This article uses transcriptions from video recordings of airline pilots at work, on actual flights, to consider some locations and the interactional significance of a feature of routine talk in the airline cockpit: and-prefaced turns. As pilots’ work is formally organized for them as many discrete and ordered tasks, and-prefacing is a local means for maintaining an ongoing sense of their conduct of a flight as a whole. By and-prefacing their talk, pilots present some new talk or task as connected (...) and relevantly next in a larger macro-sequence of work for their flight. And-prefacing is evidence of pilots’ orientation to a sense of sequence that can extend well beyond pairs of turns at talk and/or non-talk activities, or even a series of such paired sequences. It allows pilots to make salient the sequentiality of their work where the officially prescribed wordings they must use can leave this implicit. (shrink)