This paper describes one style of functional analysis commonly used in the neurosciences called task-bound functional analysis. The concept of function invoked by this style of analysis is distinctive in virtue of the dependence relations it bears to transient environmental properties. It is argued that task-bound functional analysis cannot explain the presence of structural properties in nervous systems. An alternative concept of neural function is introduced that draws on the theoretical neuroscience literature, and an argument is given to show that (...) this alternative concept of may help to overcome the explanatory limitations of task-bound functional analysis. (shrink)

An analysis of two heuristic strategies for the development of mechanistic models, illustrated with historical examples from the life sciences. In Discovering Complexity, William Bechtel and Robert Richardson examine two heuristics that guided the development of mechanistic models in the life sciences: decomposition and localization. Drawing on historical cases from disciplines including cell biology, cognitive neuroscience, and genetics, they identify a number of "choice points" that life scientists confront in developing mechanistic explanations and show how different choices result in (...) divergent explanatory models. Describing decomposition as the attempt to differentiate functional and structural components of a system and localization as the assignment of responsibility for specific functions to specific structures, Bechtel and Richardson examine the usefulness of these heuristics as well as their fallibility—the sometimes false assumption underlying them that nature is significantly decomposable and hierarchically organized. When Discovering Complexity was originally published in 1993, few philosophers of science perceived the centrality of seeking mechanisms to explain phenomena in biology, relying instead on the model of nomological explanation advanced by the logical positivists (a model Bechtel and Richardson found to be utterly inapplicable to the examples from the life sciences in their study). Since then, mechanism and mechanistic explanation have become widely discussed. In a substantive new introduction to this MIT Press edition of their book, Bechtel and Richardson examine both philosophical and scientific developments in research on mechanistic models since 1993. (shrink)

Spontaneous localization theories are a class of quantum theories which solve the so-called measurement problem by non-linearly and stochastically modifying the Schrödinger dynamics. In this paper I briefly explain where these theories are coming from, what their driving ideas and main features are, and how they were historically developed. Also, I discuss their empirical and ontological adequacy, as well as their relativistic extensions and their experimental confirmation.

Spontaneous localization theory is a quantum theory proposed by GianCarlo Ghirardi, together with Alberto Rimini and Tullio Weber in 1986. However, soon it became clear to Ghirardi that his work was more than just one theory: he actually developed a framework, a family of theories in which the wavefunction jumps, but where the ontology of the theory is underdetermined. After acknowledging that the wavefunction did not provide a satisfactory ontology, he assumed that matter was described by a continuous matter (...) density field in three-dimensional space, whose evolution is governed by a stochastic wavefunction evolution. Alternatively, Bell assumed that the wavefunction would govern a spatiotemporal event ontology, dubbed ‘flashes.’ However, not much work has been done with the perhaps most obvious possibility, namely that physical objects are made of particles. This paper has two aims. First to explain the reason why people require spontaneous localization theory to be more than just a theory about the wavefunction. This is done by showing how the problem everyone in the foundation of quantum mechanics take to be the fundamental problem of quantum mechanics, namely the measurement problem, is a red herring. Then, the paper explores the possibility of spontaneous localization theories of particles. I argue that this discussion is not a mere exercise, as spontaneous localization theories of particles may be amenable to a relativistic extension which does not require a foliation, and because in general the peculiar type of indeterminism of spontaneous localization theories may help shedding new light on the nature of the tension between quantum theory and relativity. (shrink)

Case studies in the psychophysics, modeling and localization of human vision are presented as an example of.

