Various cell types cooperate to create a highly organized and dynamic micro-environmental niche in the bone marrow. Over the past several years, the field has increasingly recognized the critical roles of the interplay between bone marrow environment and hematopoietic cells in normal and deranged hematopoiesis. These advances rely on several new technologies that have allowed us to characterize the identity and roles of these niches in great detail. Here, we review the progress of the last several years, list some of (...) the outstanding questions in the field and propose ways to target the diseased environment to better treat hematologic diseases. Understanding the extrinsic regulation by the niche will help boost hematopoiesis for regenerative medicine. Based on natural development of hematologic malignancies, we propose that combinatory targeting the niche and hematopoietic intrinsic mechanisms in early stages of hematopoietic malignancies may help eliminate minimal residual disease and have the highest efficacy. The bone marrow is the home for blood-forming hematopoietic stem and progenitor cells. Normal generation of blood and immune cells depends on highly regulated interactions between these stem and progenitor cells with their surrounding environment. Emerging evidence suggests that therapeutic interventions directed at these cellular interdependencies can help boost hematopoiesis and eradicate malignant hematopoietic cells. (shrink)

Physical activity, and likely the motivation for it, varies throughout the day. The aim of this investigation was to create a short assessment (CRAVE: Cravings for Rest and Volitional Energy Expenditure) to measure motivation states (wants, desires, urges) for physical activity and sedentary behaviors. Five studies were conducted to develop and evaluate the construct validity and reliability of the scale, with 1,035 participants completing the scale a total of 1,697 times. In Study 1, 402 university students completed a questionnaire inquiring (...) about the want or desire to perform behaviors “at the present moment (right now).” Items related to physical activity (e.g., “move my body”) and sedentary behaviors (e.g., “do nothing active”). An exploratory structural equation model (ESEM) revealed that 10 items should be retained, loading onto two factors (5 each for Move and Rest). In Study 2, an independent sample (n= 444) confirmed these results and found that Move and Rest desires were associated with stage-of-change for exercise behavior. In Study 3, 127 community-residing participants completed the CRAVE at 6-month intervals over two years- two times each session. Across-session interclass correlations (ICC) for Move (ICC = 0.72–0.95) and Rest (ICC = 0.69–0.88) were higher than when they were measured across 24-months (Move: ICC = 0.53; Rest: ICC = 0.49), indicating wants/desires have state-like qualities. In Study 4, a maximal treadmill test was completed by 21 university students. The CRAVE was completed immediately pre and post. Move desires decreased 26% and Rest increased 74%. Changes in Move and Rest desires were moderately associated with changes in perceived physical fatigue and energy. In Study 5, 41 university students sat quietly during a 50-min lecture. They completed the CRAVE at 3 time points. Move increased 19.6% and Rest decreased 16.7%. Small correlations were detected between move and both perceived energy and tiredness, but not calmness or tension. In conclusion, the CRAVE scale has good psychometric properties. These data also support tenets of the WANT model of motivation states for movement and rest (Stults-Kolehmainen et al., 2020a). Future studies need to explore how desires to move/rest relate to dynamic changes in physical activity and sedentarism. (shrink)

This book focuses on some of the most pressing methodological, ethical, and technique-philosophical questions that are connected with the concept of artificial autonomous systems. (Series: Hermeneutics and Anthropology / Hermeneutik und ...

The first edition of The Scientific Background to Modern Philosophy took the dialogue of science and philosophy from Aristotle through to Newton. This second edition adds eight chapters, taking the dialogue through the Enlightenment and up to Darwin. This anthology is an attempt to help bridge the gap between the history of science and the history of philosophy.

Imagine I hold up a Granny Smith apple for all to see. You would thereby gain justified beliefs that it was green, that it was apple, and that it is a Granny Smith apple. Under classical foundationalism, such simple visual beliefs are mediately justified on the basis of reasons concerning your experience. Under dogmatism, some or all of these beliefs are justified immediately by your experience and not by reasons you possess. This paper argues for what I call the looks (...) view of the justification of simple visual beliefs. According to the looks view, such beliefs are mediately justified on the basis of reasons concerning how the relevant things look. Unlike under classical foundationalism, under the looks view as I develop it, these reasons are public. They are public with respect to both their content and possession: with respect to content, they are not about ourselves and our experiences, and with respect to their possession, many people can have the very same looks-related reasons. (shrink)

