Deep brain stimulation (DBS) to different sites allows interfering with dysfunctional network function implicated in major depression. Because a prominent clinical feature of depression is anhedonia--the inability to experience pleasure from previously pleasurable activities--and because there is clear evidence of dysfunctions of the reward system in depression, DBS to the nucleus accumbens might offer a new possibility to target depressive symptomatology in otherwise treatment-resistant depression. Three patients suffering from extremely resistant forms of depression, who did not respond to pharmacotherapy, psychotherapy, (...) and electroconvulsive therapy, were implanted with bilateral DBS electrodes in the nucleus accumbens. Stimulation parameters were modified in a double-blind manner, and clinical ratings were assessed at each modification. Additionally, brain metabolism was assessed 1 week before and 1 week after stimulation onset. Clinical ratings improved in all three patients when the stimulator was on, and worsened in all three patients when the stimulator was turned off. Effects were observable immediately, and no side effects occurred in any of the patients. Using FDG-PET, significant changes in brain metabolism as a function of the stimulation in fronto-striatal networks were observed. No unwanted effects of DBS other than those directly related to the surgical procedure (eg pain at sites of implantation) were observed. Dysfunctions of the reward system--in which the nucleus accumbens is a key structure--are implicated in the neurobiology of major depression and might be responsible for impaired reward processing, as evidenced by the symptom of anhedonia. These preliminary findings suggest that DBS to the nucleus accumbens might be a hypothesis-guided approach for refractory major depression. (shrink)

Transcranial magnetic stimulation is a relatively non-invasive technique to interfere with the function of small cortical areas through currents induced by alternating magnetic fields emanating from a handheld coil placed directly above the targeted area. This technique has clear effects on a whole range of measures of brain function and has become an important research tool in neuropsychiatry. More recently, TMS has been studied in psychiatry mainly to assess its putative therapeutic effects in the treatment of refractory major depression. Most (...) studies indicate that both low-frequency TMS and higher frequency repetitive TMS may have some antidepressant properties. This is most interesting and opens a whole new avenue of low invasive techniques to stimulate the brain in major depression. However, definite therapeutic effects of clinical significance still remain to be demonstrated. (shrink)

Culture and Enlightenment are the two words that best characterise the essence of György Markus's career, in whose honour this book is published. Markus devoted the last twenty years of research towards a theory of cultural objectivations and their pragmatics, and the great depth of his knowledge of the history of culture and philosophy informs all his teaching and writing. The pursuit of Enlightenment ideals attains reflective self-consciousness in Markus' works; forged in the knowledge of its own (...) historicity, of the embeddedness of rationalities in culture and in an awareness of the paradoxes that cling to the conscious affirmation of ideals which are no longer self evident or beyond questioning. In taking up the challenge of these paradoxes, Markus spans the whole history of modern philosophy and culture with a matchless authority.This book draws together contributions from leading figures in contemporary philosophy, who are also friends, colleagues and former students of György Markus. The book is divided into two sections: the first presents critical assessments of various aspects of Markus' wide-ranging works; the second presents contributions in celebration of his influence and his wide interests. In their critical assessment of Markus' work and in the demonstration of his influence, the contributors hope to convey something of the breadth and something of the excitement of doing philosophy in the company of György Markus. (shrink)

Markus Lammenranta’s essay sheds light on at least one of the reasons for this. Arguing that disagreement plays a key role not only in the Pyrrhonian but also in the Cartesian skeptical arguments, he contends that these arguments are intuitively sound and that their intuitiveness cannot be accounted for unless we assume a dialectical conception of justification. As we saw, this view maintains that one is justified in holding a belief if and only if, when appropriately challenged, one is (...) able to defend it by offering reasons for it. Lammenranta claims that such a conception of justification should be accepted because it is rooted in our ordinary epistemic practices, and that most epistemologists fail to appreciate and explain the strength of disagreement-based skeptical arguments because of their adoption of an individualistic and nondialectical epistemology. (shrink)

