The microbiome of human hair follicles (HFs) has emerged as an important player in different HF and skin pathologies, yet awaits in‐depth exploration. This raises questions regarding the tightly linked interactions between host environment, nutrient dependency of host‐associated microbes, microbial metabolism, microbe‐microbe interactions and host immunity. The use of simple model systems facilitates addressing generally important questions and testing overarching, therapeutically relevant principles that likely transcend obvious interspecies differences. Here, we evaluate the potential of the freshwater polyp Hydra, to dissect (...) fundamental principles of microbiome regulation by the host, that is the human HF. In particular, we focus on therapeutically targetable host‐microbiome interactions, such as nutrient dependency, microbial interactions and host defence. Offering a new lens into the study of HF – microbiota interactions, we argue that general principles of how Hydra manages its microbiota can inform the development of novel, microbiome‐targeting therapeutic interventions in human skin disease. (shrink)

In this study of the functionally referential alarm calls in the meerkats, we tested the hypothesis that the ability to refer to a specific location was an important factor in the evolution of discrete vocalizations. We investigated what information receivers gained about the location of the predator from alarm calls with high stimulus specificity compared to alarm calls with low stimulus specificity. Furthermore, we studied whether visual cues about the localization of the predator may be available from the posture of (...) the caller. We described the general behaviour of the caller, the caller’s posture, and in particular its gaze direction. We then observed receivers responding to the different call types, to determine whether the acoustic structure of the calls was enough for them to respond in the appropriate way, or whether they used additional visual cues from the caller. We tested this with specific manipulation experiments, using three set ups of playback experiments: no caller visible; model guard with specific gaze direction; and live sentinel. Natural observations and experiments confirmed that in high urgency situations the meerkats have enough information from the acoustic structure of the call to respond appropriately. When hearing low urgency calls that are less stimuli specific, meerkats used visual cues as an additional source of information in a few cases. This may indicate that functionally referential calls evolved to denote the location of the predator, rather than the predator type or its velocity of approach. However, when discussing this result in comparison to other functionally referential calls, such as the food associated calls and recruitment calls, this localization hypothesis does not appear to apply to the functionally referential calls in general. (shrink)

Language’s intentional nature has been highlighted as a crucial feature distinguishing it from other communication systems. Specifically, language is often thought to depend on highly structured intentional action and mutual mindreading by a communicator and recipient. Whilst similar abilities in animals can shed light on the evolution of intentionality, they remain challenging to detect unambiguously. We revisit animal intentional communication and suggest that progress in identifying analogous capacities has been complicated by (i) the assumption that intentional (that is, voluntary) production (...) of communicative acts requires mental-state attribution, and (ii) variation in approaches investigating communication across sensory modalities. To move forward, we argue that a framework fusing research across modalities and species is required. We structure intentional communication into a series of requirements, each of which can be operationalised, investigated empirically, and must be met for purposive, intentionally communicative acts to be demonstrated. Our unified approach helps elucidate the distribution of animal intentional communication and subsequently serves to clarify what is meant by attributions of intentional communication in animals and humans. (shrink)

When using sample data to decide whether two populations differ, laypeople attend to the difference between group means, but largely overlook within-group variability (Obrecht, Chapman, & Gelman, 2007). We show, first, that laypeople know about and use story-implied variability when making pairwise comparisons. Then we demonstrate that participants' sensitivity to variance in a dataset is boosted when presented in a context that implies consistent variance information. Statistical data were couched in stories about electrical conductivity measurements obtained from element samples (low-variability (...) category) or body weight measurements from samples of peoples (high-variability category). We manipulated, between participants, whether the data variance matched or mismatched the story-implied variability. Participants who received data in a matching context showed high sensitivity to variance, while those in the mismatching condition did not. Laypeople use statistical data to make reasonable inferences when those data are provided in a context that makes sense. (shrink)

Instead of the existential quantifier Bernard Bolzano uses his notion of Gegenständlichkeit einer Vorstellung an sich . This approach makes it possible for him to solve the traditional problem of the predication of existence in accordance with an approach common today, namely to take existence to be primarily a property of a corresponding representation in itself, and not a characteristic of individuals. However, Bolzano considers a property of real existence to be attributable also to particular individuals, which is essentially different (...) from the usual practice. (shrink)

