Prospective memory is the ability to perform a planned action at an intended future time. This study examined the neural correlates of PM using functional near-infrared spectroscopy. This study employed a within-participants design. A laboratory PM task was adapted for use with fNIRS to investigate regions of interest and levels of brain activation during task performance in 32 participants. Participants first completed a working memory task followed by a WM plus PM task while neural activity was measured using fNIRS. Behavioral (...) results revealed an interference effect for reaction time on the WM task, whereby participants were significantly slower to respond in the WM plus PM task compared to the WM task. Ongoing task accuracies did not differ between the two conditions. fNIRS results revealed a higher level of neural activity in the fronto-polar prefrontal cortex and dorsolateral prefrontal cortex in the WM plus PM task compared to the WM Condition. These findings highlight that fNIRS is a suitable tool for studying and understanding the neural basis of PM. (shrink)

Recently discovered transcription‐independent features of p53 involve the choice of DNA damage repair pathway after PARylation, and p53's complex formation with phosphoinositide lipids, PI(4,5)P2. PARylation‐mediated rapid accumulation of p53 at DNA damage sites is linked to the recruitment of downstream repair factors and tumor suppression. This links p53's capability to sense damaged DNA in vitro and its relevant functions in cells. Further, PI(4,5)P2 rapidly accumulates at damage sites like p53 and complexes with p53, while it is required for ATR recruitment. (...) These findings help explain how p53 and PI(4,5)P2 maintain genome stability by directing DNA repair pathway choice. Additionally, there is a strong correlation between p53 sequence homology, genome mutation rates as well as lifespans across various mammalian species. Further investigation is required to better understand the connections between genome stability, tumor suppression, longevity and the transcriptional‐independent function of p53. (shrink)

Cell‐based therapies for degenerative diseases of the musculature remain on the verge of feasibility. Myogenic cells are relatively abundant, accessible, and typically harbor significant proliferative potential ex vivo. However, their use for therapeutic intervention is limited due to several critical aspects of their complex biology. Recent insights based on mouse models have advanced our understanding of the molecular mechanisms controlling the function of myogenic progenitors significantly. Moreover, the discovery of atypical myogenic cell types with the ability to cross the blood‐muscle (...) barrier has opened exciting new therapeutic avenues. In this paper, we outline the major problems that are currently associated with the manipulation of myogenic cells and discuss promising strategies to overcome these obstacles. (shrink)

Risks and benefit evaluation for controlled human infection studies, where healthy volunteers are deliberately exposed to infectious agents to evaluate vaccine efficacy, should be explicit, systematic, thorough, and non‐arbitrary. Decision analysis promotes these qualities using four steps: (1) determining explicit criteria and measures for evaluation, (2) identifying alternatives to the study, (3) defining the models used to estimate the measures for each alternative, and (4) running the models to produce the estimates and compare the alternatives. In this paper, we describe (...) how decision analysis might be applied by funders and regulators, as well as by others contemplating the use of novel controlled human infection studies for vaccine development and evaluation. (shrink)

Lymphangiogenesis is an important developmental process that is critical to regulation of fluid homeostasis, immune surveillance and response as well as pathogenesis of a number of diseases, among them cancer, inflammation, and heart failure. Specification, formation, and maturation of lymphatic blood vessels involves an interplay between a series of events orchestrated by various transcription factors that determine expression of key genes involved in lymphangiogenesis. These are traditionally thought to be under control of several key growth factors including vascular growth factor‐C (...) (VEGF‐C) and fibroblast growth factors (FGFs). Recent insights into VEGF and FGF signaling point to their role in control of endothelial metabolic processes such as glycolysis and fatty acid oxidation that, in turn, play a major role in regulation of lymphangiogenesis. These advances have significantly increased our understanding of lymphatic biology and opened new therapeutic vistas. Here we review our current understanding of metabolic controls in the lymphatic vasculature. (shrink)

This study investigates the strategies for learning Cantonese that are adopted by non-Chinese English-speaking ethnic minority university students in Hong Kong. The aim is to identify the challenges these students face in applying their strategies to learn Cantonese and to explore their learning experiences when implementing them. Drawing on questionnaire surveys and semi-structured interviews with 30 EM students at a university in Hong Kong, this study identifies these learners’ strategies, elicits their views on the use of these strategies and examines (...) their learning experiences. The findings suggest that EM students are “medium strategy users,” with social strategies being their most commonly used types of learning strategies, followed by compensation and metacognitive strategies. The more proficient Cantonese users tend to use metacognitive strategies that promote planning and are goal-oriented. Taken together, this study sheds light on the complex interplay of sociocultural variables in shaping EM university students’ Cantonese learning experience in Hong Kong. It also highlights the importance of analysing EM students’ linguistic repertoire and the local language ecology in understanding Cantonese learning in a multilingual context like Hong Kong. (shrink)

