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Mark Vincent [4]Mark D. Vincent [2]
  1.  32
    Cancer: A de‐Repression of a Default Survival Program Common to All Cells?Mark Vincent - 2012 - Bioessays 34 (1):72-82.
  2.  10
    Resistance to Cancer Chemotherapy as an Atavism?Mark Vincent - 2016 - Bioessays 38 (11):1065-1065.
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  3.  6
    Targeting Cancer's Weaknesses : Therapeutic Strategies Suggested by the Atavistic Model.Charles H. Lineweaver, Paul C. W. Davies & Mark D. Vincent - 2014 - Bioessays 36 (9):827-835.
    In the atavistic model of cancer progression, tumor cell dedifferentiation is interpreted as a reversion to phylogenetically earlier capabilities. The more recently evolved capabilities are compromised first during cancer progression. This suggests a therapeutic strategy for targeting cancer: design challenges to cancer that can only be met by the recently evolved capabilities no longer functional in cancer cells. We describe several examples of this target‐the‐weakness strategy. Our most detailed example involves the immune system. The absence of adaptive immunity in immunosuppressed (...)
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  4.  9
    Cancer Adaptations: Atavism, de Novo Selection, or Something in Between?Frédéric Thomas, Beata Ujvari, François Renaud & Mark Vincent - 2017 - Bioessays 39 (8):1700039.
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  5.  7
    Cancer: Towards a General Theory of the Target.Mark D. Vincent - 2017 - Bioessays 39 (9):1700059.
    General theories are reductionist explications of apparently independent facts. Here, in reviewing the literature, I develop a GT to simplify the cluttered landscape of cancer therapy targets by revealing they cluster parsimoniously according to only a few underlying principles. The first principle is that targets can be only exploited by either or both of two fundamentally different approaches: causality-inhibition, and ‘acausal’ recognition of some marker or signature. Nonetheless, each approach must achieve both of two separate goals, efficacy and selectivity ; (...)
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  6.  6
    Evolutionarily Conserved Stress Responses as Potential Anticancer Therapeutic Targets? [REVIEW]Mark Vincent - 2014 - Bioessays 36 (6):544-545.
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