One of the most fundamental questions in the philosophy of mathematics concerns the relation between truth and formal proof. The position according to which the two concepts are the same is called deflationism, and the opposing viewpoint substantialism. In an important result of mathematical logic, Kurt Gödel proved in his first incompleteness theorem that all consistent formal systems containing arithmetic include sentences that can neither be proved nor disproved within that system. However, such undecidable Gödel sentences can be established to (...) be true once we expand the formal system with Alfred Tarski s semantical theory of truth, as shown by Stewart Shapiro and Jeffrey Ketland in their semantical arguments for the substantiality of truth. According to them, in Gödel sentences we have an explicit case of true but unprovable sentences, and hence deflationism is refuted. -/- Against that, Neil Tennant has shown that instead of Tarskian truth we can expand the formal system with a soundness principle, according to which all provable sentences are assertable, and the assertability of Gödel sentences follows. This way, the relevant question is not whether we can establish the truth of Gödel sentences, but whether Tarskian truth is a more plausible expansion than a soundness principle. In this work I will argue that this problem is best approached once we think of mathematics as the full human phenomenon, and not just consisting of formal systems. When pre-formal mathematical thinking is included in our account, we see that Tarskian truth is in fact not an expansion at all. I claim that what proof is to formal mathematics, truth is to pre-formal thinking, and the Tarskian account of semantical truth mirrors this relation accurately. -/- However, the introduction of pre-formal mathematics is vulnerable to the deflationist counterargument that while existing in practice, pre-formal thinking could still be philosophically superfluous if it does not refer to anything objective. Against this, I argue that all truly deflationist philosophical theories lead to arbitrariness of mathematics. In all other philosophical accounts of mathematics there is room for a reference of the pre-formal mathematics, and the expansion of Tarkian truth can be made naturally. Hence, if we reject the arbitrariness of mathematics, I argue in this work, we must accept the substantiality of truth. Related subjects such as neo-Fregeanism will also be covered, and shown not to change the need for Tarskian truth. -/- The only remaining route for the deflationist is to change the underlying logic so that our formal languages can include their own truth predicates, which Tarski showed to be impossible for classical first-order languages. With such logics we would have no need to expand the formal systems, and the above argument would fail. From the alternative approaches, in this work I focus mostly on the Independence Friendly (IF) logic of Jaakko Hintikka and Gabriel Sandu. Hintikka has claimed that an IF language can include its own adequate truth predicate. I argue that while this is indeed the case, we cannot recognize the truth predicate as such within the same IF language, and the need for Tarskian truth remains. In addition to IF logic, also second-order logic and Saul Kripke s approach using Kleenean logic will be shown to fail in a similar fashion. (shrink)

In Pantsar (2014), an outline for an empirically feasible epistemological theory of arithmetic is presented. According to that theory, arithmetical knowledge is based on biological primitives but in the resulting empirical context develops an essentially a priori character. Such contextual a priori theory of arithmetical knowledge can explain two of the three characteristics that are usually associated with mathematical knowledge: that it appears to be a priori and objective. In this paper it is argued that it can also explain the (...) ... (shrink)

Intellectual humility is an interesting but underexplored disposition. The claim “I am (intellectually) humble” seems paradoxical in that someone who has the disposition in question would not typically volunteer it. There is an explanatory gap between the meaning of the sentence and the meaning the speaker expresses by uttering it. We therefore suggest analyzing intellectual humility semantically, using a psycholexical approach that focuses on both synonyms and antonyms of ‘intellectual humility’. We present a thesaurus-based method to map the semantic space (...) of intellectual humility as a heuristic to support philosophical and psychological analysis of this disposition. We find three semantic clusters that compose intellectual humility: the sensible self, the discreet self, and the inquisitive self; likewise, we find three clusters that compose its contraries: the overrated self, the underrated other, and the underrated self. (shrink)

Are our beliefs justified only relatively to a specific culture or society? Is it possible to give reasons for the superiority of our scientific, epistemic methods? Markus Seidel sets out to answer these questions in his critique of epistemic relativism. Focusing on the work of the most prominent, explicitly relativist position in the sociology of scientific knowledge – so-called 'Edinburgh relativism' or the 'Strong Programme' –, he scrutinizes the key arguments for epistemic relativism from a philosophical perspective: underdetermination and (...) norm-circularity. His main negative result is that these arguments fall short of establishing epistemic relativism. -/- Despite arguing for epistemic absolutism, Seidel aims to provide an account of non-relative justification that nevertheless integrates the basic, correct intuition of the epistemic relativist. His main positive result is that the epistemic absolutist can very well accept the idea that people using different standards of justification can be equally justified in holding their beliefs: Rational disagreement, he maintains, is perfectly possible. -/- The book provides a detailed critique of relativism in the sociology of scientific knowledge and beyond. With its constructive part it aims at making conciliatory steps in a highly embittered discussion between sociology and philosophy of science. (shrink)

