Bidirectional deep brain stimulation platforms have enabled a surge in hours of recordings in naturalistic environments, allowing further insight into neurological and psychiatric disease states. However, high amplitude, high frequency stimulation generates artifacts that contaminate neural signals and hinder our ability to interpret the data. This is especially true in psychiatric disorders, for which high amplitude stimulation is commonly applied to deep brain structures where the native neural activity is miniscule in comparison. Here, we characterized artifact sources in recordings from (...) a bidirectional DBS platform, the Medtronic Summit RC + S, with the goal of optimizing recording configurations to improve signal to noise ratio. Data were collected from three subjects in a clinical trial of DBS for obsessive-compulsive disorder. Stimulation was provided bilaterally to the ventral capsule/ventral striatum using two independent implantable neurostimulators. We first manipulated DBS amplitude within safe limits to characterize the impact of stimulation artifacts on neural recordings. We found that high amplitude stimulation produces slew overflow, defined as exceeding the rate of change that the analog to digital converter can accurately measure. Overflow led to expanded spectral distortion of the stimulation artifact, with a six fold increase in the bandwidth of the 150.6 Hz stimulation artifact from 147–153 to 140–180 Hz. By increasing sense blank values during high amplitude stimulation, we reduced overflow by as much as 30% and improved artifact distortion, reducing the bandwidth from 140–180 Hz artifact to 147–153 Hz. We also identified artifacts that shifted in frequency through modulation of telemetry parameters. We found that telemetry ratio changes led to predictable shifts in the center-frequencies of the associated artifacts, allowing us to proactively shift the artifacts outside of our frequency range of interest. Overall, the artifact characterization methods and results described here enable increased data interpretability and unconstrained biomarker exploration using data collected from bidirectional DBS devices. (shrink)

A major appellate court decision from the United States seriously questions the legal sufficiency of prevailing medical criteria for the determination of death by neurological criteria. There may be a mismatch between legal and medical standards for brain death, requiring the amendment of either or both. In South Australia, a Bill seeks to establish a legal right for a defined category of persons suffering unbearably to request voluntary euthanasia. However, an essential criterion of a voluntary decision is that it is (...) not tainted by undue influence, and this Bill falls short of providing adequate guidance to assess for undue influence. (shrink)

Anouck Alary | : La transformation du sang placentaire en une précieuse source de cellules souches a donné naissance à partir des années 1990 à une industrie globale de conservation de sang de cordon ombilical faisant désormais concurrence à un large réseau de banques publiques de sang de cordon. Cet article explore les soubassements socioculturels liés à l’émergence de cette industrie et tente d’élucider les enjeux éthiques et politiques qu’elle pose. Si les banques publiques de sang de cordon sont porteuses (...) des valeurs d’altruisme et de solidarité nationale traditionnellement liées au modèle redistributif d’échange de sang et d’organes né après la Seconde Guerre mondiale, les banques privées renvoient, elles, à des formes de solidarité bien différentes. C’est effectivement sous couvert de la solidarité familiale et de la responsabilité morale des mères de protéger leurs enfants qu’elles définissent la conservation privée comme une forme d’ « assurance biologique » contre les risques à la santé de l’enfant. En permettant aux mères d’investir leurs tissus corporels à la fois dans le futur incertain de leurs enfants et dans des thérapies cellulaires expérimentales, ces banques promeuvent un nouveau modèle de participation du/de la patient.e à la coconstitution de futures innovations thérapeutiques. Nous inscrivons ce modèle de participation dans les reconfigurations contemporaines du biopolitique que le sociologue britannique Nikolas Rose voit s’incarner dans l’émergence d’une nouvelle forme de biocitoyenneté. L’article critique finalement ces services personnalisés en soulignant qu’ils ont le potentiel d’opérer de nouvelles formes de coercition sur les mères, dans un contexte sociopolitique caractérisé par une responsabilisation accrue des individus au regard de la « bonne gestion » de leurs risques à la santé. Ces services sont aussi jugés problématiques sur le plan éthique, au vu de leur incohérence avec un principe de justice distributive défendant l’accès égal pour chaque citoyen.ne à des soins de santé de base. | : Since the 1990s, the transformation of cord blood into a precious source of stem cells has given rise to a global cord blood bank industry, which is now competing with a large network of public cord blood banks. This article explores the sociocultural context surrounding the emergence of this industry and aims at elucidating the ethical and political concerns that this industry raises. Whereas public cord blood banks are purveyors of values such as altruism and national solidarity traditionally linked to the redistributive model of human blood and organ donation that emerged after World War Two, private banks engage very different forms of solidarity. It is indeed under the guise of family solidarity and mothers’ moral responsibility to do their best to protect their children that they come to define private preservation as a form of “biological insurance” against potential risks to their children’s health. By allowing mothers to invest their bodily tissues simultaneously in their children’s uncertain future and in experimental cell therapies, these banks promote a new model of patient participation in the development of future therapeutic innovations. This article analyzes this model as embedded in the contemporary reconfiguration of biopolitics that sociologist Nikolas Rose envisions as constituting a new form of biocitizenship. The paper finally casts a critical eye on these personalized services, in particular because of the new forms of social coercion on mothers that are brought about in a social and political context characterized by an increasing moral accountability of individuals with regard to the “good management” of their own health risks. These services also appear ethically problematic in relation to political demands of distributive justice—e.g., the ideal of equal access to basic health care for every citizen. (shrink)

