Identification of non-coding RNAs (ncRNAs) has been significantly improved over the past decade. On the other hand, semantic annotation of ncRNA data is facing critical challenges due to the lack of a comprehensive ontology to serve as common data elements and data exchange standards in the field. We developed the Non-Coding RNA Ontology (NCRO) to handle this situation. By providing a formally defined ncRNA controlled vocabulary, the NCRO aims to fill a specific and highly needed niche in semantic annotation of (...) large amounts of ncRNA biological and clinical data. (shrink)
Identification of non-coding RNAs (ncRNAs) has been significantly enhanced due to the rapid advancement in sequencing technologies. On the other hand, semantic annotation of ncRNA data lag behind their identification, and there is a great need to effectively integrate discovery from relevant communities. To this end, the Non-Coding RNA Ontology (NCRO) is being developed to provide a precisely defined ncRNA controlled vocabulary, which can fill a specific and highly needed niche in unification of ncRNA biology.
Alzheimer's disease is the most common neurodegenerative disorder in today's developed world that is also increasingly picked out as a focal theme in fictional literature. In dealing with the subjectivity of human experience, such literature enhances the reader's empathy and is able to teach about moral, emotional and philosophical issues, offering the chance to see situations from a position otherwise possibly never taken by the reader. The understanding and insight so gained may well be unscientific, but the literary approach offers (...) an insight into the whole person's perspective and the particularity and uniqueness of a situation that includes ethical conflicts. A key motif of fictional literature centred around dementia remains the burden the adult-child carer is confronted with, considering the parent's remorseless decline and personality change, the sudden demand for devoted and continuous care, and the constantly changing relationship with the declining parent. In the context of an ever increasing demand for a constructive public discussion regarding end-of-life treatment of demented patients, Christine Devars (Le Piano Désaccordé) and Andrés Barba (Ahora Tocad Música de Baile) illustrate how powerful and burdensome the impact of Alzheimer's disease is on both patient and carer and what extremes may be reached under such truly exceptional circumstances. (shrink)
This paper investigates the effects of (surface) DP-internal quantifying expressions on semantic interpretation. In particular, I investigate two syntactic constructions in which an adjective takes scope out of its embedding DP, thus raising an interesting question for strict compositionality. Regarding the first construction, I follow Larson (1999) and assume that the adjective incorporates into the determiner of its DP, forming a complex quantifier [D+A]. I present new evidence in favor of this analysis. Since Larson's semantic analysis of complex quantifiers [D+A] (...) makes a wrong prediction, I propose an alternative, empirically more adequate analysis that treats D+A compounds as pluractional quantifiers in the sense of Lasersohn (1995). Finally, I turn to the second construction, arguing that – despite superficial similarities to the first construction - it should not be analyzed in terms of complex quantifier formation, but in terms of LF-movement of the adjective to Spec,DP. The discussion suggests that there is more than one way for DP-internal modifiers to take DP-external scope in natural language. (shrink)
‘Mimesis’ is a concept explored in Antiquity as well as in cultural history. It also plays an important role in the Bible. In this article we argue for ‘mimesis’ as a role model for Bible teaching in religious education. In the first part we give some insights into the concept of mimesis, drawing on ancient philosophers. ‘Mimesis’ does not denote a copy of a prescribed object; instead, the type of depiction and reference brings it into the present in an intensive, (...) creative and productive way. In the second part we want to give some examples for how ‘mimesis’ is used in the Bible itself. Biblical tradition can be described as a ‘mimetic process’. Furthermore, authors like Paul explicitly use the concept of ‘mimesis’, for example in his ethical admonition. Thus, the use of ‘mimesis’ in the Bible inspires directly our teaching on biblical genres, motifs and ways of thinking. The third part gives a draft of how the ‘mimetic didactic’ works, drawing on parables, Gospel writing, Johannine theology and coping with painful fate like Job. Mimetic hermeneutics transforms tradition in applying it into the contemporary situation. This can prove stimulating for contemporary contexts: mimesis is closely connected to tradition, but simultaneously encourages its transmission into the present day with astonishing variability and freedom. (shrink)
Cerebro-vascular events are, after neurodegenerative disorders, the most frequent cause of brain damage that leads to the patient's impaired cognitive and/or bodily functioning. While the medico-scientific discourse related to stroke suggests that patients experience a change in identity and self-concept, the present analysis focuses on the patients' personal presentation of their experience to, first, highlight their way of thinking and feeling and, second, contribute to the clinician's actual understanding of the meaning of stroke within the life of each individual. As (...) stroke ‘victims’ necessarily speak from the position of having undergone very abrupt degeneration followed by being confronted with a gradual relocation within their ‘recovery’, the present study addresses how narrative texts describe the condition, that is, the insult itself and its impairing consequences for body and mind, and how patients portray themselves within their illness. Furthermore, given that all illness narrative must remain non-representative, especially when exploring conditions that impair cognitive abilities, autobiographically inspired fiction, equally, contributes to neuroscientific perspectives on embodiment: it gives further insight into how the condition is perceived and alerts us to those aspects of the experience that are understood as particularly momentous. (shrink)
This article explores how Alzheimer’s disease caregivers struggle under the impact of a parent’s memory loss on their own personality. In particular, it analyses how caregivers perceive and, thus, present their experiences of the ever intensifying caregiving activity in terms of a ‘journey’. In doing so, this work takes into account both the patient’s continuing bodily as well as cognitive decline and its intricately linked influence on the caregiver’s physical and emotional stability. Equally, this study investigates how caregivers portray memory (...) loss, and how their portrayal fits into our conceptualisation of illness narratives and the culture of autobiographical writing. (shrink)
The guidelines of the >German Medical Association< for doctors treating the dying passed on 11. Sept. 1998 are trying to provide an ethically justified frame for medical decisions conceming the end of life. In certain justified cases they allow non-treatment decisions and allevation of pain and symptoms that might cause the patient's death while they strictly reject voluntary active euthanasia, non-voluntary euthanasia or assisted suicide.
In this article, we reconsider the syntactical analysis as well as the categorial status of two Medieval French elements, et and ne. In this connection, we illustrate and compare various approaches which principally differ with regard to the assignment of a unique category or of various categories to these elements. In the context of this comparison, we address some of the questions pertaining to their motivations and the evidence which has been offered in their favor, showing that approaches which assign (...) a unique category to et and ne, respectively, prove to be empirically more adequate. (shrink)
Zusammenfassung Der Aufsatz beschäftigt sich mit den bei Strabon überlieferten moralischen Reformen des dakischen Herrschers Burebista, die dieser zusammen mit dem Priester Dekaineos/dekinais durchgeführt haben soll. Es wird dargelegt, dass die Reformen ein literarisches Konstrukt Strabons sind, die im Kontext des Dakerbilds des augusteischen Rom und der Selbstdarstellung des Augustus zu sehen sind, und dazu dienten, die Aufgabe ehemaliger Eroberungspläne des Augustus in Dakien zu relativieren.