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Lucie Laplane
CNRS, Université Paris I Panthéon-Sorbonne
  1.  10
    Cancer Stem Cells: Philosophy and Therapies.Lucie Laplane - 2016 - Cambridge (Massachusetts): Harvard University Press.
  2. Stem Cells and the Temporal Boundaries of Development: Toward a Species-Dependent View.Lucie Laplane - 2011 - Biological Theory 6 (1):48-58.
    The tacit standard view that development ends once reproductive capacity is acquired (reproductive boundary, or ‘‘RB,’’ thesis) has recently been challenged by biologists and philosophers of biology arguing that development continues until death (death boundary, or ‘‘DB,’’ thesis). The relevance of these two theses is difficult to assess because the fact that there is no precise definition of development makes the determination of its temporal boundaries problematic. Taking into account this difficulty, this article tries to develop a new species-dependent perspective (...)
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  3.  36
    Cancer Stem Cells Modulate Patterns and Processes of Evolution in Cancers.Lucie Laplane - 2018 - Biology and Philosophy 33 (3-4):18.
    The clonal evolution model and the cancer stem cell model are two independent models of cancers, yet recent data shows intersections between the two models. This article explores the impacts of the CSC model on the CE model. I show that CSC restriction, which depends on CSC frequency in cancer cell populations and on the probability of dedifferentiation of cancer non-stem cells into CSCs, can favor or impede some patterns of evolution and some processes of evolution. Taking CSC restriction into (...)
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  4.  50
    The Boundaries of Development.Thomas Pradeu, Lucie Laplane, Michel Morange, Antonine Nicoglou & Michel Vervoort - 2011 - Biological Theory 6 (1):1 - 3.
    This special issue of Biological Theory is focused on development; it raises the problem of the temporal and spatial boundaries of development. From a temporal point of view, when does development start and stop? From a spatial point of view, what is it exactly that "develops", and is it possible to delineate clearly the developing entity? This issue explores the possible answers to these questions, and thus sheds light on the definition of development itself.
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  5.  41
    Metastasis as Supra-Cellular Selection? A Reply to Lean and Plutynski.Germain Pierre-Luc & Lucie Laplane - 2017 - Biology and Philosophy 32 (2):281-287.
    In response to Germain argument that evolution by natural selection has a limited explanatory power in cancer, Lean and Plutynski have recently argued that many adaptations in cancer only make sense at the tumor level, and that cancer progression mirrors the major evolutionary transitions. While we agree that selection could potentially act at various levels of organization in cancers, we argue that tumor-level selection is unlikely to actually play a relevant role in our understanding of the somatic evolution of human (...)
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  6.  27
    Defining "Development".Thomas Pradeu, Lucie Laplane, Karine Prévot, Thierry Hoquet, Valentine Reynaud, Giuseppe Fusco, Alessandro Minelli, Virginie Orgogozo & Michel Vervoort - unknown
    Is it possible, and in the first place is it even desirable, to define what "development" means and to determine the scope of the field called "developmental biology"? Though these questions appeared crucial for the founders of "developmental biology" in the 1950s, there seems to be no consensus today about the need to address them. Here, in a combined biological, philosophical, and historical approach, we ask whether it is possible and useful to define biological development, and, if such a definition (...)
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  7.  12
    Stem Cell Epistemological Issues. Chapter in Charbord P and Durand C (Eds) Stem Cell Biology and Regenerative Medicine.Lucie Laplane - 2015 - River Publishers.
    This chapter brings a philosophical perspective to the concept of stem cell. Three general questions both clarify the concept of stem cell and emphasize its ambiguities: (1) How should we define stem cells? (2) What makes them different from non-stem cells? (3) What is their ontology? (i.e. what kind of property is “stemness”?) Following this last question, the Chapter distinguishes four conceptions of stem cells and highlights their respective consequences for the cancer stem cell theory. Determining what kind of property (...)
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  8.  16
    Reprogramming and Stemness.Lucie Laplane - 2015 - Perspectives in Biology and Medicine 58 (2):229-246.
    Reprogramming technologies show that cellular identity can be reprogrammed, challenging the classical conception of cell differentiation as an irreversible process. If non-stem cells can be reprogrammed into stem cells, then what is it to be a stem cell, and what kind of property is stemness? This article addresses this question both philosophically and biologically, states the different possibilities, and illustrates their potential consequences for science with the example of anti-cancer therapies.
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  9. Posterior Elongation in the Annelid Platynereis Dumerilii Involves Stem Cells Molecularly Related to Primordial Germ Cells.Gazave Eve, Béhague Julien, Lucie Laplane, Guillou Aurélien, Demilly Adrien, Balavoine Guillaume & Vervoort Michel - 2013 - Developmental Biology 1 (382):246-267.
    Like most bilaterian animals, the annelid Platynereis dumerilii generates the majority of its body axis in an anterior to posterior temporal progression with new segments added sequentially. This process relies on a posterior subterminal proliferative body region, known as the "segment addition zone" (SAZ). We explored some of the molecular and cellular aspects of posterior elongation in Platynereis, in particular to test the hypothesis that the SAZ contains a specific set of stem cells dedicated to posterior elongation.We cloned and characterized (...)
     
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  10.  4
    Anya Plutynski, explaining cancer. Finding order in disorder, oxford: Oxford university press, 2018, 280pp., £47.99. [REVIEW]Lucie Laplane - 2019 - History and Philosophy of the Life Sciences 41 (4):43.
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  11.  3
    Anya Plutynski, explaining cancer. Finding order in disorder, oxford: Oxford university press, 2018, 280pp., £47.99. [REVIEW]Lucie Laplane - 2019 - History and Philosophy of the Life Sciences 41 (4):43.
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  12.  7
    Induced Pluripotent Stem Cells as New Model Systems in Oncology.Lucie Laplane, Allan Beke, William Vainchenker & Eric Solary - 2015 - Stem Cells 33:2887-2892.
    The demonstration that pluripotent stem cells could be generated by somatic cell reprogramming led to wonder if these so-called induced pluripotent stem (iPS) cells would extend our investigation capabilities in the cancer research field. The first iPS cells derived from cancer cells have now revealed the benefits and potential pitfalls of this new model. iPS cells appear to be an innovative approach to decipher the steps of cell transformation as well as to screen the activity and toxicity of anticancer drugs. (...)
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