The study deals with the matter of three of the most puzzling doctrines of Baruch Spinoza's system, the so-called 'final doctrines', which are intuitive knowledge, intellectual love of God, and the eternity of the (human) mind. Contrary to many commentators, but also in concordance with many others, this account strives to affirm the utmost importance of these doctrines to Spinoza's system as a whole, but mostly to his ethical theory. Focusing specifically on the cultivation of the human mind, the paper (...) offers partial analyses of the central notions of these doctrines and their conceptual contexts. It is argued that the cultivation of the human mind, i.e., its determination to its perfect activity, should be considered as Spinoza's ultimate ethical goal, and that the mind truly only advances to this goal by means of these cognitive, affective, and intellectual transformations of thinking. (shrink)

We present an empirical investigation on how multiple stakeholders can influence and contribute to a standard development process. Based on the analysis of comments submitted by stakeholders developing ISO 26000 standard for social responsibility, we found no significant differences between the ratio of accepted and non-accepted comments among various stakeholder groups; however, we conclude that industry is the most influential stakeholder due to the volume of the comments. We also present a set of processes that stakeholders follow to influence and (...) contribute to standards development, namely to (1) eliminate issues that are controversial and undesirable; (2) link and integrate the standard into a network of other documents and ISO standards; (3) seek consensus by highlighting areas for further dialogue or by addressing their exclusion from the standards development, (4) reinforce issues that are important; and (5) improve the content of the new standard. In conclusion, we provide a set of propositions about multi-stakeholder standards development and compare multi-stakeholder involvement in standards developed through a new committee established in existing standards setting organization [i.e., Committees within the International Organization for Standardization (ISO)] and through new standards setting organizations established for one specific task (i.e., Forest Stewardship Council). We envisage that our study will be a useful platform to monitor and evaluate future developments of ISO 26000 and other multi-stakeholder standards. (shrink)

