐actinin‐2 cannot completely compensate for the absence of α‐actinin‐3. This paper focuses on the role of skeletal muscle α‐actinins, and how possible changes in functions between these duplicates fit in the context of gene duplication paradigms. (shrink)

This special issue of AVANT is all about Cognitive Innovation. It is not about CogNovo, the interdisciplinary and international doctoral training programme that produced three different Off the Lip events. It is not about Off the Lip 2017, the novel symposium format we developed to collaboratively create a publication resulting in this special issue of AVANT. It is not about the seemingly heterogeneous collection of papers that follow this preface. Collaborative Approaches to Cognitive Innovation required something else, something we are (...) starting to capture in the four GIFT principles. While this special issue is not solely about CogNovo, Off the Lip events, or the content of the following submissions, all these aforementioned elements were necessary to shape our current understanding of Cognitive Innovation, the very process which led to numerous publications, exhibitions, and events during the past three years. In a sense, all of our previous endeavours have culminated in this collection of 26 distinct pieces of work, yet we hope and believe that this special issue also marks a beginning. Let us explain. [...]. (shrink)

The contribution of this book to the field of reconciliation is both theoretical and practical, recognizing that good theory guides effective practice and practice is the ground for compelling theory. Using a Girardian hermeneutic as a starting point, a new conceptual Gestalt emerges in these essays, one not fully integrated in a formal way but showing a clear understanding of some of the challenges and possibilities for dealing with the deep divisions, enmity, hatred, and other effects of violence.

This article illustrates how racial capitalism can enhance understandings of data, capital, and inequality through an in-depth study of digital platforms used for intervening in gender-based violence. Specifically, we examine an emergent sociotechnical strategy that uses software platforms and artificial intelligence chatbots to offer users emergency assistance, education, and a means to report and build evidence against perpetrators. Our analysis details how two reporting apps construct data to support institutionally legible narratives of violence, highlighting overlooked racialised dimensions of the data (...) capital generated through their use. We draw attention to how they reinforce property relations built on extraction and ownership, capital accumulation that reinforces benefits derived through data property relations and ownership, and the commodification of diversity and inclusion. Recognising these patterns are not unique to anti-violence apps, we reflect on how this example aids in understanding how racial capitalism becomes a constitutive element of digital platforms, which more generally extract information from users, rely on complex financial partnerships, and often sustain problematic relationships with the criminal legal system. We conclude with a discussion of how racial capitalism can advance scholarship at the intersections of data and power. (shrink)

Preparing the Next Generation of Oral Historians is an invaluable resource to educators seeking to bring history alive for students at all levels. Filled with insightful reflections on teaching oral history, it offers practical suggestions for educators seeking to create curricula, engage students, gather community support, and meet educational standards. By the close of the book, readers will be able to successfully incorporate oral history projects in their own classrooms.

Millum and Bromwich provide a thorough and thoughtful analysis of what is required for sufficient informed consent, offering distinct conceptualizations of the ethical requirements of disclo...

Zusammenfassung Die Komplexität und Dynamik des Umfeldes, in dem sich Fußballvereine bewegen, hat in der Vergangenheit enorm zugenommen. Um bei dieser Entwicklung wettbewerbsfähig zu bleiben, bedarf es entsprechender Konzepte zur Unterstützung der Unternehmensführung. So hat die durchgeführte empirische Untersuchung ihren Fokus auf das Controlling als ein unterstützendes Konzept zur zielorientierten Unternehmenssteuerung gelegt. Ziel dieser Untersuchung ist es, das Controlling in Fußballvereinen zu beschreiben und zu analysieren.

This collection of fourteen essays explores the pervasive influence and dynamic character of oratory during the Hellenistic period and survey its different manifestations in diverse literary genres and socio-political contexts, especially the dialogue between the Greek oratorical tradition and the developing oratorical practices at Rome.

