Barbara Stafford is a pioneering art historian whose research has long helped to bridge the divide between the humanities and cognitive sciences. In _A Field Guide to a New Meta-Field_, she marshals a distinguished group of thinkers to forge a ground-breaking dialogue between the emerging brain sciences, the liberal arts, and social sciences. Stafford’s book examines meaning and mental function from this dual experimental perspective. The wide-ranging essays included here—from Frank Echenhofer’s foray into shamanist hallucinogenic visions to David Bashwiner’s analysis (...) of emotion and danceability—develop a common language for implementing programmatic and institutional change. Demonstrating how formerly divided fields are converging around shared issues, _A Field Guide to a New Meta-Field _maps a high-level, crossdisciplinary adventure from one of our leading figures in visual studies. (shrink)

Cowan defines a chunk as “a collection of concepts that have strong associations to one another and much weaker associations to other chunks currently in use.” This definition does not impose any constraints on the nature and number of elements that can be bound into a chunk. We present an experiment to demonstrate that such limitations exist for visual short-term memory, and that their analysis may lead to important insights into properties of visual memory.

Barbara Maria Stafford is at the forefront of a growing movement that calls for the humanities to confront the brain’s material realities. In _Echo Objects,_ she argues that humanists should seize upon the exciting neuroscientific discoveries that are illuminating the underpinnings of cultural objects. In turn, she contends, brain scientists could enrich their investigations of mental activity by incorporating phenomenological considerations—particularly the intricate ways that images focus intentional behavior and allow us to feel thought. As a result, _Echo Objects_ is (...) a stunningly broad exploration of how complex images—or patterns that compress space and time—make visible the invisible ordering of human consciousness. Stafford demonstrates, for example, how the compound formats of emblems, symbols, collage, and electronic media reveal the brain’s grappling to construct mental objects that are redoubled by prior associations. In contrast, she shows that findings in evolutionary biology and the neurosciences are providing profound opportunities for understanding aesthetic conundrums such as the human urge to imitate and the role of narrative and nonnarrative representation. Ultimately, she makes an impassioned plea for a common purpose—for the acknowledgement that, at the most basic level, these separate projects belong to a single investigation. “Heroic.... The larger message of Stafford’s intense, propulsive prose is unassailable. If we are to get much further in the great puzzle of ‘binding’—how the perception of an image, the will to act on intention, or the forging of consciousness is assembled from the tens of thousands of neurons firing at any one moment in time—then there needs to be action on all fronts.”—_Science_. (shrink)

In this work, we evaluate the status of both theory and empirical evidence in the field of experimental rest-break research based on a framework that combines mental-chronometry and psychometric-measurement theory. To this end, we provide a taxonomy of rest breaks according to which empirical studies can be classified. Then, we evaluate the theorizing in both the basic and applied fields of research and explain how popular concepts relate to each other in contemporary theoretical debates. Here, we highlight differences between all (...) these models in the light of two symbolic categories, termed the resource-based and satiation-based model, including aspects related to the dynamics and the control mechanisms at work. Based on a critical assessment of existing methodological and theoretical approaches, we finally provide a set of guidelines for both theory building and future empirical approaches to the experimental study of rest breaks. We conclude that a psychometrically advanced and theoretically focused research of rest and recovery has the potential to finally provide a sound scientific basis to eventually mitigate the adverse effects of ever increasing task demands on performance and well-being in a multitasking world at work and leisure. (shrink)

Barbara Stafford is at the forefront of a growing movement that calls for the humanities to confront the brain’s material realities. In Echo Objects she argues that humanists should seize upon the exciting neuroscientific discoveries that are illuminating the underpinnings of cultural objects. In turn, she contends, brain scientists could enrich their investigations of mental activity by incorporating phenomenological considerations—particularly the intricate ways that images focus intentional behavior and allow us to feel thought. This, then, is a book for both (...) sides of the aisle, a stunningly broad exploration of how complex images—or patterns that compress space and time—make visible the invisible ordering of human consciousness. Stafford demonstrates, for example, how the compound formats of emblems, symbols, collage, and electronic media reveal the brain’s grappling to construct mental objects that are redoubled by prior associations. On the other hand, she compellingly shows that findings in evolutionary biology and the neurosciences are providing profound opportunities for understanding aesthetic conundrums as old and deep-seated as the human urge to imitate, the mapping of inner space, and the role of narrative and nonnarrative representation. As precise in her discussions of firing neurons as she is about the coordinating dynamics of image making, Stafford locates these major transdisciplinary issues at the intersection of art, science, philosophy, and technology. Ultimately, she makes an impassioned plea for a common purpose—for the acknowledgement that, at the most basic level, these separate projects belong to a single investigation. (shrink)