Purpose: to characterize ethics course content, structure, resources, pedagogic methods, and opinions among academic administrators and course directors at U.S. medical schools. Method: An online questionnaire addressed to academic deans and ethics course directors identified by medical school websites was emailed to 157 Association of American Medical Colleges member medical schools in two successive waves in early 2022. Descriptive statistics were utilized to summarize responses. Results: Representatives from 61 (39%) schools responded. Thirty-two (52%) respondents were course directors; 26 (43%) were (...) deans of academic affairs, medical education, or curriculum; and 3 with other roles also completed the survey (5%). All 61 schools reported some form of formal ethics education during the first year of medical school, with most (n = 54, 89%) reporting a formal mandatory introductory course during preclinical education. Schools primarily utilized lecture and small-group teaching methods. Knowledge-based examinations, attendance, and participation were most commonly used for assessment. A large majority regarded ethics as equally or more important than other foundational courses, but fewer (n = 37, 60%) provided faculty training for teaching ethics. Conclusions: Despite a response rate of 39 percent, the authors conclude that medical schools include ethics in their curricula in small-group and lecture formats with heterogeneity regarding content taught. Preclinical curricular redesigns must innovate and implement best practices for ensuring sound delivery of ethics content in future curricula. Additional large-scale research is necessary to determine said best practices. (shrink)

Higher education policy and manpower training fail to meet the requirement of rapidly-changing society and employers' expectation in Taiwan, resulting in the great gap between university education and employment. Students employability is also what all higher education institutions should focus whether a high degree of student learning outcomes can represent a high degree of students employability or not, this still unclarified. This study aims to explore the relationships among pedagogy for employability, problem-based teaching mode, absorptive capacity and student employability in (...) higher education institutions (HEIs). In terms of analyzing a total sample of 553 undergraduates from 12 Taiwanese HEIs by using structural equation model (SEM), the results show that the influences of pedagogy for employability and problem-based teaching mode on absorptive capacity and student employability are statistically positive significant. Based on the findings, specific suggestions and managerial implications for HEIs, curriculum and instruction planning, and future research are provided. (shrink)

This book's importance is derived from three sources: careful conceptualization of teacher induction from historical, methodological, and international perspectives; systematic reviews of research literature relevant to various aspects of teacher induction including its social, cultural, and political contexts, program components and forms, and the range of its effects; substantial empirical studies on the important issues of teacher induction with different kinds of methodologies that exemplify future directions and approaches to the research in teacher induction.

In this study, we examined the role of culture on early adolescents’ social reasoning about peer exclusion. A total of 80 U.S. and 149 Taiwanese early adolescents independently completed a social reasoning essay about peer exclusion. Analyses of the essays based on social-moral theories showed that U.S. students tended to reason about peer exclusion based on social conventional thinking whereas Taiwanese students were more attentive to personal and moral issues. Despite this difference, both groups of students referred to some common (...) social-moral concepts while reasoning about peer exclusion, including consideration of personal benefit, harming others’ welfare, personal concern, and punishment. The use of social reasoning strategies was similar across the two groups of students except that Taiwanese students relied more on judgment whereas U.S. students generated more alternative hypotheses. (shrink)

Identification of non-coding RNAs (ncRNAs) has been significantly improved over the past decade. On the other hand, semantic annotation of ncRNA data is facing critical challenges due to the lack of a comprehensive ontology to serve as common data elements and data exchange standards in the field. We developed the Non-Coding RNA Ontology (NCRO) to handle this situation. By providing a formally defined ncRNA controlled vocabulary, the NCRO aims to fill a specific and highly needed niche in semantic annotation of (...) large amounts of ncRNA biological and clinical data. (shrink)

Identification of non-coding RNAs (ncRNAs) has been significantly enhanced due to the rapid advancement in sequencing technologies. On the other hand, semantic annotation of ncRNA data lag behind their identification, and there is a great need to effectively integrate discovery from relevant communities. To this end, the Non-Coding RNA Ontology (NCRO) is being developed to provide a precisely defined ncRNA controlled vocabulary, which can fill a specific and highly needed niche in unification of ncRNA biology.