Refining the model for an emergency department‐based mental health nurse practitioner outpatient service The mental health nurse practitioner (MHNP) role based in the emergency department (ED) has emerged in response to an increase in mental health‐related presentations and subsequent concerns over waiting times, co‐ordination of care and therapeutic intervention. The MHNP role also provides scope for the delivery of specialised primary care. Nursing authors are reporting on nurse‐led outpatient clinics as a method of healthcare delivery that allows for enhanced access (...) to health‐care, particularly following hospital discharge. However, due to a lack of in‐depth substantiation, this mode of service delivery requires more thorough investigation. This study describes the refinement phase undertaken before the implementation and pilot evaluation of a formalised and structured MHNP outpatient service in the ED of a large inner‐city hospital in Sydney, Australia. An expert advisory panel (EAP) consisting of key local informants was convened to provide feedback on and refinement to the proposed model. This related to issues such as target population, structure and process considerations, outcome measures and interface within the overall health service. Findings from the EAP meeting are presented and discussed. The importance of linking methods with the appropriate methodology in evaluating a healthcare program is highlighted. (shrink)

In Moral Passages, Kathryn Pyne Addelson presents an original moral theory suited for contemporary life and its moral problems. Her basic principle is that knowledge and morality are generated in collective action, and she develops it through a critical examination of theories in philosophy, sociology and women's studies, most of which hide the collective nature and as a result hide the lives and knowledge of many people. At issue are the questions of what morality is, and how moral theories (...) (whether traditional or feminist) are implemented. Addelson takes up a large number of historical cases and contemporary social problems, including teen pregnancy, contraception and abortion, and gay rights. These cases allow her to see how the knowledge and lives of some people are declared deviant or immoral, while those of others appear to show the public consensus. One case she uses throughout the book is Margaret Sanger's early work on birth control with the anarcho-syndicalist movement--a revisionist history that reveals rather than hides the collective nature of morality and knowledge. Addelson shows how the usual individualist philosophies promote theories which hide the authority of the professionals who make them. A collectivist approach, she argues, must show the part professionals play in collective action. Her aim is to allow professional knowledge makers to be morally and intellectually responsible. Based on Addelson's twenty years of work in feminist philosophy and interactionist sociology as well as her long-standing involvement in women's community organization, Moral Passages investigates how morality and knowledge are collectively enacted in today's world. (shrink)

Information is a force multiplier. Knowledge of the enemy's capability and intentions may be of far more value to a military force than additional troops or firepower. Situation assessment is the ongoing process of inferring relevant information about the forces of concern in a military situation. Relevant information can include force types, firepower, location, and past, present and future course of action. Situation assessment involves the incorporation of uncertain evidence from diverse sources. These include photographs, radar scans, and other forms (...) of image intelligence, or IMINT; electronics intelligence, or ELINT, derived from characteristics (e.g., wavelength) of emissions generated by enemy equipment; communications intelligence, or COMINT, derived from the characteristics of messages sent by the enemy; and reports from human informants (HUMINT). These sources must be combined to form a model of the situation. The sheer volume of data, the ubiquity of uncertainty, the number and complexity of hypotheses to consider, the high-stakes environment, the compressed time frame, and deception and damage from hostile forces, combine to present a staggeringly complex problem. Even if one could formulate a decision problem in reasonable time, explicit determination of an optimal decision policy exceeds any reasonable computational resources. While it is tempting to drop any attempt at rational analysis and rely purely on simple heuristics, we argue that this can lead to catastrophic outcomes. We present an architecture for a ``complex decision machine'' that performs rational deliberation to make decisions in real time. We argue that resource limits require such an architecture to be grounded in simple heuristic reactive processes. We thus argue that both simple heuristics and complex decision machines are required for effective decision making in real time for complex problems. We describe an implementation of our architecture applied to the problem of military situation assessment. (shrink)

These essays critically reassess the widely accepted view that statistical methods of analysis can, and do, yield causal understanding of social phenomena. They emphasize the historical, philosophical and conceptual perspectives that underlie and inform current methodological controversies.

