Não sei por qual fatalidade sucede que as coisas das quais mais falamos entre os homens são, ordinariamente, aquelas que menos conhecemos. Tal é, entre mil outras, a matéria que pretendo tratar: o Belo. Todo mundo fala sobre isso, todo mundo raciocina sobre isso. Não há círculos no pátio, sociedades nas cidades, ecos nos campos, abóbodas nos templos, que não ressoem o Belo. Queremos o belo em toda parte: belo nas obras da natureza, belo nas produções da arte, belo nas (...) obras do espírito, belo nos costumes; e, se o encontramos em alguma parte, é pouco dizer que por ele somos tocados; somos atingidos, tomados, encantados. Mas pelo que o somos? (shrink)

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

The incarnation of the Word marks the arrival of the fullness of times. The Holy Spirit hovers with Its shadow and power over the Virgin Mary and starts the time of realization, of the promised salvation, the Messiah's arrival. Mary is the figure of the people of Israel that waits the ultimate freedom, promised by God. In it, God mounts his tent among men and relates to the men, bringing him to a new life in the Holy Spirit.

This article explores André-Marie Ampère's autobiography in order to analyse the dynamics of science in early 19th century French institutions. According to recent works that have emphasised the value of biographies in the history of science, this study examines Ampère's public self-representation to show the cultural transformations of a life dedicated to science in post-revolutionary French society. With this aim, I have interpreted this manuscript as an outstanding example of the scientific rhetoric flourishing in early 19th century French Romanticism, (...) which celebrated the life and works of men of science by means of biographies. Following this approach, Ampère's account has been analysed in relation to certain commonplaces shared with other autobiographies of that time, such as his traumatic experience linked to the French Revolution. Finally, this article discusses Ampère's autobiography as revealing an emerging model of scientific personae, i.e. a new collective way of thinking, feeling and perceiving, which announced the category of the modern scientist. (shrink)

El interés de la presente compilación es el de recoger algunas de las principales reflexiones del pensamiento político contemporáneo. Se propone como tarea central el examen y la problematización de algunos presupuestos extendidos en la tradición de la filosofía occidental. Por medio de este cuestionamiento, se busca desestabilizar asunciones que atraviesan nuestros modos habituales de concebir el sujeto, la acción y el espacio políticos, y de comprender la manera como estos son configurados por el lenguaje. Es así como una amplia (...) gama de autores encuentra un espacio común de discusión: la urgencia de plantear alternativas tanto crítica como de compresión de lo político, que permitan movilizar nuevas maneras de concebir la acción y la configuración de nuestros modos de ser en común; alternativas que incluso pueden encontrarse ya allí, a la sombra de lo político, en sus recodos escondidos, silenciados; en lugares o motivos que tal vez han pasado desapercibidos por no hacer parte de un discurso e interpretación dominantes. En particular, interesa aquí rescatar aquellas reflexiones que abordan esta tarea desde tres ejes temáticos concretos: la pregunta por la relación entre ley y violencia, la necesidad de repensar el ser en común, y, por último, el problema de cómo concebir los pasajes y discontinuidades entre la singularidad de la contingencia histórica, cultural, lingüística, y la posibilidad o promesa de lo universal. (shrink)

Central sensitization refers to the increased responsiveness of nociceptive neurons in the central nervous system after repeated or sustained peripheral nociceptor activation. It is hypothesized to play a key role in the development of chronic pain. A hallmark of central sensitization is an increased sensitivity to noxious mechanical stimuli extending beyond the injured location, known as secondary hyperalgesia. For its ability to modulate the transmission and the processing of nociceptive inputs, attention could constitute a promising target to prevent central sensitization (...) and the development of chronic pain. It was recently shown that the experimental induction of central sensitization at both forearms of healthy volunteers using bilateral high-frequency electrocutaneous stimulation (HFS), can be modulated by encouraging participants to selectively focus their attention to one arm, to the detriment of the other arm, resulting in a greater secondary hyperalgesia on the attended arm as compared to the unattended one. Given the potential value of the question being addressed, we conducted a preregistered replication study in a well-powered independent sample to assess the robustness of the effect, i.e., the modulatory role of spatial attention on the induction of central sensitization. This hypothesis was tested using a double-blind, within-subject design. Sixty-seven healthy volunteers performed a task that required focusing attention toward one forearm to discriminate innocuous vibrotactile stimuli while HFS was applied on both forearms simultaneously. Our results showed a significant increase in mechanical sensitivity directly and 20 min after HFS. However, in contrast to the previous study, we did not find a significant difference in the development of secondary hyperalgesia between the attended vs. unattended arms. Our results question whether spatial selective attention affects the development of secondary hyperalgesia. Alternatively, the non-replication could be because the bottom-up capture of attention caused by the HFS-mediated sensation was too strong in comparison to the top-down modulation exerted by the attentional task. In other words, the task was not engaging enough and the HFS pulses, including those on the unattended arm, were too salient to allow a selective focus on one arm and modulate nociceptive processing. (shrink)