本書為魯惟一教授近年新作，英文版由Leiden & Boston: Brill出版社2011年出版，將董仲舒和他的聲望放到西漢歷史和思想發展的層面上，對公元前2世紀董仲舒在思想和決策上所扮演的角色進行了深入探討，並提出了具有顛覆性的觀點。 董仲舒的生卒年約為公元前198年至約前107年。 “罷黜百家，獨尊儒術”不太可能是漢武帝接受董仲舒的建議實行的封建統治政策。作者認為，董仲舒的某些觀點，例如〈天人三策〉中的內容後來成為「儒家思想」的重要部分，但因此認為西漢時期就已經存在一個統一連貫的 思想體系，或者說董仲舒等人是在傳播這一系統化的學說，顯然是不成熟的。 一直要到東漢時，這樣的系統才逐漸建立起來，而儒家學說真正發揮效力至少要等到唐代。我們在西漢的歷史文獻中並不能找到證據證明在董仲舒的時代，「儒家」已經成為一種治理百姓的理想或方式，或是壓倒其他各家而取得 了「勝利」。 董仲舒所謂的「一統」也無關朝代和政治的統一。 從研究古代文獻的普遍標準來看，現在很難再承認董仲舒是整部今本《春秋繁露》的作者。.

El siguiente texto intenta abordar la relación existente entre los procesos de globalización-mundialización y ciertas concepciones de historia que le son solidarias. Para lo anterior apela a las reflexiones realizadas por Marc Abélès en Política de la supervivencia y Michael Hardt y Antonio Negri en Imperio. En ambos análisis se puede percibir la importancia que tiene la historia como soporte de los procesos globales que entremezclan lo político, lo económico y lo cultural, procesos que parecen avanzar, según el curso (...) de la historia, y que permiten además dar referencia de sentido a los sujetos en sus procesos identitarios y de individuación. The following text tries to approach the relation between the globalization-mondialisation process and certain conceptions of history witch are solidary with them. For the previous thing, it appeals to the reflections realized by Marc Abélès in Politics of the survival and Michael Hardt and Antonio Negri in Empire. In both analyses it is possible to perceive the importance that takes the history as a support of the global processes that intermingle the politics, the economy and culture, processes that seem to advance according to the course that history has, and they allow to give in addition reference of sense to the subjects in his processes of identity and of individuation. (shrink)

The contributors to this special issue of _Tikkun_ seek to redefine the boundaries of political and ethical responsibility by crediting a worldview in which we are held to account for the well-being of everyone who has “passed through our city,” if only momentarily. Their conclusions challenge the ethos of materialism that _Tikkun_ believes is at the root of globalized capitalism and, alternatively, articulate a social justice ethos derived from the Jewish tradition of “accompaniment,” the call to take care of those (...) who enter our common space. Contributors from Christian, Muslim, and Jewish traditions bring an interfaith perspective to the foundations of social responsibility, laying the groundwork for a new global notion of justice. Drawing on a model from Rabbinic Judaism, one contributor discusses homelessness in Los Angeles, calling us to adopt a new, radical sense of obligation in relation to our neighbors. Another offers challenging insights from the point of view of one who grew up homeless. An essay from the Christian tradition expands this model by comparing our mutual relationships to body parts that all belong to the same whole. Another essay extracts from medieval Islamic texts a vision of the state as a caregiver and then compares this vision to life in Vancouver, where citizens’ taxes underwrite robust social services for those in need. Contributors:_ _Rumee Ahmed, Aryeh Cohen, Estelle Frankel, Jill Goldberg, Lisa “Tiny” Gray-Garcia, Peter Laarman, Ana Levy-Lyons, Alexia Salvatierra Michael Lerner is editor of _Tikkun_ and rabbi of Beyt Tikkun; his writings have appeared in many national publications. Alana Yu-lan Price is managing editor of _Tikkun_. Aryeh Cohen is a contributing editor to _Tikkun_. (shrink)

Abstract:This article contextualizes the thought of the Zhuangzi 莊子 via the Classic of Poetry (Shijing 詩經), the most canonical textual tradition from the Warring States (fifth century to 221 b.c.e.) into the early imperial period. First, it reads the fantastical vignettes from the opening of chapter 1 "Free-and-Easy Wandering" (Xiaoyao you 逍遙遊), as parodies of Shi poetics. Second, it argues that the themes of "wandering" (you 遊) and "lodging" (yu 寓) stand as critical alternatives to the Shi preoccupation with homeward, (...) ruler-centric movements. Such connections open up new ways of understanding the development of Zhuangzian thought. (shrink)

