Background: We define compassion as an enduring disposition that centers upon empathetic concern for another person's suffering and the motivation to act to alleviate it. The contribution of specific candidate genes to the development of dispositional compassion for others is currently unknown. We examine candidate genes in the oxytocin and dopamine signaling pathways.Methods: In a 32-year follow-up of the Young Finns Study, we examined with multiple indicators latent growth curve modeling the molecular genetic underpinnings of dispositional compassion for others across (...) the life span. We selected five single nucleotide polymorphisms whose functions are known in humans: rs2268498, rs3796863, rs1800497, rs4680, and rs1611115. Compassion was measured with Cloninger's Temperament and Character Inventory on three repeated observations spanning 15 years. Differences between gender were tested.Results: We did not find an effect of the five SNPs in oxytocin and dopamine pathway genes on the initial levels of dispositional compassion for others. Individuals who carry one or two copies of the T-allele of DBH rs1611115, however, tend to increase faster in compassion over time than those homozygotes for the C-allele, b = 0.063. This effect was largely driven by male participants, 0.206, and was not significant in female participants when analyzed separately.Conclusions: Men who are known to have, on average, lower compassion than women seem to reduce this difference over time if they carry the T-allele of DBH rs1611115. The direction of the association indicates that dopamine signaling activity rather than overall dopamine levels might drive the development of compassion. (shrink)

The present study examined the relationship between vital exhaustion, Cloninger's temperament dimensions, and state affects during experimentally induced stress among participants aged 22–37 years. Larsen and Diener's circumplex model of affect was used to structure the self-reported affects. Temperament was measured by the Temperament and Character Inventory. Feelings of exhaustion were assessed by the Maastricht Questionnaire. Stressors used were an aversive startle task, an appetitive mental arithmetic task, and an aversive choice-deadline reaction time task. The results showed that the level (...) of vital exhaustion among healthy persons is related to unpleasant state affects other than state fatigue. Temperament also modified the relationship between vital exhaustion and affects. In addition, vital exhaustion was related to a tendency to behavioural inhibition (harm avoidance). Our findings suggest that temperament is related to feelings of exhaustion and is likely to predispose to negative affectivity when accompanied by exhaustion. (shrink)