Abstract I provide an account of the nature of seemings that explains why they are necessary for justification. The account grows out of a picture of cognition that explains what is required for epistemic agency. According to this account, epistemic agency requires (1) possessing the epistemic aims of forming true beliefs and avoiding errors, and (2) having some means of forming beliefs in order to satisfy those aims. I then argue that seeming are motives for belief characterized by their role (...) of providing us with doxastic instructions guided by our epistemic aims. Understanding the nature of seemings allows us to underwrite recent epistemological work by Michael Huemer, and shows why he was right to claim that seemings are the source of all justification. I then look at some objections both to my arguments regarding the connection between seemings and justification, and to Huemer’s related “Principle of Phenomenal Conservatism”. Content Type Journal Article Pages 1-21 DOI 10.1007/s11098-011-9830-2 Authors Matthew Skene, Syracuse University, 8330 E. Quincy Ave., I-307, Denver, CO 80237, USA Journal Philosophical Studies Online ISSN 1573-0883 Print ISSN 0031-8116. (shrink)

Dan Brock has asserted that those who claim that the early embryo has full moral status are not consistent, and that the rationality of such a position is dubious when it is adopted from a religious perspective. I argue that both claims are flawed. Starting with the second claim, which is grounded in Brock’s moral abstolutist position, I argue that Brock has provided no argument on why the religious position should be less rational than the secular position. With regard to (...) the first claim, I argue that those who hold the view that the early embryo has full moral status can be consistent even if they do not oppose sexual reproduction, even if they do not grieve as much over the loss of embryos as over the loss of other humans, even if they prefer to save one child instead of 100 embryos in the event of fire, and even if they do not accept racism and sexism. (shrink)

The scope of embryo research in the UK has been expanded by the Human Fertilisation and Embryology Regulations 2001. Two advisory bodies—the Chief Medical Officer’s Expert Group and the House of Lords’ Select Committee—presented various arguments in favour of embryo research. One of these is the view that, just as lottery tickets have relatively little value before the draw because of the low probability of their being the winning ticket, early embryos have relatively little value because of the presumed low (...) probability that they will mature into more developed embryos. This argument from probability is questioned in this paper, as well as the contention that allowing embryo destruction is incompatible with the view that embryos have full moral status. Although I challenge Savulescu’s view that early embryos should be entered into a lottery in which they are subjected to the probability of being destroyed , a revised version of Thomson’s analogy of the famous violinist defies the view that the position that the embryo has full moral status is incompatible with qualified support for embryo destruction. (shrink)

Service robotics has increasingly become the focus of reflective research on new technologies over the last decade. The current state of technology is characterized by prototypical robot systems developed for specific application scenarios outside factories. This has enabled context-based Science and Technology Studies and technology assessments of service robotic systems. This contribution describes the status quo of this reflective research as the starting point for interdisciplinary technology assessment (TA), taking account of TA studies and, in particular, of publications from the (...) ethical and empirical social science perspective. Finally, based on this status quo, evaluation criteria for service robots are developed, which are relevant for further reflective research. (shrink)

One’s account of the meaning of ethical sentences should fit – roughly, as part to whole – with one’s account of the meaning of sentences in general. When we ask, though, where one widely discussed account of the meaning of ethical sentences fits with more general accounts of meaning, the answer is frustratingly unclear. The account I have in mind is the sort of metaethical expressivism inspired by Ayer, Stevenson, and Hare, and defended and worked out in more detail recently (...) by Blackburn, Gibbard, and others. So, my first aim (§1) in this paper is to pose this question about expressivism’s commitments in the theory of meaning and to characterize the answer I think is most natural, given the place expressivist accounts attempt to occupy metaethics. This involves appeal to an ideationalist account of meaning. Unfortunately for the expressivist, however, this answer generates a problem; it’s my second aim (§2) to articulate this problem. Then, my third aim (§3) is to argue that this problem doesn’t extend to the sort of account of the meaning of ethical claims that I favor, which is like expressivism in rejecting a representationalist order of semantic explanation but unlike expressivism in basing an alternative order of semantic explanation on inferential role rather than expressive function. (shrink)

This chapter contains sections titled: Categorical Prescriptiveness Uniformity as a Moral Matter Uniformity Contrasted with Neutrality The Overridingness of Moral Principles.