The main topics of this second part of a two-part essay are some consequences of the phenomenon of vacuum polarization as the most important physical manifestation of modular localization. Besides philosophically unexpected consequences, it has led to a new constructive “outside-inwards approach” in which the pointlike fields and the compactly localized operator algebras which they generate only appear from intersecting much simpler algebras localized in noncompact wedge regions whose generators have extremely mild almost free field behavior. -/- Another consequence (...) of vacuum polarization presented in this essay is the localization entropy near a causal horizon which follows a logarithmically modified area law in which a dimensionless area (the area divided by the square of dR where dR is the thickness of a light-sheet) appears. There are arguments that this logarithmically modified area law corresponds to the volume law of the standard heat bath thermal behavior. We also explain the symmetry enhancing effect of holographic projections onto the causal horizon of a region and show that the resulting infinite dimensional symmetry groups contain the Bondi–Metzner–Sachs group. This essay is the second part of a partitioned longer paper. (shrink)

The main aim of this work is to relate integrability in QFT with a complete particle interpretation directly to the principle of causal localization, circumventing the standard method of finding sufficiently many conservation laws. Its precise conceptual-mathematical formulation as “modular localization” within the setting of local operator algebras also suggests novel ways of looking at general (non-integrable) QFTs which are not based on quantizing classical field theories.Conformal QFT, which is known to admit no particle interpretation, suggest the presence (...) of a “partial” integrability, referred to as “conformal integrability”. This manifests itself in a “braid-permutation” group structure which contains in particular informations about the anomalous dimensional spectrum. For chiral conformal models this reduces to the braid group as it is represented in Hecke- or Birman-Wenzl-algebras associated to chiral models.Another application of modular localization mentioned in this work is an alternative to the BRST formulation of gauge theories in terms of stringlike vectorpotentials within a Hilbert space setting. (shrink)

ABSTRACT This article elaborates a concept of localization through interpreting key arguments in Colombian philosopher Santiago Castro-Gómez’s early works grouped by the author under the name “genealogies of coloniality.” Following the role localization in his genealogies of coloniality reveals what Castro-Gómez calls “heterarchic articulations.” Heterarchic articulations delineate an analytic model of power that traces how multiple technologies and formations of power operating at different levels, from colonial geopolitics to individual “corpopolitics” of desire, converge and configure radically localized processes (...) of subjectivation. Localization understood in these terms, the author argues, allows Castro-Gómez to radicalize, transform, and combine Foucault’s genealogical approach and decolonial theory. The article concludes by showing that, besides radicalizing and combining genealogy and decoloniality, the localization at work in Castro-Gómez’s genealogies of coloniality serves to interpret theorizations and phenomena of contemporary violence by turning to Mexican transfeminist philosopher Sayak Valencia’s analysis of “gore capitalism.”. (shrink)

Objective: Atypical patterns of language lateralization due to early reorganizational processes constitute a challenge in the pre-surgical evaluation of patients with pharmaco-resistant epilepsy. There is no consensus on an optimal analysis method used for the identification of language dominance in MEG. This study examines the concordance between MEG source localization of beta power desynchronization and fMRI with regard to lateralization and localization of expressive and receptive language areas using a visual verb generation task.Methods: Twenty-five patients with pharmaco-resistant epilepsy, (...) including six patients with atypical language lateralization, and ten right-handed controls obtained MEG and fMRI language assessment. Fourteen patients additionally underwent the Wada test. We analyzed MEG beta power desynchronization in sensor (controls) and source space (patients and controls). Beta power decrease between 13 and 35 Hz was localized applying Dynamic Imaging of Coherent Sources Beamformer technique. Statistical inferences were grounded on cluster-based permutation testing for single subjects.Results: Event-related desynchronization of beta power in MEG was seen within the language-dominant frontal and temporal lobe and within the premotor cortex. Our analysis pipeline consistently yielded left language dominance with high laterality indices in controls. Language lateralization in MEG and Wada test agreed in all 14 patients for inferior frontal, temporal and pari... (shrink)

The progression of theories suggested for our world, from ego- to geo- to helio-centric models to universe and multiverse theories and beyond, shows one tendency: The size of the described worlds increases, with humans being expelled from their center to ever more remote and random locations. If pushed too far, a potential theory of everything (TOE) is actually more a theories of nothing (TON). Indeed such theories have already been developed. I show that including observer localization into such theories (...) is necessary and sufficient to avoid this problem. I develop a quantitative recipe to identify TOEs and distinguish them from TONs and theories in-between. This precisely shows what the problem is with some recently suggested universal TOEs. (shrink)

