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  1. Resolving the Paradox of Common, Harmful, Heritable Mental Disorders: Which Evolutionary Genetic Models Work Best?Matthew C. Keller & Geoffrey Miller - 2006 - Behavioral and Brain Sciences 29 (4):385-404.
    Given that natural selection is so powerful at optimizing complex adaptations, why does it seem unable to eliminate genes (susceptibility alleles) that predispose to common, harmful, heritable mental disorders, such as schizophrenia or bipolar disorder? We assess three leading explanations for this apparent paradox from evolutionary genetic theory: (1) ancestral neutrality (susceptibility alleles were not harmful among ancestors), (2) balancing selection (susceptibility alleles sometimes increased fitness), and (3) polygenic mutation-selection balance (mental disorders reflect the inevitable mutational load on the thousands (...)
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  2. Twin Studies to GWAS: There and Back Again.Naomi P. Friedman, Marie T. Banich & Matthew C. Keller - 2021 - Trends in Cognitive Sciences 25 (10):855-869.
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    An Evolutionary Framework for Mental Disorders: Integrating Adaptationist and Evolutionary Genetic Models.Matthew C. Keller & Geoffrey Miller - 2006 - Behavioral and Brain Sciences 29 (4):429-441.
    This response (a) integrates non-equilibrium evolutionary genetic models, such as coevolutionary arms-races and recent selective sweeps, into a framework for understanding common, harmful, heritable mental disorders; (b) discusses the forms of ancestral neutrality or balancing selection that may explain some portion of mental disorder risk; and (c) emphasizes that normally functioning psychological adaptations work against a backdrop of mutational and environmental noise. (Published Online November 9 2006).
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    Problems with the Imprinting Hypothesis of Schizophrenia and Autism.Matthew C. Keller - 2008 - Behavioral and Brain Sciences 31 (3):273-274.
    Crespi & Badcock (C&B) convincingly argue that autism and schizophrenia are diametric malfunctions of the social brain, but their core imprinting hypothesis is less persuasive. Much of the evidence they cite is unrelated to their hypothesis, is selective, or is overstated; their hypothesis lacks a clearly explained mechanism; and it is unclear how their explanation fits in with known aspects of the disorders.
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    Evolutionary Theories of Schizophrenia Must Ultimately Explain the Genes That Predispose to It.Matthew C. Keller - 2004 - Behavioral and Brain Sciences 27 (6):861-862.
    If alleles that predispose to schizophrenia have reduced Darwinian fitness, their persistence in modern times is puzzling. Burns identifies the evolutionary genetics of schizophrenia as a central issue, but his treatment of it is not clear. Recent advances in evolutionary genetics can help explain the persistence of alleles that predispose to debilitating disorders such as schizophrenia, and can buttress Burns' core argument.
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