Motivated by the developments in contemporary mathematical physics and the related interpretive and historiographical works on these developments, a structuralist and historically constitutive and constructive approach to scientific realism (SHASR) is proposed to address the challenges Thomas Kuhn raised against scientific realism, and to remove the defects of the currently available dissatisfactory responses the structuralists put forward to the challenges. The paper shows that SHASR productively exploits the insights from both Kuhn’s historicism and his critics’ structuralism, while avoids the traps (...) in both traditions. Then, after a brief comparison between SHASR and the increasingly popular neo-Kantian post-Kuhnian philosophy of science recommended and defended by Michael Freedman and some others, it concludes with a big picture about the science-world relationship derived from the notion of emergence conceptualized within the framework of SHASR, whose bearings on the Kantian question of the phenomenal - noumenal relationship are worth further explorations. (shrink)

Since Michael Polanyi coined the term “tacit knowledge” in 1958, a huge amount of literature has been produced on this topic. Gascoigne and Thornton’s monograph represents one of the most recent attempts to clarify the concept of tacit knowledge.For other recent publications on tacit knowledge see Collins , Yu and Turner . In their engagement with various thinkers, most notably Polanyi, Ryle, Heidegger, Wittgenstein, John Searle, Hubert Dreyfus, and John McDowell, etc., the authors make impressive efforts to situate the (...) discussion of tacit knowledge in the context of mainstream philosophy. They shed new light on the concept of tacit knowledge by embedding it in contemporary debates, such as those on knowing how, rule-following, conceptualism, language maste .. (shrink)

In a fluent, clear, and lively style this translation by two of Maslov's junior colleagues brings the work of the late Soviet scientist S. Yu. Maslov to a wider audience. Maslov was considered by his peers to be a man of genius who was making fundamental contributions in the fields of automatic theorem proving and computational logic. He published little, and those few papers were regarded as notoriously difficult. This book, however, was written for a broad audience of readers and (...) describes elegant examples of applications in such fields as computer science, artificial intelligence, operations research, economic modeling, and biological modeling, among others. The book also brings to light the work by the American mathematician E. L. Post, which inspired Maslov's own work in the development of a general theory and which has been long neglected by mathematicial logicians and systems theorists in the United States. The book's first chapter introduces the Rules of the Game. Part I, Mathematics of Calculi, covers E. L. Post's canonical systems, deductive systems and algorithms, and probabilistic calculi and deductive information. Part II, Horizonal Modeling, takes up a "toy" economy, the calculi of technological possibilities, and the development of rules. Part III, Vertical Modeling, deals with the topics of "to fight and to search" and the consequences of the asymmetry of cognitive mechanisms. Vladimir Lifschitz is affiliated with the Department of Computer Science at Stanford University, and Michael Gelfond with the Department of Electrical Engineering and Computer Science at the University of Texas, El Paso. Theory of Deductive Systems and Its Applicationsis included in the Foundation of Computing Series, edited by Michael Garey. (shrink)

There is an interesting convergence between Michael Polanyi and Wittgenstein with respect to the problem of doubt. Polanyi carries out his “critique of doubt” on the basis of the distinction between explicit knowledge and tacit knowledge and examines explicit doubt and tacit doubt. On the level of explicit doubt, Polanyi debunks the paradoxical nature of the principle of universal doubt and illuminates the fiduciary character of doubt. The introduction of the tacit dimension into the discussion of the problem of (...) human knowledge leads Polanyi to discover tacit doubt. Polanyi’s critique of doubt finds strong echoes in Wittgenstein, especially in his On Certainty. Nevertheless, there are important differences between two thinkers. Wittgenstein’s emphasis on the practical aspect of a world-picture and Polanyi’s sensitivity to tacit doubt are among the most prominent items that set them apart. (shrink)

This book defends a form of ethical intuitionism, according to which (i) there are objective moral truths; (ii) we know some of these truths through a kind of immediate, intellectual awareness, or "intuition"; and (iii) our knowledge of moral truths gives us reasons for action independent of our desires. The author rebuts all the major objections to this theory and shows that the alternative theories about the nature of ethics all face grave difficulties.

The first edition of The Scientific Background to Modern Philosophy took the dialogue of science and philosophy from Aristotle through to Newton. This second edition adds eight chapters, taking the dialogue through the Enlightenment and up to Darwin. This anthology is an attempt to help bridge the gap between the history of science and the history of philosophy.

