: Protection of human subjects from investigators' conflicts of interest is critical to the integrity of clinical investigation. Personal financial conflicts of interest are addressed by university policies, professional society guidelines, publication standards, and government regulation, but "intrinsic conflicts of interest"—conflicts of interest inherent in all clinical research—have received relatively less attention. Such conflicts arise in all clinical research endeavors as a result of the tension among professionals' responsibilities to their research and to their patients and both academic and financial (...) incentives. These conflicts should be disclosed to research subjects and managed as assiduously as are financial conflicts of interest. (shrink)
This paper examines a proposal to make use of IVF techniques to provide an alternative to therapeutic abortion of fetuses with genetic abnormalities. We begin by describing the proposed procedure, and then show that, considered in itself, it is morally on a par with therapeutic abortion. However, once the wider practical implications are brought into view, the proposed new procedure loses its initial appeal. The pros and cons are not sufficiently clear-cut entirely to rule out the IVF procedure, so the (...) paper concludes by indicating some further complications which may follow, should the procedure come to be adopted. (shrink)
This article is an attempt to operationalize A.N. Whitehead's ontological approach within sociology. Whitehead offers lessons and clues to a way of re-envisioning `sociological practice' so that it captures something of the nature of a `social' that is at once real and constructed, material and cultural, and processual and actual. In the course of the article, the terms `operationalize' and `sociology' will themselves be transformed, not least because the range of objects and relations of study will far outstrip those common (...) to sociology; further, the term `operationalize' would seem to retain the notion of a stable sociologist-subject translating precepts into methods. So, the article will follow Whitehead's shift in emphasis toward an understanding of much more relational, heterogeneous and emergent entities — which in turn will require new methodological approaches. In staking out these claims, we follow in an intellectual lineage in which Whitehead's presence has been profound but generally oblique. For it is clear that, while Whitehead has informed various writing, little attempt has been made to draw out, more or less systematically, some of the general methodological tactics that would allow us to practise a Whiteheadian sociology. (shrink)
In this article we explore how two enactments of HIV – the UN’s AIDS Clock and clinical trials for an HIV biomedical prevention technology or pre-exposure prophylaxis – entail particular globalizing and localizing dynamics. Drawing on Latour’s and Whitehead’s concept of proposition, and Serres’ call for a philosophy of prepositions, we use the composite notion of pre/pro-positions to trace the shifting topological status of HIV. For example, we show how PrEP emerges through topological entwinements of globalizing biomedical standardization, localizing protests (...) against PrEP trials and globalizing ethical principles. We go on to examine how our own analysis manifests a parallel topological pattern in which we deploy a globalizing argument about the localizing of the globalizing found in the AIDS Clock and the PrEP trails. Finally, we consider how the movement of ‘topology’ into the social sciences might itself benefit from a topological treatment. (shrink)
J. Michael Dunn and Gary M. Hardegree, "Algebraic Methods in Philosophical Logic", Oxford Logic Guides, no. 41, Clarendon Press, Oxford University Press, Oxford, New York, etc., 2001, pp xv + 470.
The tenuous claims of cost-benefit analysis to guide policy so as to promote welfare turn on measuring welfare by preference satisfaction and taking willingness-to-pay to indicate preferences. Yet it is obvious that people's preferences are not always self-interested and that false beliefs may lead people to prefer what is worse for them even when people are self-interested. So welfare is not preference satisfaction, and hence it appears that cost-benefit analysis and welfare economics in general rely on a mistaken theory of (...) well-being. This essay explores the difficulties, criticizes standard defences of welfare economics, and then offers a new partial defence that maintains that welfare economics is independent of any philosophical theory of well-being. Welfare economics requires nothing more than an evidential connection between preference and welfare: in circumstances in which people are concerned with their own interests and reasonably good judges of what will serve their interests, their preferences will be reliable indicators of what is good for them. (shrink)
