BackgroundIn the Canadian Alliance for Healthy Hearts and Minds cohort, participants underwent magnetic resonance imaging of the brain, heart, and abdomen, that generated incidental findings. The approach to managing these unexpected results remain a complex issue. Our objectives were to describe the CAHHM policy for the management of IFs, to understand the impact of disclosing IFs to healthy research participants, and to reflect on the ethical obligations of researchers in future MRI studies.MethodsBetween 2013 and 2019, 8252 participants were recruited with (...) a follow-up questionnaire administered to 909 participants at 1-year. The CAHHM policy followed a restricted approach, whereby routine feedback on IFs was not provided. Only IFs of severe structural abnormalities were reported.ResultsSevere structural abnormalities occurred in 8.3% of participants, with the highest proportions found in the brain and abdomen. The majority of participants informed of an IF reported no change in quality of life, with 3% of participants reporting that the knowledge of an IF negatively impacted their quality of life. Furthermore, 50% reported increased stress in learning about an IF, and in 95%, the discovery of an IF did not adversely impact his/her life insurance policy. Most participants would enrol in the study again and perceived the MRI scan to be beneficial, regardless of whether they were informed of IFs. While the implications of a restricted approach to IF management was perceived to be mostly positive, a degree of diagnostic misconception was present amongst participants, indicating the importance of a more thorough consent process to support participant autonomy.ConclusionThe management of IFs from research MRI scans remain a challenging issue, as participants may experience stress and a reduced quality of life when IFs are disclosed. The restricted approach to IF management in CAHHM demonstrated a fair fulfillment of the overarching ethical principles of respect for autonomy, concern for wellbeing, and justice. The approach outlined in the CAHHM policy may serve as a framework for future research studies.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/nct02220582. (shrink)

I explore some of the ways that assumptions about the nature of substance shape metaphysical debates about the structure of Reality. Assumptions about the priority of substance play a role in an argument for monism, are embedded in certain pluralist metaphysical treatments of laws of nature, and are central to discussions of substantivalism and relationalism. I will then argue that we should reject such assumptions and collapse the categorical distinction between substance and property.

The structure of Chiodi's book is based on Vuillemin's important hermeneutical thesis that existentialism is one more step in the program of the romantics to give an absolute foundation to finite reality through the establishment of necessary relations between subjectivity and being. These relations, once revealed, would dispel the facticity and contingency in which the natural world is enshrouded. The role of Heidegger in this tradition involves one further dialectical twist, since Heidegger centers all Western Philosophy, including his own, around (...) the problem of ground in the manner proposed by the romantics. The suggested dialectical twist is then Heidegger's Kehre, a step beyond the radical contingency of Dasein in Sein und Zeit. Indeed, this contingency, once reached, shows unequivocally the failure of the romantic program. The ground cannot be ontologically connected with any object nor with the subject; it is rather the necessary history of the ground that determines all categorial differentiations in the world, including the reflective differentiation of subject-objects. Thus it becomes important to distinguish Heidegger from Hegel since, in both, history and necessity are characteristics of the ground. Chiodi gets to the bottom of this matter by pointing to the transfer of negativity from the process of history to the end of history. For Heidegger what is necessary is the repeated withdrawal of the ground so that it may never be confused with that which is known in any revelation or through all of them. This move, though clear, would still leave a fundamental ambiguity in the later philosophy of Heidegger: language, which acts as messenger from the ground to the world, must reflect the superabundance of Being from the standpoint of the ground while it only reflects possibilities of being from the standpoint of the world. This is an ambiguity that Heidegger would want to maintain. Chiodi's interpretation of Heidegger as a neo-platonist totally destroys this ambiguity and with it the very delicate balance created by Heidegger between infinite meaning and the ability of finite words to dwell upon it.--A. de L. M. (shrink)

G. Deledalle is the author of a Histoire de la philosophie américaine, and of some excellent studies on Dewey, such as La pédagogie de Dewey, philosophie de la continuité, and "Durkheim et Dewey". These are all works that deserve full attention by students of the Golden Age of American philosophy. For a European, Deledalle has an unusual capacity to detect the vitality and freshness, but also the depth, of the growth of higher education in the U.S. in the first half (...) of this century. At the heart of this growth were philosophical ideas, and in particular those of Dewey. Philosophy did not have then dictatorial or competitive designs regarding education, the social and political sciences, psychology, or the natural sciences. It freely mingled with them, not just imparting methodological or epistemological rigor but also contributing some insights and giving the hypotheses and conclusions in these fields the character of "experiences." Experience is the guiding theme of this rich and complicated work, covering a multitude of subjects and positions. The treatment is divided into six parts dealing respectively with Dewey's leanings toward unitary experience, organic experience, dynamic experience, functional experience, instrumental experience, and transactional experience. In the study of the intellectual of Dewey's life practically all of his production is critically examined by Deledalle: a monumental task in itself, made possible by the critical bibliography of Milton Hasley Thomas. There is enough early biographical detail to make this work an effective and affectionate intellectual portrait. The best pages of this work are devoted to a thorough explication and comparative study of Dewey's final synthesis of experience. There are very helpful comparative references to Marx, Freud, Bergson, and Heidegger, and also indispensable parallels and contrasts with Peirce, James, and Whitehead. This is not a modest contribution from a regional point of view: Deledalle is, perhaps more than anybody else, aware of an ongoing international dialogue on Dewey, a dialogue that is preserving experience as a problem-complex at the front line of contemporary reflection.--A. de L. M. (shrink)