Functional localization is a central aim of cognitive neuroscience. But the nature and extent of functional localization in the human brain have been subjects of fierce theoretical debate since the 19th Century. In this essay, I first examine how concepts of functional localization have changed over time. I then analyze contemporary challenges to functional localization drawing from research on neural reuse, neural degeneracy, and the context-dependence of neural functions. I explore the consequences of these challenges for (...) topics in philosophy of science and philosophy of mind including localizationist versus anti-localizationist approaches to cognitive neuroscience, multiple realizability, reverse inference in functional neuroimaging, and the modularity of mind. (shrink)

This paper is concerned with n-localization property introduced by Newelski and Rosłanowski in [10] and getting it for CS iterations of forcing notions.

Nuclear proteins are synthesized in the cytoplasm and must subsequently enter the nucleus. Recent experiments indicate some similarities and some differences between protein localization to the nucleus and localization to other organelles.

In the general relativity theory gravitational energy-momentum density is usually described by a pseudo-tensor with strange transformation properties so that one does not have localization of gravitational energy. It is proposed to set up a gravitational energy-momentum density tensor having a unique form in a given coordinate system by making use of a bimetric formalism. Two versions are considered: (1) a bimetric theory with a flat-space background metric which retains the physics of the general relativity theory and (2) one (...) with a background corresponding to a space of constant curvature which introduces modifications into general relativity under certain conditions. The gravitational energy density in the case of the Schwarzschild solution is obtained. (shrink)

This study aims to assess the localization of Schema.org for manuscript description in the Iranian-Islamic information context using documentary and qualitative content analysis. The schema.org introduces schemas for different Web content objects so as to generate structured data. Given that the structure of Schema.org is ontological, the inheritance of the manuscript types from the properties of their parent types, as well as the localization and description of the specific properties of the manuscripts in the Iranian-Islamic information context were (...) investigated in order to improve their indexability and semantic visibility in the Web search engines. The proposed properties specific to the manuscript type and the six proposed properties to be added to the “CreativeWork” type are found to be consistent with other schema properties. In turn, these properties lead to the localization of the existing schema for the manuscript type compatibility with the Iranian-Islamic information context. This schema is also applicable to centers with published records on the Web, and if markup with these properties, their indexability and semantic visibility in Web search engines increases accordingly. The generation of structured data in the Web environment through this schema is deemed to promote the concept of the Semantic Web, and make data and knowledge retrieval easier. (shrink)

Alzheimer's disease is characterized by amyloid-beta peptide -loaded plaques in the brain. Abeta is a cleavage fragment of amyloid-beta protein precursor and over production of APP may lead to amyloidogenesis. The regulatory region of the APP gene contains consensus sites recognized by the transcription factor, specificity protein 1 , which has been shown to be required for the regulation of APP and Abeta. To understand the role of SP1 in APP biogenesis, herein we have characterized the relative distribution and (...) class='Hi'>localization of SP1, APP, and Abeta in various brain regions of rodent and primate models using immunohistochemistry. We observed that overall distribution and cellular localization of SP1, APP, and Abeta are similar and neuronal in origin. Their distribution is abundant in various layers of neocortex, but restricted to the Purkinje cell layer of the cerebellum, and the pyramidal cell layer of hippocampus. These findings suggest that overproduction of Abeta in vivo may be associated with transcriptional pathways involving SP1 and the APP gene. (shrink)

Starting from the phase space representation of quantum mechanics we provide an Euclidean system of covariance for the photon. In particular, we consider systems with the Poincaré group as the symmetry group and use a standard procedure in order to build a phase space and a localization observable on the phase space. Then we focus on the massless representations of the Poincaré group that we use to build a space localization observable for the photon.

The concept of event provides the essential bridge from the realm of virtuality of the quantum state to real phenomena in space and time. We ask how much we can gather from existing theory about the localization of an event and point out that decoherence and coarse graining—though important—do not suffice for a consistent interpretation without the additional principle of random realization.