Metaphysics and science have a long but troubled relationship. In the twentieth century the Logical Positivists argued metaphysics was irrelevant and that philosophy should be guided by science. However, metaphysics and science attempt to answer many of the same, fundamental questions: What are laws of nature? What is causation? What are natural kinds? -/- In this book, Markus Schrenk examines and explains the central questions and problems in the metaphysics of science. He reviews the development of the field from (...) the early modern period through to the latest research, systematically assessing key topics including -/- dispositions, counterfactual conditionals, laws of nature, causation, natural kinds, essence, necessity. -/- With the addition of chapter summaries and annotated further reading, Metaphysics of Science is a much-needed, clear and informative survey of this exciting area of philosophical research. It is essential reading for students and scholars of philosophy of science and metaphysics. (shrink)

It is still a widespread assumption that metaphysics and ontology deal with roughly the same questions. They are supposed to be concerned with the fundamental nature of reality and to give an account of the meaning of 'existence' or 'being' in line with the broadest possible metaphysical assumptions. Against this, Markus Gabriel proposes a radical form of ontological pluralism that divorces ontology from metaphysics, understood as the most fundamental theory of absolutely everything. He argues that the concept of existence (...) is incompatible with the existence of the world and therefore proposes his innovative no-world-view. In the context of recent debates surrounding new realism and speculative realism, Gabriel also develops the outlines of a realist epistemological pluralism. His idea here is that there are different forms of knowledge that correspond to the plurality of fields of sense that must be acknowledged in order to avoid the trap of metaphysics. (shrink)

Professor Zdeněk Mathauser, Czech aesthetician and literary scholar, expert on Husserl’s phenomenology and French and Czech Structuralism, author of many publications, including Básnivé nápovědi Husserlovy fenomenologie.

The essay investigates the possibility of a closer connection of Husserlian phenomenology and that tradition in semiotics of art which originates mainly withSchelling and Goethe. The affinity between semiotically approached tropology and phenomenology is supported if a symbol is conceived not only as an analogy of the designated, but also as its direct grasping. This grasping shows some features of rational contemplation as understood by phenomenology. Modelling symbol as a synthetic trope enables us to proceed to the model of an (...) "artistic situation" as a square generated by a decomposition of the triangle of reference. The complexity of the processes within the "square" results from a fusion of the effects of the linear, natural circuit and the feedback, culturally historical circuit. (shrink)

In this paper, I study how mathematicians are presented in western popular culture. I identify five stereotypes that I test on the best-known modern movies and television shows containing a significant amount of mathematics or important mathematician characters: (1) Mathematics is highly valued as an intellectual pursuit. (2) Little attention is given to the mathematical content. (3) Mathematical practice is portrayed in an unrealistic way. (4) Mathematicians are asocial and unable to enjoy normal life. (5) Higher mathematics is ...

Though ancient Pyrrhonian skepticism is apparently based on disagreement, this aspect of skepticism has been widely neglected in contemporary discussion on skepticism. The paper provides a rational reconstruction of the skeptical argument from disagreement that can be found in the books of Sextus Empiricus. It is argued that this argument forms a genuine skeptical paradox that has no fully satisfactory resolution. All attempts to resolve it make knowledge or justified belief either intuitively too easy or impossible.

Leading linguists and philosophers report on all aspects of compositionality, the notion that the meaning of an expression can be derived from its parts. This book explores every dimension of this field, reporting critically on different lines of research, revealing connections between them, and highlighting current problems and opportunities.

Interpreters of Machiavelli easily agree that his political writings have profoundly influenced our fundamental ideas of state and society, yet these interpreters rarely agree on what Machiavelli really thought. Did Machiavelli seek to recover classical republicanism in the Aristotelian tradition, or did he aspire to usher in modernity? Was he a cynic who assumed human beings to be inescapably wicked and offered technical advice to tyrants, or did he aim at some version of "the good life"? Did he create a (...) general theory of politics, or did he teach us that political issues should be approached in a particular contextual, dialectical, or rhetorical manner? Through systematic analysis, Markus Fischer's cogent and articulate study succeeds in resolving these questions. Well-Ordered License will appeal both to new students of Machiavelli and to scholars who have long sought to reconcile the seeming incoherence of his work. (shrink)

In this book, Markus Locker demonstrates that the paradox behind each truth claim opens a channel of communication of truths.