There are now many important contributions to the scientific study of the brain-mind continuum. These results come both from research into non-ordinary states of consciousness and into the brain's intrinsic, largely unconscious mechanisms. The larger potential of such investigations consists precisely in making the parameters of our cognitive system apparent. But they also reveal the socio-cultural uses to which these parameters are currently, or in the foreseeable future, being applied. This article wrestles with that fact. Specifically, it examines the implications (...) for those of us interested in the dynamics of visual awareness and the structural and phenomenological aspects of noticing. Because some of the key characteristics of consciousness are so ingrained that we are usually blind to them, it is all the more important to understand how and why we pay attention to certain features of our environment. Subjective consciousness pertains to the realm of inner experience as well as focusing on the external world. What Daniel Dennett terms `intentionality' or directedness towards an object is a sign of our connectedness to the outside world. Beyond connection, I am interested in how complex works of art help us cognize, confer reality, or have knowledge of what lies before our eyes. I will argue that this calibration of the agent's experience and her perception of the world is under threat today. (shrink)

Analisam-se diversos aspectos do tempo nos poemas homéricos como sejam o seu uso na narrativa ou a importância da imortalidade. Em ambos os poemas estão patentes confusões entre a época do poeta e a da narrativa, o que se nota através de comparações, mas também por misturas de materiais, ou de costumes. Do mesmo modo, a narrativa não se reduz a uma única época. Seja por uma questão de economia da narrativa, como sucede na Odisseia, seja para explicar, ou justificar, (...) aspectos relacionados com a narrativa, as alusões ao passado são uma constante. Assim sendo, pode-se dizer que os poemas homéricos levantam questões como passado e presente, mortalidade e imortalidade. (shrink)

Research over the past few decades has shown the positive influence that cognitive, social, and physical activities have on older adults’ cognitive and affective health. Especially interventions in health-related behaviors, such as cognitive activation, physical activity, social activity, nutrition, mindfulness, and creativity, have shown to be particularly beneficial. Whereas most intervention studies apply unimodal interventions, such as cognitive training, this study investigates the potential to foster cognitive and affective health factors of older adults by means of an autonomy-supportive multimodal intervention. (...) The intervention integrates everyday life recommendations for six evidence-based areas combined with psychoeducational information. This randomized controlled trial study compares the effects of a MMI and CT on those of a waiting control group on cognitive and affective factors, everyday life memory performance, and activity in everyday life. Three groups, including a total of 119 adults aged 65–86 years, attended a 5- or 10-week intervention. Specifically, one group completed a 10-week MMI, the second group completed 5-week of computer-based CT followed by a 5-week MMI, whereas the third group paused before completing the MMI for the last 5 weeks. All participants completed online surveys and cognitive tests at three test points. The findings showed an increase in the number and variability of activities in the everyday lives of all participants. Post hoc analysis on cognitive performance of MMI to CT indicate similar or better effects. Furthermore, results on far transfer variables showed interesting trends in favor of the MMI, such as increased well-being and attitude toward the aging brain. Also, the MMI group showed the biggest perceived improvements out of all groups for all self-reported personal variables. The results implicate a positive trend toward MMI on cognitive and affective factors of older adults. These tendencies show the potential of a multimodal approach compared to training a specific cognitive function. Moreover, the findings suggest that information about MMI motivates participants to increase activity variability and frequency in everyday life. Finally, the results could also have implications for the primary prevention of neurocognitive deficits and degenerative diseases. (shrink)