Part I: The representation of life -- Can life be given a real definition? -- The representation of the living individual -- The representation of the life-form itself -- Part II: Naive action theory -- Types of practical explanation -- Naive explanation of action -- Action and time -- Part III: Practical generality -- Two tendencies in practical philosophy -- Practices and dispositions as sources of the goodness of individual actions -- Practice and disposition as sources of individual action.

At the University of Sheffield during 2011 and 2012, a leading group of philosophers, psychologists, and others gathered to explore the nature and significance of implicit bias. The two volumes of Implicit Bias and Philosophy emerge from these workshops. Each volume philosophically examines core areas of psychological research on implicit bias as well as the ramifications of implicit bias for core areas of philosophy. Volume I: Metaphysics and Epistemology is comprised of two parts: “The Nature of Implicit Attitudes, Implicit Bias, (...) and Stereotype Threat,” and “Skepticism, Social Knowledge, and Rationality.” The first part contains chapters examining the relationship between implicit attitudes and “dual process” models of the mind; the role of affect in the formation and change of implicit associations; the unity (or disunity) of implicit attitudes; whether implicit biases are mental states at all; and whether performances on stereotype-relevant tasks are automatic and unconscious or intentional and strategic. The second part contains chapters examining implicit bias and skepticism; the effects of implicit bias on scientific research; the accessibility of social stereotypes in epistemic environments; the effects of implicit bias on the self-perception of members of stigmatized social groups as rational agents; the role of gender stereotypes in philosophy; and the role of heuristics in biased reasoning. (shrink)

Externalist theories of justification create the possibility of cases in which everything appears to one relevantly similar with respect to two propositions, yet one proposition is justified while the other is not. Internalists find this difficult to accept, because it seems irrational in such a case to affirm one proposition and not the other. The underlying internalist intuition supports a specific internalist theory, Phenomenal Conservatism, on which epistemic justification is conferred by appearances.

Recent studies have demonstrated neural overlap between resting state activity and self-referential processing. This “rest-self” overlap occurs especially in anterior cortical midline structures like the perigenual anterior cingulate cortex (PACC). However, the exact neurotemporal and biochemical mechanisms remain to be identified. Therefore, we conducted a combined electroencephalography (EEG)-magnetic resonance spectroscopy (MRS) study. EEG focused on pre-stimulus (e.g., prior to stimulus presentation or perception) power changes to assess the degree to which those changes can predict subjects’ perception (and judgment) of subsequent (...) stimuli as high or low self-related. MRS measured resting state concentration of glutamate, focusing on PACC. High pre-stimulus (e.g., prior to stimulus presentation or perception) alpha power significantly correlated with both perception of stimuli judged to be highly self-related and with resting state glutamate concentrations in the PACC. In sum, our results show (i) pre-stimulus (e.g., prior to stimulus presentation or perception) alpha power and resting state glutamate concentration to mediate rest-self overlap that (ii) dispose or incline subjects to assign high degrees of self-relatedness to perceptual stimuli. (shrink)

In this engaging and spirited text, Michael Lynch argues that truth does matter, in both our personal and political lives. He explains that the growing cynicism over truth stems in large part from our confusion over what truth is.

Causation: A Realist Approach Traditional empiricist accounts of causation and laws of nature have been reductionist in the sense of entailing that given a complete specification of the non-causal properties of and relations among particulars, it is therefore logically determined both what laws there are and what events are causally related. It is argued here, however, that reductionist accounts of causation and of laws of nature are exposed to decisive objections, and thus that the time has come for empiricists to (...) break with that tradition. -/- The basic goal of this book, therefore, is to set out and defend realistic accounts of those concepts. In the case of causal relations, for example, Tooley maintains that causation is basically a matter of theoretical relations between states of affairs that underlie and explain relative frequencies. He also argues that such an approach avoids the objections that tell against reductionist accounts and that it does so without making causal relations epistemologically inaccessible. (shrink)

edition (unseen), $12.95. traditions, bringing into being new modes of understanding. Paper Anthropology, and particularly ethnography, is torn between two quests, one to capture the diversity of social life and the other to discover universal principles structuring that diversity. Jackson examines these quests within the context of ethnographic fieldwork, focusing on the relationship between ethnographers and the people they study. He is concerned with defining the anthropological project as something more than the projection of the anthropologist's traditions and concerns onto (...) an alien culture. Rather, he would have the project open a genuine dialogue between people from different cultures or Annotation copyrighted by Book News, Inc., Portland, OR. (shrink)