Book MARY, André. Os antropólogos e a religião. Trad. Lúcia Mathilde Endlich Orth. São Paulo: Ideias e Letras, 2014. ISBN 978-85-6589-369-5.

Le témoignage de Sœur Marie-André du Sacré-Cœur s'inscrit parfaitement dans la dénonciation du travail forcé féminin développée par les missionnaires catholiques de Haute-Volta dans la première moitié du XXe siècle. Les missions se présentent volontiers comme les seuls lieux de protection de la population africaine contre l'exploitation abusive du travail forcé. Parfois, elles recourent à l'opinion publique métropolitaine, en dénonçant, dans la presse catholique, la mauvaise gestion ad...

Le témoignage de Sœur Marie-André du Sacré-Cœur s'inscrit parfaitement dans la dénonciation du travail forcé féminin développée par les missionnaires catholiques de Haute-Volta dans la première moitié du XXe siècle. Les missions se présentent volontiers comme les seuls lieux de protection de la population africaine contre l'exploitation abusive du travail forcé. Parfois, elles recourent à l'opinion publique métropolitaine, en dénonçant, dans la presse catholique, la mauvaise gestion ad...

English summary: Marc Andre Wiegand analyzes the neo-Kantian premises of Gustav Radbruch's legal philosophy.

Although the method of Belgian budgeting and controlling has considerably improved during recent years, there still remain a lot of shortcommings such as: frequently late introduction into Parliament of the budget, inadequate information about expenditure, rarely application of zero base budgeting aften combined with techniques which embellish the budget. Debudgeting is the most important camouflage technique. Debudgeting appears in different manners and influences not only the height but also the evolution of the budget deficit. An improvement of the budgeting technique (...) in Belgium doesn't ask fundamental changes of actual law. Just a switch in applicating the law according to the original spirit and interpretation of actual legislation, would be satisfactory to obtain an efficient and effective budget-policy. (shrink)

In the _World Library of Educationalists_, international experts themselves compile career-long collections of what they judge to be their finest pieces – extracts from books, key articles, salient research findings, major theoretical and practical contributions – so the world can read them in a single manageable volume, allowing readers to follow the themes of their work and see how it contributes to the development of the field. Mary James has researched and written on a range of educational subjects which encompass (...) curriculum, pedagogy and assessment in schools, and implications for teachers´ professional development, school leadership and policy frameworks. She has written many books and journals on assessment, particularly assessment for learning and is an expert on teacher learning, curriculum, leadership for learning and educational policy. Starting with a specially written introduction in which Mary gives an overview of her career and contextualises her selection, the chapters are divided into three parts: Educational Assessment and Learning Educational Evaluation and Curriculum Development Educational Research and the Improvement of Practice Through this book, readers can follow the different strands that Mary James has researched and written about over the last three decades, and clearly see her important contribution to the field of education. (shrink)

Dem Absurden ins Auge sehen - das ist eine Herausforderung, die mit Entzweiung, Entfremdung und demzufolge mit großer Anspannung und Anstrengung einhergeht. In solchen Momenten entgleitet uns die Welt und wir stehen, so Albert Camus, vor der alles entscheidenden Frage: Selbstmord oder Freiheit. Der vorliegende Band verhandelt Bedrohungen und Gefahren ebenso wie Potenziale und Freiheiten des Absurden. Stimmen aus Philosophie, Erziehungswissenschaft, Literatur, Kunst, Medizin und Wirtschaftswissenschaft machen dabei deutlich: Das Absurde betrifft uns alle.

Mary Daly had a complicated relationship to the Catholic tradition. While it is commonly assumed that she rejected it thoroughly, this article offers a more nuanced look at the various ways in which it shaped her thinking. What is clear is that she had a decisive impact on the Catholic tradition, indeed on religion in general. Language about the divine, images of deities, human participation in things spiritual will never be the same after her thorough-going feminist critique. Her legacy is (...) multi-faceted like the woman herself. (shrink)