The differentiation of T Lymphocytes within the thymus is an important biological phenomenon during wich these cell acquire their functions to further control the immune system. Numerous experiments under various conditions have been devised to understand the different mechanisms involved in this complex process. Nevertheless, interpretation of these experiments lead to still contradictory debatable hypotheses. Modelisation of this process through classical simulation methods cannot be envisaged because they are not adapted to modifications of the model structure, which is the point (...) of interest. For these reasons, we proposed a new approach of automatic search for model. The program consists of four independent connected modules : The generator produces model, based on the rationale of formal grammars. Protocol and experimental data are stored in a set of experiments. The simulator using a protocol and a model provides simulated results. Finally, the supervisor by comparing simulated results and experimental data, adapts the model parameters to increase their fit and either chooses a new experiment to explore, or modifies the model structure. Change of the model structure is performed among still unexplored models according to their promise level, which is iteratively evaluated relatively to previously explored models through a proposed model distance. The generator is written in Prolog and the other modules in C++. The architecture of the program allows us to modify or complete a module without changing anything in the other modules. As a consequence, the proposed modeling approach conceived to study T lymphocyte differentiation within the thymus remains independent of this biological phenomenon and can be applied to other biological problems. (shrink)
1. Introduction Geoff Cockfield, Ann Firth and John Laurent -/- 2. The Role of Thumos in Adam Smith’s System Lisa Hill -/- 3. Adam Smith’s Treatment of the Greeks in The Theory of Moral Sentiments: The Case of Aristotle Richard Temple-Smith -/- 4. Adam Smith, Religion and the Scottish Enlightenment Pete Clarke -/- 5. The ‘New View’ of Adam Smith and the Development of his Views Over Time James E. Alvey -/- 6. The Moon Before the Dawn: A Seventeenth-Century (...) Precursor of Smith’s The Theory of Moral Sentiments Jack Barbalet -/- 7. Adam Smith’s Moral Philosophy as Ethical Self-formation Ann Firth -/- 8. Science and its Applications in The Theory of Moral Sentiments David Thorpe -/- 9. Adam Smith, Charles Darwin and the Moral Sense John Laurent and Geoff Cockfield. (shrink)
In this polyphonic dialogue, Gilles Châtenay, Eric Laurent, and Jacques-Alain Miller, responding to questions by Yann Moulier Boutang and Olivier Surel, ponder the consequences of the newest waves of digital processing of data related to the personal life, and of their increasing interconnection. In this “numerical tsunami” and in the political rhetoric that supports it by promoting maximal security and risk management, they identify a resurgence of utilitarianism, and, due to the technological power thus unleashed, a considerable danger for (...) privacy. Against this trend of rationalized totalization of data related to identities, they call for citizens’ resistance and for a sustained public debate on the issue. (shrink)
Nous comparons les notions d’usage et de signification chez Ludwig Wittgenstein et Martin Heidegger. Contrairement à Jocelyn Benoist, nous pensons que l’analogie entre Wittgenstein et Heidegger n’est pas superficielle. La métaphysique de Heidegger explicite certaines présuppositions implicites de la seconde philosophie de Wittgenstein. Le pragmatisme naturaliste de Wittgenstein peut être théorisé. Notamment la notion wittgensteinienne d’usage, ou de jeu de langage, peut être comprise comme une pratique à la fois naturelle et normative régie par des règles. -/- Wittgenstein’s notions of (...) use and meaning are compared with the corresponding Heidegger’s ones. Unlike Jocelyn Benoist, we suggest that the analogy between Wittgenstein and Heidegger is not superficial. Heidegger’s metaphysics makes explicit some of the implicit presuppositions of Wittgenstein’s philosophy. Wittgenstein’s naturalistic pragmatism can be theorized. In particular, Wittgenstein’s notion of use, or language game, can be understood as both natural and normative rule- governing practice. (shrink)
Technologies of democracy are instruments based on material apparatus, social practices and expert knowledge that organize the participation of various publics in the definition and treatment of public problems. Using three examples related to the engagement of publics in nanotechnology in France (a citizen conference, a series of public meetings, and an industrial design process), the paper argues that Science and Technology Studies provide useful tools and methods for the analysis of technologies of democracy. Operations of experiments and public demonstrations (...) can be described, as well as controversies about technologies of democracy giving rise to counter-experiments and counter-demonstrations. The political value of the analysis of public engagement lies in the description of processes of stabilization of democratic orders and in the display of potential alternative political arrangements. (shrink)
We assert that one of the examples used by Keller & Miller (K&M), namely, autism, is indeed common, and heritable, but we question whether it is harmful. We provide a brief review of cognitive science literature in which autistics perform superiorly to non-autistics in perceptual, reasoning, and comprehension tasks; however, these superiorities are often occluded and are instead described as dysfunctions. (Published Online November 9 2006).
In this essay, I attempt to define the 'ethnocategory' mushi in Japanese culture, through a semantic analysis of the Chinese characters bearing the radical "mushi," and fieldwork research in rural Japan. The research offers criteria for an animal's inclusion in the category, reveals the differences in people's perception of mushi according to age and gender, and elicits a structure of the category as a series of concentric circles around a semantic core. The richness and complexity of the findings provide insight (...) into Japanese attitudes towards animals and nature. (shrink)
We generalize the intuitionistic Hyland–Ong games to a notion of polarized games allowing games with plays starting by proponent moves. The usual constructions on games are adjusted to fit this setting yielding game models for both Intuitionistic Linear Logic and Polarized Linear Logic. We prove a definability result for this polarized model and this gives complete game models for various classical systems: , λμ-calculus, … for both call-by-name and call-by-value evaluations.