In the late 19th century, physiologists such as David Ferrier, Eduard Hitzig, and Hermann Munk argued that cerebral brain functions are localized in discrete structures. By the early 20th century, this became the dominant position. However, another prominent physiologist, Friedrich Goltz, rejected theories of cerebral localization and argued against these physiologists until his death in 1902. I argue in this paper that previous historical accounts have failed to comprehend why Goltz rejected cerebral localization. I show that Goltz adhered (...) to a falsificationist methodology, and I reconstruct how he designed his experiments and weighted different kinds of evidence. I then draw on the exploratory experimentation literature from recent philosophy of science to trace one root of the debate to differences in how the German localizers designed their experiments and reasoned about evidence. While Goltz designed his experiments to test hypotheses about the functions of predetermined cerebral structures, the localizers explored new functions and structures in the process of constructing new theories. I argue that the localizers relied on untested background conjectures to justify their inferences about functional organization. These background conjectures collapsed a distinction between phenomena they produced direct evidence for (localized symptoms) and what they reached conclusions about (localized functions). (shrink)

BackgroundThe neural activity and functional networks of emotion-based cognitive reappraisal have been widely investigated using electroencephalography and functional magnetic resonance imaging. However, single-mode neuroimaging techniques are limited in exploring the regulation process with high temporal and spatial resolution.ObjectivesWe proposed a source localization method with multimodal integration of EEG and fMRI and tested it in the source-level functional network analysis of emotion cognitive reappraisal.MethodsEEG and fMRI data were simultaneously recorded when 15 subjects were performing the emotional cognitive reappraisal task. Fused (...) priori weighted minimum norm estimation with sliding windows was proposed to trace the dynamics of EEG source activities, and the phase lag index was used to construct the functional brain network associated with the process of downregulating negative affect using the reappraisal strategy.ResultsThe functional networks were constructed with the measure of PLI, in which the important regions were indicated. In the gamma band source-level network analysis, the cuneus, the lateral orbitofrontal cortex, the superior parietal cortex, the postcentral gyrus, and the pars opercularis were identified as important regions in reappraisal with high betweenness centrality.ConclusionThe proposed multimodal integration method for source localization identified the key cortices involved in emotion regulation, and the network analysis demonstrated the important brain regions involved in the cognitive control of reappraisal. It shows promise in the utility in the clinical setting for affective disorders. (shrink)

In the United States, approximately 2.53 million people sustain a concussion each year. Relative to adults, youth show greater cognitive deficits following concussion and a longer recovery. An accurate and reliable imaging method is needed to determine injury severity and symptom resolution. The primary objective of this study was to characterize concussions with diffusion tensor imaging. This was performed through a normative Z-scoring analysis of DTI metrics, fractional anisotropy, axial diffusivity, and radial diffusivity, to quantify patient-specific injuries and identify commonly (...) damaged brain regions in paediatric concussion patients relative to healthy controls. It was hypothesized that personalizing the detection analysis through normative Z-scoring would provide an understanding of trauma-induced microstructural damage. Concussion patients were volunteers recruited from the Emergency Department of the McMaster Children’s Hospital with a recent concussion, 9 males and 17 females, mean age 14.22 ± 2.64, while healthy paediatric brain DTI datasets were obtained from an MRI data repository. Significant abnormalities were commonly found in the longitudinal fasciculus, fronto-occipital fasciculus, and corticospinal tract, while unique abnormalities were localized in a number of other areas reflecting the individuality of each child’s injury. Total injury burden, determined by the number of regions containing outliers per DTI metric per patient, was used as the metric to quantify the overall injury severity of each patient. The primary outcome of this analysis found that younger patients experienced a significantly greater injury burden when measured using fractional anisotropy. These results show that DTI was able to detect microstructural changes caused by concussion, on a per-person basis, and has the potential to be a useful tool for improving diagnostic accuracy and prognosis of a concussion. (shrink)

