22 found
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  1.  6
    Scientific Practice in Modeling Diseases: Stances From Cancer Research and Neuropsychiatry.Marta Bertolaso & Raffaella Campaner - 2020 - Journal of Medicine and Philosophy 45 (1):105-128.
    In the last few decades, philosophy of science has increasingly focused on multilevel models and causal mechanistic explanations to account for complex biological phenomena. On the one hand, biological and biomedical works make extensive use of mechanistic concepts; on the other hand, philosophers have analyzed an increasing range of examples taken from different domains in the life sciences to test—support or criticize—the adequacy of mechanistic accounts. The article highlights some challenges in the elaboration of mechanistic explanations with a focus on (...)
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  2. Evidence Amalgamation, Plausibility, and Cancer Research.Marta Bertolaso & Fabio Sterpetti - 2019 - Synthese 196 (8):3279-3317.
    Cancer research is experiencing ‘paradigm instability’, since there are two rival theories of carcinogenesis which confront themselves, namely the somatic mutation theory and the tissue organization field theory. Despite this theoretical uncertainty, a huge quantity of data is available thanks to the improvement of genome sequencing techniques. Some authors think that the development of new statistical tools will be able to overcome the lack of a shared theoretical perspective on cancer by amalgamating as many data as possible. We think instead (...)
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  3.  50
    Conceptual Challenges in the Theoretical Foundations of Systems Biology.Marta Bertolaso & Emanuele Ratti - 2018 - In Mariano Bizzarri (ed.), Systems Biology. New York: Springer, Humana Press. pp. 1-13.
    In the last decade, Systems Biology has emerged as a conceptual and explanatory alternative to reductionist-based approaches in molecular biology. However, the foundations of this new discipline need to be fleshed out more carefully. In this paper, we claim that a relational ontology is a necessary tool to ground both the conceptual and explanatory aspects of Systems Biology. A relational ontology holds that relations are prior—both conceptually and explanatory—to entities, and that in the biological realm entities are defined primarily by (...)
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  4.  80
    The Pursuit of Knowledge and the Problem of the Unconceived Alternatives.Fabio Sterpetti & Marta Bertolaso - forthcoming - Topoi:1-12.
    In the process of scientific discovery, knowledge ampliation is pursued by means of non-deductive inferences. When ampliative reasoning is performed, probabilities cannot be assigned objectively. One of the reasons is that we face the problem of the unconceived alternatives: we are unable to explore the space of all the possible alternatives to a given hypothesis, because we do not know how this space is shaped. So, if we want to adequately account for the process of knowledge ampliation, we need to (...)
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  5.  22
    Hierarchies and Causal Relationships in Interpretative Models of the Neoplastic Process.Marta Bertolaso - 2011 - History and Philosophy of the Life Sciences 33 (4).
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  6.  13
    Towards an Integrated View of the Neoplastic Phenomena in Cancer Research.Marta Bertolaso - 2009 - History and Philosophy of the Life Sciences 31 (1):79 - 97.
    Cancer research has been at the forefront of biomedical activity in recent decades, and advances in molecular biology have provided a growing amount of information on the mechanisms involved in the etiopathogenesis of tumors. Nevertheless, despite these advances, the complexity of cancer is more evident, especially as different levels of phenomena are considered to explain the heterogeneity of the neoplastic process. A synthetic analysis of advances in cancer research illustrates these changes. In attempting to overcome the limits of epistemological reductionism, (...)
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  7.  22
    Systems Biology Reveals Biology of Systems.Marta Bertolaso, Alessandro Giuliani & Laura De Gara - 2011 - Complexity 16 (6):10-16.
  8.  2
    Specifically Human: Human Work and Care in the Age of Machines.Marta Bertolaso & Marta Rocchi - forthcoming - Business Ethics: A European Review.
    Business Ethics: A European Review, EarlyView.
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  9.  5
    La comprensión de la biodiversidad desde un punto de vista relacional.Luca Valera & Marta Bertolaso - 2016 - Tópicos: Revista de Filosofía 51:37-54.
    La biodiversidad suele reconocerse en diferentes disciplinas como un valor universal. Ésta apunta a la heterogeneidad de las propiedades que caracterizan al mundo biológico. Sin embargo, a pesar de su uso común, el análisis crítico de la literatura filosófica pone en evidencia cierta dificultad a conceptualizar la biodiversidad, dada una aparente dicotomía entre los elementos normativos y descriptivos del término mismo. En este artículo se sostiene que es necesario considerar el aspecto relacional de la biodiversidad con el n de resolver (...)
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  10.  41
    What and How Do Cancer Systems Biologists Explain?Anya Plutynski & Marta Bertolaso - 2018 - Philosophy of Science 85 (5):942-954.
