CRISPR germline editing therapies hold unprecedented potential to eradicate hereditary disorders. However, the prospect of altering the human germline has sparked a debate over the safety, efficacy, and morality of CGETs, triggering a funding moratorium by the NIH. There is an urgent need for practical paths for the evaluation of these capabilities. We propose a model regulatory framework for CGET research, clinical development, and distribution. Our model takes advantage of existing legal and regulatory institutions but adds elevated scrutiny at each (...) stage of CGET development to accommodate the unique technical and ethical challenges posed by germline editing. (shrink)

The central theme of this important book is that we are paying the price of an arrogance that refuses to recognize mystery. The author invites the reader to enter into the argument that he holds with himself on a great number of problems. Written in the early 1950s, Marcel's discussion of these topics are remarkably contemporary, e.g.: * Our crisis is a metaphysical, not merely social, one. * What a man is depends partly on what he thinks he is, (...) and a materialistic philosophy turns men into things. * Can a man be free except in a free country? * Stoicism is no longer a workable philosophy because today pressure can be put on the mind as well as on the body. * Technical progress is not evil in itself, but a technique is a means that, regarded as an end, can become either an idol or an excuse for self-idolatry. State control of scientific research, leading to a concentration on new means of destruction, is a calamity. * Fanaticism is an opinion that refuses to argue, and so the fanatic is an enemy of truth. * The kind of unification that science is bringing about today is really an ironing out of differences, but the only valuable kind of unity is one that implies a respect for differences. * We must beware of thinking in terms of great numbers and so blinding ourselves to the reality of individual suffering. Our philosophical approach to being is made possible only by our practical approach to our neighbor. * We must encourage the spirit of fraternity and distrust the kind of egalitarianism that is based on envy and resentment. * No man however humble should feel that he cannot spread the light among his friends. No easy solution is offered, but the author conveys his own faith that ultimately love and intelligence will triumph. (shrink)

Transformer-based Pre-Trained Language Models currently dominate the field of Natural Language Inference (NLI). We first survey existing NLI datasets, and we systematize them according to the different kinds of logical inferences that are being distinguished. This shows two gaps in the current dataset landscape, which we propose to address with one dataset that has been developed in argumentative writing research as well as a new one building on syllogistic logic. Throughout, we also explore the promises of ChatGPT. Our results show (...) that our new datasets do pose a challenge to existing methods and models, including ChatGPT, and that tackling this challenge via fine-tuning yields only partly satisfactory results. (shrink)

In this chapter, we discuss a specific kind of progress in economics, namely, progress that is pushed by the repeated use of mathematical models in most sub-branches of economics today. We adopt a functional account of progress to argue that progress in economics occurs via the use of what we call ‘common recipes’ and the use of model templates to define and solve problems of relevance for economists. We support our argument by discussing the case of twentieth-century business cycle research. (...) By presenting this case study in detail, we show how model templates are not only re-applied to different phenomena. We also show how scientists come up with them in the first place and how – once they are considered less useful – they are replaced with new ones. Finally, our case also illustrates that it is not only the mathematical structure that is re-used but that such a re-use also requires a shared conceptual vision of core properties of the phenomenon. If that vision is not shared anymore among economists, a model template can become useless and has to be replaced – sometimes through overcoming resistance – with a different one. (shrink)

Essays in this volume honor Marcel Senn on the occasion of his retirement from the law department of Universität Zürich. The contributors of the essays are colleagues and friends.

In his Confessions Jean-Jacques Rousseau tells the story of his life, from the formative experience of his humble childhood in Geneva, through the achievement of international fame as novelist and philosopher in Paris, to his wanderings as an exile, persecuted by governments and alienated from the world of modern civilization. In trying to explain who he was and how he came to be the object of others' admiration and abuse, Rousseau analyses with unique insight the relationship between an elusive but (...) essential inner self and the variety of social identities he was led to adopt. The book vividly illustrates the mixture of moods and motives that underlie the writing of autobiography: defiance and vulnerability, self-exploration and denial, passion, puzzlement, and detachment. Above all, Confessions is Rousseau's search, through every resource of language, to convey what he despairs of putting into words: the personal quality of one's own existence. (shrink)

Peut-on dire qu'une philosophie est vraie?" [et la réponse négative de Canguilhem], "La réalité des philosophies" [et l'idéalisme radical de Gueroult], "Les deux systèmes de métaphysique" [et la place de Spinoza], "Comment je vois la Nature", "Les points cardinaux de ma philosophie", "Comment philosopher", "Faire son devoir" [ce qui compte est 1'k-te] sont parmi les chapitres principaux de cet ouvrage. Ceux-ci sont secondaires : "Bergson et Eucken", "Palmyre", "Kant contre Spinoza" [sur la place des définitions]."--Page 4 of cover.