As the crisis around Covid-19 evolves, it becomes clear that there are numerous negative side-effects of the lockdown strategies implemented by many countries. Currently, more evidence becomes available that the lockdowns may have more negative effects than positive effects. For instance, many measures taken in a lockdown aimed at protecting human life may compromise the immune system, and purpose in life, especially of vulnerable groups. This leads to the paradoxical situation of compromising the immune system and physical and mental health (...) of many people, including the ones we aim to protect. Also, it is expected that hundreds of millions of people will die from hunger and postponed medical treatments. Other side effects include financial insecurity of billions of people, physical and mental health problems, and increased inequalities. The economic and health repercussions of the crisis will be falling disproportionately on young workers, low-income families and women, and thus exacerbate existing inequalities. As the virus outbreak and media coverage spread fear and anxiety, superstition, cognitive dissonance reduction and conspiracy theories are ways to find meaning and reduce anxiety. These behavioral aspects may play a role in the continuance of lockdown decisions. Based on theories regarding agnotology (i.e. the ways ignorance or doubt about certain topics is created by means of withholding or presenting information in a certain way), social influence, superstition and stress and coping, I seek to explain the social and behavioral aspects of human behavior in times of crises. Both the Covid-19 crisis itself as well as the resulting economic and (mental) health crisis are global problems that may require global solutions. I present a model of drivers and outcomes of lockdown behaviors and offer suggestions and a tool to counteract the negative psychological effects by means of online life crafting therapeutic writing interventions. (shrink)

Tacit premises of science constitute researcher’s cognitive scheme, i.e. a set of a priori conditions of knowledge acquisition and application. Couple of assumptions make Polanyi’s idea considerably different than Kantian or behavioural or structural interpretations of cognitive scheme. He sees it more in hermeneutical or habitual terms — as system of (a) skills (dispositions to act), which (b) defines the level of competence; (c) cannot be verbally articulated; (d) is embodied (and hence unaware); (e) innate or acquired through practice — (...) in master-pupil relations; (f) undergoes constant modifications when applied; (g) conditions both theoretical actions (eg. categorisation, acts of assertion), as well as practical (manual skills, acts of perception). (shrink)

The concept of Galilean Idealization is based on a pragmatically grounded relation between universes of so-called real and idealized entities. The concept was developed in the course of a critical discussion of different explications of the concept of idealization (e.g. by W. F. Barr, C. G. Hempel and L. Nowak), these being attempts to specify sufficient syntactic and semantic criterions for idealization. But this line of argument shall not be followed here. Instead, first the concept of Pragmatic Idealization, and as (...) its special case the Galilean one, is presented (1.) and certain aspects of the application of an idealized theory are discussed (2.). Then, working within the Strucuralist View of theories, definitions of the idealized variants of the diachronic theory-element and theory-net are presented (3.). (shrink)

Martin Luther King Jr. claimed that “the salvation of the world lies in the hands of the maladjusted”. I elaborate on King’s claim by focusing on the way in which we treat and understand ‘maladjustment’ that is responsive to severe trauma (e.g. PTSD that is a result of military combat or rape). Mental healthcare and our social attitudes about mental illness and disorder will prevent us from recognizing real injustice that symptoms of mental illness can be appropriately responding to, unless (...) we recognize that many emotional states (and not just beliefs!) that constitute those symptoms are warranted by the circumstances they are responsive to. I argue that there is a failure to distinguish between PTSD symptoms that are warranted emotional responses to trauma and those that are not. This results in us focusing our attention on “fixing” the agent internally, but not on fixing the world. It is only by centering questions of warrant that we will be able to understand and expose the relationship between agents’ internal mental states and their oppression. But we also need to ask when someone’s emotional response is unwarranted by their experience (as in the case of someone who develops PTSD after a non-traumatic event). If we fail to do this—as, I claim, both our mental healthcare and the broader social world fail to do—we treat warranted and unwarranted emotions as on a par. This undermines the epistemic judgment of the agent who has warranted PTSD symptoms, resulting in her failing to trust her evaluation of whether her emotional response to her own trauma is warranted by that trauma, and thus failing to recognize her own oppression. (shrink)

Through Deleuze’s conception of truth as becoming the paper discusses his relationship to Platonism. In his analysis Deleuze focuses on Plato’s Sophistes, in which Plato unwillingly subverts the very hierarchy of the world order, which he himself created. Deleuze sees the Platonic search for truth as taking place in the sphere of immanence. In the person of a sophist he goes after the simulacrum, i.e. an appearance, which subverts the rigorous hierarchy of the Platonic world. In his Logique du sens (...) Deleuze suggests that following Plato the other searchers for truth are also traveling in the sphere of immanence. Thus the truth found in the “logic of surface” is their becoming others. The paper examines the reasons, why Deleuze attaches importance to this becoming, which subverts the hierarchy of the “logic of depth” inaugurated by Platonism. (shrink)

