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Kenneth F. Schaffner [61]Kenneth Francis Schaffner [1]
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Kenneth Schaffner
University of Pittsburgh
  1.  55
    Discovery and Explanation in Biology and Medicine.Kenneth F. Schaffner - 1993 - University of Chicago Press.
    Kenneth F. Schaffner compares the practice of biological and medical research and shows how traditional topics in philosophy of science--such as the nature of theories and of explanation--can illuminate the life sciences. While Schaffner pays some attention to the conceptual questions of evolutionary biology, his chief focus is on the examples that immunology, human genetics, neuroscience, and internal medicine provide for examinations of the way scientists develop, examine, test, and apply theories. Although traditional philosophy of science has regarded scientific discovery--the (...)
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  2. Discovery and Explanation in Biology and Medicine.Kenneth F. Schaffner - 1995 - Journal of the History of Biology 28 (1):172-174.
     
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  3. Approaches to Reduction.Kenneth F. Schaffner - 1967 - Philosophy of Science 34 (2):137-147.
    Four current accounts of theory reduction are presented, first informally and then formally: (1) an account of direct theory reduction that is based on the contributions of Nagel, Woodger, and Quine, (2) an indirect reduction paradigm due to Kemeny and Oppenheim, (3) an "isomorphic model" schema traceable to Suppes, and (4) a theory of reduction that is based on the work of Popper, Feyerabend, and Kuhn. Reference is made, in an attempt to choose between these schemas, to the explanation of (...)
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  4. Discovery and Explanation in Biology and Medicine.Kenneth F. Schaffner - 1995 - British Journal for the Philosophy of Science 46 (4):621-623.
     
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  5. Reduction: The Cheshire Cat Problem and a Return to Roots.Kenneth F. Schaffner - 2006 - Synthese 151 (3):377-402.
    In this paper, I propose two theses, and then examine what the consequences of those theses are for discussions of reduction and emergence. The first thesis is that what have traditionally been seen as robust, reductions of one theory or one branch of science by another more fundamental one are a largely a myth. Although there are such reductions in the physical sciences, they are quite rare, and depend on special requirements. In the biological sciences, these prima facie sweeping reductions (...)
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  6.  73
    Ernest Nagel and Reduction.Kenneth F. Schaffner - 2012 - Journal of Philosophy 109 (8-9):534-565.
  7.  7
    Behaving: What's Genetic, What's Not, and Why Should We Care?Kenneth F. Schaffner - 2016 - Oxford University Press USA.
    Behaving presents an overview of the recent history and methodology of behavioral genetics and psychiatric genetics, informed by a philosophical perspective. Kenneth F. Schaffner addresses a wide range of issues, including genetic reductionism and determinism, "free will," and quantitative and molecular genetics. The latter covers newer genome-wide association studies that have produced a paradigm shift in the subject, and generated the problem of "missing heritability." Schaffner also presents cases involving pro and con arguments for genetic testing for IQ and for (...)
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  8.  44
    Genes, Behavior, and Developmental Emergentism: One Process, Indivisible?Kenneth F. Schaffner - 1998 - Philosophy of Science 65 (2):209-252.
    The question of the influence of genes on behavior raises difficult philosophical and social issues. In this paper I delineate what I call the Developmentalist Challenge (DC) to assertions of genetic influence on behavior, and then examine the DC through an indepth analysis of the behavioral genetics of the nematode, C. elegans, with some briefer references to work on Drosophila. I argue that eight "rules" relating genes and behavior through environmentally-influenced and tangled neural nets capture the results of developmental and (...)
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  9. The Dopamine Hypothesis of Schizophrenia: An Historical and Philosophical Analysis.Kenneth S. Kendler & Kenneth F. Schaffner - 2011 - Philosophy, Psychiatry, and Psychology 18 (1):41-63.
