PDZ (also called DHR or GLGF) domains are found in diverse membraneassociated proteins including members of the MAGUK family of guanylate kinase homologues, several protein phosphatases and kinases, neuronal nitric oxide synthase, and several dystrophin‐associated proteins, collectively known as syntrophins. Many PDZ domain‐containing proteins appear to be localised to highly specialised submembranous sites, suggesting their participation in cellular junction formation, receptor or channel clustering, and intracellular signalling events. PDZ domains of several MAGUKs interact with the C‐terminal polypeptides of a subset (...) of NMDA receptor subunits and/or with Shaker‐type K+ channels. Other PDZ domains have been shown to bind similar ligands of other transmembrane receptors. Recently, the crystal structures of PDZ domains, with and without ligand, have been determined. These demonstrate the mode of ligand‐binding and the structural bases for sequence conservation among diverse PDZ domains. (shrink)

In this fascinating study, the author analyzes the conceptual roots of molecular biology and the social matrix in which it was developed.

Often professors of higher education do not recognize the difference between teaching subject matter and teaching students. They emulate their former professor mentors without much analysis of the assets/liabilities of classroom behaviors. The absence of teaching methods in the teaching curriculum of college/university contributes to the problem. The following article describes a composite picture of the esteemed professorate depicted by an accumulation of life experiences, student stories, professorial reputations and caricatures. The categories of professorial type do not represent exclusivity, but (...) indeed are anticipated to overlap. The professorate needs to strive to use teaching methods which empower students to learn, just as we all strive to encourage the corporate world to empower their employees. (shrink)

Prior to European influence, predation by Native Americans was the major factor limiting the numbers and distribution of ungulates in the Intermountain West. This hypothesis is based on analyses of (1) the efficiency of Native American predation, including cooperative hunting, use of dogs, food storage, use of nonungulate foods, and hunting methods; (2) optimal-foraging studies; (3) tribal territory boundary zones as prey reservoirs; (4) species ratios, and sex and age of aboriginal ungulate kills; (5) impact of European diseases on aboriginal (...) populations; and (6) synergism between aboriginal and carnivore predation. Native Americans had no effective conservation practices, and the manner in which they harvested ungulates was the exact opposite of any predicted conservation strategy. Native Americans acted in ways that maximized their individual fitness regardless of the impact on the environment. For humans, conservation is seldom an evolutionarily stable strategy. By limiting ungulate numbers and purposefully modifying the vegetation with fire, Native Americans structured entire plant and animal communities. Because ecosystems with native peoples are entirely different than those lacking aboriginal populations, a “hands-off” or “natural regulation” approach by today’s land managers will not duplicate the ecological conditions under which those ecosystems developed. The modern concept of wilderness as areas without human influence is a myth. North America was not a “wilderness” waiting to be discovered, instead it was home to tens of millions of aboriginal peoples before European-introduced diseases decimated their numbers. (shrink)

The ArgumentThis paper focuses on the opening of a discursive space: the emergence of informational and scriptural representations of life and their self-negating consequences for the construction of biological meaning. It probes the notion of writing and the book of life and shows how molecular biology's claims to a status of language and texuality undermines its own objective of control. These textual significations were historically contingent. The informational representations of heredity and life were not an outcome of the internal cognitive (...) momentum of molecular biology; they were not a logical necessity of the unravelling of the base-pairing of the DNA double-helix. They were transported into molecular biology still within the protein paradigm of the gene in the 1940s and permeated nearly every discipline in the life and social sciences. These information-based models, metaphors, linguistic, and semiotic tools which were central to the formulation of the genetic code were transported into molecular biology from cybernetics, information theory, electronic computing, and control and communication systems — technosciences that were deeply embedded with the military experiences of world war II and the Cold War. The information discourse thus became fixed in molecular biology not because it worked in the narrow epistemic sense (it did not), but because it positioned molecular biology within postwar discourse and culture, perhaps within the transition to a post-modern information-based society. (shrink)

If the death of Jesus is nothing less than God's Christ hanging on a cross, we cannot speak about God—and ourselves—in any customary way. How do we preach this word of the cross as the word of life? Our answer points toward an apocalyptic homiletic.