We give the precise correspondence between polarized linear logic and polarized classical logic. The properties of focalization and reversion of linear proofs are at the heart of our analysis: we show that the tq-protocol of normalization for the classical systems and perfectly fits normalization of polarized proof-nets. Some more semantical considerations allow us to recover LC as a refinement of multiplicative.
The Fukushima accident was a crisis in Japan, and a crisis elsewhere. In Europe, the aftermath of Fukushima was a period of intense questioning, about how to ensure the safety of nuclear reactors, and how, at the same time, ensure the ability of the European Union to act as a consistent political actor in the face of potentially catastrophic risks. Using empirical material related to the post-Fukushima stress tests and the subsequent discussions about the European regulatory framework for nuclear safety, (...) this paper shows that stress tests have provided a peculiar form of European intervention, restabilizing regulatory boundaries while extending the European gaze. It describes the overall operation thereby performed as the “normalization of the crisis” whereby the exceptional situation enters the realm of the normal functioning of the public administrations, and where the actions undertaken take the form of the legal norm. (shrink)
Nous interprétons les vues philosophiques de Werner Heisenberg comme un pragmatisme et un réalisme non-métaphysique de type Wittgensteinien. La « théorie close » est une règle (concept) Wittgensteinienne. À la différence d’Alisa Bokulich qui donne raison à la position de Paul Dirac sur la nature des relations entre les théories physiques différentes, nous favorisons plutôt celle de Heisenberg. Notre position interprétant Heisenberg va aussi à l’encontre de celle de Popper: le critère d’une théorie scientifique établie (close) est sa non-falsifiabilité. -/- (...) . (shrink)
The contrast, often painted in simplistic colours, between Martin Luther King Jr. and Malcolm X as civil rights campaigners bolsters an erroneous reading of the freedom struggle of African-Americans, leaving the impression that the resort to violence and self-defence propounded by Malcolm X was a purely circumstantial departure from the general strategy of the civil rights movement. In fact, both of them reflected long on the capacity of violence and a contrario of non-violence to bring about political and social transformation (...) in the context of the extreme brutality and oppression being suffered by African-Americans. Their dilemma stemmed from an old intellectual tradition of the America of the slave period. Well before the ideas of Gandhi won over the African-American elite, and even before Henry David Thoreau laid the theoretical basis for civil disobedience, African slaves gave thought to the legitimacy and effectiveness of violence to amend their situation. The importance of the non-violent movement in the United States and the historical significance of Martin Luther King cannot be understood unless a true measure is taken of the anti-slavery struggle. While within the religious domain, the Black Church played a major role in dissuading violence, secular thought in favour of legitimate forceful rebellion also found itself confronted by a counter-argument which advanced the power of social change and resistance to injustice that non-violence could effect. This article particularly addresses the challenges to their consciences that confronted the militants of non-violence in their campaign for the abolition of slavery and notably those facing the central figure of that struggle, the former slave become the apostle of liberation, Frederick Douglass. (shrink)
This paper discusses the operations meant to act on situations of ontological uncertainties for chemicals. Using examples related to substances developed as part of nanotechnology programs, it analyses technical and social instruments meant to define the existence of these substances, as « new » or « existing » chemicals. Carbon nanotubes developed by a French company offer an illustration of containment, while the legal disputes about nano silver in the U.S. display oppositions about whether or not these compounds are equivalent (...) to colloïdal silver. The operations meant to deal with the ontological uncertainty of these substances define categories and craft political organizations. As such, they suggest developing an analytical approach able to jointly examine the ontologies of material objects and the forms of political ordering. (shrink)
We consider a computational model comparing the possible roles of and in phonetic decoding, demonstrating that these two routes can contain similar information in some communication situations and highlighting situations where their decoding performance differs. We conclude that optimal decoding should involve some sort of fusion of association and simulation in the human brain.
L’homme est un animal extraordinaire selon Platon, mais il est bien un animal. Il faut donc maîtriser et domestiquer l’animalité de l’homme. Le cas de l’alimentation montre l’importance des pulsions animales en l’homme. L’animal n’est pas l’autre de l’homme, mais l’une de ses possibilités.
The present study is an attempt to relate the multicomponent response of the cytoskeleton (CSK), evaluated in twisted living adherent cells, to the heterogeneity of the cytoskeletal structure - evaluated both experimentally by means of 3D reconstructions, and theoretically considering the predictions given by two tensegrity models composed of (four and six) compressive elements and (respectively 12 and 24) tensile elements. Using magnetic twisting cytometry in which beads are attached to integrin receptors linked to the actin CSK of living adherent (...) epithelial cells, we specifically measured the elastic CSK response at quasi equilibrium state and partitioned this response in terms of cortical and cytosolic contributions with a two-component model (i.e., a series of two Voigt bodies). These two CSK components were found to be prestressed and exhibited a stress-hardening response which both characterize tensegrity behaviour with however significant differences: compared to the cytosolic component, the cortical cytoskeleton appears to be a faster responding component, being a less prestressed and easily deformable structure. The discrepancies in elastic behaviour between the cortical and cytosolic CSK components may be understood on the basis of prestress tensegrity model predictions, given that the length and number of constitutive actin elements are taken into account. (shrink)