Humans routinely make inferences about both the contents and the workings of other minds based on observed actions. People consider what others want or know, but also how intelligent, rational, or attentive they might be. Here, we introduce a new methodology for quantitatively studying the mechanisms people use to attribute intelligence to others based on their behavior. We focus on two key judgments previously proposed in the literature: judgments based on observed outcomes (you're smart if you won the game) and (...) judgments based on evaluating the quality of an agent's planning that led to their outcomes (you're smart if you made the right choice, even if you didn't succeed). We present a novel task, the maze search task (MST), in which participants rate the intelligence of agents searching a maze for a hidden goal. We model outcome‐based attributions based on the observed utility of the agent upon achieving a goal, with higher utilities indicating higher intelligence, and model planning‐based attributions by measuring the proximity of the observed actions to an ideal planner, such that agents who produce closer approximations of optimal plans are seen as more intelligent. We examine human attributions of intelligence in three experiments that use MST and find that participants used both outcome and planning as indicators of intelligence. However, observing the outcome was not necessary, and participants still made planning‐based attributions of intelligence when the outcome was not observed. We also found that the weights individuals placed on plans and on outcome correlated with an individual's ability to engage in cognitive reflection. Our results suggest that people attribute intelligence based on plans given sufficient context and cognitive resources and rely on the outcome when computational resources or context are limited. (shrink)

In [9] it is proved the categorical isomorphism of two varieties: bounded commutative BCK-algebras and MV -algebras. The class of MV -algebras is the algebraic counterpart of the infinite valued propositional calculus L of Lukasiewicz . The main objective of the present paper is to study that isomorphism from the perspective of logic. The B-C-K logic is algebraizable and the quasivariety of BCKalgebras is the equivalent algebraic semantics for that logic . We call commutative B-C-K logic, briefly cBCK, to the (...) extension of B-C-K logic associated to the variety of commutative BCK–algebras. Moreover, we present the extension Boc of cBCK obtained by adding the axiom of “boundness”. We prove that the deductive system Boc is equivalent to L. We observe that cBCK admits two interesting extensions: the logic Boc, treated in this paper, which is equivalent to the system L of Lukasiewicz, and the logic Co that is naturally associated to the system Balo of `-groups . This constructions establish a link between L and Balo , that would be a logical approach to the categorical relationship between MV–algebras and `-groups. (shrink)

An equivalence between the category of MV-algebras and the category \ is given in Castiglioni et al. :67–92, 2014). An integral residuated lattice with bottom is an MV-algebra if and only if it satisfies the equations \ \vee = 1}\) and \ = a \wedge b}\). An object of \ is a residuated lattice which in particular satisfies some equations which correspond to the previous equations. In this paper we extend the equivalence to the category whose objects are pairs, where (...) A is an MV-algebra and I is an ideal of A. (shrink)

Barcelona, juny de 2017: el primer dimarts del mes comença amb una vaga de 24 hores de taxistes de la ciutat en contra d’Uber i Cabify. Dissabte següent, columnes de tots els barris es concentren a la Plaça Universitat contra l’augment del lloguer induït, majoritàriament, pel turisme massiu, amb AirB&B –com no–, en el punt de mira. Barcelona 0 – Economia col·laborativa 1. Era això, companys, el què n’esperàvem de l’economia del segle XXI?

Langerhans cells (LCs), residing in the epidermis, are able to induce potent immunogenic responses and also to mediate immune tolerance. We propose that tolerogenic and immunogenic responses of LCs are directed by signaling from the epidermis and involve counter‐acting gene circuits that are coupled to a core maturation gene module. We base our analysis on recent genetic and genomic findings facilitating the understanding of the molecular mechanisms controlling these divergent immune functions. Comparing gene regulatory network (GRN) analyses of various types (...) of dendritic cells (DCs) including LCs we integrate signaling‐dependent (TGFβ, EpCAM, β‐Catenin) and transcription factor (IRF4, IRF1, NFκB) regulated gene circuits that appear to orchestrate the distinctive LC functional states. Our model proposes, that while epidermal signaling in the steady‐state promotes LC tolerogenic function, the disruption of cell‐cell contacts coupled with inflammatory signaling induces LC immunogenic programing. The conceptual framework emphasizes the sensing of discrete epidermal and inflammatory cues by resident LCs in dictating their genomic programing and cell state dynamics. (shrink)