The obesity epidemic among children and adolescents in the United States continues to worsen. The most recent analysis of data from the National Health and Nutrition Examination Survey showed that the prevalence of overweight among children and adolescents – defined as a Body Mass Index at or above the 95th percentile on gender-specific BMI-for-age growth charts developed by the Centers for Disease Control and Prevention – increased significantly between 1999-2000 and 2003-2004. Over this period, the prevalence of overweight among children (...) and adolescents aged 2-19 increased 23% – from 13.9% to 17.1%. In 2003-2004, 18.8% of children aged 6-11 and 17.4% of adolescents aged 12-19 were overweight. Roughly comparable proportions of each age group were considered to be at risk of becoming overweight. (shrink)

Although researchers have paid much attention to the widespread cheating by students during their college careers and the possible sources behind such unethical behaviors, there has been less attention given to the unethical behaviors of faculty. Research on the types of unethical behaviors of faculty has pointed out the unique nature of higher education and the particular pressures placed on faculty as potential drivers of such behavior. In this paper, we examine the factors and underlying cognitive processes that may drive (...) faculty to engage in such behaviors. Specifically, we identify potential drivers of faculty unethical behavior, the cognitive processes activated by these drivers, and the types of behaviors that are considered most ethically questionable among faculty as they carry out their professional roles. We conclude with research considerations and implications of faculty misconduct on the profession. (shrink)

Nowadays, mobile telephony interruptions in our daily life activities are common because of the inappropriate ringing notifications of incoming phone calls in different contexts. Such interruptions may impact on the work attention not only for the mobile phone owners, but also for the surrounding people. Decision tree is the most popular machine-learning classification technique that is used in existing context-aware mobile intelligent interruption management model to overcome such issues. However, a single-decision tree-based context-aware model may cause over-fitting problem and thus (...) decrease the prediction accuracy of the inferred model. Therefore, in this paper, we propose an ensemble machine-learning-based context-aware mobile telephony model for the purpose of intelligent interruption management by taking into account multi-dimensional contexts and name it “E-MIIM”. The experimental results on individuals’ real-life mobile telephony data sets show that our E-MIIM model is more effective and outperforms existing MIIM model for predicting and managing individual’s mobile telephony interruptions based on their relevant contextual information. (shrink)

In this “global information age” accessing, disseminating, and controlling information is an increasingly important aspect of human life. Often these interests are expressed in the language of human rights—e.g., rights to expression, privacy, and intellectual property. As the discipline concerned with, “Facilitating the effective communication of desired information between human generator and human user” (Belkin, 1975, 22), Library and Information Science (LIS) has a central role in facilitating communication about human rights and ensuring the respect for human rights in information (...) services and systems. This paper surveys the literature at the intersection of LIS and human rights. To begin, an overview of human rights conventions and an introduction to human rights theory is provided. Then the intersections between LIS and human rights are considered. Three central areas of informational human rights—communication, privacy, and intellectual property—are discussed in detail. It is argued that communication rights in particular serve as a central linchpin in the system of human rights. (shrink)

Das Problem einer einheitlichen Grundlage alles Bestehenden hat seit jeher eine große Rolle in der Philosophie gespielt und stets auch eine große Ausstrahlung auf die Naturwissenschaft gehabt. Exemplarisch werden verschiedene Entwürfe für eine höherdimensionale einheitliche Feldtheorie diskutiert. -/- Es wird der Frage nachgegangen, was überhaupt unter der „Einheit von Theorien“ zu verstehen ist. Dabei zeigt sich, dass sich zwischen unterschiedlichen Ebenen der „Einheit von Theorien“ unterscheiden lässt. Die „Einheit von Theorien“ kann sich beziehen auf übergreifende Begriffe (z. B. Feldbegriff), auf (...) eine formal mathematische Zusammenfassung unterschied­licher Phänomene (z. B. im Rahmen der Projektiven Einheitlichen Feldtheorie), auf einen genetischen Zusammenhang von Theorien (z. B. zwischen newtonscher und relativistischer Mechanik), auf ein einheitliches Gesetz zur Erklärung unterschiedlicher Phänomene (z. B. die Maxwelltheorie als Erklärungsgrundlage elektromagnetischer Erscheinungen), aber auch auf einen gemeinsamen Referenzbereich verschiedener Theorien (z. B. phänomenologische und statistische Thermodynamik). -/- Die Verwendung höherdimensionaler Geometrien wirft die Frage nach dem ontologischen Status höherdimensionaler Raum-Zeiten auf. Handelt es sich lediglich um mathematische Formalismen, oder kommt ihnen eine eigene Realität zu? Es zeigt sich, dass beide Interpretationskonzepte ihre Berechtigung besitzen. Spielt etwa bei der Klasse der Projektiven Einheitlichen Feldtheorien (kurz: PUFT) der höherdimensionale Raum die Rolle eines Instruments zur mathematisch eleganten Darstellung, so lassen sich bei der Klasse der Kaluza-Klein-Theorien Eigenschaften ableiten, die als Hinweis auf einen ontologisch eigenständigen Realitätsstatus gedeutet werden können. Folgt man Poppers Realitätskriterium, wonach als real zu betrachten ist, was sich durch physikalische Wirkungen nachweisen lässt, so kann etwa der Einfluss der Extradimensionen auf die Dynamik des physikalischen Geschehens in der vierdimensionalen Raum-Zeit als Hinweis auf deren Realität gedeutet werden. -/- Interessant sind die höherdimensionalen einheitlichen Feldtheorien auch unter dem Blickwinkel der Wissenschaftstheorie. Da sie recht gut dem Modell des Forschungsprogramms im Sinne von Lakatos entsprechen, stellen sie gute Musterbeispiele für theoriedynamische Betrachtungen dar. (shrink)