I argue that much current thinking on externalities—at least among “lay political economists” (but even, on occasion, among professional economists)—is saddled with two analytical errors. The first is what I call coextensivism: the conflation of public goods and externalities. The second error is what I call externality profligacy: the conflation of economic and “social” externalities. The principal dangers presented by these two “dogmas on externalities” are that, while in their grips, we are under-disposed to seek negotiated, market-based solutions (of a (...) broadly Coasean nature) to challenges posed by economic externalities, and over-disposed to seek coercive, state-based solutions (of a broadly Pigouvian nature) to challenges posed by social externalities. (shrink)

This 1994 book examines the development of the ideas of the new Austrian school from its beginnings in Vienna in the 1870s to the present. It focuses primarily in showing how the coherent theme that emerges from the thought of Carl Menger, Ludwig von Mises, Friedrich Hayek, Ludwig Lachman, Israel Kirzner and a variety of new younger Austrians is an examination of the implications of time and ignorance for economic theory.

The COVID-19 pandemic continues to pose significant health, economic, and social challenges. Given that many of these challenges have moral relevance, the present studies investigate whether the COVID-19 pandemic is influencing moral decision-making and whether moralisation of behaviours specific to the crisis predict adherence to government-recommended behaviours. Whilst we find no evidence that utilitarian endorsements have changed during the pandemic at two separate timepoints, individuals have moralised non-compliant behaviours associated with the pandemic such as failing to physically distance themselves from (...) others. Importantly, our findings show that this moralisation predicts sustained individual compliance with government-recommended behaviours. (shrink)

The Case for Humanism is the premier textbook to introduce and help students think critically about the 'big ideas' of Western humanism—secularism, rationalism, materialism, science, democracy, individualism, and others—all powerful themes that run through Western thought from the ancient Greeks and the Enlightenment to the present day.

In this monograph, I offer feminist reasons to develop a multidimensional account of forgiveness as a moral, and therefore at least partially deliberative, action or set of actions, which functions as a remedy in responding to blame or condemnation, releasing offenders from the fullness of their blameworthiness, in relational contexts which therefore require considerations of power between relata. I rely on feminist philosophical account of the relational self in order to contextualise these power relations. I provide accounts of forgiveness as (...) a performative utterance, third-party forgiveness, and self-forgiveness based upon this feminist and multidimensional model of forgiveness. (shrink)

Philosophy Here and Now: Powerful Ideas in Everyday Life, Fourth Edition, is a topically organized hybrid text/reader that helps students understand, appreciate, and even do philosophy. The book emphasizes philosophical writing, reinforced with step by step coaching in how to write argumentative essays and supported by multiple opportunities to hone critical thinking. It shows students how philosophy applies to their own lives and brings the subject to life with engaging chapter ending literary selections, abundant illustrations, and a wealth of pedagogical (...) features. (shrink)

Writing Philosophy: A Student's Guide to Writing Philosophy Essays is a concise, self-guided manual that covers the basics of argumentative essay writing and encourages students to master fundamental skills quickly, with minimal instructor input. Opening with an introductory chapter on how to read philosophy, the book then moves into the basics of writing summaries and analyzing arguments. It provides step-by-step instructions for each phase of the writing process, from formulating a thesis, to creating an outline, to writing a final draft, (...) supplementing this tutorial approach with model essays, outlines, introductions, and conclusions. Skills essential to evaluating arguments, citing sources, avoiding plagiarism, detecting fallacies, and formatting final drafts are dealt with in detail. The final two chapters serve as a reference guide to common mistakes and basic skills in sentence construction, writing style, and word choice. Employing a rulebook format similar to that of the classic Elements of Style (by Strunk, White, and Angell), Lewis Vaughn distills helpful writing advice into simple rules that students can easily remember and apply--and that instructors can refer to when reviewing student papers. These rules cover essay organization, sentence structure, documentation styles, plagiarism, grammar, usage, and more. Written in a clear and engaging style and incorporating samples of student writing, Writing Philosophy is an indispensable resource for virtually any philosophy course. (shrink)

