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Leemon Mchenry [67]Leemon B. McHenry [58]Leemon Benton McHenry [1]
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Leemon McHenry
California State University, Northridge
  1. Clinical Trials and Drug Promotion.Jon Jureidini, Leemon McHenry & Peter Mansfield - 2008 - International Journal of Risk and Safety in Medicine 20:73-81.
    Selective reporting is prevalent in the medical literature, particularly in industry-sponsored research. In this paper, we expose selective reporting that is not evident without access to internal company documents. The published report of study 329 of paroxetine in adolescents sponsored by GlaxoSmithKline claims that “paroxetine is generally well tolerated and effective for major depression in adolescents”. By contrast, documents obtained during litigation reveal that study 329 was negative for efficacy on all 8 protocol specified outcomes and positive for harm.
     
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  2. Descriptive and Revisionary Theories of Events.Leemon B. McHenry - 1996 - Process Studies 25:90-103.
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  3. Whitehead, Quantum Mechanics and Local Realism.Leemon McHenry - 2002 - Process Studies 31 (1):164-170.
  4. On the Origin of Great Ideas: Science in the Age of Big Pharma.Leemon B. McHenry - 2005 - Hastings Center Report 35 (6):17-19.
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  5. Whitehead's Panpsychism as the Subjectivity of Prehension.Leemon B. McHenry - 1995 - Process Studies 24:1-14.
  6.  9
    Science and the Pursuit of Wisdom: Studies in the Philosophy of Nicholas Maxwell.Leemon McHenry - 2009 - Frankfurt, Germany: Ontos Verlag.
    Nicholas Maxwell's provocative and highly-original philosophy of science urges a revolution in academic inquiry affecting all branches of learning, so that the single-minded pursuit of knowledge is replaced with the aim of helping people realize what is of value in life and make progress toward a more civilized world. This volume of essays from an international, interdisciplinary group of scholars engages Maxwell in critical evaluation and celebrates his contribution to philosophy spanning forty years. Several of the contributors, like Maxwell, took (...)
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  7. The Citalopram CIT-MD-18 Pediatric Depression Trial: A Deconstruction of Medical Ghostwriting, Data Manipulation and Academic Malfeasance.Leemon McHenry, Jon Jureidini & Jay Amsterdam - 2016 - International Journal of Risk and Safety in Medicine 28:33-43.
    This paper is a deconstruction of a ghostwritten report of a randomized, double-blind, placebo-controlled efficacy and safety trial of citalopram in depressed children and adolescents conducted in the United States. Court documents revealed that protocol-specified outcome measures showed no statistically significant difference between citalopram and placebo. However, the published article concluded that citalopram was safe and significantly more efficacious than placebo for children and adolescents, with possible adverse effects on patient safety.
     
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  8. Industry-Sponsored Ghostwriting in Clinical Trial Reporting: A Case Study.Leemon McHenry & Jon Jureidini - 2008 - Accountability in Research 15 (3):152-167.
    In this case study from litigation, we show how ghostwriting of clinical trial results can contribute to the manipulation of data to favor the study medication. Study 329 for paroxetine pediatric use was negative for efficacy and positive for harm. Yet the ghostwritten publication from this study concluded that paroxetine provided evidence of efficacy and safety and continues to be influential. Despite the role of named authors in revisions of the manuscript, the sponsor company remained in control of the message.
     