Investigating perceptual and cognitive abilities of zoo animals might help to improve their husbandry and enrich their daily life with new stimuli. Developing new environmental enrichment programs and devices is hence necessary to promote species-specific behaviours that need to be maintained in controlled environments. As far as we are aware, no study has ever tested the potential benefits of motion illusions as visual enrichment for zoo animals. Starting from a recent study showing that domestic cats are spontaneously attracted by a (...) well-known motion illusion, the Rotating Snake (RS) illusion, we studied whether this illusion could be used as a visual enrichment for big cats. We observed the spontaneous behaviour of three lionesses when three different visual stimuli were placed in their environment: the RS illusion and two control stimuli. The study involved two different periods: the baseline and the RS period, in which the visual stimuli were provided to the lionesses. To assess whether the lionesses were specifically attracted by the RS illusion, we collected data on the number of interactions with the stimuli, as well as on the total time spent interacting with them. To investigate the effect of the illusion on the animals’ welfare, individual and social behaviours were studied and compared between the two periods. The results showed that two lionesses out of three interacted more with the RS stimulus than with the two control stimuli. The fact that the lionesses seemed to be more inclined to interact with the RS stimulus indirectly suggests the intriguing possibility that they were attracted by the illusory motion. Moreover, behavioural changes between the two periods were reported for one of the lionesses, highlighting a reduction in self-directed behaviours and an increase in attentive behaviours, suggesting positive welfare implications. Thus, behavioural observations made before and during the presentation of the stimuli showed that our visual enrichment actually provided positive effects in lionesses. These results call for the development of future studies on the use of visual illusions in the enrichment programs of zoo animals. (shrink)

One of the most important social cognitive skills in humans is the ability to “put oneself in someone else’s shoes,” that is, to take another person’s perspective. In socially situated communication, perspective taking enables the listener to arrive at a meaningful interpretation of what is said and what is meant by the speaker. To successfully decode the speaker’s meaning, the listener has to take into account which information he/she and the speaker share in their common ground. We here further investigated (...) competing accounts about when and how CG information affects language comprehension by means of reaction time measures, accuracy data, event-related potentials, and eye-tracking. Early integration accounts would predict that CG information is considered immediately and would hence not expect to find costs of CG integration. Late integration accounts would predict a rather late and effortful integration of CG information during the parsing process that might be reflected in integration or updating costs. Other accounts predict the simultaneous integration of privileged ground and CG perspectives. We used a computerized version of the referential communication game with object triplets of different sizes presented visually in CG or PG. In critical trials, CG information had to be integrated while privileged information had to be suppressed. Listeners mastered the integration of CG. Yet, slower RTs, and enhanced late positivities in the ERPs showed that CG integration had its costs. Moreover, eye-tracking data indicated an early anticipation of referents in CG but an inability to suppress looks to the privileged competitor, resulting in later and longer looks to targets in those trials, in which CG information had to be considered. Our data therefore support accounts that foresee an early anticipation of referents to be in CG but a rather late and effortful integration if conflicting information has to be processed. We show that both perspectives, PG and CG, contribute to socially situated language processing and discuss the data with reference to theoretical accounts and recent findings on the use of CG information for reference resolution. (shrink)

I. EXECUTIVE SUMMARY The MRCT Center Post-trial Responsibilities: Continued Access to an Investigational Medicine Framework outlines a case-based, principled, stakeholder approach to evaluate and guide ethical responsibilities to provide continued access to an investigational medicine at the conclusion of a patient’s participation in a clinical trial. The Post-trial Responsibilities (PTR) Framework includes this Guidance Document as well as the accompanying Toolkit. A 41-member international multi-stakeholder Workgroup convened by the Multi-Regional Clinical Trials Center of Brigham and Women’s Hospital and Harvard University (...) (MRCT Center) developed this Guidance and Toolkit. Project Motivation A number of international organizations have discussed the responsibilities stakeholders have to provide continued access to investigational medicines. The World Medical Association, for example, addressed post-trial access to medicines in Paragraph 34 of the Declaration of Helsinki (WMA, 2013): “In advance of a clinical trial, sponsors, researchers and host country governments should make provisions for post-trial access for all participants who still need an intervention identified as beneficial in the trial. This information must also be disclosed to participants during the informed consent process.” This paragraph and other international guidance documents converge on several consensus points: • Post-trial access (hereafter referred to as “continued access” in this Framework [for terminology clarification – see definitions]) is the responsibility of sponsors, researchers, and host country governments; • The plan for continued access should be determined before the trial begins, and before any individual gives their informed consent; • The protocol should delineate continued access plans; and • The plan should be transparent to potential participants and explained during the informed consent process. -/- However, there is no guidance on how to fulfill these responsibilities (i.e., linking specific responsibilities with specific stakeholders, conditions, and duration). To fill this gap, the MRCT Center convened a working group in September of 2014 to develop a framework to guide stakeholders with identified responsibilities. This resultant Framework sets forth applicable principles, approaches, recommendations and ethical rationales for PTR regarding continued access to investigational medicines for research participants. (shrink)

