Telomeres are protective caps for chromosome ends that are essential for genome stability. Broken chromosomes missing a telomere will not be maintained unless the chromosome is ‘healed’ with the formation of a new telomere. Chromosome healing can be a programmed event following developmentally regulated chromosome fragmentation, or it may occur spontaneously when a chromosome is accidentally broken. In this article we discuss the consequences of telomere loss and the possible mechanisms that the enzyme telomerase employs to form telomeres de novo (...) on broken chromosome ends. (shrink)

This article looks at the human rights protection in transitional post-uprising Tunisia, from 2011 to 2017, offering insights into the willingness to both protect human rights and build capacity in Tunisia. It focuses on the establishment of an adequate legal framework in Tunisia, with particular attention being paid to the constitution-making process and, on the establishment, the strengthening of certain institutional capacities, such as the constitutional court and the Truth and Dignity Commission. The article first gives a brief historical overview (...) of the human rights situation in Tunisia. This is followed by an analysis of the willingness and capacity to protect human rights in post-uprising transitional Tunisia, in both the 2011–2014 and 2014–2017 periods.This article is based on evidence from a series of semi-structured interviews I conducted with the key political actors from various political parties, and actors from NGOs working on human rights, during field research in Tunisia in October-November 2017, supplemented by secondary literature. (shrink)

The question that arises in this article is whether we can find elements of phenomenology in Bernard Lonergan’s Trinitarian theology.With help of other Lonergan scholars, I have discovered that modern thinking plays an important role in the theology and philosophy ofthis Jesuit author. Moreover, the terminology of modern philosophy coexists with the terminology of classical and especially Tomisticthought. This article is interested in the elements that Lonergan takes from the modern philosophy and emphasizes the centrality ofHusserlian phenomenology among the other (...) modern authors used by Lonergan. Following the research of the Jesuit thinker, I speakabout two parallel realities coexisting in his Trinitarian theology. Lonergan tries to realize their synthesis, but at the same time healso recognizes their distinctiveness. The most relevant result of this coexistence is obtained through the replacement of the metaphysical differentiation between the level of substance and the level of the three Persons, so that, instead of having the elements of classical theology, Lonergan predicates at the same time that God subsists as well as the Trinitarian Persons subsist. Through this assertion he emphasizes the identity between God’s existence and the existence of the three divine Persons, and eliminates the classical differentiation that might be closer to the danger of subordinating the three Persons to the one God. (shrink)

Work on essence of Advaita Vedanta philosophy.

A nonlinear differential equation model is proposed to study the dynamics of HIV/AIDS and its effects on workforce productivity. The disease-free equilibrium point of the model is shown to be locally asymptotically stable when the associated basic reproduction number $$\mathcal{{R}}_{0}$$ is less than unity. The model is also shown to exhibit multiple endemic states for some parameter values when $$\mathcal{{R}}_{0} 1$$. Global asymptotic stability of the disease-free equilibrium is guaranteed only when the fractions of the Susceptible subclass populations are within (...) some bounds. Optimal control analysis of the model revealed that the most cost effective strategy that should be adopted in the fight against HIV/AIDS spread within the workforce is one that seeks to prevent infections and the treatment of infected individuals. (shrink)

Background The Regional Committee for Africa of the World Health Organization (WHO) in 2001 expressed concern that some health-related studies undertaken in the Region were not subjected to any form of ethics review. In 2003, the study reported in this paper was conducted to determine which Member country did not have a national research ethics committee (REC) with a view to guiding the WHO Regional Office in developing practical strategies for supporting those countries. Methods This is a descriptive study. The (...) questionnaire was prepared and sent by diplomatic pouch to all the 46 Member States in the WHO African Region, through the WHO country representatives, for facilitation and follow up. The data were entered in Excel spreadsheet and subsequently exported to STATA for analysis. A Chi-Squared test (χ 2) for independence was undertaken to test the relationship between presence/absence of Research Ethics Committee (REC) and selected individual socioeconomic and health variables. Results The main findings were as follows: the response rate was 61% (28/46); 64% (18/28) confirmed the existence of RECs; 36% (10/28) of the respondent countries did not have a REC (although 80% of them reported that they had in place an ad hoc ethical review mechanism); 85% (22/26) of the countries that responded to this question indicated that ethical approval of research proposals was, in principle, required; and although 59% of the countries that had a REC expected it to meet every month, only 44% of them reported that the REC actually met on a monthly basis. In the Chi-Squared test, only the average population in the group of countries with a REC was statistically different (at 5% level of significance) from that of the group of countries without a REC. Conclusion In the current era of globalized biomedical research, good ethics stewardship demands that every country, irrespective of its level of economic development, should have in place a functional research ethics review system in order to protect the dignity, integrity and safety of its citizens who participate in research. (shrink)