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  9.  5
    Of Sophists and Spin-Doctors: Industry-Sponsored Ghostwriting and the Crisis of Academic Medicine.Leemon McHenry - 2010 - Mens Sana Monographs 8 (1):129.
    Ghostwriting for medical journals has become a major, but largely invisible, factor contributing to the problem of credibility in academic medicine. In this paper I argue that the pharmaceutical marketing objectives and use of medical communication firms in the production of ghostwritten articles constitute a new form of sophistry. After identifying three distinct types of medical ghostwriting, I survey the known cases of ghostwriting in the literature and explain the harm done to academic medicine and to patients. Finally, I outline (...)
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  10.  11
    The Axiomatic Matrix of Whitehead's Process and Reality.Leemon B. McHenry - 1986 - Process Studies 15 (3):172-180.
    This essay compares the fundamental metaphysical principles, the Categoreal Scheme of A. N. Whitehead's Process and Reality with the axiomatic-deductive scheme of Whitehead and Russell's Principia Mathematica to reveal the influence of mathematical logic on Whitehead's metaphysics.
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  11.  2
    Ghost-Managed Medicine: Big Pharma’s Invisible Hands by Sergio Sismondo. [REVIEW]Leemon B. McHenry - 2019 - Kennedy Institute of Ethics Journal 29.
    Ghost-Managed Medicine exposes the conspiracy to conceal all of the players in the marketing of drugs, including ghostwriters, key opinion leaders, patient advocacy organizations, contract research organizations, publication planners, and even medical journal editors and publishers. The credibility of the claims conveyed by the industry depends on the invisibility of these players.
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  12.  22
    Quine and Whitehead: Ontology and Methodology.Leemon McHenry - 1997 - Process Studies 26 (1/2):2-12.
    In this essay I make a case for a number of common themes between A. N. Whitehead and W. V. Quine in their approach to ontology. Both philosophers espoused a view of metaphysics as continuous with natural science and stressed the importance of physics in the development of ontology. As a consequence of the revolutionary developments in modern physics, both Whitehead and Quine contend that events are ontologically basic, but differ on the status of properties in their respective systems.
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  13.  10
    Philosophy of Physics: Space and Time by Tim Maudlin. [REVIEW]Leemon McHenry - 2012 - Process Studies 41 (2):349-353.
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  14. The Paroxetine 352 Bipolar Trial: A Study in Medical Ghostwriting.Leemon McHenry & Jay Amsterdam - 2012 - International Journal of Risk and Safety in Medicine 24 (4):221-231.
    The problem of ghostwriting in corporate-sponsored clinical trials is of concern to medicine, bioethics, and government agencies. We present a study of the ghostwritten archival report of an industry-sponsored trial comparing antidepressant treatments for bipolar depression: GlaxoSmithKline (GSK) paroxetine study 352.
     
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  15.  30
    Consciousness, Reality and Value: Essays in Honour of T.L.S. Sprigge.Pierfrancesco Basile & Leemon B. McHenry (eds.) - 2007 - Ontos.
    The contributions gathered in this volume, written by philosophers of international reputation or by acknowledged scholars in their specialized fields of ...
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  16. 1. Front Matter Front Matter.Jim Good, Jim Garrison, Leemon McHenry, Corey McCall, Susan Dunston, Zach VanderVeen, Melvin L. Rogers, James A. Dunson Iii, Mary Magada-Ward & Michael Sullivan - 2010 - Journal of Speculative Philosophy 24 (2).
     
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  17. Ghosts in the Machine: Comment on Sismondo.Leemon McHenry - 2009 - Social Studies of Science 39 (6):943-47.
    Sergio Sismondo argues that pharmaceutical industry-sponsored research and ghostwriting produce genuine knowledge and science (albeit commercial science) not different from established medical science. In this essay I critically evaluate Sismondo' view and conclude that the commercial medical science that has created the ghostwriting industry is a corruption of science and not merely science done in a new corporate mode. Serious harm to patients has resulted from misrepresented commercial biomedical research.
     
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  18. Popper and Maxwell on Scientific Progress.Leemon McHenry - 2009 - In Science and the Pursuit of Wisdom: Studies in the Philosophy of Nicholas Maxwell. Frankfurt, Germany: pp. 233-248.
    Karl Popper's celebrated theory of falsification provides a rigorous view of science but it has been criticized as failing to explain how science makes progress. In this essay, I compare Popper's falsificationism with Nicholas Maxwell's aim-oriented empiricism and examine the role that metaphysics plays in explaining scientific progress.
     
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  19. Analytical Critiques of Whitehead's Metaphysics.Leemon McHenry & George W. Shields - 2017 - Journal of the American Philosophical Association 3 (2):483-503.
    Analytic philosophers have criticized A. N. Whitehead’s metaphysics for being obscure, yet several such philosophers have espoused positions in metaphysics and philosophy of mind that were advanced by Whitehead in the 1920s. In this paper, we evaluate the merits and demerits of these criticisms by Bertrand Russell, W. V. Quine, Karl Popper and others and then demonstrate the affinities and contrasts in the positions advanced by Galen Strawson, David Chalmers, Thomas Nagel and Whitehead regarding so-called “analytic panexperientialism.”.
     