    This essay selectively reviews, from an historical and philosophical perspective, the dopamine (DA) hypothesis of schizophrenia (DHS; Table 1 lists the abbreviations used in this essay). Our goal is not to adjudicate the validity of the theory—although we arrive at a generally skeptical conclusion—but to focus on the process whereby the DHS has evolved over time and been evaluated. Since its inception, the DHS has been the most prominent etiologic theory in psychiatry and is still referred to widely in current (...)
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  10. The Watson-Crick Model and Reductionism.Kenneth F. Schaffner - 1969 - British Journal for the Philosophy of Science 20 (4):325-348.
  11.  16
    A Philosophical Overview of the Problems of Validity for Psychiatric Disorders.Kenneth F. Schaffner - 2012 - In Kenneth S. Kendler & Josef Parnas (eds.), Philosophical Issues in Psychiatry Ii: Nosology. Oxford University Press. pp. 169.
  12. Einstein Versus Lorentz: Research Programmes and the Logic of Theory Evaluation.Kenneth F. Schaffner - 1974 - British Journal for the Philosophy of Science 25:45.
  13.  31
    Reductionism in Biology: Prospects and Problems.Kenneth F. Schaffner - 1974 - PSA: Proceedings of the Biennial Meeting of the Philosophy of Science Association 1974:613 - 632.
  14.  39
    The Peripherality of Reductionism in the Development of Molecular Biology.Kenneth F. Schaffner - 1974 - Journal of the History of Biology 7 (1):111-139.
    I have not attempted to provide here an analysis of the methodology of molecular biology or molecular genetics which would demonstrate at what specific points a more reductionist aim would make sense as a research strategy. This, I believe, would require a much deeper analysis of scientific growth than philosophy of science has been able to provide thus far. What I have tried to show is that a straightforward reductionist strategy cannot be said to be follwed in important cases of (...)
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  15.  18
    The Challenge of Psychiatric Nosology and Diagnosis.Drozdstoj Stoyanov, Peter K. Machamer, Kenneth F. Schaffner & Rayito Rivera‐Hernández - 2012 - Journal of Evaluation in Clinical Practice 18 (3):704-709.
  16.  26
    Extrapolation From Animal Models.Kenneth F. Schaffner - 2001 - In MachamerPeter (ed.), Theory and Method in the Neurosciences. pp. 200.
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  17.  30
    Theory Structure in the Biomedical Sciences.Kenneth F. Schaffner - 1980 - Journal of Medicine and Philosophy 5 (1):57-97.
  18.  64
    Exemplar Reasoning About Biological Models and Diseases: A Relation Between the Philosophy of Medicine and Philosophy of Science.Kenneth F. Schaffner - 1986 - Journal of Medicine and Philosophy 11 (1):63-80.
    the structure of medical science with a special focus on the role of generalizations and universals in medicine, and (2) philosophy of medicine's relation with the philosophy of science. I argue that a usually overlooked aspect of Kuhnian paradigms, namely, their characteristic of being "exemplars", is of considerable significance in the biomedical sciences. This significance rests on certain important differences from the physical sciences in the nature of theories in the basic and the clinical medical sciences. I describe those differences (...)
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  19.  61
    Correspondence Rules.Kenneth F. Schaffner - 1969 - Philosophy of Science 36 (3):280-290.
    The traditional role which correspondence rules, coordinating definitions, or semantical rules, have in a logical analysis of a scientific theory is questioned by providing an alternative analysis. The alternative account suggests that scientific theories are "meaningful" prior to the establishment of correspondence rules, and that correspondence rules are introduced to permit explanation and testing in the "observational" sector. The role of models is briefly assessed in connection with this prior or "antecedent theoretical meaning," and a causal sequence analysis of a (...)
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  20. Etiological Models in Psychiatry : Reductive and Nonreductive Approaches.Kenneth F. Schaffner - 2008 - In Kenneth S. Kendler & Josef Parnas (eds.), Philosophical Issues in Psychiatry: Explanation, Phenomenology, and Nosology. Johns Hopkins University Press.