Tesettür kavramı temel mahiyeti ve amacı açısından İslam dini kapsamında değerlendirilecek dini bir pratiktir. İslam’da kadının giyim konusundaki sınırlarının belirlenmesi, bedenin gizlenmesi açısından tesettür kavramı önem taşımaktadır. Fakat modernleşme ekseniyle değişme ve gelişmeler gösteren tesettür anlayışının, tüketim kültürü ve moda ile birleşen, bu modern çağın gereklerine ayak uyduran yeni bir tesettür anlayışı ve imajıyla karşı karşıya kaldığı görülmektedir. Özellikle gençlerin giyim tercihlerinde tesettürün modernleşme dinamiklerinden etkilenmesi söz konudur. Bu çalışmada tesettürlü gençlerin giyim tercihlerinde tesettür algısının, tüketim kültürü ve moda ile (...) bütünleşmesi sonucu ortaya çıkan “tesettür modası” ile olan münasebeti ve temelde tesettürün özsel ve şekilsel değişiklikleri ile bu değişikliklere sebep olan faktörlerin etkisi ortaya konulmuştur. Teorik ve uygulamalı bir anket ile gençlerin tesettür tercihi ve algısının değişim ve dönüşüm nedenleri, bu dönüşüme etki eden unsurlar sorgulanmıştır. (shrink)

Abrogation (naskh) is one of the controversial themes of Islamic studies, especially in later period that of principle of exegesis (uṣūl al-tafsīr). However, the recent studies on abrogation (naskh) do not offer a comprehensive analysis on the concept. In fact, the problem of naskh (abrogation) is in need of a systematic and holistic approach, which would only be possible with a detailed study on how the concept of abrogation (naskh) is understood in Islamic interpretive tradition (tafsīr). With this purpose in (...) mind, this article intends to examine two points regarding the term abrogation: first, the article will offer a analytical reflection on the diverse views of naskh, and then it will highlight how Ibn Kathīr (d. 1373) understood and applied this term to his hermeneutical framework. By doing so, the present study aims to show Ibn Kathīr’s position in Islamic interpretive tradition on the matter of naskh. The key conclusion of this study is that although Ibn Kathīr is one of the representatives of the traditional riwayah (sound transmission through a chain of exegetes) exegesis, he advances his interpretive hermeneutics with multiple aspects that also involves dirayah (personal opinion) exegesis (tafsīr). SUMMARY The problem of naskh (abrogation) is one of the most important and controversial themes of science and principle of exegesis (ʿilm wan a-l uṣūl al-tafsīr) in Islamic tradition. In order to understand naskh, which is claimed to be occurred in the Qur’ānic text, it is necessary to involve the time of the revelation of the Qur’ān. An analysis of this period reveals that first Muslims regard the naskh as a natural process of the revelation and do not dispute over this matter. In other words, the controversial theme naskh is perceived by first addresses of the Qur’ān as a hermeneutical characteristic of the Qur’ānic revelation. Therefore, naskh was not considered as a controversial concept and debated its origins based on the question whether it organically belonged to the revelation. It will be clear that the different views on naskh (abrogation), particularly after the time of the Companions is not a conceptual problem; rather Muslim scholars differed in their methodological approaches to naksh. Naskh has not been questioned as a concept in early Islamic tradition. Rather it has gradually developed over the centuries. Naskh has been elaborated with the terms of uṣūl al-fiqh (principles of Law), such as takhṣīṣ (specification) and taqyīd (restriction) and its conceptual meaning has been extended after, particularly Abū ʿAbdullah Muḥammad b. Idris b. ʿAbbas al-Shāfiʿī (d. 820). To sum up, naskh is regarded with a methodological perspective. However, in the field of Turkish Islamic studies, especially after the Cumhuriyet, the term naskh is not regarded as a natural consequence of the process of tanzīl (revelation of the Qur’ān) neglecting the gradual aspect of revelation and the disputes over the term has been concluded either rejecting or simply accepting this concept without providing a satisfactory result on the matter. This article examines one of the most prominent Muslim exegete Ibn Kathīr’s (d. 1373) approach to the problem of naskh in the context of previous modern scholarship on naskh (abrogation). However, the analysis of Ibn Kathīr’s perception of naskh does not claim to be exhaustive on the matter. This requires a more comprehensive study on the concept of naskh, which is clearly beyond the scope of this article. Therefore, the present study intends to specifically focus on general aspect of Ibn Kathīr’s understanding of naskh and how his perception is presented in modern studies. When Ibn Kathīr’s commentary is analysed, it becomes clear that his understanding of naskh is significant and not necessarily in line with his riwayah (sound transmission through a chain of exegetes) tafsīr (exegesis). For example, he notes the dates between abrogating and abrogated Qur’ānic verses and claims that it is necessary to find certain proofs to validate the claim of abrogation (naskh) for particular legal judgments and verses, which clearly shows that Ibn Kathīr approaches to the problem of naskh with a methodological perspective. Ibn Kathīr’s interpretation of the well known Qur’ānic verse Q 2.106 in a different sense and most importantly his consideration of the matter only in the Qur’ānic context are clear examples of his methodological approach. His interpretation of Q 2.106 simply shows that he meticulously distinguish between the acceptance of naskh as a concept and as an interpretive method. The modern studies on naskh, on the contrary, consider the matter only on the base of a conceptual analysis. Ibn Kathīr prefers to transmit the traditional opinions based on personal interpretation and interprets some Qur’ānic verses. This is clearly his method of re-interpretation based on rational thinking (taʾwīl). His way of rational reasoning leads Ibn Kathīr to the rejection of naskh (abrogation) and the restriction of Qur’ānic verses that are related to the theory of abrogating and abrogated verses (nāsikh-mansūkh). This clearly proves that Ibn Kathīr does not merely adopts and employs the method of riwayah, which is contrary to the supposition that he is the exegete of a commentary that heavily draws on hadith reports and transmitted traditional reports. In fact, this most importantly shows that Ibn Kathīr’s Qur’ān commentary can also be regarded as a dirayah (personal opinion) tafsīr (exegesis) and that there are enough material in traditional Muslim Qur’ānic exegesis to re-analyse the problem of naskh (abrogation). Relying on this last point, this article argues that a comprehensive analysis of naskh requires a research on the traditional interpretive sources. Therefore, it might be helpful to reconsider the matter of naskh with its conceptual background in the works of traditional Muslim exegetes rather than focusing only on whether the concept naskh exits or not in the origins of the Qur’ānic revelation. At this point, an analysis of Ibn Kathīr’s perception of naskh and his rational reasoning that is employed in his commentary will contribute to the understanding of the theory of naskh (abrogation) in the tradition of Qur’ānic exegesis. (shrink)

