Deep brain stimulation has been regarded as an efficient and safe treatment for Parkinson’s disease since being approved by the Food and Drug Administration in 1997. It is estimated that more than 150 000 patients have been implanted, with a forecasted rapid increase in uptake with population ageing. Recent longitudinal follow-up studies have reported a significant increase in postoperative survival rates of patients with PD implanted with DBS as compared with those not implanted with DBS. Although DBS tends to increase (...) life expectancy for most patients with PD, this medical benefit does not come without attendant negative consequences. For example, emerging forms of iatrogenic harms are sometimes induced—harms which were not initially expected when clinicians proposed neurosurgery and patients or their guardians consented to the treatment. We report and discuss the clinical case of a patient who was implanted with DBS more than 20 years ago and is now experiencing unexpected stages of PD. This case illustrates how extending the life span without improving quality of life may introduce a burden of harms for patients and families. As well, this case shows why we should prepare for the expanding numbers of PD-implanted patients experiencing a gain of longevity but with severe stages of disease leading to diminution in quality of life. This newly observed effect of DBS treatment requires us to explore ethical questions related to iatrogenic harms, informed consent, end of life and caregivers’ burden. (shrink)

It is likely that internal factors play an important role in restricting the possible avenues of evolutionary change from any starting point. Internal selective processes operating on premutational disturbances, on mutations, and on developmental phases may usefully be separated from the adaptive selection of phenotypes. The precise structural and morphological consequences of internal factors should soon become an isolable problem owing to a) the observational correlation of definite changes in hereditary specificity with particular developmental consequences; and b) the progressive theoretical (...) identification of the coordinative conditions in organisms. Increasing clarity regarding the coordinative conditions should throw light on the “mutational selection rules” and on the differentiative mutations which led to the most important steps in the past history of evolution.Die Wege der Evolution können sowohl durch innere Auslese der Genotypen wÄhrend der Entwicklung als auch durch die Äussere Darwinische Auslese der Phenotypen bestimmt werden. Seit 1949 haben sich zumindest fünf Forscher mit dieser Möglichkeit befasst. Es ist zur Zeit möglich, zwischen den beiden Arten von Zuchtwahl theoretisch und experimentell zu unterscheiden.Les chemins de l'évolution peuvent Être déterminés non seulement par la sélection extérieure Darwinienne des phénotypes mais aussi par la sélection intérieure des genotypes pendant le développement. Depuis 1949 aux moins cinq investigateurs en ont considéré la possibilité. Il est possible à présent de faire la distinction entre les deux types de sélection dans la théorie comme dans l'expérience. (shrink)

This essay examines the origin of genotype-environment interaction, or G×E. "Origin" and not "the origin" because the thesis is that there were actually two distinct concepts of G×E at this beginning: a biometric concept, or \[G \times E_B\], and a developmental concept, or \[G \times E_D \]. R. A. Fisher, one of the founders of population genetics and the creator of the statistical analysis of variance, introduced the biometric concept as he attempted to resolve one of the main problems in (...) the biometric tradition of biology - partitioning the relative contributions of nature and nurture responsible for variation in a population. Lancelot Hogben, an experimental embryologist and also a statistician, introduced the developmental concept as he attempted to resolve one of the main problems in the developmental tradition of biology - determining the role that developmental relationships between genotype and environment played in the generation of variation. To argue for this thesis, I outline Fisher and Hogben's separate routes to their respective concepts of G × E; then these separate interpretations of G × E are drawn on to explicate a debate between Fisher and Hogben over the importance of G × E, the first installment of a persistent controversy. Finally, Fisher's \[G \times E_B\] and Hogben's \[G \times E_D \] are traced beyond their own work into mid-2Oth century population and developmental genetics, and then into the infamous IQ Controversy of the 1970s. (shrink)

