19 found
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  1.  12
    “It's My Blood”: Ethical Complexities in the Use, Storage and Export of Biological Samples: Perspectives From South African Research Participants.Keymanthri Moodley, Nomathemba Sibanda, Kelsey February & Theresa Rossouw - 2014 - BMC Medical Ethics 15 (1):4.
    The use of biological samples in research raises a number of ethical issues in relation to consent, storage, export, benefit sharing and re-use of samples. Participant perspectives have been explored in North America and Europe, with only a few studies reported in Africa. The amount of research being conducted in Africa is growing exponentially with volumes of biological samples being exported from the African continent. In order to investigate the perspectives of African research participants, we conducted a study at research (...)
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  2.  13
    “It’s all about trust”: reflections of researchers on the complexity and controversy surrounding biobanking in South Africa.Keymanthri Moodley & Shenuka Singh - 2016 - BMC Medical Ethics 17 (1):57.
    Biobanks are precariously situated at the intersection of science, genetics, genomics, society, ethics, the law and politics. This multi-disciplinarity has given rise to a new discourse in health research involving diverse stakeholders. Each stakeholder is embedded in a unique context and articulates his/her biobanking activities differently. To researchers, biobanks carry enormous transformative potential in terms of advancing scientific discovery and knowledge. However, in the context of power asymmetries in Africa and a distrust in science born out of historical exploitation, researchers (...)
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  3.  4
    Penile Transplantation as an Appropriate Response to Botched Traditional Circumcisions in South Africa: An Argument Against.Keymanthri Moodley & Stuart Rennie - 2018 - Journal of Medical Ethics 44 (2):86-90.
    Traditional male circumcision is a deeply entrenched cultural practice in South Africa. In recent times, there have been increasing numbers of botched circumcisions by untrained and unscrupulous practitioners, leading to genital mutilation and often, the need for penile amputation. Hailed as a world’s first, a team of surgeons conducted the first successful penile transplant in Cape Town, South Africa in 2015. Despite the euphoria of this surgical victory, concerns about the use of this costly intervention in a context of severe (...)
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  4.  9
    The Ethics of Talking About ‘HIV Cure’.Stuart Rennie, Mark Siedner, Joseph D. Tucker & Keymanthri Moodley - 2015 - BMC Medical Ethics 16 (1):18.
    In 2008, researchers reported that Timothy Brown , a man with HIV infection and leukemia, received a stem-cell transplant that removed HIV from his body as far as can be detected. In 2013, an infant born with HIV infection received anti-retroviral treatment shortly after birth, but was then lost to the health care system for the next six months. When tested for HIV upon return, the child had no detectable viral load despite cessation of treatment. These remarkable clinical developments have (...)
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  5.  6
    Engaging with Community Advisory Boards in Lusaka Zambia: Perspectives From the Research Team and CAB Members.Alwyn Mwinga & Keymanthri Moodley - 2015 - BMC Medical Ethics 16 (1):1-11.
    BackgroundThe use of a Community Advisory Board is one method of ensuring community engagement in community based research. To identify the process used to constitute CABs in Zambia, this paper draws on the perspectives of both research team members and CAB members from research groups who used CABs in Lusaka. Enabling and restricting factors impacting on the functioning of the CAB were identified.MethodsAll studies approved by the University of Zambia Bioethics Research Committee from 2008 – 2012 were reviewed to identify (...)
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  6.  57
    Challenges in Biobank Governance in Sub-Saharan Africa.Ciara Staunton & Keymanthri Moodley - 2013 - BMC Medical Ethics 14 (1):35.
    Biological sample and data transfer within and out of Africa is steeped in controversy With the H3Africa project now aiming to establish biobanks in Africa, it is essential that there are ethical and legal governance structures in place to oversee the operation of these biobanks. Such governance is essential to ensuring that donors are protected, that cultural perspectives are respected and that researchers have a ready availability of ethically sourced biological samples.
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  7.  8
    "It's for a Good Cause, Isn't It?" - Exploring Views of South African TB Research Participants on Sample Storage and Re-Use.Gerrit van Schalkwyk, Jantina de Vries & Keymanthri Moodley - 2012 - BMC Medical Ethics 13 (1):19-.
    Background: The banking of biological samples raises a number of ethical issues in relation to the storage,export and re-use of samples. Whilst there is a growing body of literature exploringparticipant perspectives in North America and Europe, hardly any studies have been reportedin Africa. This is problematic in particular in light of the growing amount of research takingplace in Africa, and with the rise of biobanking practices also on the African continent. Inorder to investigate the perspectives of African research participants, we (...)
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  8.  11
    Results of a Self-Assessment Tool to Assess the Operational Characteristics of Research Ethics Committees in Low- and Middle-Income Countries.Henry Silverman, Hany Sleem, Keymanthri Moodley, Nandini Kumar, Sudeshni Naidoo, Thilakavathi Subramanian, Rola Jaafar & Malini Moni - 2015 - Journal of Medical Ethics 41 (4):332-337.
  9.  24
    Microbicide Research in Developing Countries: Have We Given the Ethical Concerns Due Consideration?Keymanthri Moodley - 2007 - BMC Medical Ethics 8 (1):1-7.
    Background HIV prevention research has been fraught with ethical concerns since its inception. These concerns were highlighted during HIV vaccine research and have been elaborated in microbicide research. A host of unique ethical concerns pervade the microbicide research process from trial design to post-trial microbicide availability. Given the urgency of research and development in the face of the devastating HIV pandemic, these ethical concerns represent an enormous challenge for investigators, sponsors and Research Ethics Committees (RECs) both locally and internationally. Discussion (...)
