Results for 'Ketamine'

24 found
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  1.  21
    Ketamine Enhanced Psychotherapy: Preliminary Clinical Observations on its Effectiveness in Treating Death Anxiety.Eli Kolp, M. Young, Harris Friedman, Evgeny Krupitsky & Karl Jansen - 2007 - International Journal of Transpersonal Studies 26 (1):1-17.
    Ketamine, a dissociative anesthetic commonly used by US physicians, has recently been shown to be a powerful anti-depressant and is also capable of eliciting transpersonal experiences that can be transformative. Although currently approved in the US only for use as an anesthetic, physicians there can legally prescribe it off-label to treat various psychological/ psychiatric problems and it has been used for these non-anesthetic purposes in Argentina, Iran, Mexico, Russia, and the UK, as well as in the US. The literature (...)
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  2.  66
    Ketamine as a primary predictor of out-of-body experiences associated with multiple substance use.Leanne K. Wilkins, Todd A. Girard & J. Allan Cheyne - 2011 - Consciousness and Cognition 20 (3):943-950.
    Investigation of “out-of-body experiences” has implications for understanding both normal bodily-self integration and its vulnerabilities. Beyond reported associations between OBEs and specific brain regions, however, there have been few investigations of neurochemical systems relevant to OBEs. Ketamine, a drug used recreationally to achieve dissociative experiences, provides a real-world paradigm for investigating neurochemical effects. We investigate the strength of the association of OBEs and ketamine use relative to other common drugs of abuse. Self-report data from an online survey indicate (...)
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  3.  50
    The ketamine model for schizophrenia.Murray Alpert & Burt Angrist - 2003 - Behavioral and Brain Sciences 26 (1):82-83.
    This commentary compares clinical aspects of ketamine with the amphetamine model of schizophrenia. Hallucinations and loss of insight, associated with amphetamine, seem more schizophrenia-like. Flat affect encountered with ketamine is closer to the clinical presentation in schizophrenia. We argue that flat affect is not a sign of schizophrenia, but rather, a risk factor for chronic schizophrenia.
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  4. Ketamine effects on memory reconsolidation favor a learning model of delusions.P. R. Corlett, V. Cambridge, J. M. Gardner, J. S. Piggot, D. C. Turner, J. C. Everitt, F. S. Arana, H. L. Morgan, A. L. Milton, J. L. Lee, M. R. Aitken, A. Dickinson, B. J. Everitt, A. R. Absalom, R. Adapa, N. Subramanian, J. R. Taylor, J. H. Krystal & P. C. Fletcher - 2013 - PLoS ONE 8 (6):e65088.
  5.  38
    S-ketamine influences strategic allocation of attention but not exogenous capture of attention.Isabella Fuchs, Ulrich Ansorge, Christoph Huber-Huber, Anna Höflich & Rupert Lanzenberger - 2015 - Consciousness and Cognition 35:282-294.
  6.  37
    Ketamine: 50 Years of Modulating the Mind.Linda Li & Phillip E. Vlisides - 2016 - Frontiers in Human Neuroscience 10.
  7.  16
    Toward Synergies of Ketamine and Psychotherapy.David S. Mathai, Victoria Mora & Albert Garcia-Romeu - 2022 - Frontiers in Psychology 13.
    Ketamine is a dissociative drug that has been used medically since the 1970s primarily as an anesthetic agent but also for various psychiatric applications. Anecdotal reports and clinical research suggest substantial potential for ketamine as a treatment in conjunction with psychological interventions. Here, we review historical and modern approaches to the use of ketamine with psychotherapy, discuss the clinical relevance of ketamine’s acute psychoactive effects, propose a unique model for using esketamine with Acceptance and Commitment Therapy, (...)
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  8. Is Off-label repeat prescription of ketamine as a rapid antidepressant safe? Controversies, ethical concerns, and legal implications.Melvyn W. Zhang, Keith M. Harris & Roger C. Ho - 2016 - BMC Medical Ethics 17 (1):1-8.
    BackgroundDepressive disorders are a common form of psychiatric illness and cause significant disability. Regulation authorities, the medical profession and the public require high safety standards for antidepressants to protect vulnerable psychiatric patients. Ketamine is a dissociative anaesthetic and a derivative of a hallucinogen. Its abuse is a major worldwide public health problem. Ketamine is a scheduled drug and its usage is restricted due to its abuse liability. Recent clinical trials have reported that ketamine use led to rapid (...)