This article is the result of an empirical research project analyzing the decision behaviour of Austrian managers in ethical dilemma situations. While neoclassical economic theory would suggest a pure economic rational basis for management decisions, the empirical study conducted by the authors put other concepts to a test, thereby analyzing their importance for managerial decision making: specific notions of fairness, reciprocal altruism, and commitment. After reviewing some of the theoretical literature dealing with such notions, the article shows the results of (...) an online survey working with scenarios depicting ethical dilemma situations. By judging such scenarios the respondents showed their preference for the named concepts, though with different degrees of confirmation. The results (with all limitations of an online survey in mind) support the theoretical work on the named concepts: Fairness elements (including Rawlsian principles of justice and an understanding of fairness as conceived by a reference transaction) play a major part in management decisions in ethical dilemma situations. Also, commitment as a behaviour that sticks to rules even if personal welfare is negatively touched, and reciprocal altruism as a cooperative behaviour that expects a reciprocal beneficial action from other persons have been concepts used by Austrian managers when analyzing ethical dilemmas. The article also tries to put the results into a comparative perspective by taking into account other studies on ethical decision factors conducted with, e.g. medical doctors or journalists, and by discussing intercultural implications of business ethics. (shrink)

Studie věnuje pozornost problematice demokratizace vědy, v jejímž rámci zaujímá klíčové postavení otázka, v jaké míře a zda vůbec má mít široká veřejnost možnost zasahovat do vědní a výzkumné politiky a participovat na rozhodování v odborných záležitostech. První část studie je věnována představení dvou radikálně odlišných a vzájemně protichůdných pohledů na tuto problematiku, které byly rozpracovány v rámci poválečné filosofie vědy v dílech Michaela Polanyiho a Paula Feyerabenda a v různých podobách spolu soupeří dodnes. Tyto dva pohledy, jež nás (...) staví před volbu mezi odborností na úkor demokracie a demokracií na úkor odbornosti, jsou následně podrobeny kritickému zhodnocení a v opozici k nim je představen alternativní pohled rozvíjený v rámci vědních studií Harrym Collinsem a Robertem Evansem, jenž překračuje nutnost této volby a na základě sociologických výzkumů fenoménu odbornosti nabízí způsob, jak lze odbornost a demokratické hodnoty sloučit dohromady. (shrink)