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  20.  20
    The Multiverse Conjecture: Whitehead’s Cosmic Epochs and Contemporary Cosmology.Leemon McHenry - 2011 - Process Studies 40 (1):5-24.
    Recent developments in cosmology and particle physics have led to speculation that our universe is merely one of a multitude of universes. While this notion, the multiverse hypothesis, is highly contested as legitimate science, it has nonetheless struck many physicists as a necessary consequence of the effort to construct a final, unified theory. In Process and Reality, his magnum opus, Alfred North Whitehead advanced a cosmology as part of his general metaphysics of process. Part of this project involved a theory (...)
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  21.  34
    Tribute: T.L.S. Sprigge, the Last Idealist.Leemon McHenry - 2007 - Chromatikon: Annales de la Philosophie En Procès / Yearbook of Philosophy in Process 3:282-289.
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  22.  17
    Naturalized and Pure Metaphysics: A Reply to Hutto.Leemon McHenry - 1998 - Bradley Studies 4 (1):97-101.
  23.  13
    Filozofia Procesu I Jej Metafilozofia by Piotr Gutowski. [REVIEW]Leemon McHenry - 1995 - Process Studies 24:96-99.
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  24.  22
    The Effectiveness of Causes.Leemon B. McHenry - 1985 - Review of Metaphysics 39 (2):351-353.
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  25.  11
    Analytical Critiques of Whitehead's Metaphysics.Leemon B. Mchenry & George W. Shields - 2016 - Journal of the American Philosophical Association 2 (3):483-503.
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  26.  29
    Sprigge's Ontology of Consciousness.Leemon McHenry - 2010 - Royal Institute of Philosophy Supplement 67:5-20.
    Timothy Sprigge advanced an original synthesis of panpsychism and absolute idealism. He argued that consciousness is an irreducible, subjective reality that is only grasped by an introspective, phenomenological approach and constructed his ontology from what is revealed in the phenomenology. In defending the unique place of metaphysics in the pursuit of truth, he claimed that scientific investigation can never discover the essence of consciousness since it can only provide descriptions of structure and function in what we normally think of as (...)
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  27.  10
    Quine's Pragmatic Ontology.Leemon B. Mchenry - 1995 - Journal of Speculative Philosophy 9 (2):147 - 158.
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  28.  20
    The Emergence of Whitehead's Metaphysics.Leemon B. McHenry - 1986 - Review of Metaphysics 39 (3):563-566.
  29.  11
    Whitehead’s “Approximation” to Bradley.Lewis S. Ford & Leemon McHenry - 1993 - Idealistic Studies 23 (2/3):103-109.
  30.  3
    Let Them Eat Prozac: The Unhealthy Relationship Between the Pharmaceutical Industry and Depression by David Healy. [REVIEW]Leemon B. McHenry - 2007 - Mens Sana Monographs 5 (1):228-232.
  31.  3
    The Philosophical Writings of Victor A. Lowe (1907-1988).Leemon B. McHenry - 1989 - Transactions of the Charles S. Peirce Society 25 (3):333 - 339.
  32.  4
    Whitehead and Bradley: A Comparative Analysis.Michael Partridge & Leemon B. McHenry - 1992 - Philosophical Quarterly 43 (173):545.
    In his magnum opus, Process and Reality, Alfred North Whitehead claims a special affinity to Oxford philosopher Francis Herbert Bradley. McHenry clarifies exactly how much of Whitehead's metaphysics is influenced by and accords with the main principles of Bradley's "absolute idealism." He argues that many of Whitehead's doctrines cannot be understood without an adequate understanding of Bradley, in terms of both affinities and contrasts. He evaluates the arguments between them and explores several important connections with William James, Josiah Royce, George (...)
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  33.  40
    Consciousness and Morality in the Philosophy of T. L. S. Sprigge.Leemon McHenry - 2010 - Journal of Speculative Philosophy 24 (2):121-137.
    T. L. S. Sprigge produced an eclectic yet highly original system of metaphysics and ethics, a synthesis of panpsychism, absolute idealism, and utilitarianism, at a time in which orthodox analytical philosophy could only view this system as an anachronism of the nineteenth century. His critics claim that his philosophy has only historical interest to a small group of specialists in the relatively dormant tradition of British Idealism, that an attempt to defend his view of consciousness is a hopeless nonstarter, and (...)