Mediation is an alternative dispute resolution process that is becoming more and more popular particularly in English-speaking countries. In contrast to traditional litigation it has not benefited from technological advances and little research has been carried out to make this increasingly widespread practice more efficient. The study of argumentation in dispute mediation hitherto has largely been concerned with theoretical insights. The development of argumentation theories linked to computational applications opens promising new horizons since computational tools could support mediators, making sessions (...) quicker and more efficient. For this, we need tools for close analysis of mediation discourse in order to explore the argumentative activity in depth, and ultimately get an accurate image of how dialogues unfold in this particular context. This paper therefore aims at laying the foundations of a theory of close analysis for discourse in dispute mediation. Theories provided by the literature serve as a basis for argumentative analyses of transcripts of mediation sessions in order to deliver a clear image of the argumentative structure. Analyses of the argumentative strategies in mediation discourse will allow for the development of a dialogue protocol that can be used to develop operational models which can be embodied in software to help make the mediation process easier and more effective. (shrink)

Bipedalism is one of the criteria that paleoanthropologists use in order to interpret the fossil record and to determine if a specimen belongs to the human lineage. In the context of such interpretations, bipedalism is considered to be a unique characteristic of this lineage that also marks its origin. This conception has largely remained unchallenged over the last decades, in spite of fossil discoveries that led to the emergence of bipedalism in the human lineage being shifted back by several millions (...) of years. In this paper, I analyze the uses of this criterion in paleoanthropology and demonstrate that interpretative biases are at play in interpretations of hominin remains. By discussing Darwin’s hypotheses about the evolution of bipedalism, I identify major theoretical issues that need to be addressed in the current debates on hominin evolution. First, the assumption that “man alone has become a biped” is analyzed in the light of recent empirical data. Three major issues are discussed: the definition of “man”, i.e. “human”, the uniqueness of human bipedalism, and the equivocal meaning of being a “biped”. Then, I highlight some of Darwin’s remarks that may be helpful for current debates in paleoanthropology, regarding natural selection in locomotor evolution, as well as taxonomic and phylogenetic significance of functional features. Finally, I analyze two examples of how fossil discoverers referred to Darwin in the recent years and discuss his role as an intellectual support. (shrink)

This research investigated the effect of divided attention at encoding on feeling-of-knowing . Participants had to learn a 60 word-pair list under two experimental conditions, one with full attention and one with divided attention . After that, they were administered episodic FOK tasks with a cued-recall phase, a FOK phase and a recognition phase. Our results showed that DA at encoding altered not only memory performance, but also FOK judgments and FOK accuracy. These findings throw some light on the central (...) role of the quality of memory encoding to make accurate FOK judgments and provide new evidence supporting the relationship between memory and metamemory judgments. (shrink)

The perception of time cannot be reduced to a simple percept produced by an internal clock. The aim of the present study was therefore to investigate the role of the individual consciousness of time on temporal judgments. In the present study, the participants’ awareness of attention-related time distortions was assessed using a metacognitive questionnaire. The participants were also required to verbally judge a series of stimulus durations in a single or a dual task condition. The results revealed that time was (...) underestimated in the dual task compared to the single task. However, the accuracy of time judgments improved in line with the participants’ individual awareness of attentional time distortion: The more aware they were of the role of attention in time perception, the lower the time distortions they exhibited. Conscious awareness of time therefore plays a role in the accuracy of the time judgments made by human beings. (shrink)

Until recently the British zoologist Lancelot Hogben has usually appeared as a campaigning socialist, an anti-eugenicist or a popularizer of science in the literature. The focus has mainly been on Hogben after he became a professor of social biology at the London School of Economics in 1930. This paper focuses on Hogben’s life in the 1920s. Early in the decade, while based in London, he focused on cytology, but in 1922, after moving to Edinburgh, he turned his focus on (...) experimental zoology, first concentrating on vertebrate endocrinology and later moving over to the comparative physiology of invertebrate muscle. In the early 1920s Hogben played an active role in the development of experimental zoology in Britain. As such he was a fearless critic of evolutionary and metaphysical speculations. But in this period Hogben’s career prospects were seriously hampered by his confrontational nature and serious depression. As a result he was forced to leave Britain in 1925. He first accepted a position in Canada and in the period 1927–1930 he was a professor of zoology in South Africa. This paper will also add crucial new material to James Tabery’s recent discussion of the history behind Hogben’s ideas about the interaction of heredity and environment in individual development. In addition a previously unknown Lamarckian controversy will be discussed. (shrink)