Obviously, science matters to philosophy. But is philosophy also constrained by science? Naturalism is roughly the view that answers positively. However, even among proponents of naturalism, how science constrains philosophy has always been (and still is) a subject of debate. There are two basic dimensions in which the debate takes place, which give rise to two different kinds of naturalism: ontological and methodological. The former concerns what there is, while the latter deals with the methods whereby we acquire knowledge and (...) beliefs. Ontological Naturalism is loosely the view that all of what there is belongs to the natural world, where the natural world is the world described by the natural sciences. By maintaining, in turn, that the ultimate structure of the world is what the natural sciences say it to be, it is to some extent close to Physicalism, according to which what most fundamentally exist are the entities and properties posited by basic physics. On the other hand, methodological naturalism is often thought of as making an epistemological claim akin to scientism—the claim that the best (perhaps the unique) approach to acquiring knowledge is that of natural sciences. Accordingly, it holds that the very same methods used to arrive at scientific theories are the only legitimate ones to be employed by philosophy.Each of these horns of naturalism implies important consequences for our understanding of the relationship between science and many areas of philosophy, including metaphysics. From the methodological point of view, naturalism might be said to entail the denial that our conception of reality needs to include whatever is exclusively accessible to metaphysical theorizing (or to “first philosophy”), understood as a distinct mode of inquiry that lacks ties to the results and practices of the sciences. Indeed, methodological naturalism is usually assumed to reject the project of a priori theorizing, and it is perhaps hard to see how the traditional metaphysics, as well as current analytical metaphysics, might be in the business of developing and assessing synthetic theories of the world supported by a posteriori evidence. From the ontological point of view, naturalism sees science as already giving us a full account of everything, including our place within that picture. Despite this, the debate around the nature of metaphysics remains very much alive (and complex), spreading its influence all across philosophy and our view of the world. The upshot is that much of metaphysical work is nowadays motivated by the naturalist desire to accommodate what the natural sciences have taught us about the world. This special issue stems exactly from the ongoing debate between naturalist and non-naturalist metaphysicians and aims to assess the prospects of naturalized projects in metaphysics and their relationships to traditional metaphysics.Are science and metaphysics separable enterprises? Should allowable metaphysical theories be constrained by and continuous with natural sciences? Does successful scientific research presuppose metaphysics? These are some of the questions addressed in the contributions comprising this special issue. In response, most of them undertake theoretical commitments of a general naturalist stamp, others challenge their philosophical cogency, while still others discuss and contrast the various versions of naturalism that are currently at the center of many metaphysical debates—which often involve some mixture of the two above-mentioned ones, in different proportions. As a result, this special issue hopes to represent the state of the art drawn from different perspectives, helping somehow to clarify extent and ongoing work in metaphysics with respect to the challenges posed by naturalist thinking and eventually to pave the way for future developments and discussions.The issue opens with Don Ross's paper “A flexible, sloppy blob? Ontology, AI, and the role of metaphysics.” In it, Ross defends a naturalized metaphysics that, in contrast with traditional metaphysical projects, is driven directly by fundamental physics. Therefore, since fundamental physics is taken to be the authoritative source of knowledge on the general structure of the universe, metaphysics should neither be separated from nor transcend it. In particular, he rejects more recent works on building metaphysical foundations for applied ontology—e.g., metaphysics for the foundations of AI—as somehow apt to vindicate the value of analytic metaphysics for the edifice of human knowledge. At the same time, however, he points out how his naturalist (methodological) naturalist approach neither incorporates nor implies a physicalistic reduction.Ferdinando Ceravolo and Steven French, in their contribution “What is a Naturalized Principle of Composition?” also support the project of a methodologically naturalized metaphysics. They focus on Van Inwagen's General Composition Question (GCQ). Specifically, they address the issue concerning whether GCQ could be underpinned by principles that are found to be naturalistically acceptable—that is, constrained and informed by advanced physical knowledge. Arguing positively, they outline two candidates for naturalistically accredited principles of composition and explore the various costs of choosing between them.Along the same lines, in his essay “Naturalism and the Question of Ontology,” Javier Cumpa argues for a naturalistic approach in metaontology based on the project of Wilfrid Sellars. He proposes a naturalistic criterion of relational substantivity for ontological questions, which is held to be naturalistic insofar as it relies on the epistemic value and the degree of understanding of the world in line with science that those questions provide us. Cumpa's view is certainly methodologically naturalist, however, although ontologically he does not seem to be committed to metaphysical notions such as ontological categories, he endorses what he calls an “Impure Eliminativism about Categories.”A more straightforward version of eliminativism is advocated by Otávio Bueno in his chapter “Dispensing with Facts, Substances, and Structures.” He contends that, even though ontological categories (i.e., structures, substances, and facts) play a central role in metaphysical theorizing, we do not need to be committed to their existence. Unlike metaphysical realists – who see true thought or assertion as adequately shaped in terms of the correct representation of completely thought and/or language independent bits of reality – he accounts for metaphysical discourse by offering a naturalist account of the linguistic practice that govern it, but without the ontological commitments that realism recommends. Nevertheless, by dropping realism he does not aim to drop metaphysics as an important form of understanding the world. In order to qualify metaphysical judgements as meaningful, he explores and invokes a distinctive deflationary strategy. The result is a view that takes metaphysical discourse literally but without ontologically inflationary maneuvers.The same deflationary strategy is pursued by Anjan Chakravartty in his piece “Last Chance Saloons for Natural Kind Realism.” But rather than on ontological categories in general, he focuses on natural kinds, arguing against realist views that contend for their mind-independent existence. Nevertheless, he shows how a deflationary approach to kinds, while rejecting kind realism, can be integrated with broader realist doctrines such as scientific realism. That is, we need not be committed to either the existence of these posits or with the metaphysically inflationary interpretations that support them in order to invoke these items in scientific theorizing and to vindicate as objective or mind-independent the truth or falsity of scientific as well as everyday claims about natural kinds.In contrast to the previous standpoints, in her article “Metaphysics as Essentially Imaginative and Aiming at Understanding,” Michaela M. McSweeney defends a non-naturalist view of metaphysics. She explores the idea that metaphysics is essentially imaginative and (at least in part) “up to us.” But treating metaphysics as essentially imaginative makes metaphysics methodologically different from scientific inquiry and more akin to art. Nevertheless, she maintains, it can still be deemed epistemologically valuable to the extent that imagination can lead to understanding. On her view, the central goal of the metaphysical project thus turns out to be understanding rather than truth.The closing paper of the issue investigates precisely the relationship between methodological naturalism and ontological naturalism. In “Methodological naturalism undercuts ontological naturalism,” Peter Forrest argues that the combination of ontological with methodological naturalism is untenable. According to his view, one way to defend ontological naturalism is to retain a version of nominalism: specifically, what he calls Redundancy Nominalism (a kind of deflationary nominalism). On the other hand, methodological naturalism requires adopting Categorial Realism. This means being a realist about universals in at least a minimal way. As a result, the fundamental description that methodological naturalism requires proves be contrary to ontological naturalism, whose precondition, in turn, is not available to methodological naturalists. This leads him to criticize ontological naturalism as a belief but, at the same time, to vindicate it as a speculation. (shrink)