Assertion is governed by an epistemic norm requiring knowledge. This idea has been hotly debated in recent years, garnering attention in epistemology, philosophy of language, and linguistics. This chapter presents and extends the main arguments in favor of the knowledge norm, from faulty conjunctions, several conversational patterns, judgments of permission, excuse, and blame, and from showing how. (Paired with a chapter by Peter J. Graham and Nikolaj J. L. L. Pedersen, "Knowledge is Not Our Norm of Assertion.").

The moral enhancement of human beings is a constant theme in the history of humanity. Today, faced with the threats of a new, globalised world, concern over this matter is more pressing. For this reason, the use of biotechnology to make human beings more moral has been considered. However, this approach is dangerous and very controversial. The purpose of this article is to argue that the use of another new technology, AI, would be preferable to achieve this goal. Whilst several (...) proposals have been made on how to use AI for moral enhancement, we present an alternative that we argue to be superior to other proposals that have been developed. (shrink)

Examines traditional sites of binary thinking in ancient Greek texts and culture to demonstrate surprising ambiguity, especially with regard to sexual difference.

Als geronnene Wiederholungen prägen Rituale unseren Alltag und unser Zusammenleben maßgeblich. Nicht von ungefähr galten sie lange Zeit als Inbegriff des Konservativen, Starren und Förmlichen. Eine gänzlich durchritualisierte Welt wäre zweifellos eine unfreie Welt. Im Zeitalter der Deregulierung, der Hyperaktivität und des Aufmerksamkeitsdefizits wird nun ihre Halt gebende und strukturierende Seite wiederentdeckt.Die AutorInnen reflektieren gesellschaftskritisch Theorien und psychoanalytische Erfahrungen rund um das Thema Rituale und widmen sich den folgenden Fragen: Werden Rituale zu Widerstandsnestern gegen die allgemeine Flüchtigkeit? Können sie als (...) Angelpunkte des Innehaltens und als Wegbahner unbeirrten Denkens eine neue kritische Potenz erhalten?Mit Beiträgen von Thomas Dietzel, Gesa Foken, Dirk Hofmeister, Katharina Lacina, Konrad Paul Liessmann, Nina Reis Saroldi, Elisabeth Rohr, Jochen Schade, Hans-Ernst Schiller, Edgar Weiß, Laura Wolf und Carsten Wonneberger. (shrink)

Borders are essentially imaginary structures, but their effects are very real. This volume explores both geopolitical and conceptual borders through an interdisciplinary lens, bridging the disciplines of philosophy and literature. With contributions from scholars around the world, this collection closely examines the concepts of race, nationality, gender, and sexuality in order to reveal the paradoxical ambiguities inherent in these seemingly solid binary oppositions, while critiquing structures of power that produce and police these borders. As a political paradigm, liminality may be (...) embraced by marginal subjects and communities, further blurring the boundaries between oppressive distinctions and categories. (shrink)

This paper explores some surprising effects of psychological trauma on memory and develops the puzzle of observer memory for trauma. Memory for trauma tends to have a third-person perspective, or observer perspective. But it appears observer memory, by having a novel visual point of view, tends to misrepresent the past. And many find it plausible that if a memory type tends to misrepresent, it cannot yield knowledge of, or justification for believing, details of past events. But it is also plausible (...) that, with respect to details of past trauma, observer memory can yield knowledge or justification. I argue for a novel set of views that offers a way out of the puzzle: observer memory does tend to misrepresent, but it still has epistemic power regarding details of the past, although with special limits; but observer memory for trauma has other epistemic powers too, in that it allows for a kind of self-awareness. (shrink)

What is it to know someone? Epistemologists rarely take up this question, though recent developments make such inquiry possible and desirable. This paper advances an account of how such interpersonal knowledge goes beyond mere propositional and qualitative knowledge about someone, giving a central place to second-personal treatment. It examines what such knowledge requires, and what makes it distinctive within epistemology as well as socially. It assesses its theoretic value for several issues in moral psychology, epistemic injustice, and philosophy of mind. (...) And it offers an account of the complex content in play if interpersonal knowledge is to be understood in terms of its mental states and their functions. (shrink)

In 2010, the German Federal Ministry of Education and Research started a series of citizens’ dialogues on future technologies. In the context of the German history of public participation in technology-oriented policy making, these dialogues are unique for at least two reasons: The Federal Ministry retains the responsibility for the entire process and is heavily involved in its planning, organization and communication, and the number of participants and process elements is significantly higher than in most other participative events. The paper (...) presents insights into the political background of the citizens’ dialogues, its general concept as well as first observations from the dialogue rounds on energy and high-tech medicine. In addition, it discusses reactions of other political actors and expectations regarding legitimacy and representativeness of the dialogue results. (shrink)