  21.  85
    Model Organisms and Behavioral Genetics: A Rejoinder.Kenneth F. Schaffner - 1998 - Philosophy of Science 65 (2):276-288.
    In this rejoinder to the three preceding comments, I provide some additional philosophical warrant for the biomedical sciences' focus on model organisms. I then relate the inquiries on model systems to the concept of 'deep homology', and indicate that the issues that appear to divide my commentators and myself are in part empirical ones. I cite recent work on model organisms, and especially C. elegans that supports my views. Finally, I briefly readdress some of the issues raised by Developmental Systems (...)
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  22.  60
    Theory Structure, Reduction, and Disciplinary Integration in Biology.Kenneth F. Schaffner - 1993 - Biology and Philosophy 8 (3):319-347.
    This paper examines the nature of theory structure in biology and considers the implications of those theoretical structures for theory reduction. An account of biological theories as interlevel prototypes embodying causal sequences, and related to each other by strong analogies, is presented, and examples from the neurosciences are provided to illustrate these middle-range theories. I then go on to discuss several modifications of Nagel''s classical model of theory reduction, and indicate at what stages in the development of reductions these models (...)
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  23. Neuroethics: Reductionism, Emergence, and Decision-Making Capacities.Kenneth F. Schaffner - forthcoming - Neuroethics: Mapping the Field.
     
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  24.  17
    Reduction in Biology and Medicine.Kenneth F. Schaffner - 2011 - In Fred Gifford (ed.), Philosophy of Medicine. Elsevier. pp. 16--137.
  25. Ethical Problems in Clinical Trials.Kenneth F. Schaffner - 1986 - Journal of Medicine and Philosophy 11 (4):297-315.
  26.  35
    Rendering Clinical Psychology an Evidence‐Based Scientific Discipline: A Case Study.Drozdstoj St Stoyanov, Peter K. Machamer & Kenneth F. Schaffner - 2012 - Journal of Evaluation in Clinical Practice 18 (1):149-154.
  27. Logic of Discovery and Diagnosis in Medicine.Kenneth F. Schaffner (ed.) - 1985 - University of California Press.
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  28.  61
    Medical Informatics and the Concept of Disease.Kenneth F. Schaffner - 2000 - Theoretical Medicine and Bioethics 21 (1):85-100.
    This paper attempts to address the general questionwhether information technologies, as applied in thearea of medicine and health care, have or are likelyto change fundamental concepts regarding disease andhealth. After a short excursion into the domain ofmedical informatics I provide a brief overview of someof the current theories of what a disease is from amore philosophical perspective, i.e. the ``valuefree'' and ``value laden'' view of disease. Next, Iconsider at some length, whether health careinformatics is currently modifying fundamentalconcepts of disease. To (...)
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  29.  36
    Molecular Genetics, Reductionism, and Disease Concepts in Psychiatry.Herbert W. Harris & Kenneth F. Schaffner - 1992 - Journal of Medicine and Philosophy 17 (2):127-153.
    The study of mental illness by the methods of molecular genetics is still in its infancy, but the use of genetic markers in psychiatry may potentially lead to a Virchowian revolution in the conception of mental illness. Genetic markers may define novel clusters of patients having diverse clinical presentations but sharing a common genetic and mechanistic basis. Such clusters may differ radically from the conventional classification schemes of psychiatric illness. However, the reduction of even relatively simple Mendelian phenomena to molecular (...)
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  30.  47
    Behavior at the Organismal and Molecular Levels: The Case of C. Elegans.Kenneth F. Schaffner - 2000 - Philosophy of Science 67 (3):288.