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  9.  49
    Becoming-Metal: On Knowledge by Ketamine.Joshua Ramey - 2023 - Deleuze and Guattari Studies 17 (4):526-544.
    Within the context of the so-called psychedelic renaissance, ketamine (C13H16CINO) has been increasingly used for therapeutic purposes. While ketamine clearly has healing powers, what interests me here is less ketamine for healing than what I will call the possibility of knowledge by ketamine. Drawing upon Deleuze and Guattari's arguments for the centrality of metal and metallurgy as a perspective on matter, I speculate that knowledge by ketamine is not identical with, yet verges on, a kind (...)
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  10.  18
    Effects of acute ketamine infusion on visual working memory encoding: a study using ERPs.Haenschel Corinna, Koychev Ivan, El-Deredy Wael & Deakin Bill - 2015 - Frontiers in Human Neuroscience 9.
  11.  24
    Ethical Considerations for Clinical Research and Off-label Use of Ketamine to Treat Mood Disorders: The Balance Between Risks and Benefits.Roger C. Ho & Melvyn W. Zhang - 2017 - Ethics and Behavior 27 (8):681-699.
    Previous research conducted in 1999 highlighted ethical concerns behind challenge studies inducing psychosis with ketamine and made recommendations to enhance ethical standards. Recently, a plethora of clinical trials have evaluated the efficacy of ketamine to treat mood disorders, which lead to complex ethical issues. Pharmaceutical companies and researchers hope to profit by developing patentable variations on ketamine for treating depression. Media have labeled ketamine as a “miracle” antidepressant. Some clinics offer expensive off-label use of ketamine (...)
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  12.  85
    Toward an Explanation of the Genesis of Ketamine-Induced Perceptual Distortions and Hallucinatory States.Alfredo Pereira Jr - 2003 - Brain and Mind 4 (3):307-326.
  13.  27
    Research Moratoria and Off-Label Use of Ketamine.Andrea Segal & Dominic Sisti - 2016 - American Journal of Bioethics 16 (4):60-61.
    We wish to point out an additional consequence of the Catch-22 described by Andreae and colleagues (Andreae et al. 2016). The decades-long research gridlock of controlled drugs has unintentionally...
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  14.  12
    Taste aversion in mice using phencyclidine and ketamine as the aversive agents.Frank Etscorn & Patricia Parson - 1979 - Bulletin of the Psychonomic Society 14 (1):19-21.
  15.  25
    Ethical parameters of challenge studies inducing psychosis with ketamine.Carl L. Tishler & Lisa B. Gordon - 1999 - Ethics and Behavior 9 (3):211 – 217.
  16.  21
    Virtual Reality as a Moderator of Psychedelic-Assisted Psychotherapy.Agnieszka D. Sekula, Luke Downey & Prashanth Puspanathan - 2022 - Frontiers in Psychology 13:813746.
    Psychotherapy with the use of psychedelic substances, including psilocybin, lysergic acid diethylamide (LSD), ketamine, and 3,4-methylenedioxymethamphetamine (MDMA), has demonstrated promise in treatment of post-traumatic stress disorder (PTSD), anxiety, addiction, and treatment-resistant depression. Psychedelic-assisted psychotherapy (PP) represents a unique psychopharmacological model that leverages the profound effects of the psychedelic experience. That experience is characterized by strong dependency on two key factors: participant mindset and the therapeutic environment. As such, therapeutic models that utilize psychedelics reflect the need for careful design that (...)
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  17.  20
    Is the Requirement for First-Person Experience of Psychedelic Drugs a Justified Component of a Psychedelic Therapist’s Training?Nathan Emmerich & Bryce Humphries - 2024 - Cambridge Quarterly of Healthcare Ethics 33 (4):548-557.
    Recent research offers good reason to think that various psychedelic drugs—including psilocybin, ayahuasca, ketamine, MDMA, and LSD—may have significant therapeutic potential in the treatment of various mental health conditions, including post-traumatic stress disorder, depression, existential distress, and addiction. Although the use of psychoactive drugs, such as Diazepam or Ritalin, is well established, psychedelics arguably represent a therapeutic step change. As experiential therapies, their value would seem to lie in the subjective experiences they induce. As it is the only way (...)
