If stem cell-based therapies are developed, we will likely confront a difficult problem of justice: for biological reasons alone, the new therapies might benefit only a limited range of patients. In fact, they might benefit primarily white Americans, thereby exacerbating long-standing differences in health and health care.

Histone variant exchange is a novel epigenetic regulator of cognition. We speculate that H2A.Z, a variant of canonical histone H2A, exerts unique effects on transcription during distinct stages of memory formation, ultimately acting to maintain memory of previous transcriptional states and poise genes for re‐activation. Hippocampus‐dependent memory formation is initiated by transient expression of memory‐related genes, which support the storage of recently acquired memories. Soon after, memories undergo systems consolidation, which transfers memories from the hippocampus to the cortex for long‐term (...) storage, and requires ongoing re‐activation of memory‐related genes. We speculate that learning‐induced H2A.Z eviction from nucleosomes initially contributes to stimulus‐induced transcriptional induction needed for the initial process of memory consolidation. During systems consolidation, we speculate that delayed incorporation of H2A.Z into nucleosomes of memory‐related genes in the cortex is needed to poise genes for rapid re‐activation, thus supporting the long‐term process of memory stabilization.Also watch the Video Abstract. (shrink)

The expansion of ethics review, beyond its origins in medical research, is the subject of growing critical analysis internationally, especially from social science researchers. Our study builds on this analysis by considering ethics review specifically within tertiary-based educational research. As a foundation for a larger study, we explore the reporting of ethics review within articles from a snapshot of education journals. A cross-sectional review considered 125 articles from 24 journals spanning medical and nurse education, the Scholarship of Teaching and Learning, (...) and educational technology. Among similar types of research our findings highlight variation in institutional ethical review processes and outcomes. Despite most journals providing guidelines for reporting ethics review, adherence to these guidelines by authors or editors was not always evident, but more likely in health-related education journals. We argue that identified areas of variation may reflect the differing influence and proximity of biomedical values. This influence has been under examined in tertiary-based educational research but may contribute to inequitable learning, researching and publishing experiences, potentially adding to negative sentiment about ethics review. (shrink)

: In 1998, researchers discovered that embryonic stem cells could be derived from early human embryos. This discovery has raised a series of ethical and public-policy questions that are now being confronted by multiple international organizations, nations, cultures, and religious traditions. This essay surveys policies for human embryonic stem cell research in four regions of the world, reports on the recent debate at the United Nations about one type of such research, and reviews the positions that various religious traditions have (...) adopted regarding this novel type of research. In several instances the religious traditions seem to have influenced the public-policy debates. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Kennedy Institute of Ethics Journal 10.2 (2000) 171-174 [Access article in PDF] Bioethics Inside the Beltway The Oversight of Human Gene Transfer Research LeRoy Walters Jesse Gelsinger's death last September in a gene transfer study being conducted at the University of Pennsylvania has helped to spark a national debate. In part, this debate parallels the broader discussion of how human subjects research should be reviewed and regulated (...) in the United States. However, human gene transfer research is one of a handful of biomedical technologies that seem to deserve special attention, at least in the early years of their development.The major participants in the national debate on human gene transfer include the National Institutes of Health (NIH), the Food and Drug Administration (FDA), the National Bioethics Advisory Commission, members of Congress, biotechnology and pharmaceutical companies, disease-oriented advocacy groups, reporters, and academics. At the December 1999 meeting of the NIH Recombinant DNA Advisory Committee (RAC), the protocol that involved Jesse Gelsinger was a central focus of discussion, but other topics emerged as well. One ad hoc panel reviewed adverse events that had occurred in other research protocols using adenovirus vectors, while a second proposed changes in the general system for reporting adverse events to NIH and the RAC.During the first several months of the year 2000, the United States Congress also became involved in the human gene transfer debate. In February, Senator Bill Frist (R-TN) convened a hearing to which Jesse Gelsinger's father, representatives of NIH and FDA, and several other witnesses were invited. At approximately the same time, the House Commerce Committee and its Subcommittee on Oversight and Investigations initiated their own inquiries, asking the Office of Inspector General at the Department of Health and Human Services to review the oversight roles of NIH and FDA. In March and April, the House committee also wrote directly to the NIH Director, the FDA Commissioner, and the President of the University of Pennsylvania, requesting extensive documentation on gene transfer, in general, and the trial in which Jesse Gelsinger was involved, in particular. Congressman Henry Waxman (D-CA) and Senator Edward Kennedy (D-MA) have also raised questions and proposed solutions in multiple letters to the NIH Director and the Secretary of Health and Human Services. [End Page 171]The major general questions that have emerged from this discussion are the following:(1) What kinds of information about adverse events should be reported by researchers or sponsors during the course of human gene transfer trials?(2) To what group or groups should adverse-event information be reported? How often and in what ways should the information be analyzed?(3) Should the information about adverse events remain confidential, or should it be discussed publicly?(4) How can the disclosure and consent process in gene transfer trials be improved?(5) Which federal agency should have primary responsibility for overseeing human gene transfer research, and how can it best fulfill its oversight role?How these questions are answered will have immediate relevance to the field of human gene transfer research as it enters into its next phase. At the same time, the models that are created for this important cutting-edge field also may be useful in other complex or controversial arenas of biomedical research, for example, xenotransplantation or human embryonic stem-cell research. In addition, the lessons learned from this one important area of human subjects research may suggest ways to improve protections for all the volunteers who make clinical research--and medical progress--possible.In the remainder of this article, I will turn from reporting, in as objective a way as possible, on the status of the public policy debate about human gene transfer research to suggesting measures for improving the current oversight system for such research. My initial general recommendation is that we should not expect a single regulatory agency to be solely responsible for a field as large and dynamic as human gene transfer research. Rather, there should be some helpful redundancy or, to change the metaphor, checks and balances in the public oversight of this field. Thus, an... (shrink)