In his commentary on the Mencius 6A : 15 passage "the organ of the heartmind is thinking," Zhu Xi writes: "The heart-mind is capable of thinking and this thinking is its functional role ".1 The heart-mind is also said to "possess a multitude of li and respond to ten-thousand events ". Zhu Xi regularly associates this heart-mind as "thinking" that "responds to ten-thousand events" with a special process he refers to as "zhijue" 知覺. For instance, he explains that "the heart-mind (...) is our zhijue, which presides over the body and responds to thing-events " (Zhuzi wenji... (shrink)

Using multisource data and multilevel analysis, we propose that the ethical stance of supervisors influences subordinates’ perceptions of corporate social responsibility which in turn influences subordinates’ trust in the organization resulting in their taking increased personal social responsibility and engagement in organizational citizenship behaviors oriented toward both the organization and other individuals. Using a multilevel model, we assessed the extent to which ethical leadership and CSR at the work unit level impacts subordinates’ behaviors mediated by organizational trust at the individual (...) level. We employed a sample of 71 work unit supervisors and 308 subordinates from five businesses of a conglomerate company located in mainland China. Subordinates were asked to rate supervisory ethical leadership practices, CSR, and their extent of organizational trust. Supervisors were asked to rate the personal social responsibility taking and OCB of their respective subordinates. A multilevel path analysis revealed that ethical leadership has a positive effect on CSR at the work unit level and that CSR has a positive cross-level effect on organizational trust at the individual level, which in turn significantly and positively impacts OCB through the mediating effect of taking personal social responsibility. Results are discussed in the context of China’s manufacturing sector. (shrink)