In her article, Barbara M. Staff ord argues for the conception of literacy that would encompass visual skills besides the traditional emphasis on verbal competence. Image itself is important, not merely the information it may convey. Moreover, a more extens ive notion of education is necessitated by the process of radical perceptual and conceptual changes that have been occurring since the Enlightenment and are all-pervasive in Postmodernism. The new-found power and ubiquity of images needs to be recogn ized in order (...) to surpass the limitative, yet enduring Platonic distrust in visual culture. Medical, environmental, physical, legal, and other practices have nonetheless profoundly benefited from the technologies of visualization. Examples from the 18th century visual endeavors such as preserving fragmented cultures, exhibit ion of diversity, and the externalization of somatic experience show, how images challenge the restrictions of human compreh ension. With the advent of visual and electronically generated culture, the time is ripe to edify images from their low status. Visual cognition as the crucial element of knowledge should be reflected in a hybrid art-science, public policy, as well as pedagogy. (shrink)

Received opinion holds that it would be more efficient, hence more economical, to compress and thus dissolve the holdings of the Warburg Institute Library into an overarching university library system. This essay argues two points: first, that we should not be automatically persuaded by the popular and largely unexamined goal of efficiency; and second, that the Library indeed requires its own space but that that space must now be reconceived. In line with Aby Warburg's belief that the past should engage (...) the present by expanding and refreshing it, the Warburg Institute Library's rare and singular collections are less about the books and more about the uniqueness of the content and what it does. This essay proposes that what makes the Library vital to today's networked epistemology is the insights that its volumes provide to the varieties of human ordering, organization, formatting, and categorization—visibly exhibited in the spatial arrangement of its holdings. As its users have long felt, the Warburg is more than a library: it is a complex physical space demonstrating the formal evolution or framing of human thought. The Warburg should thus be reconceived as a “house museum” along these lines. (shrink)

BackgroundThe psychological burden possibly deriving from not immediately undergoing radical treatment for prostate cancer could be a potential disadvantage of active surveillance, especially in the eve of some relevant clinical exams [i.e., re-biopsy, prostate-specific antigen test, and medical examination]. Even if it is known from the literature that the majority of PCa men in AS do not report heightened anxiety, there is a minority of patients who show clinically significant levels of anxiety after diagnosis. The present study aimed to investigate (...) if demographic, clinical, and psychological variables at the entrance in AS were associated with the risk of developing clinically significant PCa-related anxiety 2 months before the first re-biopsy and to offer psychological support to improve quality of life.Materials and MethodsA total of 236 patients participated in the PCa Research International: AS protocol and in PRIAS-QoL study. Demographic/clinical features, health-related QoL domains, coping with cancer, PCa-related anxiety [Memorial Anxiety Scale for PCa ], personality traits, and decision-making-related factors were assessed at T0. MAX-PC was also administered at T1. PCa-related anxiety at T1 was considered to be of clinical significance if the MAX-PC score was ≥1.5. Multivariable logistic regression coupled to bootstrap was used to detect factors associated with high levels of anxiety.ResultsThe median age was 64.4 years. Fifty-six patients reported MAX-PC total score above the cutoff. Three factors were associated with a high level of PCa anxiety at T1: anxious preoccupation [odds ratio = 4.36], extraversion, and prostate-related symptoms. Physical well-being was associated with a low PCa anxiety subscale ; neuroticism and functional well-being were associated with PSA anxiety. Neuroticism and helplessness/hopelessness were associated with fear of progression.ConclusionOnly a partial portion of the sample experienced significant levels of anxiety after 10 months. Psychological assessment should be routinely conducted to detect risk factors for increased anxiety, offering tailored psychological interventions aimed at promoting interpersonal awareness and emotional well-being. (shrink)

