Paediatric genomic research raises particularly challenging questions on whether and under what circumstances to return research results. In the paediatric context, decision-making is guided by the best interests of the child framework, as enshrined in the 1989 international Convention on the Rights of the Child. According to this Convention, rights and responsibilities are shared between children, parents, researchers, and the state. These "relational" obligations are further complicated in the context of genetic research.

Volume 19, Issue 5, May 2019, Page 36-38.

This article examines the complex and contemporary issue of the return of research results in biobanks. After suggesting the exclusion of some adjacent issues usually flanking the debate, this article reviews the current practices of biobanks on the disclosure of research results to participants. It then focuses more specifically on the debate in the literature before turning to a review of the typology of recent reforms being put forward.

In 2009, Time magazine named “biobanks” as one of the 10 ideas changing the world. These organized collections of human biological material and associated data have been identified as “vital research tools in the drive to uncover the consequences of human health and disease.” Since their inception, however, biobanks have faced ethical and legal challenges. Whether these pertain to informed consent, access by researchers, commercialization, confidentiality, or governance, biobanks must continue to address jurisdictional matters, operational difficulties, and normative frameworks that (...) strive to stay abreast of current scientific innovation. Yet, with some biobanks now having completed their recruitment objectives and with research currently being performed on their data and samples, one topic has become the focus of ongoing debates: the return of research results to participants. (shrink)

In an era of unrivalled sequencing, computation and networking capability, international sharing of genomic samples and data is becoming a modus operandi for modern medical research. Researchers are collaborating to establish large collections with global scale. Having never before set foot outside the cell, the molecules that shape us are being digitized and launched across the globe. Protecting individual privacy interests in this information is a central challenge of the genomic research era. This article reviews international privacy norms governing human (...) genomic biobanks and databases. It will not directly consider biobanks established for other health-related purposes, such as screening or therapy. A genomic biobank is “a hybrid infrastructure,” an organized collection of human biological material combined with associated health information: physical measurements, outcome data in medical records, and epidemiological information, as well as genomic data derived from the samples. (shrink)

In this paper, we outline the policy implications of mobile health research conducted at the international level. We describe the manner in which such research may have an international dimension and argue that it is not likely to be excluded from conventionally applicable international regulatory tools. We suggest that closer policy attention is needed for this rapidly proliferating approach to health research.

Machine learning is an increasingly significant part of modern healthcare, transforming the way clinical decisions are made and health resources are managed. These developme...

The DAMA project is an observatory for rare processes and it is operative deep underground at the Gran Sasso National Laboratory of the I.N.F.N. In particular, the DAMA/LIBRA (Large sodium Iodide Bulk for RAre processes) set-up consists of highly radiopure NaI(Tl) detectors for a total sensitive exposed mass of ≃250 kg. Recent results, obtained by this set-up by exploiting the model independent annual modulation signature of Dark Matter (DM) particles, have confirmed and improved those obtained by the former DAMA/NaI experiment. (...) A model independent evidence for the presence of Dark Matter particles in the galactic halo is cumulatively obtained at 8.2 σ C.L. No systematics or side reactions able to account for the measured modulation amplitude and to contemporaneously satisfy all the many specific requirements of the signature have been found or suggested by anyone over more than a decade. An example of one of the many possible model dependent corollary quests for the candidate particles and for the related astrophysical, nuclear and particle physics scenarios is presented considering the whole cumulative exposure. Future perspectives are shortly addressed. (shrink)

© 2014, The Author. A search for supersymmetry in events with large missing transverse momentum, jets, at least one hadronically decaying tau lepton and zero or one additional light leptons, has been performed using 20.3fb−1of proton-proton collision data at √ s= 8 TeV recorded with the ATLAS detector at the Large Hadron Collider. No excess above the Standard Model background expectation is observed in the various signal regions and 95% confidence level upper limits on the visible cross section for new (...) phenomena are set. The results of the analysis are interpreted in several SUSY scenarios, significantly extending previous limits obtained in the same final states. In the framework of minimal gauge-mediated SUSY breaking models, values of the SUSY breaking scale Λ below 63 TeV are excluded, independently of tan β. Exclusion limits are also derived for an mSUGRA/CMSSM model, in both the R-parity-conserving and R-parity-violating case. A further interpretation is presented in a framework of natural gauge mediation, in which the gluino is assumed to be the only light coloured sparticle and gluino masses below 1090 GeV are excluded. (shrink)