We conducted an experiment to test whether altering the saliency of information provided by experts in fictitious news stories on climate change triggered different emotions among readers. Based on appraisal theories of emotions in the psychology literature, we hypothesized that 1) news stories that presented climate change related threats as diffuse and uncertain would elicit greater levels of anxiety, while 2) stories that provided a specific target to blame would induce greater anger, and 3) those that underlined the potential of (...) technology and human efforts to solve climate change related issues would elicit greater levels of hope. We found that while all news stories concerning climate change elicited high levels of anxiety, there were statistically significant differences between the emotions expressed by participations in the expected directions. We discuss the potential implications of these findings for climate change communication and for public opinion on climate change. (shrink)

I try to show that Berkeley's theory of ideas is not a variant of Locke's. We can find such an interpretation of Berkeley in Thomas Reid. So, we could call this interpretation a 'traditional interpretation'. This traditional interpretation has an influence still now, for example, Tomida interprets Berkeley in this line (Tomida2002). We will see that this traditional interpretation gives a serious problem to Berkeley (section 1). And I am going to present an argument against this traditional interpretation (section 2).

The integration of issues related to sustainability in management curricula is a subject of growing interest, especially as organizations – businesses and universities alike – are urged to take their share of responsibilities in the face of crises and need to deeply transform our lifestyles towards a more sustainable world. This article’s purpose is to explore the challenges and opportunities of integrating sustainability issues in business schools’ curricula. The conceptual argument developed in the article leads us to suggest that the (...) integration of sustainability in management schools could be conceptualized as a trajectory of continuous improvement over time. (shrink)

Cet article porte sur la reconstruction des relations entre Hydro-Québec et la Nation crie de 1994 à 2015. En 1994, le report sine die du projet hydroélectrique de Grande-Baleine par le premier ministre Jacques Parizeau marque à la fois une « victoire » pour les Cris opposés à ce projet et le paroxysme du conflit entre ces derniers et Hydro-Québec. Par contraste, deux décennies plus tard, en 2015, les deux parties s’accordent à décrire comme excellentes et constructives les relations entre (...) la société d’État et la Nation crie. L’intérêt distinctif de cette contribution qui vise à analyser le processus de transition de rapport conflictuel à partenariat réside dans le fait qu’elle a été coécrite par deux des protagonistes, l’un d’Hydro-Québec, l’autre du gouvernement de la Nation crie, et par deux chercheurs, dans le but de favoriser une compréhension commune de ces événements. Cet effort « d’écrire l’histoire à plusieurs mains », au-delà des clivages passés et présents, représente un effort de synthèse qui vise à enrichir notre compréhension des processus et des démarches d’acceptabilité sociale. (shrink)

On considère souvent Lévinas comme philosophe de l’Autre. Mais on sait également que son premier concept emblématique est l’il y a. Comment peut-on expliquer l’absence de l’Autre dans la première pensée de Levinas? Notre étude propose de mettre en relation celle-ci et sa critique de la philosophie moderne y inclut la phénoménologie.Face à la faille virtuelle de la phénoménologie, le jeune Lévinas était déjà conscient de la limite de la philosophie moderne supposant toujours un sujet pensant inébranlable. Les thématiques que (...) le jeune Levinas a choisi d’analyser comme nausée, honte, etc étaient en effet les vécus ignorés par la tradition philosophique de la conscience lucide. En réduisant le sujet pensant à l’état d’il y a, Lévinas tente de montrer la nécessité de l’Autre. La réduction du sujet pensant par le concept d’il y a est la première étape pour arriver à cette nécessité.Se suele considerar a Lévinas como el filósofo del “Otro”. Pero es sabido igualmente que su primer concepto emblemático es el “hay”. ¿Cómo se puede explicar la ausencia del “Otro” en la primera etapa del pensamiento de Levinas? Nuestro estudio pro-pone ponerlo en relación con su crítica de la filosofía moderna incluyendo la fenomenología.Frente al virtual fallo de la fenomenología, el joven Levinas era ya consciente del límite de la filosofía moderna, que suponía siempre un sujeto pensante inquebrantable. Las temáticas que el joven Levinas decide analizar, como la náusea, la vergüenza, etc., constituían en efec-to vivencias ignoradas por la tradición filosófica de la conciencia lúcida. Al reducir el sujeto pensante al estado de “hay”, Lévinas intenta mostrar la necesidad del “Otro”. La reducción del sujeto pensante por el concepto de “hay” es la primera etapa para llegar a esta necesidad. (shrink)