The image of wine has a “spiritual sense”, which helps the faithful to understand the principles of their belief. Its mystery is connected with the theme of “sober inebriation”, developed by Philo of Alexandria and Origen, and culminating in Ambrose. The good wines that the bride enjoys before the groom’s arrival are a symbol of the good doctrines of the OT, whose teachings are however inferior to the revelation of the incarnate Christ. Good, sweet wine, meanwhile, refers to the doctrines (...) of the NT interpreted spiritually, the logos that helps us begin to know Christ, to bind ourselves to him in ecclesial unity and to love our neighbour. It also leads us to the “winepress”, i.e. renouncing superfluous land, becoming “full of must” and inebriated, so that we can dedicate ourselves to contemplation. The vine has a Christological value and catechetical function, dating back to John 15.1, which is often quoted with Saint Paul. The place where the vine is born and develops is the soul; the Logos supports its flowering in those who, by their free will, choose to flourish. The cluster of grapes refers to Christ, or to the victory of the righteous; the many grapes that he contains are believers. The vineyard is a symbol of the church formed by the pagans, of the commandments of God, or of the good things that God gave to man, who did not preserve them, having been stripped of them by the devil. The guardians of the vineyard are angels or priests. (shrink)

Gregory of Nyssa’s bearing in Qohelet 3:5b to wealth, rather than to the matrimonial “embrace”, is unusual by comparison withother ancient exegeses; it seems to be motivated not only by the acoluthia which characterizes his spiritual interpretation of the passage Qo. 3:2-8, but also by the crucial importance he gives to catharsis, as one the qualities he considered necessary for the exegete.

Background Regionalised models of health care delivery have important implications for people with disabilities and chronic illnesses yet the ethical issues surrounding disability and regionalisation have not yet been explored. Although there is ethics-related research into disability and chronic illness, studies of regionalisation experiences, and research directed at improving health systems for these patient populations, to our knowledge these streams of research have not been brought together. Using the Canadian province of Ontario as a case study, we address this gap (...) by examining the ethics of regionalisation and the implications for people with disabilities and chronic illnesses. The critical success factors we provide have broad applicability for guiding and/or evaluating new and existing regionalised health care strategies. Discussion Ontario is in the process of implementing fourteen Local Health Integration Networks (LHINs). The implementation of the LHINs provides a rare opportunity to address systematically the unmet diverse care needs of people with disabilities and chronic illnesses. The core of this paper provides a series of composite case vignettes illustrating integration opportunities relevant to these populations, namely: (i) rehabilitation and services for people with disabilities; (ii) chronic illness and cancer care; (iii) senior's health; (iv) community support services; (v) children's health; (vi) health promotion; and (vii) mental health and addiction services. For each vignette, we interpret the governing principles developed by the LHINs – equitable access based on patient need, preserving patient choice, responsiveness to local population health needs, shared accountability and patient-centred care – and describe how they apply. We then offer critical success factors to guide the LHINs in upholding these principles in response to the needs of people with disabilities and chronic illnesses. Summary This paper aims to bridge an important gap in the literature by examining the ethics of a new regionalisation strategy with a focus on the implications for people with disabilities and chronic illnesses across multiple sites of care. While Ontario is used as a case study to contextualize our discussion, the issues we identify, the ethical principles we apply, and the critical success factors we provide have broader applicability for guiding and evaluating the development of – or revisions to – a regionalised health care strategy. (shrink)

Drawing on a landscape analysis of existing data-sharing initiatives, in-depth interviews with expert stakeholders, and public deliberations with community advisory panels across the U.S., we describe features of the evolving medical information commons. We identify participant-centricity and trustworthiness as the most important features of an MIC and discuss the implications for those seeking to create a sustainable, useful, and widely available collection of linked resources for research and other purposes.

This collection brings together fourteen contributions by authors from around the globe. Each of the contributions engages with questions about how local and global bioethical issues are made to be comparable, in the hope of redressing basic needs and demands for justice. These works demonstrate the significant conceptual contributions that can be made through feminists' attention to debates in a range of interrelated fields, especially as they formulate appropriate responses to developments in medical technology, global economics, population shifts, and poverty.