Aufgrund der Dominanz eines okonomistisch verengten Rationalitatsideals wird Vertrauen zunehmend als Reputationskalkul oder quasi-vertragliche Kreditbeziehung definiert. MIchaela I. ABdelhamid zeigt: Was hier als "Vertrauen" bezeichnet wird, soll vielmehr der Wertschopfung sowie der Legitimation strategischer Entscheidungen, Sanktionen und Abhangigkeitsverhaltnisse dienen. MIt verstandlichen Analysen und Begriffsscharfungen bietet sie die Grundlage, um die Probleme solcher Inszenierungen erkennen oder auch die Gegenstande sogenannter Vertrauenskrisen reflektieren zu konnen.

Kunst als Projektionsfläche, Kunst als Ausdruck, Kunst als Gesellschaftskritik: Die Beitragenden dieses Bandes reflektieren unterschiedliche Dimensionen und Spannungslinien des Verhältnisses von Kunst und Kritik und untersuchen dabei das künstlerische Gestaltungs- und Inszenierungspotenzial aus interdisziplinärer Perspektive. Mit der Verflechtung von wissenschaftlichen Beiträgen und Kunstperformances erschliessen sie eine Bandbreite an unterschiedlichen Bedeutungszusammenhängen und Entwicklungsdynamiken von zentralen Diskursen der Kunstlandschaft unter Berücksichtigung u.a. architektonischer, philosophischer, kunsthistorischer, musikwissenschaftlicher und aktionistischer Aspekte"--Back cover.

Is God's foreknowledge compatible with human freedom? One of the most attractive attempts to reconcile the two is the Ockhamistic view, which subscribes not only to human freedom and divine omniscience, but retains our most fundamental intuitions concerning God and time: that the past is immutable, that God exists and acts in time, and that there is no backward causation. In order to achieve all that, Ockhamists distinguish ‘hard facts’ about the past which cannot possibly be altered from ‘soft facts’ (...) about the past which are alterable, and argue that God's prior beliefs about human actions are soft facts about the past. (shrink)