10 found
  1. The Placebo Phenomenon and Medical Ethics: Rethinking the Relationship Between Informed Consent and Risk–Benefit Assessment.Franklin G. Miller & Luana Colloca - 2011 - Theoretical Medicine and Bioethics 32 (4):229-243.
    It has been presumed within bioethics that the benefits and risks of treatments can be assessed independently of information disclosure to patients as part of the informed consent process. Research on placebo and nocebo effects indicates that this is not true for symptomatic treatments. The benefits and risks that patients experience from symptomatic treatments can be shaped powerfully by information about these treatments provided by clinicians. In this paper we discuss the implications of placebo and nocebo research for risk–benefit assessment (...)
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  2.  7
    Are Open‐Label Placebos Ethical? Informed Consent and Ethical Equivocations.Charlotte Blease, Luana Colloca & Ted J. Kaptchuk - 2016 - Bioethics 30 (6):407-414.
    The doctor-patient relationship is built on an implicit covenant of trust, yet it was not until the post-World War Two era that respect for patient autonomy emerged as an article of mainstream medical ethics. Unlike their medical forebears, physicians today are expected to furnish patients with adequate information about diagnoses, prognoses and treatments. Against these dicta there has been ongoing debate over whether placebos pose a threat to patient autonomy. A key premise underlying medical ethics discussion is the notion that (...)
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  3.  52
    The Legitimacy of Placebo Treatments in Clinical Practice: Evidence and Ethics.Franklin G. Miller & Luana Colloca - 2009 - American Journal of Bioethics 9 (12):39-47.
    Physicians commonly recommend ?placebo treatments?, which are not believed to have specific efficacy for the patient's condition. Motivations for placebo treatments include complying with patient expectations and promoting a placebo effect. In this article, we focus on two key empirical questions that must be addressed in order to assess the ethical legitimacy of placebo treatments in clinical practice: 1) do placebo treatments have the potential to produce clinically significant benefit? and 2) can placebo treatments be effective in promoting a therapeutic (...)
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  4. Relieving Pain Using Dose-Extending Placebos.Luana Colloca, Paul Enck & David DeGrazia - 2016 - PAIN 157:1590-1598.
    Placebos are often used by clinicians, usually deceptively and with little rationale or evidence of benefit, making their use ethically problematic. In contrast with their typical current use, a provocative line of research suggests that placebos can be intentionally exploited to extend analgesic therapeutic effects. Is it possible to extend the effects of drug treatments by interspersing placebos? We reviewed a database of placebo studies, searching for studies that indicate that placebos given after repeated administration of active treatments acquire medication-like (...)
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    The Placebo Effect: Illness and Interpersonal Healing.Franklin G. Miller, Luana Colloca & Ted J. Kaptchuk - 2009 - Perspectives in Biology and Medicine 52 (4):518-539.
  6.  16
    Patient Autonomy and Provider Beneficence Are Compatible.Howard Brody & Luana Colloca - 2013 - Hastings Center Report 43 (6):6-6.
  7.  70
    Semiotics and the Placebo Effect.Franklin G. Miller & Luana Colloca - 2010 - Perspectives in Biology and Medicine 53 (4):509-516.
    Despite growing scientific interest in the placebo effect and increasing understanding of neurobiological mechanisms (Finniss et al. 2010), theoretical conceptualization of the placebo effect remains primitive (Miller, Colloca, and Kaptchuk 2009). Mechanistic research on this phenomenon appears largely free-floating, with little guidance by any systematic theoretical paradigm. A partial explanation is the pervasive conceptual confusion that characterizes thinking about the placebo effect. The philosopher of science Adolf Grunbaum noted that "the medical and psychiatric literature on placebos and their effects is (...)
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    Tell Me the Truth and I Will Not Be Harmed: Informed Consents and Nocebo Effects.Luana Colloca - 2017 - American Journal of Bioethics 17 (6):46-48.
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    The Placebo Phenomenon: A Narrow Focus on Psychological Models.Nathalie Peiris, Maxie Blasini, Thelma Wright & Luana Colloca - 2018 - Perspectives in Biology and Medicine 61 (3):388-400.
    One of the most successful physicians I have ever known, has assured me, that he used more bread pills, drops of colored water, and powders of hickory ashes, than of all other medicines put together. It was certainly a pious fraud.Clinicians and other health-care practitioners have known for hundreds of years that different procedures with unclear mechanisms of action or efficaciousness can still result in subjective improvement of clinical symptoms. Many scholars have attempted to define the placebo effect. This has (...)
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    Informed Consent: Hints From Placebo and Nocebo Research.Luana Colloca - 2015 - American Journal of Bioethics 15 (10):17-19.