An equivalence between the category of MV-algebras and the category $${{\rm MV^{\bullet}}}$$ MV ∙ is given in Castiglioni et al. :67–92, 2014). An integral residuated lattice with bottom is an MV-algebra if and only if it satisfies the equations $${a = \neg \neg a, \vee = 1}$$ a = ¬ ¬ a, ∨ = 1 and $${a \odot = a \wedge b}$$ a ⊙ = a ∧ b. An object of $${{\rm MV^{\bullet}}}$$ MV ∙ is a residuated lattice which in (...) particular satisfies some equations which correspond to the previous equations. In this paper we extend the equivalence to the category whose objects are pairs, where A is an MV-algebra and I is an ideal of A. (shrink)

The contemporary confluence of globalization and ethical pluralism is at the origin of many ethical challenges that confront business nowadays, both in practice and in theory. One of the challenges arising from the development of globalization has to do with respect for cultural diversity. It is often said that the success of economic globalization tends towards social and cultural homogeneity. To the extent that cultural diversity is usually seen as a valuable reality, that global trend seems to contradict our efforts (...) to respect ethical pluralism, both personal and cultural, within society. In this paper I argue that (a) ethical minimalism, despite its emphasis on tolerance and justice, does not take pluralism seriously into account in present-day society, and (b) ethical minimalism is not suited to balancing the homogenizing trend of globalization. Certainly ethical norms are necessary, but by no means are they sufficient in themselves to encourage either justice or tolerance; nor are they sufficient to inspire and encourage good practices and sound regulations. Instead, virtue-based ethics has the capacity of inspiring and encouraging good practices. Particularly, virtue-based ethics is able to inspire a serious dialogue about ethical and legal issues both in the public arena and within organizations. (shrink)

This methodological article provides a Mixed Method approach to analyze how the Teaching Personal and Social Responsibility (TPSR) Model is feasible to enhance student’s autonomy. The objective is to detect how teachers’ behavior-oriented patterns shift in response to continuing professional development to reinforce TPSR strategies. We compared the application of TPSR by three teachers who had previously attended a training course for this model, with that of an expert in the model. A total of 44 sessions of primary and secondary (...) school semesters in various subjects, taught by all four teachers and comprising 120 students. A mixed-method approach followed in the study involved: a) the Observational System of Teaching Oriented Responsibility (OSTOR), which revealed how the teachers’ behavior patterns shifted over their interventions, and b) the Tool for Assessing Responsibility-Based Education (TARE 2.0.), which focused on perceived behaviors by teachers and student behaviors. Data analysis was conducted for a) the T-pattern detection technique, b) polar coordinate analysis to obtain detailed sequences of instruction, and c) descriptive and correlational analysis from the TARE. The mixed-method analysis of data confirms how the TPSR improved the teaching behaviors of the three teachers in training compared with the expert teacher. (shrink)

Aquest treball explora la concepció de l'anàlisi de Moore tot relacionant-la amb la sevadefensa del sentit comú i el llenguatge ordinari com el seu vehicle d'expressió. La secció 1 estudiael paper que l'anàlisi representa en la seva filosofia, així com la seva importància perafrontar problemes filosòfics. La secció 2 descriu en què consisteix l'anàlisi segons Moore, discuteixels criteris que ha de satisfer una anàlisi correcta, i classifica els diferents tipus d'anà-lisi trobats en els escrits de Moore, alhora que nega que (...) se'ls pugui considerar lingüístics oconceptuals. La secció 3 aclareix les nocions de sentit comú i llenguatge ordinari, subratllantla preeminència d'aquell. La discussió es proposa de resoldre dues qüestions: a ) c o mes pot reconèixer una proposició del sentit comú, i b ) com es pot reconèixer si tal proposicióés vertadera. Finalment, ens concentrem en el paper concedit al sentit comú i/o llenguatgeordinari com a pedra de toc a l'hora d'acceptar o rebutjar arguments filosòfics. (shrink)

