16 found
Order:
Disambiguations
Louis J. Goldberg [12]Louis Goldberg [4]
  1. The OBO Foundry: Coordinated evolution of ontologies to support biomedical data integration.Barry Smith, Michael Ashburner, Cornelius Rosse, Jonathan Bard, William Bug, Werner Ceusters, Louis J. Goldberg, Karen Eilbeck, Amelia Ireland, Christopher J. Mungall, Neocles Leontis, Philippe Rocca-Serra, Alan Ruttenberg, Susanna-Assunta Sansone, Richard H. Scheuermann, Nigam Shah, Patricia L. Whetzel & Suzanna Lewis - 2007 - Nature Biotechnology 25 (11):1251-1255.
    The value of any kind of data is greatly enhanced when it exists in a form that allows it to be integrated with other data. One approach to integration is through the annotation of multiple bodies of data using common controlled vocabularies or ‘ontologies’. Unfortunately, the very success of this approach has led to a proliferation of ontologies which itself creates obstacles to integration. The Open Biomedical Ontologies (OBO) consortium has set in train a strategy to overcome this problem. Existing (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   145 citations  
  2. How Is Meaning Grounded in the Organism?Liz Stillwaggon Swan & Louis J. Goldberg - 2010 - Biosemiotics 3 (2):131-146.
    In this paper we address the interrelated questions of why and how certain features of an organism’s environment become meaningful to it. We make the case that knowing the biology is essential to understanding the foundation of meaning-making in organisms. We employ Miguel Nicolelis et al’s seminal research on the mammalian somatosensory system to enrich our own concept of brain-objects as the neurobiological intermediary between the environment and the consequent organismic behavior. In the final section, we explain how brain-objects advance (...)
    Direct download (5 more)  
     
    Export citation  
     
    Bookmark   26 citations  
  3. Biodynamic Ontology: Applying BFO in the Biomedical Domain.Barry Smith, Pierre Grenon & Louis Goldberg - 2004 - Studies in Health and Technology Informatics 102:20–38.
    Current approaches to formal representation in biomedicine are characterized by their focus on either the static or the dynamic aspects of biological reality. We here outline a theory that combines both perspectives and at the same time tackles the by no means trivial issue of their coherent integration. Our position is that a good ontology must be capable of accounting for reality both synchronically (as it exists at a time) and diachronically (as it unfolds through time), but that these are (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   33 citations  
  4.  58
    Biosymbols: Symbols in Life and Mind.Liz Stillwaggon Swan & Louis J. Goldberg - 2010 - Biosemiotics 3 (1):17-31.
    The strong continuity thesis postulates that the properties of mind are an enriched version of the properties of life, and thus that life and mind differ in degree and not kind. A philosophical problem for this view is the ostensive discontinuity between humans and other animals in virtue of our use of symbols—particularly the presumption that the symbolic nature of human cognition bears no relation to the basic properties of life. In this paper, we make the case that a genuine (...)
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark   28 citations  
  5. A terminological and ontological analysis of the NCI thesaurus.Werner Ceusters, Barry Smith & Louis Goldberg - 2005 - Methods of Information in Medicine 44 (4):498-507.
    We performed a qualitative analysis of the Thesaurus in order to assess its conformity with principles of good practice in terminology and ontology design. We used both the on-line browsable version of the Thesaurus and its OWL-representation (version 04.08b, released on August 2, 2004), measuring each in light of the requirements put forward in relevant ISO terminology standards and in light of ontological principles advanced in the recent literature. Version 04.08b of the NCI Thesaurus suffers from the same broad range (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   21 citations  
  6. Towards an ontology of pain.Barry Smith, Werner Ceusters, Louis J. Goldberg & Richard Ohrbach - 2011 - In Barry Smith, Werner Ceusters, Louis J. Goldberg & Richard Ohrbach (eds.), Towards an ontology of pain. Keio University Press.
    We present an ontology of pain and of other pain-related phenomena, building on the definition of pain provided by the International Association for the Study of Pain (IASP). Our strategy is to identify an evolutionarily basic canonical pain phenomenon, involving unpleasant sensory and emotional experience based causally in localized tissue damage that is concordant with that experience. We then show how different variant cases of this canonical pain phenomenon can be distinguished, including pain that is elevated relative to peripheral trauma, (...)
    Direct download  
     
    Export citation  
     
    Bookmark   8 citations  
  7. A biosemiotic analysis of Braille.Louis J. Goldberg & Liz Stillwaggon Swan - 2011 - Biosemiotics 4 (1):25-38.
    Abstract A unique aspect of human communication is the utilization of sets of well- delineated entities, the morphology of which is used to encode the letters of the alphabet. In this paper, we focus on Braille as an exemplar of this phenomenon. We take a Braille cell to be a physical artifact of the human environment, into the structure of which is encoded a representation of a letter of the alphabet. The specific issue we address in this paper concerns an (...)
    Direct download (4 more)  
     