People in a prevention focus tend to view their goals as duties and obligations, whereas people in a promotion focus tend to view their goals as hopes and aspirations. The current research suggests that people’s attention goes to somewhat different experiences when they describe their hopes versus duties. Two studies randomly assigned participants (N = 953) to describe a hope versus duty. Specifically, Study 1 asked participants to describe a personal experience of pursuing a hope versus duty, and Study 2 (...) asked participants to describe a current hope versus duty they had. I analyzed these descriptions with Linguistic Inquiry and Word Count 2015. Consistent with earlier research on regulatory focus, participants wrote more about positive outcomes when describing hopes and social relationships when describing duties. The current research suggests that the effectiveness of common regulatory focus and regulatory fit manipulations could depend on participants’ freedom to choose the experiences they bring to mind when they describe their hopes and duties. (shrink)

Prevention focus is a self-regulatory orientation that serves the need for security, and promotion focus is a self-regulatory orientation that serves the need for growth. From mid-March to early April 2020, did people judge prevention focus to be more useful than promotion focus for responding to COVID-19? Our study tested and showed support for this hypothesis with 401 American and Canadian participants, who we sampled in 100-person waves on the first four Thursdays of the pandemic. For this study, we developed (...) a new measure of the judged usefulness of promotion and prevention focus. Additionally, results showed that the judged usefulness of promotion and prevention focus related positively to support of the psychological needs for autonomy and relatedness, respectively, in responding to COVID-19. Exploratory analyses showed that day-to-day differences in autonomy, competence, and relatedness support and in promotion and prevention focus tended to be small, which is notable given the large-scale changes to social distancing, employment, and media coverage of the virus during this time. Our research could be useful for crafting persuasive advocacy and narrative communications that encourage social distancing to protect others about whom people care most. (shrink)

Proponents of the public goods argument ('PGA') seek to ground the authority of the state on its putative indispensability as a means of providing public goods. But many of the things we take to be public goods – including many of the goods commonly invoked in support of the PGA – are actually what we might term publicized goods. A publicized good is any whose ‘public’ character results only from a policy decision to make some good freely and universally available. (...) This fact poses complications for the PGA, insofar as the set of possible publicized goods is quite extensive indeed. (shrink)

Recent debate regarding transgender persons’ bathroom-utilization prerogatives raises broader issues concerning current practices of sex segregation more generally. I argue that the only consistently Progressive position on bathroom access is an outright opposition to any form of bathroom segregation. This opposition, in turn, entails a thorough-going rejection of all types of sex- and gender-segregation. I then suggest that Progressives uncomfortable with such wide-ranging implications may wish to consider the merits of a certain Traditionalist position on such matters—one that counsels caution (...) and legislative forbearance when it comes to overturning long-standing customs (such as those embodied in current practices of sex-segregation). (shrink)

This article theorizes the politics of witnessing and grief in the context of the embodied experience of cows raised for dairy in the Pacific Northwestern United States. Bearing witness to the mundane features of dairy production and their impact on cows' physical and emotional worlds enables us to understand the violence of commodification and the political dimensions of witnessing the suffering of an Other. I argue that greater attention should be paid to the uneven hierarchies of power in the act (...) of bearing witness. Centering the animal as a subject of witnessing allows us to see with particular clarity the ethical ambiguities at work in witnessing while at the same time attending to the importance of witnessing-as-politics. My project here is to lay bare moments of emotional and physical turmoil not seen as such—the lives that are rendered ungrievable—and examine how we can and should respond to them. Thus, this article contributes to feminist conversations about witnessing, grief, and the political function of emotion. (shrink)

In this article, I focus on two problematic aspects of British health-promotion campaigns regarding feeding children, particularly regarding breastfeeding and obesity. The first of these is that health-promotion campaigns around “lifestyle” issues dehumanize mothers with their imagery or text, stemming from the ongoing undervaluing and objectification of mothers and women. Public health-promotion instrumentalizes mothers as necessary components in achieving its aims, while at the same time undermining their agency as persons and interlocutors by tying “mother” to particular images. This has (...) a double effect: first, it excludes mothers who do not fit the campaign picture of a mother; second, it encloses those who do fit the picture into an objectified image of motherhood that is defined by and subject to the dominant white, heteropatriarchal gaze. The second problem is that campaigns place unjustified demands on mothers, which stem from a misinterpretation of the maternal duty to benefit. I argue that nutrition-related health concerns regarding children are improperly framed as individual failures of maternal duty, rather than as failures of a system to function correctly. These arguments ultimately support shifting the focus of responsibility for issues around childhood nutrition away from mothers and back toward policymakers. (shrink)