Several articles have recently appeared arguing that there really are no viable alternatives to mechanistic explanation in the biological sciences (Kaplan and Bechtel; Kaplan and Craver). We argue that mechanistic explanation is defined by localization and decomposition. We argue further that systems neuroscience contains explanations that violate both localization and decomposition. We conclude that the mechanistic model of explanation needs to either stretch to now include explanations wherein localization or decomposition fail or acknowledge that there are counterexamples (...) to mechanistic explanation in the biological sciences. (shrink)

William Uttal's The new phrenology is a broad attack on localization in cognitive neuroscience. He argues that even though the brain is a highly differentiated organ, "high level cognitive functions" should not be localized in specific brain regions. First, he argues that psychological processes are not well-defined. Second, he criticizes the methods used to localize psychological processes, including imaging technology: he argues that variation among individuals compromises localization, and that the statistical methods used to construct activation maps are (...) flawed. Neither criticism is compelling. First, as we illustrate, there are behavioral measures which offer at least weak constraints on psychological attribution. Second, though imaging does face methodological difficulties associated with variation among individuals, these are broadly acknowledged; moreover, his specific criticisms of the imaging work, and in particular of fMRI, misrepresent the methodology. In concluding, we suggest a way of framing the issues that might allow us to resolve differences between localizationist models and more distributed models empirically. (shrink)

The problem of finding a covariant expression for the distribution and conservation of gravitational energy-momentum dates to the 1910s. A suitably covariant infinite-component localization is displayed, reflecting Bergmann's realization that there are infinitely many gravitational energy-momenta. Initially use is made of a flat background metric (or rather, all of them) or connection, because the desired gauge invariance properties are obvious. Partial gauge-fixing then yields an appropriate covariant quantity without any background metric or connection; one version is the collection of (...) pseudotensors of a given type, such as the Einstein pseudotensor, in _every_ coordinate system. This solution to the gauge covariance problem is easily adapted to any pseudotensorial expression (Landau-Lifshitz, Goldberg, Papapetrou or the like) or to any tensorial expression built with a background metric or connection. Thus the specific functional form can be chosen on technical grounds such as relating to Noether's theorem and yielding expected values of conserved quantities in certain contexts and then rendered covariant using the procedure described here. The application to angular momentum localization is straightforward. Traditional objections to pseudotensors are based largely on the false assumption that there is only one gravitational energy rather than infinitely many. (shrink)

The aim of this contribution is to analyze the difficulties and possible inconsistencies one may encounter when attempting to integrate substance philosophy and process philosophy. I argue that it is impossible to avoid these problems, and offer a typology that helps to understand the tensions involved in attempts to integrate these two worldviews.

This dissertation reconsiders some traditional issues in the foundations of quantum mechanics in the context of relativistic quantum field theory (RQFT); and it considers some novel foundational issues that arise first in the context of RQFT. The first part of the dissertation considers quantum nonlocality in RQFT. Here I show that the generic state of RQFT displays Bell correlations relative to measurements performed in any pair of spacelike separated regions, no matter how distant. I also show that local systems in (...) RQFT are "open" to influence from their environment, in the sense that it is generally impossible to perform local operations that would remove the entanglement between a local system and any other spacelike separated system. The second part of the dissertation argues that RQFT does not support a particle ontology -- at least if particles are understood to be localizable objects. In particular, while RQFT permits us to describe situations in which a determinate number of particles are present, it does not permit us to speak of the location of any individual particle, nor of the number of particles in any particular region of space. Nonetheless, the absence of localizable particles in RQFT does not threaten the integrity of our commonsense concept of a localized object. Indeed, RQFT itself predicts that descriptions in terms of localized objects can be quite accurate on the macroscopic level. The third part of the dissertation examines the so-called observer-dependence of the particle concept in RQFT -- that is, whether there are any particles present must be relativized to an observer's state of motion. Now, it is not uncommon for modern physical theories to subsume observer-dependent descriptions under a more general observer-independent description of some underlying state of affairs. However, I show that the conflicting accounts concerning the particle content of the field cannot be reconciled in this way. In fact, I argue that these conflicting accounts should be thought of as "complementary" in the same sense that position and momentum descriptions are complementary in elementary quantum mechanics. (shrink)