Abstract In the new millennium there have been important empirical developments in the philosophy of mathematics. One of these is the so-called “Empirical Philosophy of Mathematics”(EPM) of Buldt, Löwe, Müller and Müller-Hill, which aims to complement the methodology of the philosophy of mathematics with empirical work. Among other things, this includes surveys of mathematicians, which EPM believes to give philosophically important results. In this paper I take a critical look at the sociological part of EPM as a case study of (...) ... (shrink)

In very general terms, an agent is a being with the capacity to act, and 'agency' denotes the exercise or manifestation of this capacity. The philosophy of action provides us with a standard conception and a standard theory of action. The former construes action in terms of intentionality, the latter explains the intentionality of action in terms of causation by the agent’s mental states and events. From this, we obtain a standard conception and a standard theory of agency. There are (...) alternative conceptions of agency, and it has been argued that the standard theory fails to capture agency. Further, it seems that genuine agency can be exhibited by beings that are not capable of intentional action, and it has been argued that agency can and should be explained without reference to causally efficacious mental states and events. Debates about the nature of agency have flourished over the past few decades in philosophy and in other areas of research. In philosophy, the nature of agency is an important issue in the philosophy of mind, the philosophy of psychology, the debates on free will and moral responsibility, in ethics, meta-ethics, and in the debates on the nature of reasons and practical rationality. For the most part, this entry focuses on conceptual and metaphysical questions concerning the nature of agency. In the final sections, it provides an overview of empirically informed accounts of the sense of agency and of various empirical challenges to the commonsense assumption that our reasons and our conscious intentions make a real difference to how we act. (shrink)

Where do we come from? Are we merely a cluster of elementary particles in a gigantic world receptacle? And what does it all mean? In this highly original new book, the philosopher Markus Gabriel challenges our notion of what exists and what it means to exist. He questions the idea that there is a world that encompasses everything like a container life, the universe, and everything else. This all-inclusive being does not exist and cannot exist. For the world itself (...) is not found in the world. And even when we think about the world, the world about which we think is obviously not identical with the world in which we think. For, as we are thinking about the world, this is only a very small event in the world. Besides this, there are still innumerable other objects and events: rain showers, toothaches and the World Cup. Drawing on the recent history of philosophy, Gabriel asserts that the world cannot exist at all, because it is not found in the world. Yet with the exception of the world, everything else exists; even unicorns on the far side of the moon wearing police uniforms. Revelling in witty thought experiments, word play, and the courage of provocation, Markus Gabriel demonstrates the necessity of a questioning mind and the role that humour can play in coming to terms with the abyss of human existence. (shrink)

In “How Art Teaches: A Lesson from Goodman”, Markus Lammenranta inquires if and how artworks can convey propositional knowledge about the world. Lammenranta argues that the cognitive role of art can be explained by revising Nelson Goodman’s theory of symbols. According to Lammenranta, the problem of Goodman’s theory is that, despite providing an account of art’s symbolic function, it denies art the possibility of mediating propositional knowledge. Lammenranta claims that Goodman’s theory can be augmented by enlarging it with an (...) account of direct reference developed by Bertrand Russell and contemporary philosophy of language. On this basis, an expanded version of Goodman’s theory can explain how artworks can express propositions even without being linguistic, representational, or non-fictive. Lammenranta explicates his theory by explaining how abstract paintings and literary fictions can mediate propositional claims about the actual, everyday world. (shrink)

We propose a multi-step evaluation schema designed to help procurement agencies and others to examine the ethical dimensions of autonomous systems to be applied in the security sector, including autonomous weapons systems.

A provoking new approach to how we understand metaphors thoroughly comparing and contrasting the claims made by relevance theorists and cognitive linguists. The resulting hybrid theory shows the complementarity of many positions as well as the need and possibility of achieving a broader and more realistic theory of our understanding.