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  34.  23
    Quine and Whitehead on Ontological Reduction: Properties Reconsidered.Christine Holmgren & Leemon McHenry - 2012 - Process Studies 41 (2):261-286.
    W.V.O. Quine and A.N. Whitehead shared a dualistic ontology of concrete and abstract objects but differed sharply on the status of properties. In this essay, we explore Whitehead’s reasons for admitting properties into his ontology and Quine’s objections. In the course of examining Quine’s position we demonstrate some deficiencies in his position and conclude that in spite of his claims, neither space-time coordinate systems nor classes can do all the ontological work of properties.
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  35.  4
    The Philosophy of Evidence-Based Medicine by Jeremy Howick. [REVIEW]Leemon McHenry - 2017 - Kennedy Institute of Ethics Journal 27 (3):1-5.
    The idea that prescribing physicians should be guided by the most reliable scientific evidence seems obvious, but the actual methodology of evidence-based medicine was only introduced in the early 1990s by an international group of clinicians and researchers led by Gordon Guyatt. Since then it has provided a new paradigm for the scientific foundation of medicine and has influenced other disciplines outside of medicine, for example, evidence-based psychotherapy, science and government. The novel concept of evidence-based medicine is based on hierarchies (...)
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  36.  2
    The God of Metaphysics by Timothy Sprigge.Leemon B. McHenry - 2007 - Process Studies 36 (1):146-150.
  37.  7
    Unsnarling the World-Knot: Consciousness, Freedom, and the Mind-Body Problem by David Griffin. [REVIEW]Leemon McHenry - 1999 - Faith and Philosophy 16 (2):269-272.
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  38.  2
    The Passage of Nature by Dorothy Emmet. [REVIEW]Leemon B. McHenry - 1992 - Review of Metaphysics 46 (2):401-402.
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  39.  2
    The Ontology of the Past: Whitehead and Santayana.Leemon B. McHenry - 2000 - Journal of Speculative Philosophy 14 (3):219-231.
    This essay examines the question of the ontological basis for historical propositions and contrasts the positions of A. N. Whitehead and George Santayana, i.e., presentism vs. eternalism. I argue that Whitehead's presentism is a more satisfactory solution to how propositions refer to the past.
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  40.  15
    Is Science Neurotic? By Nicholas Maxwell. [REVIEW]Leemon B. McHenry - 2006 - Review of Metaphysics 59 (3):657-659.
  41.  13
    Index of Articles, Discussions, and Book Reviews.Leemon B. McHenry - 2001 - Process Studies 30 (1):184-203.
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  42.  13
    The Philosophical Writings of Victor A. Lowe (1907-1988).Leemon B. McHenry - 1989 - Transactions of the Charles S. Peirce Society 25 (3):333 - 339.
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  43.  12
    Philosophers and Friends.Leemon B. McHenry - 1997 - Process Studies 26 (3/4):338-339.
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  44.  26
    The Ontology of the Past: Whitehead and Santayana.Leemon B. McHenry - 2000 - Journal of Speculative Philosophy 14 (3):219-231.
  45.  15
    The New Aspects of Time. Its Continuity and Novelties Selected Papers in the Philosophy of Science by Milič Čapek.Leemon B. McHenry - 1992 - Review of Metaphysics 45 (3):604-605.
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  46.  10
    The God of Metaphysics.Leemon B. McHenry - 2007 - Process Studies 36 (1):146-150.
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  47.  9
    Sprigge’s Philosophical Idealism.Leemon Mchenry - 2003 - Bradley Studies 9 (2):109-125.
  48.  15
    Bradley, James, and Whitehead on Relations.Leemon B. Mchenry - 1989 - Journal of Speculative Philosophy 3 (3):149 - 169.
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  49.  14
    A Brief History of Time.Leemon B. McHenry - 1989 - Review of Metaphysics 42 (3):626-628.
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  50.  14
    From an Ontological Point of View by John Heil. [REVIEW]Leemon B. Mchenry - 2004 - Review of Metaphysics 57 (3):620-622.
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