In his book on Karl Barth Professor T. F. Torrance spoke at one point of ‘the great watershed of modern theology’. ‘There are,’ he wrote, 1 ‘two basic issues here. On the one hand, it is the very substance of the Christian faith that is at stake, and on the other hand, it is the fundamental nature of scientific method, in its critical and methodological renunciation of prior understanding, that is at stake. This is the great watershed of modern theology: (...) either we take the one way or the other – there is no third alter native… one must go either in the direction taken by Barth or in the direction taken by Bultmann.’. (shrink)

In recent years the writings of Ludwig Wittgenstein have received much attention from philosophers in general and especially from philosophers interested in religion; and there is no doubt that Wittgenstein's legacy of thought is both highly suggestive and highly problematical. It seems likely, however, that the vogue which Wittgenstein now enjoys owes not a little to his peculiar place in the development of modern philosophy and, in particular, of that empiricist tradition in philosophy which stems from what has been called (...) the revolution in philosophy in the early decades of the present century. (shrink)

Excerpt from Essai sur la Vie Et le Caractere de J.-J. Rousseau Montmorency, que j avais a ma porte, et comme s'il n'y avait des vieillards qu'a Paris, et que partout ailleurs ils fussent hors d'etat de vivre. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst (...) repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works. (shrink)

Maternal opioid use during pregnancy is a growing national problem and can lead to newborns developing neonatal opioid withdrawal syndrome soon after birth. Recent data demonstrates that nearly every 15 min a baby is born in the United States suffering from NOWS. The primary treatment for NOWS is opioid replacement therapy, commonly oral morphine, which has neurotoxic effects on the developing brain. There is an urgent need for non-opioid treatments for NOWS. Transcutaneous auricular neurostimulation, a novel and non-invasive form of (...) electrostimulation, may serve as a promising alternative to morphine. tAN is delivered via a multichannel earpiece electrode worn on and around the left ear, targeting two cranial nerves—the vagus and trigeminal nerves. Prior research suggests that auricular neurostimulation exerts an anxiolytic effect on the body by releasing endogenous opioids and reduces withdrawal symptoms in adults actively withdrawing from opioids. In this first-in-human prospective, open-label trial, we investigated tAN as an adjuvant to morphine therapy in eight infants >33 weeks gestational age suffering from NOWS and receiving oral morphine treatment. Infants received tAN for 30 min 1 h before receiving a morphine dose. tAN was delivered at 0.1 mA below perception intensity at two different nerve targets on the ear: Region 1, the auricular branch of the vagus nerve; and Region 2, the auriculotemporal nerve. tAN was delivered up to four times daily for a maximum of 12 days. The primary outcome measures were safety [heart rate monitoring, Neonatal Infant Pain Scale, and skin irritation] and morphine length of treatment. tAN was well-tolerated and resulted in no unanticipated adverse events. Comparing to the national average of 23 days, the average oral morphine LOT was 13.3 days and the average LOT after tAN initiation was 7 days. These preliminary data suggest that tAN is safe and may serve as a promising alternative adjuvant for treating NOWS and reducing the amount of time an infant receives oral morphine. (shrink)

It is a curious fact that the much maligned ontological argument to prove the existence of God has in recent times enjoyed a revival of interest to which even Karl Barth, the arch-enemy of natural theology has contributed; but since the revival of interest has appared in a wide diversity of intellectual contexts, both philosophical and theological, the revival is itself almost as problematic as the argument itself.

In his article ‘Professor Bartley's Theory of Rationality and Religious Belief’ Mr W. D. Hudson has brought considerable clarification to the rather confused situation occasioned by Professor W. W. Bartley's book The Retreat to Commitment and its subsequent discussion; but the process can, I think, be carried still further.