This book places the philosophy of Simone Weil into conversation with contemporary environmental concerns in the Anthropocene. The book offers a systematic interpretation of Simone Weil, making her ethical philosophy more accessible to non-Weil scholars. Weil's work has been influential in many fields, including politically and theologically-based critiques of social inequalities and suffering, but rarely linked to ecology. Kathryn Lawson argues that Weil's work can be understood as offering a coherent approach with potentially widespread appeal applicable to our ethical (...) relations to much more than just other human beings. She suggests that the process of 'decreation' in Weil is an expansion of the self which might also come to include the surrounding earth and a vast assemblage of others. This allows readers to consider what it means to be human in this time and place, and to contemplate our ethical responsibilities both to other humans and also to the more-than-human world. Ultimately, the book uses Weil's thought to propose a decreative ecological ethics that decenters the human being by cultivating human actions towards an ecological ethics. This book will be useful for Simone Weil scholars and academics, as well as students and researchers interested in environmental ethics in departments of comparative literature, theory and criticism, philosophy, and environmental studies. (shrink)

That each of these questions has provided occasion for disagreement among able scholars can be readily confirmed by anyone willing to sample even a few items of the now voluminous contemporary literature dealing with this chapter. Indeed, anyone who has puzzled over Aristotle's text and tried to make sense of the relevant secondary literature will be able to sympathize with D. C. Williams' opinion that "tracing coherent philosophical arguments in De Interpretatione is rather like finding shapes in a cloud." Still, (...) I remain convinced that it should be possible to achieve a measure of agreement about the meaning and significance of Aristotle's text beyond any which has yet been attained. Toward this end I shall propose and defend in this paper a set of answers to the disputed questions - which seem to me to do justice both to the text and to the fact that scholarly opinion on these matters has diverged so sharply. (shrink)

Learn to think critically with the leading introduction to reasoning and argumentation. Highlights In clear, reader-friendly language, The Power of Critical Thinking provides an engaging introduction to argumentation, deductive and inductive reasoning, inferencing, and evaluating scientific theories New Critical Thinking and the Media boxes in each chapter apply the principles of critical thinking to the realms of media, advertising, and news New content on "fake news," the COVID-19 pandemic, and other important contemporary topics reflects the changing world in which today's (...) students must apply their critical thinking abilities New and updated exercises offer extensive opportunities for students to practise the skills through which they will become active, engaged critical thinkers Additional online resources-including a study guide and practice quizzes for students as well as an instructor's manual, a test bank, and PowerPoint slides for instructors-offer stimulating materials to enhance the learning and teaching experiences. About the Authors Chris MacDonald is an associate professor and chair of the Law and Business Department at the Ted Rogers School of Management, Toronto Metropolitan University. Lewis Vaughn is an independent scholar and author of several textbooks on philosophy, ethics, and critical thinking. (shrink)

Though sometimes maligned, “trolleyology” offers an effective means of opening and framing, not only classes in ethics, but indeed any introductory philosophy course taking a broadly “puzzle-based” approach. When properly sequenced, a subset of the thought experiments that are trolleyology’s stock-in-trade can generate a series of puzzles illustrating the shortcomings of our untutored moral intuitions, and which thus motivate the very enterprise of moral theorizing. Students can be engaged in the attempt to resolve said puzzles, inasmuch as they’re accessible and (...) compelling, and their resolutions generally easy to achieve. Once thus engaged, students can be directed to the fact that they had already rolled up their sleeves and begun “doing philosophy.” In this way, engagement with trolleyological puzzles can serve as a “microcosm” for philosophy more broadly, illustrating the processes of critical thinking that are likewise the stock-in-trade of philosophers across many different domains of inquiry. (shrink)