Kasm does not offer any concept of proof which is regulative for all metaphysics, for he is convinced that each metaphysical approach requires its own proper logic and methodology. Within this pluralistic framework he seeks to discern the structure of formal truth as expressed in the concept of proof inherent in various metaphysical approaches.--L. S. F.

RésuméLa notion de «rationalité de l'Univers » a varié au cours du temps, le long dialogue de l'esprit et de la nature ayant toujours abouti à ce que Le Roy appelait « l'évolution de l'évidence et la plasticité de la raison ».L'échec de l'explication mécanique de l'Univers a conduit James Jeans à déclarer que le monde ressemble plutôt « à une grande pensée » qu'à une grande machine », car on ne peut en donner qu'une description mathématique. En réalité, la (...) physique moderne n'est ni plus ni moins mathématique que l'ancienne; elle est seulement plus générale. James Jeans confond les mathématiques pures et les mathématiques appliquées.Eddington prétend déduire les lois générales et les constantes physiques de la nature de considérations épistémologiques a priori. C'est un retour à Kant. Malheureusement les postulate dont il part comme évidents n'ont point paru tels au XVIIe siècle et n'ont été admis que sous la contrainte de l'expérience. Sa théorie ne prévoit ni les neutrons ni les mésons. Elle est vouée à l'échec.La possibilité de trouver un formalisme mathématique applicable à un domaine expérimental ne préjuge en rien la rationalité de l'Univers, car un mathématicien habile sera toujours capable de faire rentrer même un monde « erratique » dans un vêtement mathématique approprié. (shrink)

Thought, according to Hegel, is not only the product of a faculty of a subject, or a means by which a thinking subject tries to grasp a world that is alien to him. It is also the very structure of the world, that is disclosed to a subject through the thinking activity of a subject. The fundamental question that crosses the whole post-Kantian philosophy is that of the relation between thought and reality, i.e. the question of whether reality depends on (...) the categorial requirements imposed by the thinking subject, or whether reality maintains some form of independence from the thinking subject. Seen from this standpoint, Hegel can be read both as an author who radicalizes Kant’s transcendental perspective, and also as a critic of that perspective. In other words, he can be seen as an idealist: according to Hegel, any philosophy is idealist if it claims that something finite, qua finite, is essentially connected with something other. He can also be seen as an anti-idealist: insofar as his philosophy aims to overcome a hyper-transcendentalist perspective, i.e. it is so since it rejects idealism as subjective idealism. Moreover, Hegel’s anti-idealism can be characterized as realism. This is because, if we admit that overcoming transcendentalism without falling back again on a pre-critical conception of thought and of reality involves an idea of thought which is not reducible to a "mentalistic" conception of it, we need to conceive of thought as something that is not alien to reality. Hegel conceives of thought as intimately connected with the world, as its own rational structure. This “realism” of thought is what makes Hegelian idealism, so to speak, anti-idealistic. Through this "realism" of thought Hegel pursues two goals. On the one hand, Hegel attempts to overcome a subjectivistic and instrumentalistic conception of thought, according to which a subject talks and relates to a reality that is always only a construction of him, and so it is necessarily the simulacrum of something that remains inaccessible in its truth. On the other hand, Hegel attempts to overcome a conception of reality characterized merely as alien and opposite to thought itself, and which is the counterpart of the subjectivistic and instrumentalistic conception of thought. By pursuing these two goals it should be gained a conception of reality which could warrant some form of objectivity, but which cannot be equated with the substantialistic conception of the pre-Kantian metaphysics. (shrink)

Robert Stern has argued that Levinas is a kind of command theorist and that, for this reason, Løgstrup can be understood to have provided an argument against Levinas. In this paper, I discuss Levinas’s use of the vocabulary of demand, order, and command in the light of Jewish philosophical accounts of such notions in the work of Martin Buber, Franz Rosenzweig, and Emil Fackenheim. These accounts revise the traditional Jewish idea of command and I show that Levinas’s use of this (...) vocabulary is also revisionary. I show that in light of this tradition of discussion, Levinas’s use is not susceptible to the interpretation Stern proposes and thus that the Løgstrup-style argument cannot be used against Levinas. (shrink)