Mezhepler, İslam düşünce tarihinin -tenkid edilse dahi- bir parçasıdırlar. Bu oluşumların sâlikleri arasında onaylanması zor bazı olayların vuku bulduğu tarihi bir hakikattir. Bununla beraber mezkûr teşekküllerin İslam düşünce dünyasının oluşumuna büyük katkı sağladıkları da su götürmez bir gerçektir. Zira her farklılık beraberinde yeni tezleri doğurmuş ve her tez de peşinden anti-tezler geliştirmiştir. Fikri hareketlilikler de İslam düşüncesini başka bir medeniyete nasip olmayacak bir kültürel zenginlikle taçlandırmıştır. Bu meyanda Hâricîler, İslam düşünce tarihinin ilk ortaya çıkan oluşumudur. Hâricîler tarihi süreçte çeşitli etkenlerle (...) önce kendi içinde gruplara ayrılmış ve daha sonra bu gruplardan sadece İbâzîler günümüze kadar varlıklarını devam ettirmişlerdir. Teşekkül dönemlerinden itibaren Hâricîler entelektüel bir birikimden daha çok kılıç-kalkanla meşhur olmuşlardır. Bu durum onların ilmî faaliyetlere yeterince zaman ayırmalarını da engellemiştir. Bu sebeple tarihi süreçte oluşmuş olan Hâricî literatür diğer teşekküllere göre son derece azdır. Ancak Hâricîlerle aralarında bazı fikri yakınlıklar bulunsa da bu mevzuda İbâzîleri ayrı değerlendirmek daha sağlıklı sonuçlar elde etmenin yolunu açacaktır. Zira kaynaklarda Hâricî kategorisinde zikredilen eserlerin neredeyse tamamı İbâzîlere aittir. Ayrıca İbâzîler çoğunlukla Hâricîlerle beraber ele alınıp bir ayırıma gitmeden değerlendirilerek ilmi literatürlerinin az olduğu ifade edilmektedir. Hâlbuki nüfuslarıyla kıyaslandığında ortaya koydukları eserlerin azımsanmayacak miktarlarda olduğunu ifade etmek mümkündür. Yapılan taramalarda -son zamanlarda sınırlı miktarda bazı araştırmalar yapılmış olsa da- İbâzîler hakkında yapılan çalışmaların ülkemizde yeterli miktarda olmadığı akademik camiada malum olan bir vakıadır. Binaenaleyh bu araştırma, gerek İbâzî tefsir alanında çalışmalar yapacak araştırmacılara bir katkı sağlamak gerekse İslam toplumunun bir parçası olan İbâzîlerle ilgili ülkemizde eksikliği hissedilen araştırmalara bir yenisini eklemek gayesiyle yapılmıştır. Dolayısıyla bu çalışmada Hâricî ve İbâzî grupların tarihi süreçte bugüne kadar oluşturdukları tefsir literatürlerinin ele alınıp tanıtılması hedeflenmiştir. (shrink)

c.c.c. posets are characterised in terms of N-generic conditions. This characterisation can be applied to get simple proofs of many facts about c.c.c. forcing including $\operatorname{Con}(MA + \neg CH)$.