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  10. Patients as Consumers of Health Care in South Africa: The Ethical and Legal Implications. [REVIEW]Kirsten Rowe & Keymanthri Moodley - 2013 - BMC Medical Ethics 14 (1):15.
    South Africa currently has a pluralistic health care system with separate public and private sectors. It is, however, moving towards a socialised model with the introduction of National Health Insurance. The South African legislative environment has changed recently with the promulgation of the Consumer Protection Act and proposed amendments to the National Health Act. Patients can now be viewed as consumers from a legal perspective. This has various implications for health care systems, health care providers and the doctor-patient relationship.
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  11.  8
    Delineating the Role of Penile Transplantation When Traditional Male Circumcisions Go Wrong in South Africa.Stuart Rennie & Keymanthri Moodley - forthcoming - Journal of Medical Ethics:medethics-2019-105414.
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  12.  25
    Synergies, Tensions and Challenges in HIV Prevention, Treatment and Cure Research: Exploratory Conversations with HIV Experts in South Africa.Keymanthri Moodley, Theresa Rossouw, Ciara Staunton & Christopher J. Colvin - 2016 - BMC Medical Ethics 17 (1):26.
    BackgroundThe ethical concerns associated with HIV prevention and treatment research have been widely explored in South Africa over the past 3 decades. However, HIV cure research is relatively new to the region and significant ethical and social challenges are anticipated. There has been no published empirical enquiry in Africa into key informant perspectives on HIV cure research. Consequently, this study was conducted to gain preliminary data from South African HIV clinicians, researchers and activists.MethodsIn-depth interviews were conducted on a purposive sample (...)
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  13.  18
    HIV Vaccine Trial Participation in South Africa - an Ethical Assessment.Keymanthri Moodley - 2002 - Journal of Medicine and Philosophy 27 (2):197 – 215.
    Trial participation in the proposed HIV Vaccine Trials in South Africa is discussed in the context of the ethical tension that exists between international ethical research standards and local standards of care and cultural norms in the Third World. The important concepts of informed consent, risk-benefit ratio and fair treatment of trial participants are interpreted differently in traditional, rural African communities, where a moderate form of communitarianism referred to as "Ubuntu" or "communalism" is still prevalent. Research is an altruistic endeavor (...)
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  14.  3
    The Psychology of “Cure” - Unique Challenges to Consent Processes in HIV Cure Research in South Africa.Keymanthri Moodley, Ciara Staunton, Theresa Rossouw, Malcolm de Roubaix, Zoe Duby & Donald Skinner - 2019 - BMC Medical Ethics 20 (1):9.
    Consent processes for clinical trials involving HIV prevention research have generated considerable debate globally over the past three decades. HIV cure/eradication research is scientifically more complex and consequently, consent processes for clinical trials in this field are likely to pose a significant challenge. Given that research efforts are now moving toward HIV eradication, stakeholder engagement to inform appropriate ethics oversight of such research is timely. This study sought to establish the perspectives of a wide range of stakeholders in HIV treatment (...)
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  15.  28
    The Implications of Methylphenidate Use by Healthy Medical Students and Doctors in South Africa.Chad Beyer, Ciara Staunton & Keymanthri Moodley - 2014 - BMC Medical Ethics 15 (1):20.
    The use of medical stimulants to sustain attention, augment memory and enhance intellectual capacity is increasing in society. The use of Methylphenidate for cognitive enhancement is a subject that has received much attention in the literature and academic circles in recent times globally. Medical doctors and medical students appear to be equally involved in the off-label use of Methylphenidate. This presents a potential harm to society and the individual as the long-term side effect profile of this medication is unknown.
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  16.  6
    Disparate Compensation Policies for Research Related Injury in an Era of Multinational Trials: A Case Study of Brazil, Russia, India, China and South Africa.George Rugare Chingarande & Keymanthri Moodley - 2018 - BMC Medical Ethics 19 (1):8.
    Compensation for research related injuries is a subject that is increasingly gaining traction in developing countries which are burgeoning destinations of multi center research. However, the existence of disparate compensation rules violates the ethical principle of fairness. The current paper presents a comparison of the policies of Brazil, Russia, India, China and South Africa. A systematic search of good clinical practice guidelines was conducted employing search strategies modeled in line with the recommendations of ADPTE Collaboration. The search focused on three (...)
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  17.  8
    The Paywall as Metaphor and Symptom.Stuart Rennie & Keymanthri Moodley - 2017 - American Journal of Bioethics 17 (10):17-18.
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  18.  8
    Autonomy of the child in the South African context: is a 12 year old of sufficient maturity to consent to medical treatment?Wandile Ganya, Sharon Kling & Keymanthri Moodley - 2016 - BMC Medical Ethics 17 (1):66.
    A child is a developing person with evolving capacities that include autonomy, mental capacity and capacity to assume responsibility. Hence, children are entitled to participatory rights in South Africa as observed in the Children’s Act 38 of 2005. According to section 129 of the Act a child may consent to his or her own medical treatment provided that he or she is over the age of 12 years and is of sufficient maturity and decisional capacity to understand the various implications (...)
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  19.  2
    Rules of engagement: perspectives on stakeholder engagement for genomic biobanking research in South Africa.Ciara Staunton, Paulina Tindana, Melany Hendricks & Keymanthri Moodley - 2018 - BMC Medical Ethics 19 (1):13.
    Genomic biobanking research is undergoing exponential growth in Africa raising a host of legal, ethical and social issues. Given the scientific complexity associated with genomics, there is a growing recognition globally of the importance of science translation and community engagement for this type of research, as it creates the potential to build relationships, increase trust, improve consent processes and empower local communities. Despite this level of recognition, there is a lack of empirical evidence of the practise and processes for effective (...)
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