This 44-chapter volume tackles a quickly-evolving field of inquiry, mapping the existing discourse as part of a general attempt to place current developments in historical context; at the same time, breaking new ground in taking on novel subjects and pursuing fresh approaches. The term "A.I." is used to refer to a broad range of phenomena, from machine learning and data mining to artificial general intelligence. The recent advent of more sophisticated AI systems, which function with partial or full autonomy and (...) are capable of tasks which require learning and 'intelligence', presents difficult ethical questions, and has drawn concerns from many quarters about individual and societal welfare, democratic decision-making, moral agency, and the prevention of harm. This work ranges from explorations of normative constraints on specific applications of machine learning algorithms today-in everyday medical practice, for instance-to reflections on the (potential) status of AI as a form of consciousness with attendant rights and duties and, more generally still, on the conceptual terms and frameworks necessarily to understand tasks requiring intelligence, whether "human" or "A.I.". (shrink)

Palabras pronunciadas por Markus Gabriel en el marco del encuentro internacional "Presente del idealismo alemán" organizado por el Departamento de Filosofía de la Universidad Nacional de Colombia. Conferencia que tuvo lugar el 9 de octubre de 2009.

Intellectual humility can be broadly construed as being conscious of the limits of one’s existing knowledge and capable to acquire more knowledge, which makes it a key virtue of the information age. However, the claim “I am (intellectually) humble” seems paradoxical in that someone who has the disposition in question would not typically volunteer it. There is an explanatory gap between the meaning of the sentence and the meaning the speaker ex- presses by uttering it. We therefore suggest analyzing intellectual (...) humility semantically, using a psycholexical approach that focuses on both synonyms and antonyms of ‘intellectual humili- ty’. We present a thesaurus-based methodology to map the semantic space of intellectual hu- mility and the vices it opposes as a heuristic to support philosophical and psychological anal- ysis of this disposition. We performed the mapping both in English and German in order to test for possible cultural differences in the understanding of intellectual humility. In both lan- guages, we find basically the same three semantic dimensions of intellectual humility (sensi- bility, discreetness, and knowledge dimensions) as well as three dimensions of its related vic- es (self-overrating, other-underrating and dogmatism dimensions). The resulting semantic clusters were validated in an empirical study with English (n=276) and German (n=406) par- ticipants. We find medium to high correlations (0.54-0.72) between thesaurus similarity and perceived similarity, and we can validate the labels of the three dimensions identified in the study. But we also find indications of the limitations of the thesaurus methodology in terms of cluster plausibility. We conclude by discussing the importance of these findings for construct- ing psychometric scales for intellectual humility. (shrink)

The spheres of communication theory, semiotics, linguistics and partly also the modern information technologies had in Bohemia and, especially, in Prague, a city with one of the first European universities, good traditions, very stimulating conditions and a good interdisciplinary atmosphere. This atmosphere had its foundations in traditions of one of the European intellectual and cultural cross-roads connecting Slavic, German and Jewish values. In the period between the two world wars Prague had a Czech university, a German university and many years (...) a Russian university for Russian emmigrants. Simultaneously, this country represented an island of democracy in the period of the rise of totalitarian regimes and ideologies. The researchers working in Prague participated together with intellectuals in Vienna, Warsaw and Berlin in the rise of the analytical philosophy, in establishing new conceptions of linguistics and in other scientific initiatives. Some of these traditions and centres of scientific initatives were strongly damaged by two occupations during and then after the second world war. Therefore, the re-establishment of these traditions and centres belonged to the important tasks of the social, cultural and intellectual transformations after the democratic changes and the fall of totalitarian systems and ideologies at the end of the eighties. The fruitful collaboration of the old and the young generations in the attempts to re-establish the old traditions in connections with the topical scientific trends belongs to the important tasks of contemporary scientific activities in the research institutes and university departments. (shrink)

Although an important part of the origins of analytic philosophy can be traced back to philosophy in Austria in the first part of the twentieth century, remarkably little is known about the specific contribution made by Austrian philosophy and philosophers. In The Austrian Contribution to Analytic Philosophy prominent analytic philosophers take a fresh look at the roots of analytic philosophy in the thought of influential but often overlooked Austrian philosophers, including Brentano, Meinong, Bolzano, Husserl, and Witasek. The contributors to this (...) volume investigate central topics in theoretical philosophy, such as intentionality, consciousness, memory, attributes, and truth as well as political philosophy and aesthetics. This original collection will be of interest to anyone studying the origins of analytic philosophy as well as contemporary debates in philosophy of language, metaphysics and mind. (shrink)

The book addresses the constitution of the high culture of modernity as an uneasy unity of the sciences, including philosophy, and the arts. Their internal dynamism and strain is established through, on the one hand, the relationship of the author - work - recipient, and, on the other, the respective roles of experts and the market.