Historians agree that the second half of the twentieth century saw widespread changes in the structure of biological science in universities. This shift was, and continues to be, characterized by the de-differentiation of nineteenth and early twentieth century disciplines, with increasing emphasis on the methods and authority of molecular fields. Yet we currently lack appreciation of the dynamics that underpinned these changes, and of their tangible effects on the working practices of those involved. In this article we examine the wholesale (...) reform of biological science at the University of Manchester, England, that occurred in two successive steps in 1986 and 1993. We examine how reform was enabled by economic and political factors, as staff seized upon national pressures; in so doing, we emphasize how this reform was shaped by a generational view of the biological sciences as a one field, unified by molecular techniques. We assess how the success of these reforms was tied to new management policies that rewarded research activity in molecular fields, and refigured teaching as a punishment for research inactivity. We close by showing how our analysis fits amongst, and can contribute to, ‘big picture’ debates in the history and sociology of knowledge. (shrink)

Socio-emotional impairments are key symptoms of Autism Spectrum Disorders. This work proposes to analyze the neuronal activity related to the discrimination of emotional prosodies in autistic children as follows. Firstly, a database for single words uttered in Mexican Spanish by males, females, and children will be created. Then, optimal acoustic features for emotion characterization will be extracted, followed of a cubic kernel function Support Vector Machine in order to validate the speech corpus. As a result, human-specific acoustic properties of emotional (...) voice signals will be identified. Secondly, those identified acoustic properties will be modified to synthesize the recorded human emotional voices. Thirdly, both human and synthesized utterances will be used to study the electroencephalographic correlate of affective prosody processing in typically developed and autistic children. Finally, and on the basis of the outcomes, synthesized voice-enhanced environments will be created to develop an intervention based on social-robot and Social StoryTM for autistic children to improve affective prosodies discrimination. This protocol has been registered at BioMed Central under the following number: ISRCTN18117434. (shrink)

Le présent article s’intéresse aux arguments égalitariens qui défendent une ouverture des frontières nationales car ces dernières discriminent injustement, selon eux, les perspectives individuelles à l’échelle mondiale. Pour égaliser des opportunités aujourd’hui séparées par les frontières des États, il faudrait généraliser la liberté de mouvement transnationale. Nous confrontons cette thèse au cas de l’Union européenne où le statut des Européens circulant librement dans un autre pays leur a progressivement donné les mêmes droits sociaux que ceux dont jouissent les ressortissants du (...) pays d’accueil. Cela a contribué à égaliser les opportunités à l’échelon européen malgré l’absence d’harmonisation des systèmes de protection sociale et de leur financement. À partir de quelques arrêts de la Cour de justice de l’Union européenne, nous confrontons la thèse égalitarienne à trois réserves. La première, qui souligne la menace de la liberté de circulation pour la justice sociale intérieure, est rejetée pour des raisons empiriques. La seconde concerne la possibilité pour la liberté de circulation d’être le support de droits sociaux. Enfin, l’absence de solidarité dans l’Union européenne révèle que la défense égalitarienne d’une ouverture des frontières peut difficilement valoir sans être assortie de mécanismes distributifs au niveau européen. (shrink)

Ce billet a déjà été publié dans Rouge, études diachroniques. Regards croisés de l'art préhistorique à l'art contemporain le 24 juin 2018. Nous remercions Mathilde Buratti de nous avoir autorisé à le reproduire ici. Kupka, artiste complet du XXe siècle notamment connu pour ses abstractions colorées, est à l'honneur au Grand Palais jusqu'au 30 juillet 2018. Cette rétrospective met en avant la conception originale du peintre. Tout au long de sa carrière, tant dans ses productions abstraites que - Arts (...) plastiques et autres – GALERIE – Nouvel article. (shrink)

Avoiding the seductive trap of utopianism, Whyte approaches this challenge by defining the terms of a potentially worldwide consensus of heart, mind, and will ...