Aquest treball explora la concepció de l'anàlisi de Moore tot relacionant-la amb la sevadefensa del sentit comú i el llenguatge ordinari com el seu vehicle d'expressió. La secció 1 estudiael paper que l'anàlisi representa en la seva filosofia, així com la seva importància perafrontar problemes filosòfics. La secció 2 descriu en què consisteix l'anàlisi segons Moore, discuteixels criteris que ha de satisfer una anàlisi correcta, i classifica els diferents tipus d'anà-lisi trobats en els escrits de Moore, alhora que nega que (...) se'ls pugui considerar lingüístics oconceptuals. La secció 3 aclareix les nocions de sentit comú i llenguatge ordinari, subratllantla preeminència d'aquell. La discussió es proposa de resoldre dues qüestions: a ) c o mes pot reconèixer una proposició del sentit comú, i b ) com es pot reconèixer si tal proposicióés vertadera. Finalment, ens concentrem en el paper concedit al sentit comú i/o llenguatgeordinari com a pedra de toc a l'hora d'acceptar o rebutjar arguments filosòfics. (shrink)

MEDIEVAL LOGICS LAMBERT MARIE DE RIJK (ed.), Die mittelalterlichen Traktate De mod0 opponendiet respondendi, Einleitung und Ausgabe der einschlagigen Texte. (Beitrage zur Geschichte der Philosophie und Theologie des Mittelalters, Neue Folge Band 17.) Miinster: Aschendorff, 1980. 379 pp. No price stated. THE SEVENTEENTH CENTURY MARTA FATTORI, Lessico del Novum Organum di Francesco Bacone. Rome: Edizioni dell'Ateneo 1980. Two volumes, il + 543, 520 pp. Lire 65.000. VIVIAN SALMON, The study of language in 17th century England. (Amsterdam Studies in the (...) Theory and History of Linguistic Science, Series 111: Studies in theHistory of Linguistics, Volume 17.) Amsterdam: John Benjamins B.V., 1979.x + 218 pp. Dfl. 65. Theoria cum Praxi. Zum Verhaltnis von Theorie und Praxis im 17. und 18. Jahrhundert. (Akten des 111. Internationalen Leibnizkongress, Hannover, 12. bis 17.November 1977, Band 111: Logik, Erkenntnistheorie, Wissenschaftstheorie, Metaphysik, Theologie.) Wiesbaden: Franz Steiner Verlag, 1980. vii + 269 pp. DM 48. CLASSICAL AND NON-CLASSICAL LOGICS MICHAEL CLARK, The place of syllogistic in logical theory. Nottingham: University of Nottingham Press, 1980. ix + 151 pp. £3.00. A.F. PARKER-RHODES, The theory of indistinguishables. Dordrecht, Boston and London: D. Reidel Publishing Company, 1981. xvii + 216 pp. Dfl.90.00/$39.50. NICHOLAS RESCHER and ROBERT BRANDOM, The logic of inconsistency. Oxford:Basil Blackwell, 1980. x + 174 pp. f 11.50. MISCELLANEOUS J. ZELENY, The logic of Marx. Translated from the German by T. Carver. Oxford: Basil Blackwell, 1980. xcii + 247 pp. £12.50. FELIX KAUFMANN, The infinite in mathematics. Edited by Brian McGuinness. Introduction by E. Nagel. Translation from the German by Paul Foulkes. Dordrecht: Reidel, 1978. xvii + 235 pp. Dfl 85/$39.50 (cloth); Dfl 45/$19.95 (paper). PAMELA MCCORDUCK, Machines who think. San Francisco: W.H. Freeman and Company, 1979. xiv + 275 pp. $14.95. J. MITTELSTRASS (ed.), Enzyklopadie Philosophie und Wissenschaftstheorie Bd. 1 : A-G. Mannheim, Wien, Ziirich: Bibliographisches Institut, 1980. 835 pp. DM 128. (shrink)

Recensión de A. Gutmann, La educación democrática. Una teoría política de la educación, Paidós, Barcelona, 2001 y B. Brick, En defensa de la política, Tusquets, Barcelona, 2001.

