With this treatise, an insightful exploration of the probabilistic connection between philosophy and the history of science, the famous economist breathed new life into studies of both disciplines. Originally published in 1921, this important mathematical work represented a significant contribution to the theory regarding the logical probability of propositions. Keynes effectively dismantled the classical theory of probability, launching what has since been termed the “logical-relationist” theory. In so doing, he explored the logical relationships between classifying a proposition as “highly probable” (...) and as a “justifiable induction.” Unabridged republication of the classic 1921 edition. (shrink)

In addition to a somewhat detailed exposition of certain portions of what may be called the book-work of formal logic, the following pages contain a number of problems worked out in detail and unsolved problems, by means of which the student may test his command over logical processes. In the expository portions of Parts I, II, and III, dealing respectively with terms, propositions, and syllogisms, the traditional lines are in the main followed, though with certain modifications; e.g., in the systematisation (...) of immediate inferences, and in several points of detail in connexion with the syllogism. For purposes of illustration Euler's diagrams are employed to a greater extent than is usual in English manuals. In Part IV, which contains a generalisation of logical processes in their application to complex inferences, a somewhat new departure is taken. So far as I am aware this part constitutes the first systematic attempt that has been made to deal with formal reasonings of the most complicated character without the aid of mathematical or other symbols of operation, and without abandoning the ordinary non-equational or predicative form of proposition. This attempt has on the whole met with greater success than I had anticipated; and I believe that the methods formulated will be found to be both as easy and as effective as the symbolical methods of Boole and his followers. The book concludes with a general and sure method of solution of what Professor Jevons called the inverse problem, and which he himself seemed to regard as soluble only by a series of guesses. (shrink)

This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and (...) made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

The transmission of electrical impulses in nerve and muscle cells depends fundamentally on the operation of specific ion channels in their membranes. Recent technical advances in electrical recording from cell membranes have permitted the analysis of the properties of single ion channels and the measurement of gating currents. The results have revealed considerable complexities, in particular in the operation of voltage‐gated sodium channels, and in the relationships between the several open and closed states of the channels. An important new development (...) is the cloning and analysis of the structural genes for the acetylcholine receptor and sodium channel protein, which promises to yield fresh insights into the functioning of these proteins. (shrink)

The large size of the individual axons in the motor nerves of certain invertebrates has facilitated technical approaches that were not feasible elsewhere. A brief account is given of the way in which giant axons have taken and held the lead in research on the mechanism of conduction.