    Caenorhabditis elegans (C. elegans) is a tiny worm that has become the focus of a large number of worldwide research projects examining its genetics, development, neuroscience, and behavior. Recently several groups of investigators have begun to tie together the behavior of the organism and the underlying genes, neural circuits, and molecular processes implemented in those circuits. Behavior is quintessentially organismal--it is the organism as a whole that moves and mates--but the explanations are devised at the molecular and neurocircuit levels, and (...)
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  31.  34
    Theories, Models, and Equations in Systems Biology.Kenneth F. Schaffner - 2007 - In Fred C. Boogerd, Frank J. Bruggeman, Jan-Hendrik S. Hofmeyr & Hans V. Westerhoff (eds.), Systems Biology: Philosophical Foundations. Elsevier. pp. 145--162.
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  32.  10
    The Meta‐Language of Psychiatry as Cross‐Disciplinary Effort: In Response to Zachar (2012).Drozdstoj Stoyanov, Peter K. Machamer, Kenneth F. Schaffner & Rayito Rivera‐Hernández - 2012 - Journal of Evaluation in Clinical Practice 18 (3):710-720.
  33.  53
    Introduction.Kenneth F. Schaffner - 1981 - Journal of Medicine and Philosophy 6 (2):93-100.
  34.  54
    Introduction.Kenneth F. Schaffner - 1984 - Journal of Medicine and Philosophy 9 (2):127-134.
  35.  53
    Liberals Ate My Genes?Kenneth F. Schaffner, Ullica Segerstrale, Paul E. Griffiths & Steven Pinker - 2004 - Metascience 13 (1):28-51.
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  36.  23
    Coming Home to Hume: A Sociobiological Foundation for a Concept of 'Health' and Morality.Kenneth F. Schaffner - 1999 - Journal of Medicine and Philosophy 24 (4):365 – 375.
    Assessing the normative status of concepts of health and disease involves one in questions regarding the relationship between fact and value. Some have argued that Christopher Boorse's conception of health and disease lacks such a valuational element because it cannot account for types of harms which, while disvalued, do not have evolutionarily dysfunctional consequences. I take Boorse's account and incorporate some Humean-like sociobiological assumptions in order to respond to this challenge. The possession of moral sentiments, I argue, offers an evolutionary (...)
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  37. Medicine, Philosophy Of.Kenneth F. Schaffner & H. Tristram Engelhardt Jr - 1998 - In Craig Edward (ed.), Routledge Encyclopedia of Philosophy. Routledge. pp. 264-269.
     
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  38.  18
    Theories and Explanations in Biology.Kenneth F. Schaffner - 1969 - Journal of the History of Biology 2 (1):19-33.
    It seems that the above account of explanation-strategy in the area of temperature adaptation underscores many of the points made earlier. First, it discloses the fruitful interaction of classical, evolutionary, and molecular approaches. Secondly, it indicates that biological characterizations are not rival accounts to chemical ones. Thirdly, it stresses the importance of the DNA sequence order in chemical explanations of biological organisms.One feature which this area does not seem to reveal, which genetics does, is the development of a biological (that (...)
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  39.  21
    Interactions Among Theory, Experiment, and Technology in Molecular Biology.Kenneth F. Schaffner - 1994 - PSA: Proceedings of the Biennial Meeting of the Philosophy of Science Association 1994:192 - 205.
    This article examines how a molecular "solution" to an important biological problem-how is antibody diversity generated? was obtained in the 1970s. After the primarily biological clonal selection theory (CST) was accepted by 1967, immunologists developed several different contrasting theories to complete the SCST. To choose among these theories, immunology had to turn to the new molecular biology, first to nucleic acid hybridization and then to recombinant DNA technology. The research programs of Tonegawa and Leder that led to the "solution" are (...)
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  40.  18
    Case Studies: The Last Patient in a Drug Trial.Peter P. Sordillo & Kenneth F. Schaffner - 1981 - Hastings Center Report 11 (6):21.