The last quarter of the twentieth century has given rise to reproductive technologies and arrangements that in the earlier part of the century could only be dreamed of by the authors of science fiction. We stand in the middle of this reproductive revolution, trying to cope with the developments that have already occurred but with an uneasy sense that the future may be even more complicated ethically than the past and the present. In this brief essay, I will survey recent (...) ethical and public-policy discussions of two reproductive techniques (assisted insemination and in vitro fertilization) and one reproductive arrangement (surrogate motherhood). After distinguishing three phases in the normative debate, I will briefly comment on some of the characteristics of, and continuing ambiguities in, the ethical debate of the past 25 years. At the conclusion of the essay, I will attempt to anticipate three future issues in ethics and reproduction. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Kennedy Institute of Ethics Journal 14.3 (2004) vii-viii [Access article in PDF] John C. Fletcher 1931-2004 John Fletcher was one of the pioneers in the still-young field of bioethics. In this short tribute, I can only hope to highlight a few of the many contributions he made to the field.For many of us, our first introduction to John occurred in October 1971. At an international symposium sponsored by the (...) Kennedy Foundation, the film "Who Should Survive?" depicted the dramatic case of an infant with Down syndrome and an intestinal blockage. The parents of the infant refused surgery to relieve the obstruction, and the healthcare providers for the infant decided not to pursue a court order permitting the surgery. During a period of approximately two weeks the infant was allowed to die.In the second part of "Who Should Survive?" John was one of several panelists invited to discuss the decisions made in this case. After acknowledging how troubling the infant's death was to him, John nonetheless sought to be empathic with the parents. He pointed out that in the re-enactment of the case the faces of the parents were never seen, and he worried that the film did not permit the parents to discuss the reasons for the choice they had made. John realized that his position would not be shared by most other panelists. Yet he had the courage to take an unpopular stand and to challenge other panelists—and the audience—not to reach premature closure on complex ethical dilemmas.Already in 1967, John had begun contributing to the literature of bioethics. His essay "Human Experimentation: Ethics in the Consent Situation," appeared in Law and Contemporary Problems. At the time, John was deeply immersed in studying the ethical dimensions of research with human subjects at the NIH Clinical Center. Paul Ramsey cited John's work with appreciation in his 1970 book, The Patient as Person. By the time he completed his dissertation at Union Theological Seminary in 1969, John was arguably one of the best trained bioethicists in the world—before there was a field of bioethics.After serving as chaplain, teaching at Virginia Theological Seminary, and founding and leading a seminary without walls in Washington, DC, John became the chief of the ethics program at the NIH Clinical Center in 1977. There he had the unenviable task of providing a second review for all clinical protocols emerging from the intramural programs of the NIH institutes. John discovered that in some cases the institutional review boards of the institutes had overlooked important ethical questions. This role also [End Page vii] required courage. At times John found it necessary to challenge senior NIH researchers, even institute directors, and to request protocol revisions that in his view were required for the protection of human subjects.In 1980, after Martin Cline had performed an unauthorized gene transfer experiment involving thalassemia patients, John joined with physician W. French Anderson to write an essay entitled "Gene Therapy in Human Beings: When Is It Ethical to Begin?" [New England Journal of Medicine 303: 1293-97]. Not only did this essay help to defuse a potentially explosive problem for NIH, which had funded Cline's research. It also provided a set of guidelines for the conduct of human gene transfer research that is of continuing relevance today.At times John disagreed with federal policies on research, for example, conservative policies on human embryo research. He also chafed at the idea of subjecting his publications to prior NIH review, both for accuracy and for political correctness. Thus, he welcomed the opportunity to move to the University of Virginia in 1987. There his academic career flowered, and he enjoyed some of his most productive years of research and writing.Among his many contributions during these later years, John participated as Committee co-chair in an effort to "redress the wrongs of Tuskegee." The Tuskegee Syphilis Study Legacy Committee proposed in May 1996 that President Clinton apologize to the participants in the Tuskegee study on behalf of the federal government. In May 1997, the President did in... (shrink)

