10 found
Order:
  1.  34
    Why is It Hard to Make Progress in Assessing Children’s Decision-Making Competence?Irma M. Hein, Pieter W. Troost, Alice Broersma, Martine C. De Vries, Joost G. Daams & Ramón J. L. Lindauer - 2015 - BMC Medical Ethics 16 (1):1.
    For decades, the discussion on children’s competence to consent to medical issues has concentrated around normative concerns, with little progress in clinical practices. Decision-making competence is an important condition in the informed consent model. In pediatrics, clinicians need to strike a proper balance in order to both protect children’s interests when they are not fully able to do so themselves and to respect their autonomy when they are. Children’s competence to consent, however, is currently not assessed in a standardized way. (...)
    Direct download (6 more)  
     
    Export citation  
     
    Bookmark   13 citations  
  2.  90
    Informed Consent Instead of Assent is Appropriate in Children From the Age of Twelve: Policy Implications of New Findings on Children’s Competence to Consent to Clinical Research.Irma M. Hein, Martine C. De Vries, Pieter W. Troost, Gerben Meynen, Johannes B. Van Goudoever & Ramón J. L. Lindauer - 2015 - BMC Medical Ethics 16 (1):1-7.
    BackgroundFor many decades, the debate on children’s competence to give informed consent in medical settings concentrated on ethical and legal aspects, with little empirical underpinnings. Recently, data from empirical research became available to advance the discussion. It was shown that children’s competence to consent to clinical research could be accurately assessed by the modified MacArthur Competence Assessment Tool for Clinical Research. Age limits for children to be deemed competent to decide on research participation have been studied: generally children of 11.2 (...)
    Direct download (5 more)  
     
    Export citation  
     
    Bookmark   9 citations  
  3.  30
    Ethical Issues at the Interface of Clinical Care and Research Practice in Pediatric Oncology: A Narrative Review of Parents' and Physicians' Experiences.Martine C. de Vries, Mirjam Houtlosser, Jan M. Wit, Dirk P. Engberts, Dorine Bresters, Gertjan Jl Kaspers & Evert van Leeuwen - 2011 - BMC Medical Ethics 12 (1):18.
    BackgroundPediatric oncology has a strong research culture. Most pediatric oncologists are investigators, involved in clinical care as well as research. As a result, a remarkable proportion of children with cancer enrolls in a trial during treatment. This paper discusses the ethical consequences of the unprecedented integration of research and care in pediatric oncology from the perspective of parents and physicians.MethodologyAn empirical ethical approach, combining a narrative review of qualitative studies on parents' and physicians' experiences of the pediatric oncology research practice, (...)
    Direct download (14 more)  
     
    Export citation  
     
    Bookmark   9 citations  
  4.  32
    A Case Against Something That is Not the Case: The Groningen Protocol and the Moral Principle of Non-Maleficence.Martine C. de Vries & A. A. Eduard Verhagen - 2008 - American Journal of Bioethics 8 (11):29-31.
  5.  30
    The Use of Dogmas in Pediatric Research Ethics.Martine C. de Vries - 2015 - American Journal of Bioethics 15 (11):18-19.
    Direct download (3 more)  
     
    Export citation  
     
    Bookmark   1 citation  
  6.  22
    A Case Against Something That is Not the Case: The Groningen Protocol and the Moral Principle of Non-Maleficence.Martine C. de Vries & Aa Eduard Verhagen - 2008 - American Journal of Bioethics 8 (11):29 - 31.
  7.  13
    The Right to an Open Future Concerning Genetic Information.Annelien L. Bredenoord, Martine C. De Vries & Hans van Delden - 2014 - American Journal of Bioethics 14 (3):21-23.
  8.  11
    Participation in a Single-Blinded Pediatric Therapeutic Strategy Study for Juvenile Idiopathic Arthritis: Are Parents and Patient-Participants in Equipoise?Petra C. E. Hissink Muller, Bahar Yildiz, Cornelia F. Allaart, Danielle M. C. Brinkman, Marion van Rossum, Lisette W. A. van Suijlekom-Smit, J. Merlijn van den Berg, Rebecca ten Cate & Martine C. de Vries - 2018 - BMC Medical Ethics 19 (1):1-9.
    Background Genuine uncertainty on superiority of one intervention over the other is called equipoise. Physician-investigators in randomized controlled trials need equipoise at least in studies with more than minimal risks. Ideally, this equipoise is also present in patient-participants. In pediatrics, data on equipoise are lacking. We hypothesize that 1) lack of equipoise at enrolment among parents may reduce recruitment; 2) lack of equipoise during participation may reduce retention in patients assigned to a less favoured treatment-strategy. Methods We compared preferences of (...)
    Direct download (4 more)  
     
    Export citation  
     
    Bookmark  
  9.  4
    The Duty to Support Learning Health Systems: A Broad Rather Than a Narrow Interpretation.Rieke van der Graaf, Wouter van Dijk, Sara J. M. Laurijssen, Ewoud Schuit, Diederick E. Grobbee & Martine C. de Vries - 2021 - American Journal of Bioethics 21 (1):14-16.
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark  
  10.  4
    The Duty to Support Learning Health Systems: A Broad Rather Than a Narrow Interpretation.Rieke van der Graaf, Wouter van Dijk, Sara J. M. Laurijssen, Ewoud Schuit, Diederick E. Grobbee & Martine C. De Vries - 2020 - American Journal of Bioethics 21 (1):14-16.
    As of October 23, 2020, almost 42 million cases of COVID-19 have been reported globally. Although many different treatments have been applied in infected...
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark