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  1.  25
    Evaluating Evidence of Mechanisms in Medicine.Veli-Pekka Parkkinen, Christian Wallmann, Michael Wilde, Brendan Clarke, Phyllis Illari, Michael P. Kelly, Charles Norell, Federica Russo, Beth Shaw & Jon Williamson - 2018 - Dordrecht, Netherlands: Springer.
    The use of evidence in medicine is something we should continuously seek to improve. This book seeks to develop our understanding of evidence of mechanism in evaluating evidence in medicine, public health, and social care; and also offers tools to help implement improved assessment of evidence of mechanism in practice. In this way, the book offers a bridge between more theoretical and conceptual insights and worries about evidence of mechanism and practical means to fit the results into evidence assessment procedures.
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  2.  57
    The Importance of Values in Evidence-Based Medicine.Michael P. Kelly, Iona Heath, Jeremy Howick & Trisha Greenhalgh - 2015 - BMC Medical Ethics 16 (1):69.
    Evidence-based medicine has always required integration of patient values with ‘best’ clinical evidence. It is widely recognized that scientific practices and discoveries, including those of EBM, are value-laden. But to date, the science of EBM has focused primarily on methods for reducing bias in the evidence, while the role of values in the different aspects of the EBM process has been almost completely ignored.
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  3.  9
    The Need for a Rationalist Turn in Evidence-Based Medicine.Michael P. Kelly - 2018 - Journal of Evaluation in Clinical Practice 24 (5):1158-1165.
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  4.  21
    The Use of Mechanistic Evidence in Drug Approval.Jeffrey K. Aronson, Adam La Caze, Michael P. Kelly, Veli-Pekka Parkkinen & Jon Williamson - 2018 - Journal of Evaluation in Clinical Practice 24 (5):1166-1176.
    The role of mechanistic evidence tends to be under‐appreciated in current evidence‐based medicine, which focusses on clinical studies, tending to restrict attention to randomized controlled studies when they are available. The EBM+ programme seeks to redress this imbalance, by suggesting methods for evaluating mechanistic studies alongside clinical studies. Drug approval is a problematic case for the view that mechanistic evidence should be taken into account, because RCTs are almost always available. Nevertheless, we argue that mechanistic evidence is central to all (...)
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  5.  7
    Diagnostic Categories in Autobiographical Accounts of Illness.Michael P. Kelly - 2015 - Perspectives in Biology and Medicine 58 (1):89-104.
  6.  14
    The Integration of Social, Behavioral, and Biological Mechanisms in Models of Pathogenesis.Michael P. Kelly, Rachel S. Kelly & Federica Russo - 2014 - Perspectives in Biology and Medicine 57 (3):308-328.
    One of the guiding principles of modern medical and health sciences is the discovery and description of the modes of origin and the actions of pathogenic precursors of disease. This principle facilitates the design of interventions to reduce the burden of mortality and morbidity in individuals and populations. This enterprise is challenging because of the complexity of the pathogenic mechanisms involved. Although highly intricate descriptions of these mechanisms have been developed, they have mainly been at the biological level. In this (...)
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