In 1969, the field of human genetics was in its infancy. Amniocentesis was a new technique for prenatal diagnosis, and a newborn genetic screening program had been established in one state. There were also concerns about the potential hazards of genetic engineering. A research group at the Hastings Center and Paul Ramsey pioneered in the discussion of genetics and bioethics. Two principal techniques have emerged as being of enduring importance: human gene transfer research and genetic testing and screening. This essay (...) tracks the development and use of these techniques and considers the ethical issues that they raise. (shrink)

According to a prevalent and rather influential typology, the just war and the crusade are antitheses in four respects. The requisite authority for a just war is the prince or the state; the crusade, on the other hand, is fought “under the auspices of the Church or of some inspired religious leader.” Second, the cause or aim of the just war is to protect society from offenses against life and property; in contrast, the object of the crusade is to promote (...) a religious or quasi-religious ideal. Third, the attitude of just warriors is one of reluctant resignation to performing an unpleasant but necessary task; crusaders, however, welcome the opportunity to wreak vengeance on the enemy. Finally, whereas the just war is characterized by moderation in the use of military. means, the crusade almost inevitably leads to indiscriminate violence. (shrink)

This essay explores some moral problems raised by experimentation involving the human fetus. In the first part of the essay three examples of fetal experimentation from the medical literature are described in some detail. Next, the ethical and legal arguments employed in the two major existing public policy-documents on fetal experimentation are analyzed. Finally, the author seeks to identify four fundamental presuppositions which underlie divergent normative positions on the problem of fetal experimentation.

Walters provides commentary on Diderot's translation of Shaftesbury's An Inquiry Concerning Virtue or Merit. By comparing the translation and notes, he demonstrates the evolution of Diderot's thought and artistic skill, discusses the difference between theism and deism, the question of universal order, and compares atheism with free thought. After an analysis of religious fanaticism and social and political abuses, he turns his attention to virtue, as it relates to happiness, objective values, the moral sense, the passions, and self-interest. A (...) final chapter deals with the style of the Essai. (shrink)

Participants have known Poteat as teacher or colleague or author over various periods of time and assess him according to these various relationships. Polanyi is given less attention largely because he has been less difficult to understand. Poteat’s approach is the more radical because he attempts to take the implications of Polanyi’s thinking further. Central to comprehending the nature of their differences are an understanding (1) of their different perceptions of transcendence and (2) of the contrasting groundings they provide for (...) reality. (shrink)