Within the field of didactics of second language teaching, it is believed that phonic errors cannot be completely corrected due to the significant influence of L1. However, improving the processes of acquisition of an L2 implies learning pronunciation properly. Given the importance of pronunciation for communication, it is necessary to deeply know the nature of phonic errors, which requires a specific classification aimed to describe, classify and categorize them. This article is intended to test the validity and efficiency of the (...) taxonomy developed in the project AACFELE. To accomplish our objective we: a) collected the most significant phonic errors made by learners of Spanish from nine different nationalities and b) categorized those errors. As a result, we found that the classification entails plenty of trouble caused by the impossibility of marking the boundaries of the numerous phenomena involved in the pronunciation of a sound; that is why we considered the need of redefining some of the suggested categories and assessed the adequacy of maintaining other ones less useful. Despite these circumstances, the most significant outcome was the reliable proof that the taxonomy AACFELE allowed us to label and describe diverse phonic errors using common criteria, which represents the first step to accurately study phonic acquisition of a foreign language. (shrink)

The purpose of this paper is to view Kant's approach to education in the broader context of Kant's philosophy of culture and history as a process whose direction should be reflectively assumed by human freedom, in the light of man's moral vocation. In this context, some characteristic tensions of his enlightened approach to education appear. Thus, while Kant takes the educational process to be a radically moral enterprise all the way through—and hence, placed in a relational context—he also aspires to (...) constitute education as a science, to be improved through experiments, thereby paving the way for a systemic approach to education; in spite of its moral inspiration, his systemic approach not only could enter into conflict with the moral demand of taking each individual subject as an end, but is also marked by an intrinsic paradox, already involved in the ambiguity of the term ‘humanity’, which might mean a) humanity as a moral disposition present in each individual human being or b) humanity as a whole, as the ‘human species’. (shrink)

In Understanding Moral Obligation (2012), Robert Stern sets out to provide a fresh interpretation of the role of autonomy in Kant’s moral philosophy and attempts to rectify J. B. Schneewind’s standard account in The Invention of Autonomy (1998). While Stern agrees that Kant’s resort to autonomy is at the basis of a constructivist account of moral obligation, he claims that autonomy plays no role in Kant’s theory of value, such that, in this respect, Kant remains a realist. Accordingly, Stern characterizes (...) Kant’s moral philosophy as a “hybrid” view because he sees it as involving a compromise between realism with regard to value and constructivism with regard to obligation. Stern’s interpretation relies on a sharp distinction between value and obligation. The purpose of the present article is to question his reliance on that rigid distinction, which involves intermixing theoretical and practical reason and assumes a distorted view of human agency. (shrink)

I argue that Rawls’ reading of Kant has been a major influence on the work of some contemporary Kantian scholars. Rawls’ influence on the new Kantian moral theory can be recognized in several points: a) the conception of philosophy as a “deeply practical project”, which leads to the adoption of a first-person approach to ethics; b) the reception of Kant’s philosophy within a pragmatic context, which leads to play down the metaphysical implications of Kant’s dualisms, in favor of an interpretation (...) which seems plausible within a political culture given in advance c) a characteristic interpretation of Kant’s moral constructivism, which while stressing the primacy of the right over the good, tries to specify the ways in which the good plays a role in morals, thereby opening a way to show the relevance of the empirical in Kant’s ethics d) an approach to Kant’s practical reason which stresses the complementarities between the Hypothetical and the Categorical Imperative, interpreted in the light of Rawls’ distinction between the Rational and the Reasonable; e) the central role played by the concept of “rational nature” in the new Kantian moral theory, which may likewise be related to Rawls’ concern for clarifying the conception of the person behind his approach to practical reason. (shrink)