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  18.  94
    In defence of Kant's moral prohibition on suicide solely to avoid suffering.G. Vong - 2008 - Journal of Medical Ethics 34 (9):655-657.
    In Ian Brassington’s article in a previous issue of this journal, he argues that suicide for the purpose of avoiding suffering is not, as Kant has contended, contrary to the moral law. Brassington’s objections are not cogent because they rely upon the exegetically incorrect premise that according to Kant the priceless value of personhood is in the noumenal world that we have no perception of. On the basis of Kant’s normative, metaphysical and epistemological theory, I argue, contrary to Brassington, that (...)
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  19.  42
    Research With Controlled Drugs: Why and Why Not? Response to Open Peer Commentaries on “An Ethical Exploration of Barriers to Research on Controlled Drugs”.Michael H. Andreae, Evelyn Rhodes, Tyler Bourgoise, George M. Carter, Robert S. White, Debbie Indyk, Henry Sacks & Rosamond Rhodes - 2016 - American Journal of Bioethics 16 (4):1-3.
    We examine the ethical, social, and regulatory barriers that may hinder research on therapeutic potential of certain controversial controlled substances like marijuana, heroin, or ketamine. Hazards for individuals and society and potential adverse effects on communities may be good reasons for limiting access and justify careful monitoring of these substances. Overly strict regulations, fear of legal consequences, stigma associated with abuse and populations using illicit drugs, and lack of funding may, however, limit research on their considerable therapeutic potential. We (...)
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  20.  83
    A systems model of altered consciousness: Integrating natural and drug-induced psychoses.Franz X. Vollenweider & Mark A. Geyer - 2001 - Brain Research Bulletin. Special Issue 56 (5):495-507.
  21.  55
    Exploring space consciousness other dissociative experiences: a Japanese perspective.Ornella Corazza - 2010 - Journal of Consciousness Studies 17 (7-8):7-8.
    The field of consciousness studies has long benefitted from the investigation of non- ordinary states of consciousness, both spontaneous and facilitated by mind-altering agents. In the present study, I look at the implications of spontaneous near-death experiences and experiences facilitated by the dissociative anaesthetic ketamine. These experiences reputedly have similar phenomenologies, such as a feeling of dying, motion through darkness, entering another realm, visions of light, and a sense of separation from the physical body. To assess whether ketamine (...)
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  22.  24
    Factors Influencing Perceived Helpfulness and Participation in Innovative Research:A Pilot Study of Individuals with and without Mood Symptoms.Jane Paik Kim, Tenzin Tsungmey, Maryam Rostami, Sangeeta Mondal, Max Kasun & Laura Weiss Roberts - 2022 - Ethics and Behavior 32 (7):601-617.
    Little is known about how individuals with and without mood disorders perceive the inherent risks and helpfulness of participating in innovative psychiatric research, or about the factors that influence their willingness to participate. We conducted an online survey with 80 individuals (self-reported mood disorder [n = 25], self-reported good health [n = 55]) recruited via MTurk. We assessed respondents’ perceptions of risk and helpfulness in study vignettes associated with two innovative research projects (intravenous ketamine therapy and wearable devices), as (...)
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  23. The biochemical basis of coma.J. R. Smythies - 1999 - Psycoloquy 10 (26).
    Current research on the neural basis of consciousness is based mainly on neuroimaging, physiology and psychophysics. This target article reviews what is known about biochemical factors that may contribute to the development of consciousness, based on loss of consciousness (i.e., coma). There are two theories of the biochemical mode of action of general anaesthetics. One is that anaesthesia is a direct (i.e., not receptor-mediated) effect of the anaesthetic on cellular neurophysiological function; the other is that some alteration of receptor function (...)
     
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  24.  14
    (1 other version)Excited Delirium: What’s Psychiatry Got to do With It?Paul B. Lieberman - 2023 - Philosophy Psychiatry and Psychology 30 (4):353-356.
    In lieu of an abstract, here is a brief excerpt of the content:Excited DeliriumWhat’s Psychiatry Got to do With It?Paul B. Lieberman, MDIf in life we are surrounded by death, so too in the health of our intellect by madness.—WittgensteinDelirium is a medical syndrome defined as “a relatively acute decline in cognition that fluctuates over hours or days” whose primary manifestation is a deficit of attention. It is common, estimated to occur in 10% to more than 50% of hospitalized patients, (...)
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