15 found
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  1. Varieties of Living Things: Life at the Intersection of Lineage and Metabolism.John Dupré & Maureen A. O'Malley - 2009 - Philosophy, Theory, and Practice in Biology 1 (20130604).
    We address three fundamental questions: What does it mean for an entity to be living? What is the role of inter-organismic collaboration in evolution? What is a biological individual? Our central argument is that life arises when lineage-forming entities collaborate in metabolism. By conceiving of metabolism as a collaborative process performed by functional wholes, which are associations of a variety of lineage-forming entities, we avoid the standard tension between reproduction and metabolism in discussions of life – a tension particularly evident (...)
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  2. Fundamental issues in systems biology.Maureen A. O'Malley & John Dupré - 2005 - Bioessays 27 (12):1270-1276.
    In the context of scientists' reflections on genomics, we examine some fundamental issues in the emerging postgenomic discipline of systems biology. Systems biology is best understood as consisting of two streams. One, which we shall call ‘pragmatic systems biology’, emphasises large‐scale molecular interactions; the other, which we shall refer to as ‘systems‐theoretic biology’, emphasises system principles. Both are committed to mathematical modelling, and both lack a clear account of what biological systems are. We discuss the underlying issues in identifying systems (...)
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  3.  46
    Knowledge-Making Distinctions in Synthetic Biology.Maureen A. O'Malley, Alexander Powell, Jonathan F. Davies & Jane Calvert - 2008 - Bioessays 30 (1):57-65.
    Synthetic biology is an increasingly high-profile area of research that can be understood as encompassing three broad approaches towards the synthesis of living systems: DNA-based device construction, genome-driven cell engineering and protocell creation. Each approach is characterized by different aims, methods and constructs, in addition to a range of positions on intellectual property and regulatory regimes. We identify subtle but important differences between the schools in relation to their treatments of genetic determinism, cellular context and complexity. These distinctions tie into (...)
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  4.  26
    Histories of molecules: Reconciling the past.Maureen A. O'Malley - 2016 - Studies in History and Philosophy of Science Part A 55 (C):69-83.
  5.  59
    Microbiota-gut-brain research: A critical analysis.Katarzyna B. Hooks, Jan Pieter Konsman & Maureen A. O'Malley - 2019 - Behavioral and Brain Sciences 42:1-40.
    Microbiota-gut-brain research is a fast-growing field of inquiry with important implications for how human brain function and behaviour are understood. Researchers manipulate gut microbes to reveal connections between intestinal microbiota and normal brain functions or pathological states. Many claims are made about causal relationships between gut microbiota and human behaviour. By uncovering these relationships, MGB research aims to offer new explanations of mental health and potential avenues of treatment. So far, limited evaluation has been made of MGB's methods and its (...)
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  6.  48
    Disciplinary baptisms: A comparison of the naming stories of genetics, molecular biology, genomics and systems biology.Alexander Powell, Maureen A. O'Malley, Staffan Mueller-Wille, Jane Calvert & John Dupré - 2007 - History and Philosophy of the Life Sciences 29 (1):5-32.
    Understanding how scientific activities use naming stories to achieve disciplinary status is important not only for insight into the past, but for evaluating current claims that new disciplines are emerging. In order to gain a historical understanding of how new disciplines develop in relation to these baptismal narratives, we compare two recently formed disciplines, systems biology and genomics, with two earlier related life sciences, genetics and molecular biology. These four disciplines span the twentieth century, a period in which the processes (...)
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  7.  62
    The Study of Socioethical Issues in Systems Biology.Maureen A. O'Malley, Jane Calvert & John Dupré - 2007 - American Journal of Bioethics 7 (4):67-78.
    Systems biology is the rapidly growing and heavily funded successor science to genomics. Its mission is to integrate extensive bodies of molecular data into a detailed mathematical understanding of all life processes, with an ultimate view to their prediction and control. Despite its high profile and widespread practice, there has so far been almost no bioethical attention paid to systems biology and its potential social consequences. We outline some of systems biology's most important socioethical issues by contrasting the concept of (...)
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  8.  32
    The ecological virus.Maureen A. O'Malley - 2016 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 59:71-79.
    Ecology is usually described as the study of organisms interacting with one another and their environments. From this view of ecology, viruses – not usually considered to be organisms – would merely be part of the environment. Since the late 1980s, however, a growing stream of micrographic, experimental, molecular, and model-based (theoretical) research has been investigating how and why viruses should be understood as ecological actors of the most important sort. Viruses, especially phage, have been revealed as participants in the (...)
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  9.  44
    Microbes, mathematics, and models.Maureen A. O'Malley & Emily C. Parke - 2018 - Studies in History and Philosophy of Science Part A 72:1-10.
    Microbial model systems have a long history of fruitful use in fields that include evolution and ecology. In order to develop further insight into modelling practice, we examine how the competitive exclusion and coexistence of competing species have been modelled mathematically and materially over the course of a long research history. In particular, we investigate how microbial models of these dynamics interact with mathematical or computational models of the same phenomena. Our cases illuminate the ways in which microbial systems and (...)
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  10.  75
    Evolutionary systems biology: What it is and why it matters.Orkun S. Soyer & Maureen A. O'Malley - 2013 - Bioessays 35 (8):696-705.
    Evolutionary systems biology (ESB) is a rapidly growing integrative approach that has the core aim of generating mechanistic and evolutionary understanding of genotype‐phenotype relationships at multiple levels. ESB's more specific objectives include extending knowledge gained from model organisms to non‐model organisms, predicting the effects of mutations, and defining the core network structures and dynamics that have evolved to cause particular intracellular and intercellular responses. By combining mathematical, molecular, and cellular approaches to evolution, ESB adds new insights and methods to the (...)
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  11.  25
    Causal clarity and deeper dimensions in microbiota-gut-brain research.Katarzyna B. Hooks, Jan Pieter Konsman & Maureen A. O'Malley - 2019 - Behavioral and Brain Sciences 42.
    Our analysis of microbiota-gut-brain research took MGB to task for some of its methods, concepts, and interpretations. Commentators then raised numerous issues about the neuroscientific and microbiome aspects of MGB and how it can be understood as a field. We respond by addressing the dimensionality and causal focus of MGB.
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  12. Part IV. Is evolution fundamental when it comes to defining biological ontology?: Is evolution fundamental when it comes to biological ontology?Maureen A. O'Malley - 2020 - In Shamik Dasgupta, Brad Weslake & Ravit Dotan (eds.), Current Controversies in Philosophy of Science. London: Routledge.
     
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  13.  17
    Small Things, Big Consequences: Microbiological Perspectives on Biology.Michael J. Duncan, Pierrick Bourrat, Jennifer Deberardinis & Maureen A. O'Malley - 2013 - In Kostas Kampourakis (ed.), The Philosophy of Biology: A Companion for Educators. Springer. pp. 1--373.
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  14.  22
    The scientific importance of asking questions at meetings: Why virtual debate is not enough.Maureen A. O'Malley & Sabina Leonelli - 2011 - Bioessays 33 (1):35-37.
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  15.  41
    Review of 'Philosophy of Biology' (Garvey, 2007). [REVIEW]Maureen A. O'Malley & Daniel J. Nicholson - 2008 - Notre Dame Philosophical Reviews 2008 (10).