Jakob Friedrich Fries is one of the most important representatives of the Critical Philosophy, someone who built immediately on the original Kantian philosophy. -/- Fries was born in 1773 in Barby (on the Elbe). In 1805 he was extraordinary professor for philosophy in Jena and in the same year was ordinary professor for philosophy in Heidelberg. Returning to Jena in 1816, one year later he was compulsorily retired because of his participation at the nationalistic and republican Wartburg Festival. In 1924 (...) he obtained a professorship for physics and mathematics, and in 1838 he was given back a professorship for philosophy. He died in 1843 in Jena. -/- The book summarizes the research results of the DFG-Project "Jakob Friedrich Fries' Influence on the Sciences of the 19th Century". The research project was carried out by Dr. Kay Herrmann (Institute of Philosophy, Jena University) and Prof. Dr. Wolfram Hogrebe (Institute of Philosophy, Bonn University). Such a study has special importance. There is available a large amount of literature about the "speculative contemporaries" of Fries, like Fichte, Schelling, and Hegel. In contrast to the "speculative philosophy", there has been published only a few studies about the Friesian natural philosophy. Fries was, in his natural-philosophical studies, looking for a link between philosophy and modern sciences, wheras his "speculative philosophical" contemporaries felt obligated to stick primarily to a descriptive, phenomenal view of nature. So far the question "How was mathematical natural philosophy regarded by scientists and mathematicians of the 19th century?" has hardly been investigated. Archival studies showed that this gap in Fries-research can be filled. The Friesian correspondence turned out to be a rich gold mine. -/- The present publication is more than a research report. The monographic first part is intended to introduce the foundations of the Friesian theory of cognition, the Friesian methodology, and the Friesian natural philosophy. This should facilitate entry into Friesian philosophy. -/- The Friesian theory is analyzed from two points of view: •How did Fries suceed in continuing and improving the Kantian approach? Is Fries able to remove the weak points of Kantian philosophy? -/- •What is the current significance of the Friesian approach? There are some interesting similarities between the Friesian approach and modern philosophical theories (such like Chomsky's theory of "universal grammer"). The lasting core of the Friesian theory of cognition is: To use empirical studies for working on philosophical problems. -/- Chapters 3 and 4 are scientific-historically oriented. These chapters analyze the Friesian position in scientific and mathematical debates (debates about the a priori foundations of physics, the problem of the identification of physics as an independent discipline, the problem of the boundary between chemistry and physics, the problem of mathematization of the sciences, the theory of the imponderabilia, the systematics and structure of sciences and mathematics, problems of infinity, the differential calculus, the theory of parallel lines) and the relation between Fries and the scientists of the 19th century. The book contains the latest findings gained by evaluation of the Friesian unpublished work (for example the correspondence with W. Weber, C. F. Gauß, E. F. Apelt, O. Schlömilch, Ch. Reichel, B. A. v. Lindenau, L. Gmelin, E. G. Fischer, A. N. Scherer, J. S. C. Schweigger) -/- One result of the research project is that some important scientists took a favourable view of the Friesian theory, but the influence of the Friesian philosophy on the sciences of the 19th century was very limited. The causes are very complex: An anti-natural-philosophical spirit of age, the limits of the Kantian inspired philosophy and some unfavourable aspects in the biography of Fries. -/- For the first time the voluminous Fries-Reichel-correspondence was evaluated. The Fries-Reichel-correspondence contains the Friesian approach to prove the 11th Euclidean axiom, and the whole transcript of the Friesian attempt at proof is given. // Der erste Teil des Buches will in die Grundprobleme Fries’scher Erkenntnis­theorie, Methodenlehre und Naturphilosophie einführen, wobei das Hauptaugenmerk auf die Fortführung der kantischen Ansätze durch Fries sowie auf die aktuelle Interpretation der Fries’schen Lehre gerichtet ist. Der wissenschaftshistorisch ausgerichtete zweite Teil analysiert Fries’ Stellung zu naturwissenschaftlichen und mathematischen Diskussionsrichtungen (Probleme der Identifizierung der Physik als eigenständige Disziplin, der Grenzziehung zwischen Physik und Chemie, der Mathematisierung der Naturwissenschaften, der Imponderabilientheorie, der Systematik von Naturwissenschaft und Mathematik, des Unendlichen, der Parallelentheorie usw.) sowie sein Verhältnis zu Naturwissenschaftlern und Mathematikern seiner Zeit. Das Buch enthält neue Erkenntnisse, die aus der Auswertung zahlreicher Nachlassmaterialien gewonnen wurden. Erstmalig wird unter dem Blickwinkel „Fries als Naturwissenschaftler und Mathematiker“ auch der sehr umfangreiche Reichel-Briefwechsel ausgewertet. Dem Reichel-Briefwechsel entstammt auch Fries’ Versuch eines Beweises des Parallelenaxioms, der in diesem Buch erstmalig in transkribierter Form vollständig vorliegt. -/- . (shrink)