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  41. Philosophy of Biology, Psychology, and Neuroscience-The Organism in Philosophical Focus-Behavior at the Organismal and Molecular Levels: The Case of C. Elegans.Manfred D. Laubichier & Kenneth F. Schaffner - 2000 - Philosophy of Science 67 (3).
     
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  42. Interpretive Practices in Medicine.Kenneth F. Schaffner - 2010 - In Peter K. Machamer & Gereon Wolters (eds.), Interpretation: Ways of Thinking About the Sciences and the Arts. University of Pittsburgh Press.
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  43.  52
    Introduction.Kenneth F. Schaffner - 1989 - Journal of Medicine and Philosophy 14 (2):103-107.
  44.  43
    Modeling Medical Diagnosis: Logical and Computer Approaches.Kenneth F. Schaffner - 1981 - Synthese 47 (1):163 - 199.
    In the present article I have surveyed several approaches to modeling the clinical diagnostic process. I have argued that at this point of the field's development, logics which simulate the reasoning patterns and knowledge base of expert clinicians represent research programs that are most likely to succeed. No logic of diagnosis has yet attained the status of being definitive; in spite of striking progress much more research and testing is required. On the basis of various existing logics, I have attempted (...)
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  45.  52
    Paradigm Changes in Organ Transplantation: A Journey Toward Selflessness?Kenneth F. Schaffner - 1998 - Theoretical Medicine and Bioethics 19 (5):425-440.
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  46.  40
    Further Thoughts on the Dopamine Hypothesis of Schizophrenia.Kenneth S. Kendler & Kenneth F. Schaffner - 2011 - Philosophy, Psychiatry, and Psychology 18 (1):73-75.
    We are gratified at the largely positive comments on our essay on the dopamine hypothesis of schizophrenia (DHS) by these two distinguished commentators from the fields of biological psychiatry (Dr. Tamminga) and the philosophy of psychiatry (Dr. Murphy). There is little that they have said with which we disagree. Rather, we want to expand briefly on their commentaries.We found Dr. Tamminga's reactions to be particularly fascinating because she has been an "insider" to the story of the DHS as it has (...)
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  47.  7
    Of Medicine.Kenneth F. Schaffner - 1992 - In Merrilee H. Salmon (ed.), Introduction to the Philosophy of Science. Hackett. pp. 310.
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  48. Medical Informatics and the Concept of Disease.Kenneth F. Schaffner - 2000 - Theoretical Medicine and Bioethics: Philosophy of Medical Research and Practice 21 (1):85-101.
    This paper attempts to address the general question whether information technologies, as applied in the area of medicine and health care, have or are likely to change fundamental concepts regarding disease and health. After a short excursion into the domain of medical informatics I provide a brief overview of some of the current theories of what a disease is from a more philosophical perspective, i.e., the "value free" and "value laden" view of disease. Next, I consider at some length, whether (...)
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  49. Theory Change in Immunology Part I: Extended Theories and Scientific Progress.Kenneth F. Schaffner - 1992 - Theoretical Medicine and Bioethics 13 (2).
    This two-part article examines the competition between the clonal selection theory and the instructive theory of the immune response from 1957–1967. In Part I the concept of a temporally extended theory is introduced, which requires attention to the hitherto largely ignored issue of theory individuation. Factors which influence the acceptability of such an extended theory at different temporal points are also embedded in a Bayesian framework, which is shown to provide a rational account of belief change in science. In Part (...)
     
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  50. Theory Change in Immunology Part II: The Clonal Selection Theory.Kenneth F. Schaffner - 1992 - Theoretical Medicine and Bioethics 13 (2).
    This two-part article examines the competition between the clonal selection theory and the instructive theory of the immune response from 1957–1967. In Part I the concept of a temporally extended theory is introduced, which requires attention to the hitherto largely ignored issue of theory individuation. Factors which influence the acceptability of such an extended theory at different temporal points are also embedded in a Bayesian framework, which is shown to provide a rational account of belief change in science. In Part (...)
     
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