We regularly appeal to claims of the form it seems that p in defense of a claim p. When we do so, we typically take it seems that p to be a reason for thinking that p but also a reason that “gets at” a relevant body of facts and its support for p. Other things being equal, we should want to vindicate our ordinary beliefs on this matter. We should want to vindicate the claim that facts about things seeming (...) certain ways can be reasons to think that things are that way while at the same time being somehow derivative reasons, that is, reasons only because they “get at” support from a certain body of facts. However, on the dominant view of how things seem—subjectivism—it is hard to see how to secure this result. Subjectivism takes how things seem to be a matter of how things do or would seem to some relevant subject. What we need is a defensible, nonsubjectivist account of how things seem. I propose and defend an account according to which, roughly, it seems that p iff the body of facts in the relevant perspective supports that p. (shrink)

This book examines a main theme in religious epistemology, namely, the possibility of knowledge of God. Most often philosophers consider the rationality or justification of propositional belief about God, particularly beliefs about the existence and nature of God; and they will assess the conditions under which, if there is a God, such propositional beliefs would be knowledge, particularly in light of counter-evidence or the availability of religious disagreement. This book surveys such familiar areas, then turns toward newer and less-developed terrain: (...) interpersonal epistemology, namely what it is to know another person. It then explores the prospects for understanding what it might take to know God relationally, the contours of which are significant for many theistic traditions. (shrink)

The aim in this paper is to focus on one of the proposals about successful perception that has led its adherents to advance some kind of disjunctive account of experience. The proposal is that we should understand the conscious sensory experience involved in successful perception in relational terms. I first try to clarify what the commitments of the view are, and where disagreements with competing views may lie. I then suggest that there are considerations relating to the conscious character of (...) our perception of events that speak in its favour. (shrink)

A timely book that uses science fiction to provoke reflection and discussion on philosophical issues From the nature of mind to the ethics of AI and neural enhancement, science fiction thought experiments fire the philosophical imagination, encouraging us to think outside of the box about classic philosophical problems and even to envision new ones. Science Fiction and Philosophy explores puzzles about virtual reality, transhumanism, whether time travel is possible, the nature of artificial intelligence, and topics in neuroethics, among other timely (...) issues. This thought-provoking volume is suitable for students and general readers but also examines new and more advanced topics of interest to seasoned philosophers and scientists. Susan Schneider is Assistant Professor in the department of philosophy at the University of Pennsylvania and an Affiliated Faculty Member at the Institutes for Research in Cognitive Science and Center for Cognitive Neuroscience. (shrink)

Deleuze & Guattari, Politics and Education mobilizes Deleuzian-Guattarian philosophy as a revolutionary alternative to the lingering forms of transcendence, identity politics, and nihilism endemic to Western thought. Operationalizing Deleuze and Guattari's challenge to contemporary philosophy, this book presents their view as a revolutionary alternative to the lingering forms of transcendence, identity politics, and nihilism endemic to the current state of Western formal education. This book offers an experimental approach to theorizing, creating an entirely new way for educational theorists to approach (...) their work as the task of revolutionizing life itself. Examining new conceptual resources for grappling with and mapping a sustainable political alternative to the cliche's that saturate contemporary educational theory, this collection of essays works toward extracting a genuine image of education and learning that exists in sharp contrast to both the neo-liberal educational project and the critical pedagogical tradition. (shrink)

On Sense and Direct Reference: Readings in the Philosophy of Language focuses on the debate between neo-Fregeans and neo-Russellians in philosophy of language. With a foreword by Nathan Salmon, the volume collects more than 40 of the most important papers in philosophy of language in the last 40 years; including David Kaplan's "Demonstratives" and "Afterthoughts", and a paper written by Scott Soames especially for the volume. It is suitable for advanced undergraduate and graduate courses.