La 4ème de couv. indique : "À quatre-vingt-quatorze ans, Marcel Conche a encore quelque chose à dire sur la nature, l'infini, la vérité, la tradition, la création, le moi, le silence, le tragique, l’amour, la mort ou les mathématiques, mais aussi sur Héraclite, Descartes, Kant, Leibniz et, principalement, sur Spinoza.".

Decision outcomes sometimes result in negative emotions. This can occur when a decision appears to be wrong in retrospect, and/or when the obtained decision outcome does not live up to expectations. Regret and disappointment are the two emotions that are of central interest in the present article. Although these emotions have a lot in common, they also differ in ways that are relevant to decision making. In this article we review theories and empirical findings concerning regret and disappointment. We first (...) discuss how regret and disappointment differ with respect to their antecedent conditions, appraisals, and phenomenology. We also discuss possible behavioural consequences of experiencing these emotions. Next, we consider how the anticipation of regret and disappointment may influence decision making. We use regret and disappointment theory, developed by the economists Bell (1982, 1985), and Loomes and Sugden (1982, 1986, 1987), as a framework for our discussion. Finally, we argue that combining the theoretical approaches and research paradigms of behavioural decision theory with emotion theories will significantly increase our knowledge of antecedents and consequences of emotions. (shrink)

-- -- ḥeleḳ 2. Sofisṭim. Soḳraṭes. Aflaṭon.

L'ouvrage présente, à partir d'une thèse empruntée à chacun, quinze auteurs qui ont contribué - et pour la plupart contribuent encore - au débat ...

Regret and disappointment have in common the fact that they are experienced when the outcome of a decision is unfavourable: They both concern “what might have been”, had things been different. However, some regret and disappointment theorists regard the differences between these emotions as important, arguing that they differ with respect to the conditions under which they are felt, and how they affect decision making. The goal of the present research was to examine whether and how these emotions also differ (...) with respect to the way in which they are experienced. Participants were asked torecall aninstance of intense regret or disappointment andto indicate what they felt, thought, felt like doing, did, and were motivated to do during this experience (cf. Roseman, Wiest, & Swartz, 1994). Significant differences between regret and disappointment were found in every category. These differences were most pronounced for “action tendencies” (what participants felt like doing) and “emotivations” (what they were motivated to do). These results suggest that the two emotions have differential implications for future behaviour. (shrink)

The Routledge Companion to Sounding Art presents an overview of the issues, methods, and approaches crucial for the study of sound in artistic practice. Thirty-six essays cover a variety of interdisciplinary approaches to studying sounding art from the fields of musicology, cultural studies, sound design, auditory culture, art history, and philosophy. The companion website hosts sound examples and links to further resources. The collection is organized around six main themes: Sounding Art: The notion of sounding art, its relation to sound (...) studies, and its evolution and possibilities. Acoustic Knowledge and Communication: How we approach, study, and analyze sound and the challenges of writing about sound. Listening and Memory: Listening from different perspectives, from the psychology of listening to embodied and technologically mediated listening. Acoustic Spaces, Identities and Communities: How humans arrange their sonic environments, how this relates to sonic identity, how music contributes to our environment, and the ethical and political implications of sound. Sonic Histories: How studying sounding art can contribute methodologically and epistemologically to historiography. Sound Technologies and Media: The impact of sonic technologies on contemporary culture, electroacoustic innovation, and how the way we make and access music has changed. With contributions from leading scholars and cutting-edge researchers, The Routledge Companion to Sounding Art is an essential resource for anyone studying the intersection of sound and art. (shrink)

This anthology is a unique compilation of scientific contributions on the topic of measurement and understanding, showing how terms such as number, measurement, understanding, model, pattern are used in a wide variety of disciplines. Based on the results and experiences from their own projects, 23 researchers comment on the potentials and limitations of individual methodological approaches and success factors of interdisciplinary collaboration. In doing so, they sound out the different significance of quantification and empirical evidence for their own disciplines and (...) examine the influence of methodological approaches on existing models and images. The common goal is to want to understand the world; the methods, however, are highly diverse. (shrink)

This chapter contains section titled: The Diversity of Experimental Practices in Biology Model Organisms Experimental Systems and the “New Experimentalism” in Biology The Nature of Evidence Objectivity and Realism Acknowledgment References Further Reading.

In Kreative Gegensätze Marcel Bubert analyses the debates among medieval scholastics on the social usefulness of learned knowledge in their specific social and cultural contexts. In particular, he shows how the skepticism towards the scholars as well as the tensions between the University of Paris, the French royal court, and the citizens of Paris had profound effects on the scientific community, and led to very different views on the utility of philosophy. Some Masters responded to the expectations of society (...) by emphasizing the autonomy of philosophical cognition. Others departed radically from this notion of science "for its own sake", and created decidedly "practical" concepts of knowledge. The examination of these contentious relations shows how the dynamics of mutual demarcation within this "constellation" became intellectually prolific by way of generating highly original and innovative responses to the question of the utility of philosophy. (shrink)