Biobanks are increasingly being created specifically for research purposes. Concomitantly, we are seeing significant and evolving shifts in research ethics in relation to biobanking. Three discrete shifts are identified in this article. The first extends the ethical focus beyond the protection of human subjects to the promotion of broader community benefits of research utilizing biobanked resources, and an expectation that these benefits will be shared. The second involves the evolution of the traditional consent paradigm for future research uses of biobanks (...) resources that are not in contemplation at the time of donation. The third involves a move away from single project management to more dynamic governance accountability to research participants and the public. These shifts may take different local and institutional forms but share common recognizable elements. (shrink)

In this paper we present an equivalence between the category of commutative regular rings and the category of Boolean-valued fields, i.e., Boolean-valued sets for which the field axioms are true. The author used this equivalence in [12] to develop a Galois theory for commutative regular rings. Here we apply the equivalence to give an alternative construction of an algebraic closure for any commutative regular ring.Boolean-valued sets were developed in 1965 by Scott and Solovay [10] to simplify independence proofs in set (...) theory. They later were applied by Takeuti [13] to obtain results on Hilbert and Banach spaces. Ellentuck [3] and Weispfenning [14] considered Boolean-valued rings which consisted of rings and associated Boolean-valued relations. To the author's knowledge, the present work is the first to employ the Boolean-valued sets of Scott and Solovay to obtain results in algebra.The idea that commutative regular rings can be studied by examining the properties of related fields is not new. For several years algebraists and logicians have investigated commutative regular rings by representing a commutative regular ring as a subdirect product of fields or as the ring of global sections of a sheaf of fields over a Boolean space. These representations depend, as does the work presented here, on the fact that the set of central idempotents of any ring with identity forms a Boolean algebra. The advantage of the Boolean-valued set approach is that the axioms of classical logic and set theory are true in the Boolean universe. Therefore, if the axioms for a field are true for a Boolean-valued set, then other properties of the set can be deduced immediately from field theory. (shrink)

We present the first comprehensive taxonomic revision and review the biology of the olingos, the endemic Neotropical procyonid genus Bassaricyon, based on most specimens available in museums, and with data derived from anatomy, morphometrics, mitochondrial and nuclear DNA, field observations, and geographic range modeling. Species of Bassaricyon are primarily forest-living, arboreal, nocturnal, frugivorous, and solitary, and have one young at a time. We demonstrate that four olingo species can be recognized, including a Central American species (Bassaricyon gabbii), lowland species with (...) eastern, cis-Andean (Bassaricyon alleni) and western, trans-Andean (Bassaricyon medius) distributions, and a species endemic to cloud forests in the Andes. The oldest evolutionary divergence in the genus is between this last species, endemic to the Andes of Colombia and Ecuador, and all other species, which occur in lower elevation habitats. Surprisingly, this Andean endemic species, which we call the Olinguito, has never been previously described; it represents a new species in the order Carnivora and is the smallest living member of the family Procyonidae. We report on the biology of this new species based on information from museum specimens, niche modeling, and fieldwork in western Ecuador, and describe four Olinguito subspecies based on morphological distinctions across different regions of the Northern Andes. (shrink)

This article uses computerized analysis of text, along with a close reading of text, to trace change and development in Burkitt's lymphoma research. While past researchers have focused on the way a text enters the literature, we wish to learn what happens to knowledge claims after they arrive in the published literature. In order to explain why some claims are successfully solidified into facts while others remain as isolated, unsupported claims, we rely upon the notion of the material and social (...) technology required to do successful work in a research area. (shrink)

Founded on Eastern wisdom traditions, the martial art of Aikido focuses on moral and spiritual development through psycho-physiological harmonization of the mind, body and spirit. The purpose of this article is to explain the effects of Aikido practices on enhancing communication and mindfulness in entrepreneurial contexts. In addition, the article introduces research on Aikido aimed at enhancing cross-organizational and cross-cultural exchanges where unmediated, proxemic interpersonal interactions are supplanted by virtual (synchronous and asynchronous) communications media, such as e-mail and voice mail.