In Measuring the Immeasurable Mind: Where Contemporary Neuroscience Meets the Aristotelian Tradition, Matthew Owen argues that despite its nonphysical character, it is possible to empirically detect and measure consciousness. -/- Toward the end of the previous century, the neuroscience of consciousness set its roots and sprouted within a materialist milieu that reduced the mind to matter. Several decades later, dualism is being dusted off and reconsidered. Although some may see this revival as a threat to consciousness science aimed at (...) measuring the conscious mind, Owen argues that measuring consciousness, along with the medical benefits of such measurements, is not ruled out by consciousness being nonphysical. Owen proposes the Mind-Body Powers model of neural correlates of consciousness, which is informed by Aristotelian causation and a substance dualist view of human nature inspired by Thomas Aquinas, who often followed Aristotle. In addition to explaining why there are neural correlates of consciousness, the model provides a philosophical foundation for empirically discerning and quantifying consciousness. En route to presenting and applying the Mind-Body Powers model to neurobiology, Owen rebuts longstanding objections to dualism related to the mind-body problem. With scholarly precision and readable clarity, Owen applies an oft forgotten yet richly developed historical vantage point to contemporary cognitive neuroscience. (shrink)

Does a flourishing life involve pursuing passionate attachments? Can we choose what these passionate attachments will be? This book offers an original theory of how we can actively cultivate our passionate attachments. The author argues that not only do we have reason to view passionate attachments as susceptible to growth, change, and improvement, but we should view these entities as amenable to self-cultivation. He uses Pierre Hadot's and Michel Foucault's accounts of Hellenistic self-cultivation as vital conceptual tools to formulate a (...) theory of cultivating our passionate attachments. First, their accounts offer the conceptual resources for a philosophical theory of how we can cultivate our passionate attachments. Second, the exercises of self-cultivation they focus on allow us to outline a practical method though which we can cultivate our passionate character. Doing this brings out a significantly new dimension to the role of the passionate attachments in the flourishing life and offers theoretical and practical accounts of how we can cultivate them based on the Hellenistic conception of self-directed character change. Cultivating Our Passionate Attachments will be of interest to advanced students and scholars working in virtue ethics, moral philosophy, and ancient philosophy. (shrink)

In 2005, Charles Mills published “‘Ideal Theory’ as Ideology” in Hypatia: a withering critique of much of contemporary political philosophy and ethics. For Mills such work in philosophy failed to attend to the realities of social life and politics, and in remaining silent on actual issues of domination and oppression served an ideological role in supporting the interests of white bourgeois men. Around the time that Charles Mills launched his broadside against ideal theory, trans theorists had been fighting their own (...) battle against the abstraction of theory from the realities of trans lives and oppression. Vivian Namaste (2000) and Jay Prosser (1998) argued that contemporary gender theory failed to justice to the actuality of trans life, retreating instead to understanding trans life through literary archetypes and idealized radical figures. In this chapter I’ll compare Mills’ critique of ideal theory with the transfeminist critique of 1990s gender theory, arguing that they share much in common. Centrally, both critiques share an underlying commitment to theory needing to be grounded in the actuality of oppression and power relations. This common thread, I suggest, must continue to guide transfeminist thought and action: contra Marquis Bey (2022) transfeminist thought and praxis must continue to be about trans lives, about the oppression of trans women, and about ways of actually achieving liberation from our current dire position. (shrink)

Han Solo‐orphan, laconically cool Corellian smuggler, Rebel general, and martyr for the Resistance, is one of the most‐loved characters in the Star Wars universe. His emotional and moral development throughout the original trilogy into a trusted friend, Leia's lover, and a warrior for Rebel values is inspiring. In the sequel trilogy, he's returned to smuggling and reluctantly re‐assumes the mantle of father to Ben Solo, an alienated and ultimately patricidal son, but even death fails to stop him from offering fatherly (...) advice to bring Kylo Ren back to the light side. In a universe of tyrants, freedom‐fighters, Force‐sensitives, Jedi, and Sith, everybody seems to be peddling a philosophy. But Han Solo is a scoundrel, a skeptic, and a Corellian who seems to want to evade a philosophical life. Skepticism, anti‐authoritarianism, and a desire to demystify–to strip away pretensions to reveal the true, but often ugly face of reality. (shrink)

It's often thought that when we reason to new judgments in inference, we aim at believing the truth, and that this aim of ours can explain important psychological and normative features of belief. I reject this picture: the structure of aimed activity shows that inference is not guided by a truth‐aim. This finding clears the way for a positive understanding of how epistemic goods feature in our doxastic lives. We can indeed make sense of many of our inquisitive and deliberative (...) activities as undertaken in pursuit of such goods; but the evidence‐guided inferences in which those activities culminate will require a different theoretical approach. (shrink)