    In this article, we argue, first, that there are very different research projects that fall under the heading of “systems biology of cancer.” While they share some general features, they differ in their aims and theoretical commitments. Second, we argue that some explanations in systems biology of cancer are concerned with properties of signaling networks and how they may play an important causal role in patterns of vulnerability to cancer. Further, some systems biological explanations are compelling illustrations of how “top-down” (...)
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  11.  3
    In Silico Modeling: The Human Factor.Marta Bertolaso & Miles MacLeod - 2016 - Humana Mente 9 (30).
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  12.  19
    On the Structure of Biological Explanations: Beyond Functional Ascriptions in Cancer Research.Marta Bertolaso - 2013 - Epistemologia 36 (1):112-130.
  13.  25
    Uncoupling Mereology and Supervenience: A Dual Framework for Emergence and Downward Causation.Marta Bertolaso - 2017 - Axiomathes 27 (6):705-720.
    The philosophical discussion of emergence is often focused on properties of ‘wholes’ that are evaluated as emergent with respect to the properties of ‘parts’. Downward causation is, consequently, evaluated as some kind of causal influence of whole properties over parts properties. Yet, several important cases in scientific practice seem to be pursuing hypotheses of parts properties emerging from wholes properties, inverting the instinctive association of emergence with wholes. Furthermore, some areas of reflection which are very important for emergence, e.g., the (...)
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  14.  15
    Real and Virtual Clinical Trials: A Formal Analysis.Barbara Osimani, Marta Bertolaso, Roland Poellinger & Emanuele Frontoni - 2018 - Topoi 38 (2):411-422.
    If well-designed, the results of a Randomised Clinical Trial can justify a causal claim between treatment and effect in the study population; however, additional information might be needed to carry over this result to another population. RCTs have been criticized exactly on grounds of failing to provide this sort of information Evidence, inference and enquiry. Oxford University Press, New York, 2011), as well as to black-box important details regarding the mechanisms underpinning the causal law instantiated by the RCT result. On (...)
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  15. The Two Sides of the Hour Anal< Tic and s< Nthetic Approaches in Cancer Research.Marta Bertolaso - 2011 - Ludus Vitalis 19 (3):73-95.
     
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  16.  19
    Evandro Agazzi, Ragioni e limiti del formalismo. Saggi di filosofia della logica e della matematica, a cura e con una Prefazione di Fabio Minazzi, FrancoAngeli, Milano, 2012, pp. 336. Mario Agostinelli, Roberto Meregalli, Pierattilio Tronconi, Cercare il Sole. Dopo Fukushima, Prefazione di Riccardo Petrella, Introduzione di Enrico. [REVIEW]Maria Cristina Amoretti, Rossana Avanzi, Francesco Barone, Marta Bertolaso & Cosimo Caputo - 2012 - Epistemologia 35:347-349.
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  17. Epistemology in Life Sciences. An Integrative Approach to a Complex System Like Cancer.Marta Bertolaso - 2011 - Ludus Vitalis 19 (36):245-249.
  18.  7
    La indeterminación biológica y las perspectivas sistémicas de la biología contemporánea.Marta Bertolaso - 2013 - Anuario Filosófico 46 (2):365 - 386.
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  19. Biological Robustness. Emerging Perspectives From Within the Life Sciences.Marta Bertolaso, Silvia Caianiello & Emanuele Serrelli (eds.) - 2018 - Springer.
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  20. Introduction: Issues About Robustness in the Practice of Biological Sciences.Marta Bertolaso, Emanuele Serrelli & Silvia Caianiello - 2018 - In Marta Bertolaso, Silvia Caianiello & Emanuele Serrelli (eds.), Biological Robustness. Emerging Perspectives From Within the Life Sciences. Springer.
    Robustness has lately become a bridging notion, in particular across the sciences of the natural and the artificial, crucial for prediction and control of natural and artificial systems in recent scientific practice, in biomedicine, neurobiology and engineering, as well as for risk management, planning and policy in ecology, healthcare, markets and economy. From biological, neurological and societal systems, arising by the interplay of self-organizing dynamics and environmental pressures, to the current sophisticated engineering that aims at artificially reproducing the adaptability and (...)
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  21. The Non-Reductionist Dimension of Reductionism in Experimental Research From Molecular Models to Those Systemic in Cancer Research.Marta Bertolaso - 2012 - Rivista di Filosofia Neo-Scolastica 104 (4):687-705.
     
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  22.  3
    The Hand.Nicola Di Stefano & Marta Bertolaso (eds.) - 2017 - Springer Verlag.
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