Artikkelen vurderer hvorvidt ID-kravet, som begrenser asylsøkeres anledning til å søke arbeid, er etisk velbegrunnet innenfor rammene av en liberal rettskultur. Videre anlegges et konsekvensetisk perspektiv fordi ID-kravet er konsekvensetisk begrunnet, og det kan da foretas en immanent kritikk. Det vises at ID-kravet innebærer en begrensning av asylsøkeres negative og positive frihet, og at forsvarere av ID-kravet dermed må bevise at kravet har så gode konsekvenser at det legitimerer en slik begrensning av asylsøkeres frihet. Både generelle overveielser av ID-kravets fordeler (...) og ulemper og konkrete data tilsier at bevisbyrden ikke er oppfylt. Følgelig må det enten frembringes empiri som tilsier at ID-kravet likevel har bedre konsekvenser, eller det bør gis en annen type begrunnelse enn den konsekvensetiske for ID-kravet, eller ID-kravet bør avskaffes.Nøkkelord: asylsøkere, arbeid, liberalt demokrati, konsekvensialismeEnglish summary: Undocumented migrants' right to apply for work. A consequentialist assessmentThe article evaluates whether the Norwegian ID-demand, which limits asylum seekers' opportunity for work, is ethically well founded within the limits of a liberal, legal culture. The argument operates within a consequentialist normative theory because the ID-demand is justified in terms of its consequences, and an immanent critique of the demand can therefore be carried out. It is argued that the ID-demand imposes restrictions on the negative and positive liberty of asylum seekers, and defenders of the ID-demand will then have a burden of proof to show that the demand has such good consequences that it will legitimise these restrictions. Both general considerations and specific data clearly indicate that this burden of proof is not satisfied. Hence, one must either provide new data that indicate that the ID-demand after all has better consequences, defend the ID-demand in terms of something other than its consequences or reject the ID-demand. (shrink)

El pensamiento del autor [Francisco Romero], orientándose en la dirección fenomenológico- axiológica y espiritualista de Husserl, Scheler, Hartmann y también de Ortega, quiere alcanzar una visión propia del hombre; bien que por la misma limitación del método fenomenológico adoptado, su indagación se detenga casi exclusivamente en la actividad y manifestaciones del hombre, en su aparecer más que en su ser estrictamente tal. He aquí, resumida suscíntamente, la obra. Lo que constituye al hombre es la intencionalidad: la polaridad sujetoobjeto. Tal carácter (...) intencional se revela ante todo en el conocimiento y, dentro de éste, principalmente en el juicio. La intencionalidad volítiva o afectiva se estructura bajo la dirección de la intencionalidad cognoscitiva, a la que Romero confiere la supremacía. A medida que se perfecciona la intencionalidad, se acrecienta también la individualidad, hasta alcanzar en la intencionalidad del hombre la conciencia de sí. Esta intencionalidad, pre-espírítual, propia y constitutiva del hombre, no es salida o trascendencia perfecta, pues siempre encierra un regreso al operante : es un éxodo para retornar al sujeto. En este punto R. retorna uno de sus ternas favoritos: la cultura, que se constituye también por la intencionalidad, pero en función no de objeto sino de realización de valores. La cultura no es sino la modificación del ser natural por la actividad intencional valorante. R., se detiene en largos análisis sobre la intencionalidad cultural individual y social y sus relaciones, en la díreccíón de H. Freyer y M. Scheler, aunque siempre buscando elaborar una explicación propia. (shrink)

En el ámbito de la lógica matemática existe un problema sobre la relación lógica entre dos versiones débiles del Axioma de elección (AE) que no se ha podido resolver desde el año 2000 (aproximadamente). Tales versiones están relacionadas con ultrafiltros no principales y con Propiedades Ramsey (Bernstein, Polarizada, Subretículo, Ramsey, Ordinales flotantes, etc). La primera versión débil del AE es la siguiente (A): “Existen ultrafiltros no principales sobre el conjunto de los números naturales (ℕ)”. Y la segunda versión débil del (...) AE es la siguiente (B): “Existen ultraflitros sobre ℕ”. Se sabe que A implica B, pero se desconoce si B implica A. Di Prisco y Henle conjeturan en los artículos ([1], [2]) que esto no ocurre, es decir, conjeturan que B no implica A, en otras palabras, conjeturan que A es más fuerte estrictamente que B, que A es independiente de B, pero esto no se ha podido demostrar todavía aunque se ha intentado hacer desde hace aproximadamente 21 años. Una descripción detallada de este problema abierto puede encontrarse en esta ponencia (dictada en el marco del Día Mundial de la Lógica 14-01-2022) y en el artículo [3]. [1] C. Di Prisco y H. Henle. “Doughnuts, Floating Ordinals, Square Brackets, and Ultraflitters”. Journal of Symbolic Logic 65 (2000) 462-473. [2] C. Di Prisco y H. Henle. “Partitions of the reals and choice”. En “Models, algebras and proofs”. X. Caicedo y C.M. Montenegro. Eds. Lecture Notes in Pure and Appl. Math, 203, Marcel Dekker, 1999. [3] F. Galindo. “Tópicos de ultrafiltros”. Divulgaciones Matemáticas. Vol. 21, No 1-2, 2020. (shrink)