This study was conducted during 111 days of coronavirus disease 2019 lockdown and reviewed current media articles that revealed government bodies and institutions have come to view people not as priceless treasures, but in terms of the money they can generate and the economic value they may give to a nation. This view was contrasted with the historic Christian concept of inherent royalty and value that is intrinsic to all people, and embodied in monarchs and bishops. This study focuses on (...) a review of historical literature and biblical texts around monarchy and the episcopacy in light of current media articles related to COVID-19. It found that politics and policy need to be grounded into the more fundamental aspects of our human condition and that it is the compassion and care people have for those who are more fragile: be it financially, physically, mentally or spiritually, that bishops and monarchs should be embodying in a time of COVID-19.Contribution: This study drew its key insights from contested historical thoughts on the role of monarchs and bishops. The results of this line of thinking challenge us as we consider the future function and role of these positions, and what they mean in times of crises. The key insight gained is the reminder that the lives of all people in our communities are important as each person holds an intrinsic value that cannot be traded for the sake of a country’s economy and business desires to turn a profit during the COVID-19 pandemic. (shrink)

This is intended as an introductory statement to the explorations undertaken in the essays that follow. The authors of these essays attempt to introduce the reader to some of the insights of Michael Polanyi and their implications for the reader who wishes to come to a greater understanding of modern technological society, which — for better or worse — has come to define his very existence. Arguably, no twentieth-century thinker has probed more deeply than Polanyi into the dynamics of scientific (...) discovery or demonstrated more courage in his willingness to think outside the box of ruling orthodoxies and, consequently, come up with more profound insights and radically new ways of understanding the processes of scientific inquiry, their technological implications, and the sometimes fateful, but potentially fruitful, relationships that exist among science, technology, and society. Each of the following nine authors, grounded in different fields of study and research, but also in a common appreciation of Polanyi’s contributions, offers valuable insights into this multi-faceted subject. (shrink)

Despite fundamental differences in the epistemologies presented by Oakeshott and Polanyi, there are some important areas of common concern which suggest further exploration. Focus here is on Oakeshott’s epistemological and disciplinary boundaries in his The Voice of Liberal Leaming.

What does it mean to be a rational language user? What is it to obey linguistic rules? What is the proper account of linguistic competence? A Fregean answer to these questions would make essential appeal to the notion of sense: we are masters of a language to the extent that we are able to recognise the cognitive value of its expressions; we are rational judges regarding truth-value assignments to the extent that we are sensitive to the ways in which the (...) sense of an expression guides us in the semantic evaluation process; and as for obeying rules, it is our ability to respond to how sense directs us, for a particular assertion of a sentence, towards the determination of its truth-value that best exemplifies what it is like to follow a linguistic rule. My thesis explores a cluster of closely interrelated issues arising from these questions. Accordingly, in tracing the routes of sense my dissertation places itself at the intersection of the philosophy of language, linguistics, philosophy of logic, and meta-ethics—and indeed, I end up agreeing with Allan Gibbard that the theory of meaning really belongs to meta-ethical reflection. Chapter 1 introduces some of the main research questions that I try to address in the rest of the thesis. In chapter 2 I state a number of theses which I take to be the defining ones for semanticism. I show that they form a class of jointly incompatible commitments. I choose nonsense as a problem case for compositionality and I argue that it forces the semanticist to abandon either the learnability or the compositionality constraint. The escape route I adopt, going radically minimalist about content, is incompatible with another key semanticist thesis, namely, that grasp of meaning is grasp of truth-conditions. In chapter 3, I consider the account of atomic meanings given by both the semanticist and the pragmaticist and I conclude that on neither account does interpretation come out as a process of rational choice between candidate bearers of content. Again, I suggest the lesson from indeterminacy is that we ought to embrace an ineradicably minimal conception of content. In chapter 4 I turn my attention to the meaning of the logical constants and I argue that indeterminacy worries extend to the very heart of the compositional machinery. Chapter 5 examines the view that logic is the science of reasoning. Unsurprisingly, I conclude that a defence of this claim requires endorsing content-minimalism. In chapter 6 I conclude my dissertation by sketching a radical view of content minimalism and I try to show how it can solve the puzzles I had been considering over the course of the previous chapters. (shrink)