Background:The first wave of the COVID-19 pandemic caused a shortage of qualified nurses in Spain. As a result, the government authorized the hiring of senior students.Objectives:To explore the ethical dilemmas and ethical conflicts experienced by final-year nursing students who worked during the first outbreak of the COVID-19 pandemic in Spain.Research design:A qualitative exploratory study was conducted using purposive sampling. Semi-structured interviews were carried out using a question guide. Interviews took place via a private video chat room platform. A thematic, inductive (...) analysis was performed of the information gathered.Participants and research context:Eighteen nursing students were recruited from two universities of Madrid, aged between 18 and 65 years old, enrolled in the fourth year of nursing studies and who were hired under a relief contract for health professionals during the pandemic.Ethical considerations:The present study was carried out in accordance with the Declaration of Helsinki, and the study was approved by the Local Ethics Committee of Universidad Rey Juan Carlos.Results:Three specific themes emerged: (a) coping with patient triage, (b) difficulties in providing end-of-life care, and (c) coping with patient death. Nursing students participated in the process of patient selection for resource allocation and ICU bed occupancy. They were shown how to care for patients who were not admitted to the ICU, in their last moments and were faced with the difficulties of applying end-of-life care. Finally, the nursing students were confronted with the death of their patients, in overwhelming numbers and under adverse conditions.Conclusions:These findings can help shed light on the ethical dilemmas and ethical conflicts faced by novice nursing students, incorporated into the workforce during the COVID-19 pandemic. Moreover, it was described that students may normalize the death due to the exhaustion and overwhelmed routine. (shrink)

Georgians' acquaintance with Islam was with the first Arab raids. From the first Muslim Arab domination, Georgians started to become Muslims with cultural interaction. Islam spread especially in Eastern Georgia during the time of Muslim Arabs, Seljuks and Mongols. The spread of Islam in Western Georgia started with the Ottomans. The Ottoman Empire's contact with Georgia begins with the conquest of Trabzon by Fatih Sultan Mehmed. When the Ottomans contacted the region, the geography of Georgia was divided into small kingdoms. (...) With the conquest of Trabzon, the Georgian border was reached and in 1479, Acaristan, Borcka and Maçahel surroundings joined the Ottoman lands. On the one hand, Sukhumi was captured from the north. Then, continuing to advance in the region, Yavuz Sultan Selim paid tribute to the Kingdom of Güryel and Imeret (Açıkbaş) in 1508 during his governorship of Trabzon. Thus, the Ottoman borders had reached beyond the Black Sea coast into Western Georgia. As a result of the increasing relations around Adjaria, which came under Ottoman rule, Islamization began to spread rapidly among the people. Contrary to what is claimed, the spread of Islam in the region did not spread from the ruling strata to the lower, but from the popular strata to the ruling strata. This process was surprisingly fast. In the process of Islamization, many mosques, masjids and schools were built in Adjara, especially with the help of the people. The foundations operating in the region and the mosques and masjids serving under them show that, contrary to the claims of Russian and Georgian historians, Islamization took place rapidly at the beginning of the 17th century in Adjara. In this process, many mosques, masjids and schools were built in the region. In this research, based on the numerous Hurufat records belonging to Adjara, Batumi, Gönye, Çürüksu and Maçahel, the Islamization process will be evaluated by making a social reading with the data obtained from the religious structures established in the rural settlements of the Adjara geography and their officials. Evaluations were made on the Islamization process in Adjara by making a social reading. (shrink)

(I) Aristotle of Stagira (384-322 BC) 0) A closed geocentric spherical cosmology. (Adopted from the great mathematician, Eudoxus, c. 400 to 347 BC; via Calippus; but Aristotle unifies their separate schemes for different heavenly bodies). (Aristotle cites mathematicians as estimating radius of earth: in fact 200% of correct figure. Eratosthenes ca. 250 BC estimates radius of earth as 120% of correct).

Guido de Ruggiero (1888-1948) was perhaps the greatest Italian intellectual historian in the twentieth century. He was a fierce champion of liberalism, an ardent opponent of Fascism, an insightful critic and interpreter of his contemporaries, and a formidable philosopher in his own right. Idealism & Experience: The Philosophy of Guido de Ruggiero comprises eight new critical essays, as well as English translations of five of de Ruggiero's most important shorter writings, which chart the development of his thought between 1914 and (...) 1946. Taken together, these essays reveal the range, richness and philosophical sophistication of de Ruggiero's ideas, enabling Anglophone readers to appreciate their enduring relevance in our own troubled times. (shrink)