The 1940s and 1950s were marked by intense debates over the origin of drug resistance in microbes. Bacteriologists had traditionally invoked the notions of ‘training’ and ‘adaptation’ to account for the ability of microbes to acquire new traits. As the field of bacterial genetics emerged, however, its participants rejected ‘Lamarckian’ views of microbial heredity, and offered statistical evidence that drug resistance resulted from the selection of random resistant mutants. Antibiotic resistance became a key issue among those disputing physiological vs. genetic (...) explanations of variation in bacteria. Postwar developments connected with the Lysenko affair gave this debate a new political valence.Proponents of the neo-Darwinian synthesis weighed in with support for the genetic theory. However, certain features of drug resistance seemed inexplicable by mutation and selection, particularly the phenomenon of ‘multiple resistance’—the emergence of resistance in a single strain against several unrelated antibiotics. In the late 1950s, Tsutomu Watanabe and his collaborators solved this puzzle by determining that resistance could be conferred by cytoplasmic resistance factors rather than chromosomal mutation. These R factors could carry resistance to many antibiotics and seemed able to promote their own dissemination in bacterial populations. In the end, the vindication of the genetic view of drug resistance was accompanied by a recasting of the ‘gene’ to include extrachromosomal hereditary units carried on viruses and plasmids. (shrink)

In a recent article ‘The Problem of Natural Theology’, Professor N. H. G. Robinson has considered the requirements of a ‘genuinely empirical natural theology’. For the first section of it, a very clear sorting-out of recent debates on the ontological argument, I have nothing but admiration. It ends with the question: ‘Granted that if we think of God we must think of him as necessarily existing, why must we think of God at all?’, followed by the comment: ‘We seem thrown, (...) without any prospect of rest, between apriorism and [Barthian] empiricism’. Robinson is rightly dissatisfied with that situation, and in his second section he raises the question whether there cannot be an approach to God which the debates on the ontological arguments have overlooked and which may be properly called an ‘empirical’ one, free from Barthian presuppositions. He finds what seems to be such an approach in Professor E. L. Mascall's Existence and Analogy but concludes that it is in fact after all a form of ‘rationalism’. In the third section he criticises Professor T. F. Torrance's defence of Barth's position in a way which seems to me most satisfactory, and in the fourth he makes his own positive proposals. With these I am in substantial agreement. It is only his account of Mascall's position, in particular at the end of his second section, which seems to call for critical comment. (shrink)

The period between 1945 and 1952 marked the development of Professor Ryle's conception of the principles of inference as performance rules. This development has paralleled that of his now well-known distinction between knowing-how and knowing-that. Indeed, the former is a corollary to the latter. Beginning with the inaugural address to the Aristotelian Society in 1945 and reaching full fruition in The Concept of Mind in 1949, it finds its most detailed and illuminating expression in “‘If’, ‘So’, and ‘Because’,” which appeared (...) in 1950. The present essay will attempt to explore this conception of rules in some detail, in the hope of clarifying the nature of Professor Ryle's views on classical logic and on certain problems within the philosophy of logic. Professor Ryle belongs, if his views may be so labeled, to the school of informal language analysts. On the other hand, we incline more toward formalism. We tend to agree with those philosophers who consider certain schemata indispensable tools for the solution of philosophical problems. Logic and the philosophy of logic are, as everyone knows, the areas in which the formalists’ technique originated. In these areas it is accepted by virtually everybody. The only recent exception is a group of English writers, many of whom take their inspiration from Ryle. One may hope, then, that the present criticism of Ryle's view from the other standpoint will throw some light on both positions. What follows falls naturally into two parts. The first deals mainly with Ryle's objections to current logical theory, the second with his own philosophy of logic. (shrink)