    Export citation  
     
    Bookmark   3 citations  
  8. Ontology and the Future of Dental Research Informatics.Barry Smith, Louis J. Goldberg, Alan Ruttenberg & Michael Glick - 2010 - Journal of the American Dental Association 141 (10):1173-75.
    How do we find what is clinically significant in the swarms of data being generated by today’s diagnostic technologies? As electronic records become ever more prevalent – and digital imaging and genomic, proteomic, salivaomics, metabalomics, pharmacogenomics, phenomics and transcriptomics techniques become commonplace – fdifferent clinical and biological disciplines are facing up to the need to put their data houses in order to avoid the consequences of an uncontrolled explosion of different ways of describing information. We describe a new strategy to (...)
    Direct download  
     
    Export citation  
     
    Bookmark   3 citations  
  9.  67
    Face Recognition and the Social Individual.Louis J. Goldberg - 2013 - Biosemiotics 6 (3):573-583.
    Face recognition depends upon the uniqueness of each human face. This is accomplished by the patterns formed by the unique relationship among face features. Unique face-patterns are produced by the intrusion of random factors into the process of biological growth and development. Processes are described which enable a unique face-pattern to be represented as a percept in the visual sensory system. The components of the face recognition system are analyzed as is the manner in which the precept is connected through (...)
    Direct download (5 more)  
     
    Export citation  
     
    Bookmark   2 citations  
  10.  37
    On the Genetic and Epigenetic Bases of Primate Signal Processing.Louis J. Goldberg & Leonard A. Rosenblum - 2013 - Biosemiotics 6 (2):161-176.
    Four sequential, sub-processes are identified as the fundamental steps in the processing of signals by big-brained animals. These are, Detection of the signal, its Representation in correlated sensory brain structure, the Interpretation of the signal in another part of the brain and the Expression of the receiver’s response. We label this four-step spatiotemporal process DRIE. We support the view that when the context within which such signals are produced and received is relatively constant, the DRIE process can be ultimately assimilated (...)
    Direct download (5 more)  
     
    Export citation  
     
    Bookmark   2 citations  
  11. The significance of SNODENT.Louis Goldberg, Werner Ceusters, John Eisner & Barry Smith - 2005 - Medical Informatics Europe 2005: 737-742.
    SNODENT is a dental diagnostic vocabulary incompletely integrated in SNOMED-CT. Nevertheless, SNODENT could become the de facto standard for dental diagnostic coding. SNODENT's manageable size, the fact that it is administratively self-contained, and relates to a well-understood domain provides valuable opportunities to formulate and test, in controlled experiments, a series of hypothesis concerning diagnostic systems. Of particular interest are questions related to establishing appropriate quality assurance methods for its optimal level of detail in content, its ontological structure, its construction and (...)
    No categories
    Direct download  
     
    Export citation  
     
    Bookmark  
  12. More about ontology: Response.Barry Smith, Louis Goldberg, Michael Glick & Alan Ruttenberg - 2011 - Journal of the American Dental Association 142 (3):252-254.
    Letter commenting on the paper Barry Smith, Louis J. Goldberg, Alan Ruttenberg & Michael Glick, "Ontology and the Future of Dental Research Informatics", Journal of the American Dental Association 141 2010;(10):1173-75 with responses by the authors of the paper.
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark  
  13.  48
    The Egg as a Semiotic Gateway to Reproduction.Franco Giorgi, Luis Emilio Bruni & Louis J. Goldberg - 2013 - Biosemiotics 6 (3):489-496.
    The egg behaves as a prospective cell sustaining the developmental processes of the future embryo. In biosemiotic terms, this apparent teleonomic behaviour can be accounted for without referring to the exclusive causal role played by its genetic makeup. We envision two different processes that are uniquely found in the oocyte: (1) the first involves the mechanisms by which large amounts of mRNA accumulate in the ooplasm to establish the embryo axes prior to fertilization; (2) the second involves transfer of an (...)
    Direct download (5 more)  
     
    Export citation  
     
    Bookmark  
  14.  91
    The Codes of Recognition.Louis J. Goldberg & Leonard A. Rosenblum - 2014 - Biosemiotics 7 (2):279-298.
    This paper is divided into two parts. Part I focuses on the manner in which the components of the face recognition system work together so that a perceiver, within several hundred milliseconds after seeing a familiar face, is able to both identify the face of the perceived and recall elements of the history of past encounters with the perceived. Face recognition plays a crucial role in enabling both human and nonhuman primates to interact in collaborative social groups. This critical function (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  15.  16
    The failure of current strategies in the study of central pattern generators.Louis J. Goldberg - 1980 - Behavioral and Brain Sciences 3 (4):548-549.
  16.  40
    Introduction: Mentis Naturalis. [REVIEW]Liz Stillwaggon Swan & Louis J. Goldberg - 2013 - Biosemiotics 6 (3):297-300.