The question that arises in this article is whether we can find elements of phenomenology in Bernard Lonergan’s Trinitarian theology.With help of other Lonergan scholars, I have discovered that modern thinking plays an important role in the theology and philosophy ofthis Jesuit author. Moreover, the terminology of modern philosophy coexists with the terminology of classical and especially Tomisticthought. This article is interested in the elements that Lonergan takes from the modern philosophy and emphasizes the centrality ofHusserlian phenomenology among the other (...) modern authors used by Lonergan. Following the research of the Jesuit thinker, I speakabout two parallel realities coexisting in his Trinitarian theology. Lonergan tries to realize their synthesis, but at the same time healso recognizes their distinctiveness. The most relevant result of this coexistence is obtained through the replacement of the metaphysical differentiation between the level of substance and the level of the three Persons, so that, instead of having the elements of classical theology, Lonergan predicates at the same time that God subsists as well as the Trinitarian Persons subsist. Through this assertion he emphasizes the identity between God’s existence and the existence of the three divine Persons, and eliminates the classical differentiation that might be closer to the danger of subordinating the three Persons to the one God. (shrink)

Les controverses impliquant entreprises et communautés locales autour de grands projets de développement défraient l’actualité. Dans le contexte actuel de multiplication des controverses socio-économico-environnementales et de demande grandissante d’implication de la société civile dans la prise de décision liée aux projets dits de développement, le concept d’acceptabilité sociale s’impose comme un défi de gestion dans le microsome des promoteurs de projets majeurs, des décideurs publics et dans la sphère médiatique. Ces enjeux – qui introduisent de nouvelles formes d’incertitudes managériales et (...) sociotechniques – donnent lieu à de nouveaux défis théoriques pour la recherche en management. Ainsi, notre étude suggère d’ancrer l’acceptabilité sociale dans les développements récents du socioconstructivisme, offrant une nouvelle conceptualisation de ce concept sur la base de la production interactive d’ordres négociés. Ce faisant, notre cadre conceptuel permet une meilleure compréhension du processus par lequel les entreprises et les parties prenantes locales négocient leurs champs d’actions, et du processus par lequel les entreprises parviennent à développer et à cultiver l’acceptabilité sociale de leurs projets en développant et en maintenant des formes organisationnelles hybrides favorisant la cohabitation de plusieurs logiques d’action. (shrink)

[fr] La présente étude a pour but de contribuer, par l´examen des textes du dīwān du plus ancien poète populaire mauritanien connu, Saddūm Wuld Nd̆aṛtu, à identifier le vocabulaire ancien et à en expliquer la signification. Nous interrogeons ce dīwān en tant qu´ unique témoin conservé de l´époque de l´auteur (18ème siècle) pour qu´il nous aide à identifier dans ses poèmes les mots anciens qui sont depuis longtemps tombés en désuétude et sont aujourd´hui considérés comme des archaïsmes, des termes étranges (...) ou peu familiers à la plupart des locuteurs ou à tous. L´étude comprend, d´une part une description du contexte historique dans lequel vivait le poète et, d´autre part, une brève présentation du contenu du dīwān, avant d´aborder le sujet principal, à savoir le vocabulaire ancien du ḥassāniyya contenu dans l´ouvrage. Quant aux caractéristiques communes de ce vocabulaire, il convient de noter l´abondance de termes issus du champ lexical de la guerre (batailles, armes, chevaux, etc.). (shrink)

Publication date: 11 June 2018 Source: Author: Jude Nwafor Eze, Umar Aliyu, Abdulmalik Alhaji-Baba, Muhammad Alfa This research evaluates the farmers’ vulnerability to climate change in Niger State. Strategies for reducing the effect of climate change have regularly been made without experimental foundations and adequate information on farmers’ vulnerability to climate change in the study area. Thus, integrated farmers’ vulnerability assessment approach was employed by classifying socioeconomic and biophysical indicators of vulnerability into adaptive capacity, sensitivity and exposure to determine (...) the farmers’ vulnerability to climate change. This is based on the Intergovernmental Panel on Climate Change’s definition of vulnerability. The study adopted a survey design and the method utilized for the study was questionnaire administered to 400 households in the study area. The results indicate that the farmers’ vulnerability was low in zone A with a mean index of 2.86, very low in zone B with a mean index of 3.74, and high in zone C with a mean index of 1.95. It is recommended that measures should be taken to integrate climate change adaptation into Niger State development process. These measures should include improvement in adoption of good agricultural practices. (shrink)